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The map label for this gene is hemF [H]

Identifier: 93005074

GI number: 93005074

Start: 285217

End: 286227

Strand: Reverse

Name: hemF [H]

Synonym: Pcryo_0243

Alternate gene names: 93005074

Gene position: 286227-285217 (Counterclockwise)

Preceding gene: 93005075

Following gene: 93005073

Centisome position: 9.35

GC content: 47.58

Gene sequence:

>1011_bases
ATGAGCATTCCAAATATAGATAACGATATCAATGTGTCGGCGACCGATACAACAACAACACCAAGCCATCATGACATCAT
GCGCGTGCGTGAATTTCTAGTCGATTTGCAAGCGCGTATCTGCCAAGCCCTAGAAGCGCAAGAAAGTGATGGCTGCACTG
ATGCACAGAAAGCCACTACCTTTGTCCCTGACGATTGGGAGCGCCCTGAAGGTGGTGGTGGTCGCTCGTGCGTGTTGGCA
GACGGCGAAGTGATAGAAAAAGCCGGCGTTATGTTTAGTCATATACACGTCCAAAACCTGCCTGCTTCAGCAACTGCGCG
TCATCCTGACATTGCTGGTCGTAAAGCACAGGCAATGGGCGTATCTCTTGTTGTGCACCCCAAAAACCCTCACGTTCCCA
CTAGTCATGCCAATGTACGCTTGTTTATTGCCGAAGCAGAAGGCAAAGACCCTATTTGGTGGTTTGGTGGCGGTTTTGAT
TTAACGCCATTTTATCCTGTGCTTGCTGACTGCGTGCATTGGCATCAAGTCTGTCATGACCTCTGTGCACCTTTTGGCGA
CAGTATTTATCCTGATTTCAAGCAATGGTGCGACGAGTATTTCCATTTGCGTCATCGTGATGAGCAGCGCGGTATCGGCG
GCTTATTTTATGATGACGTCAATACTGAAAGTCGCGGTTGGGATTTTGAAACCTGCTTTAAATTTATGCAAGCGGTCGGT
AATGGCTATCTTGAAGGTATGCTACCAATTTTTGAGCAGCGTAAAAATCTGTCCTATACTGAAGCAGAGCGTGAATTTCA
GCTCTATCGCCGAGGTCGCTATGTTGAATACAACCTCGTTTATGACCGCGGCACTCTATTTGGTCTACAAAGTAATGGGC
GTATTGAATCTATCTTGGTCAGTATGCCGCCGCTTGCCAGTTGGCACTATCGCTTTGAACCAGATCAGGGCACGCCTGAG
TTTGAGTTGACTGACTTCTACCTAAAACCGCGTGATTGGTTGACTTTATAA

Upstream 100 bases:

>100_bases
TGAATATCTAGCGACCAAGCGCGATCGTATGGGTCATCTATTAGACACAGATTTTAATACCACCCTACACCTTAATAAAT
AGCAAATAATCAGATATTTT

Downstream 100 bases:

>100_bases
TCGGGATTGGCATAATAACTTACTAGTATTTATTGGTTTTGATATAAATCATTTTATTGTTCAAAAGGTCAGCTAATCAT
GCTGACCTTTTTTATTTTAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSIPNIDNDINVSATDTTTTPSHHDIMRVREFLVDLQARICQALEAQESDGCTDAQKATTFVPDDWERPEGGGGRSCVLA
DGEVIEKAGVMFSHIHVQNLPASATARHPDIAGRKAQAMGVSLVVHPKNPHVPTSHANVRLFIAEAEGKDPIWWFGGGFD
LTPFYPVLADCVHWHQVCHDLCAPFGDSIYPDFKQWCDEYFHLRHRDEQRGIGGLFYDDVNTESRGWDFETCFKFMQAVG
NGYLEGMLPIFEQRKNLSYTEAEREFQLYRRGRYVEYNLVYDRGTLFGLQSNGRIESILVSMPPLASWHYRFEPDQGTPE
FELTDFYLKPRDWLTL

Sequences:

>Translated_336_residues
MSIPNIDNDINVSATDTTTTPSHHDIMRVREFLVDLQARICQALEAQESDGCTDAQKATTFVPDDWERPEGGGGRSCVLA
DGEVIEKAGVMFSHIHVQNLPASATARHPDIAGRKAQAMGVSLVVHPKNPHVPTSHANVRLFIAEAEGKDPIWWFGGGFD
LTPFYPVLADCVHWHQVCHDLCAPFGDSIYPDFKQWCDEYFHLRHRDEQRGIGGLFYDDVNTESRGWDFETCFKFMQAVG
NGYLEGMLPIFEQRKNLSYTEAEREFQLYRRGRYVEYNLVYDRGTLFGLQSNGRIESILVSMPPLASWHYRFEPDQGTPE
FELTDFYLKPRDWLTL
>Mature_335_residues
SIPNIDNDINVSATDTTTTPSHHDIMRVREFLVDLQARICQALEAQESDGCTDAQKATTFVPDDWERPEGGGGRSCVLAD
GEVIEKAGVMFSHIHVQNLPASATARHPDIAGRKAQAMGVSLVVHPKNPHVPTSHANVRLFIAEAEGKDPIWWFGGGFDL
TPFYPVLADCVHWHQVCHDLCAPFGDSIYPDFKQWCDEYFHLRHRDEQRGIGGLFYDDVNTESRGWDFETCFKFMQAVGN
GYLEGMLPIFEQRKNLSYTEAEREFQLYRRGRYVEYNLVYDRGTLFGLQSNGRIESILVSMPPLASWHYRFEPDQGTPEF
ELTDFYLKPRDWLTL

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=312, Percent_Identity=44.2307692307692, Blast_Score=254, Evalue=6e-68,
Organism=Escherichia coli, GI1788777, Length=310, Percent_Identity=60.6451612903226, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=41.0094637223975, Blast_Score=229, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17864388, Length=330, Percent_Identity=43.3333333333333, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 38328; Mature: 38197

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPNIDNDINVSATDTTTTPSHHDIMRVREFLVDLQARICQALEAQESDGCTDAQKATT
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCC
FVPDDWERPEGGGGRSCVLADGEVIEKAGVMFSHIHVQNLPASATARHPDIAGRKAQAMG
CCCCCCCCCCCCCCCEEEEECCHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHCCC
VSLVVHPKNPHVPTSHANVRLFIAEAEGKDPIWWFGGGFDLTPFYPVLADCVHWHQVCHD
EEEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
LCAPFGDSIYPDFKQWCDEYFHLRHRDEQRGIGGLFYDDVNTESRGWDFETCFKFMQAVG
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHC
NGYLEGMLPIFEQRKNLSYTEAEREFQLYRRGRYVEYNLVYDRGTLFGLQSNGRIESILV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCEEEEEE
SMPPLASWHYRFEPDQGTPEFELTDFYLKPRDWLTL
ECCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
SIPNIDNDINVSATDTTTTPSHHDIMRVREFLVDLQARICQALEAQESDGCTDAQKATT
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCC
FVPDDWERPEGGGGRSCVLADGEVIEKAGVMFSHIHVQNLPASATARHPDIAGRKAQAMG
CCCCCCCCCCCCCCCEEEEECCHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCHHCCC
VSLVVHPKNPHVPTSHANVRLFIAEAEGKDPIWWFGGGFDLTPFYPVLADCVHWHQVCHD
EEEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
LCAPFGDSIYPDFKQWCDEYFHLRHRDEQRGIGGLFYDDVNTESRGWDFETCFKFMQAVG
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHC
NGYLEGMLPIFEQRKNLSYTEAEREFQLYRRGRYVEYNLVYDRGTLFGLQSNGRIESILV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCEEEEEE
SMPPLASWHYRFEPDQGTPEFELTDFYLKPRDWLTL
ECCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA