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The map label for this gene is ribA [H]

Identifier: 93005075

GI number: 93005075

Start: 286246

End: 286920

Strand: Reverse

Name: ribA [H]

Synonym: Pcryo_0244

Alternate gene names: 93005075

Gene position: 286920-286246 (Counterclockwise)

Preceding gene: 93005078

Following gene: 93005074

Centisome position: 9.38

GC content: 44.44

Gene sequence:

>675_bases
ATGTCATATCAATTTATTACTAGCGCCAAATTGCCTACTCGTCACGGCGAGTTTGATATTCATATCTTTGAGAATGATGA
GGGTCAAGAGCATGTGATGCTGACGGTAGGTCTGCCTGTGTTTGATCAAACGGATATTGCCGACAGCAGCTTAAATCAAA
AAGATGATGCTTTATCAGAACGCCCTATTCCTTTAATAAGAATTCATTCTGAGTGCTTAACTGGTGACGCTTTTAGCTCC
TTAAAATGTGATTGCGGCCCACAGCTAAATACCGCTATGGATGCGATACAAAAAACGGGCTGCGGGGCGATTTTATATCT
GCGCCAAGAAGGGCGCGGCATCGGTCTGACCAATAAAATCCGTGCTTACGCCTTACAAGATCAAGGTCACGATACTCTAG
ATGCCAACCTTATGTTGGGGTTGCCTGCTGATGCGCGTATCTATGATATGTGCGGACCGATGCTTGCTCATGTAGGCGTT
AATGCTGTGCGCCTTATCACCAATAATCCTAGTAAAGTCGCTTACTTAACCGAGCATGGTATCGATGTCATTGAGCGGGT
GCCATTAGTCGTTGGGGTGAATGATATGAATGCTGAATATCTAGCGACCAAGCGCGATCGTATGGGTCATCTATTAGACA
CAGATTTTAATACCACCCTACACCTTAATAAATAG

Upstream 100 bases:

>100_bases
ATACTATCTTGCAAACCCGCTAGCTTACAAGAACTTAGCTATTATAATAAAGCTATGTCAGACAGTGAGCGCCACGATGA
TCAGCTTATGCAGGGCATTA

Downstream 100 bases:

>100_bases
CAAATAATCAGATATTTTATGAGCATTCCAAATATAGATAACGATATCAATGTGTCGGCGACCGATACAACAACAACACC
AAGCCATCATGACATCATGC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSYQFITSAKLPTRHGEFDIHIFENDEGQEHVMLTVGLPVFDQTDIADSSLNQKDDALSERPIPLIRIHSECLTGDAFSS
LKCDCGPQLNTAMDAIQKTGCGAILYLRQEGRGIGLTNKIRAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHVGV
NAVRLITNNPSKVAYLTEHGIDVIERVPLVVGVNDMNAEYLATKRDRMGHLLDTDFNTTLHLNK

Sequences:

>Translated_224_residues
MSYQFITSAKLPTRHGEFDIHIFENDEGQEHVMLTVGLPVFDQTDIADSSLNQKDDALSERPIPLIRIHSECLTGDAFSS
LKCDCGPQLNTAMDAIQKTGCGAILYLRQEGRGIGLTNKIRAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHVGV
NAVRLITNNPSKVAYLTEHGIDVIERVPLVVGVNDMNAEYLATKRDRMGHLLDTDFNTTLHLNK
>Mature_223_residues
SYQFITSAKLPTRHGEFDIHIFENDEGQEHVMLTVGLPVFDQTDIADSSLNQKDDALSERPIPLIRIHSECLTGDAFSSL
KCDCGPQLNTAMDAIQKTGCGAILYLRQEGRGIGLTNKIRAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHVGVN
AVRLITNNPSKVAYLTEHGIDVIERVPLVVGVNDMNAEYLATKRDRMGHLLDTDFNTTLHLNK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=214, Percent_Identity=50.9345794392523, Blast_Score=198, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=45.2941176470588, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 24720; Mature: 24589

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQFITSAKLPTRHGEFDIHIFENDEGQEHVMLTVGLPVFDQTDIADSSLNQKDDALSE
CCCEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHC
RPIPLIRIHSECLTGDAFSSLKCDCGPQLNTAMDAIQKTGCGAILYLRQEGRGIGLTNKI
CCCEEEEEECHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCE
RAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHVGVNAVRLITNNPSKVAYLTEHG
EEEEECCCCCCEECCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
IDVIERVPLVVGVNDMNAEYLATKRDRMGHLLDTDFNTTLHLNK
HHHHHHCCEEEEECCCCCHHEEHHHHHCCCEECCCCCCEEEECC
>Mature Secondary Structure 
SYQFITSAKLPTRHGEFDIHIFENDEGQEHVMLTVGLPVFDQTDIADSSLNQKDDALSE
CCEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHC
RPIPLIRIHSECLTGDAFSSLKCDCGPQLNTAMDAIQKTGCGAILYLRQEGRGIGLTNKI
CCCEEEEEECHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCE
RAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHVGVNAVRLITNNPSKVAYLTEHG
EEEEECCCCCCEECCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
IDVIERVPLVVGVNDMNAEYLATKRDRMGHLLDTDFNTTLHLNK
HHHHHHCCEEEEECCCCCHHEEHHHHHCCCEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA