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The map label for this gene is proA

Identifier: 93005153

GI number: 93005153

Start: 390011

End: 391312

Strand: Reverse

Name: proA

Synonym: Pcryo_0322

Alternate gene names: 93005153

Gene position: 391312-390011 (Counterclockwise)

Preceding gene: 93005164

Following gene: 93005152

Centisome position: 12.79

GC content: 46.62

Gene sequence:

>1302_bases
ATGAGTCAAACCAATACCACAGACGTAACCGCTTATATGCAAAATGTTGGTAAAGAAGCGCGCGCTGCATCCAGAGCACT
GGCTGCTGCCAATACGGGTGACAAAAATGCTGCACTGATGGCGATTCACGATGTATTAAAGAACGCTAAGCAAGATATTT
TAGCCGCCAATACAGTTGATATGGACAATGGACAAAAGAACGACCTAGATGCTGCGCTGCTTGATCGCTTGGAGTTAAAT
GACGCCCGCTTTGATGGCATGTTACAAGGTCTAAAAGACGTTGCGGCATTGCCTGACCCTATTGGTGAGGTTACAGACAT
GACGTATCGTCCGTCGGGTATTCATCTGGGCAAAATGCGCGTGCCACTTGGTGTGGTCGGTATGATTTATGAGTCGCGTC
CCAATGTCACTTTGGAAGCAGCCTCGCTCGCACTAAAGTCAGGTAATGCCATCATTTTACGTGGCGGCTCTGAAGCATTT
GAGTCCAATCAAGCGATTGCCAAATGTATTTTAGAAGGACTAAAAAACGTTGGTATGTCTGAGTATAGTGTCCAAGTACT
AGAGACCACTGACCGTGCTGCCGTCGGTGAGCTTATCACTATGACAGAGTATGTTGATGTTATCGTACCACGCGGCGGTA
AAGGGCTGATTGAACGTATCAGCCGCGATGCACGCGTGCCTGTTATTAAGCACTTAGATGGCAACTGTCATACCTTTATC
GACAGTGATGCTGATCCTGAGATTGCCATTAACGTGAGTGTCAATGCCAAAACCCATCGCTATGGTACTTGTAATACCAT
GGAAACCTTGTTGGTCGATGAAGCCATCGCTGATGAGCTGTTACCAAAAATTGCCGAAGCCATCGTCGAAGCCGATAATG
CGATGCAACTACGCCTTGATGATAAAGCGCAGGCTATTCTGAACGATAACACTATCCTTAAAGGCCATTTATCAGCCGCC
ACCGCTGAAGATTGGGATACCGAATATCTCGCCCCTATCCTCGCGATTAAAATATTATCCGGCATTGATGAGGCGATTGA
GCATATCAACACCCATGGCAGTCATCATACCGATGTTATCATTACAGATAACTATACCAAGTCACAGCGATTTATCCGCG
AAGTCGACTCAGCAAGCGTGATGATTAACGCCTCTAGCCGTTTTGCCGATGGTTTTGAATATGGTCTTGGTGCCGAAATT
GGTATCTCAACTGACAAGATTCATGCGCGTGGACCTGTCGGACTTGAAGGCTTAACTTCACAAAAGTGGATTGTTTATGG
TCATGGCGAAACGCGTGCCTAA

Upstream 100 bases:

>100_bases
TACTATCGAACTAATCTCCTCTATGTTAAATAGCAGAGTGCCATTAGAGCGCTAAAGAACACTGATTGTTTTCTATTTAT
AACTATAAGGAAGAATATTT

Downstream 100 bases:

>100_bases
TTTATTACGTCTTCACTACAATTTATAATGTCGTCTGCAGTATAATTGTTACAGAACGTCAGCTTAATTGCTGGCGTTTT
TTTATTATTAATAACTATAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSQTNTTDVTAYMQNVGKEARAASRALAAANTGDKNAALMAIHDVLKNAKQDILAANTVDMDNGQKNDLDAALLDRLELN
DARFDGMLQGLKDVAALPDPIGEVTDMTYRPSGIHLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAF
ESNQAIAKCILEGLKNVGMSEYSVQVLETTDRAAVGELITMTEYVDVIVPRGGKGLIERISRDARVPVIKHLDGNCHTFI
DSDADPEIAINVSVNAKTHRYGTCNTMETLLVDEAIADELLPKIAEAIVEADNAMQLRLDDKAQAILNDNTILKGHLSAA
TAEDWDTEYLAPILAIKILSGIDEAIEHINTHGSHHTDVIITDNYTKSQRFIREVDSASVMINASSRFADGFEYGLGAEI
GISTDKIHARGPVGLEGLTSQKWIVYGHGETRA

Sequences:

>Translated_433_residues
MSQTNTTDVTAYMQNVGKEARAASRALAAANTGDKNAALMAIHDVLKNAKQDILAANTVDMDNGQKNDLDAALLDRLELN
DARFDGMLQGLKDVAALPDPIGEVTDMTYRPSGIHLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAF
ESNQAIAKCILEGLKNVGMSEYSVQVLETTDRAAVGELITMTEYVDVIVPRGGKGLIERISRDARVPVIKHLDGNCHTFI
DSDADPEIAINVSVNAKTHRYGTCNTMETLLVDEAIADELLPKIAEAIVEADNAMQLRLDDKAQAILNDNTILKGHLSAA
TAEDWDTEYLAPILAIKILSGIDEAIEHINTHGSHHTDVIITDNYTKSQRFIREVDSASVMINASSRFADGFEYGLGAEI
GISTDKIHARGPVGLEGLTSQKWIVYGHGETRA
>Mature_432_residues
SQTNTTDVTAYMQNVGKEARAASRALAAANTGDKNAALMAIHDVLKNAKQDILAANTVDMDNGQKNDLDAALLDRLELND
ARFDGMLQGLKDVAALPDPIGEVTDMTYRPSGIHLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAFE
SNQAIAKCILEGLKNVGMSEYSVQVLETTDRAAVGELITMTEYVDVIVPRGGKGLIERISRDARVPVIKHLDGNCHTFID
SDADPEIAINVSVNAKTHRYGTCNTMETLLVDEAIADELLPKIAEAIVEADNAMQLRLDDKAQAILNDNTILKGHLSAAT
AEDWDTEYLAPILAIKILSGIDEAIEHINTHGSHHTDVIITDNYTKSQRFIREVDSASVMINASSRFADGFEYGLGAEIG
ISTDKIHARGPVGLEGLTSQKWIVYGHGETRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=419, Percent_Identity=34.8448687350835, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI62912457, Length=419, Percent_Identity=34.8448687350835, Blast_Score=249, Evalue=5e-66,
Organism=Escherichia coli, GI1786438, Length=421, Percent_Identity=42.9928741092637, Blast_Score=347, Evalue=9e-97,
Organism=Caenorhabditis elegans, GI17569967, Length=419, Percent_Identity=33.890214797136, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569969, Length=419, Percent_Identity=33.890214797136, Blast_Score=249, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=432, Percent_Identity=39.1203703703704, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI21357643, Length=415, Percent_Identity=39.0361445783133, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PSYCK (Q1QDZ7)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_579590.1
- ProteinModelPortal:   Q1QDZ7
- SMR:   Q1QDZ7
- STRING:   Q1QDZ7
- GeneID:   4034085
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_0322
- NMPDR:   fig|335284.3.peg.1011
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   Q1QDZ7
- ProtClustDB:   PRK00197
- BioCyc:   PCRY335284:PCRYO_0322-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46674; Mature: 46543

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTNTTDVTAYMQNVGKEARAASRALAAANTGDKNAALMAIHDVLKNAKQDILAANTVD
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEECEEE
MDNGQKNDLDAALLDRLELNDARFDGMLQGLKDVAALPDPIGEVTDMTYRPSGIHLGKMR
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEECCCCEEECEEE
VPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAFESNQAIAKCILEGLKNVGMS
CCHHHEEEEEECCCCEEEEEEHEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
EYSVQVLETTDRAAVGELITMTEYVDVIVPRGGKGLIERISRDARVPVIKHLDGNCHTFI
CEEEEEEECCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCCEECCCCEEEEE
DSDADPEIAINVSVNAKTHRYGTCNTMETLLVDEAIADELLPKIAEAIVEADNAMQLRLD
CCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
DKAQAILNDNTILKGHLSAATAEDWDTEYLAPILAIKILSGIDEAIEHINTHGSHHTDVI
CHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
ITDNYTKSQRFIREVDSASVMINASSRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTS
EECCCCHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCEECCCCCCEECCCCCCCCCCCC
QKWIVYGHGETRA
CCEEEEECCCCCC
>Mature Secondary Structure 
SQTNTTDVTAYMQNVGKEARAASRALAAANTGDKNAALMAIHDVLKNAKQDILAANTVD
CCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEECEEE
MDNGQKNDLDAALLDRLELNDARFDGMLQGLKDVAALPDPIGEVTDMTYRPSGIHLGKMR
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEECCCCEEECEEE
VPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAFESNQAIAKCILEGLKNVGMS
CCHHHEEEEEECCCCEEEEEEHEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
EYSVQVLETTDRAAVGELITMTEYVDVIVPRGGKGLIERISRDARVPVIKHLDGNCHTFI
CEEEEEEECCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCCCCCCCEECCCCEEEEE
DSDADPEIAINVSVNAKTHRYGTCNTMETLLVDEAIADELLPKIAEAIVEADNAMQLRLD
CCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
DKAQAILNDNTILKGHLSAATAEDWDTEYLAPILAIKILSGIDEAIEHINTHGSHHTDVI
CHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
ITDNYTKSQRFIREVDSASVMINASSRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTS
EECCCCHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCEECCCCCCEECCCCCCCCCCCC
QKWIVYGHGETRA
CCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA