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The map label for this gene is yngG [H]

Identifier: 91790346

GI number: 91790346

Start: 4768926

End: 4771115

Strand: Reverse

Name: yngG [H]

Synonym: Bpro_4514

Alternate gene names: 91790346

Gene position: 4771115-4768926 (Counterclockwise)

Preceding gene: 91790350

Following gene: 91790345

Centisome position: 91.75

GC content: 65.98

Gene sequence:

>2190_bases
ATGAATGCAACCATGTCAAATTCTCACGTATTGATCAGTGAAGTCGGCCCCCGCGACGGTCTGCAATCGGTCAAGGCCAC
CATGCCGACAGCCGACAAGCTGCGCTGGATTGACGCGCTTTACAAAGCCGGCGTGCGCGAAATTGAAGTGGCTTCCTTCG
TGCCGGCCCGGCTGCTGCCGCAGATGGCCGATGCCGCTGAGGTGGTGCGCCATGCGATCACGCTGCCCGGCCTCACGGTG
ATGGCGCTGGTGCCCAACCGCCGCGGCGCGGAGGCGGCGCTGGCGGCCGGCGTGCACAAGCTGACGATGCCGGTGTCGGC
CAGTGCCGCGCATTCGCTGGCCAATGTGCGCAAGACGCGCGAAGAGATGGTCGAGGAAGTGCGCGCCATCTCTGACCTGC
GCCGCGATCTCGCGCCTCACGTCAGGCTCGAAGCCGCCATTTCCACCGCCTTCGGTTGCACGCTGCAGGGCGAGGTGCCC
GAAGACGACGTGATCCGGCTGGCCGCGCAATGCATTGCGGCCGGTGCCGACGAGTCGGGCCTGTCGGACACCGTCGGCTA
TGCCAACCCGGCGCAGGTGCGCCGCCTGTTCCGGCGCCTGCGTGCCGAAATCGGCCGCCACGCCGGCGCGGCCCACATGC
ACAACACCCGCGGCCTGGGCCTGGCCAATTGCCTGGCCGCGTATGACGAAGGCGTTCGCACCTTCGACGCGTCGCTCGGT
GGCCTGGGCGGCTGCCCCTATGCGCCGGGCGCGTCGGGCAACGTCGTCACCGAAGACCTGGTTTTCATGTTCGAGGCCAT
GGGCGTGCCGACCGGCATTGATCTCGAAAAACTCATGGCCGCGCGCGCGCCGCTGATGGCCGGGCTGCCGGGCGAGCCGG
TGTATGGCATGACACCCGAGGCCGGCCTGCCCAGGGGCTTTGTCCAGGGCGCACGCATGACGGCAACTGCCACACCCATC
CCTGACGAAAGCAACAACAGCAGCAACAGCGAGATCAGCGACACACCGCTGCCCTACGCCGGCATCCGCGTCGTCGAATT
CACCCACATGGTGATGGGCCCGACCTGCGGCCTGCTGCTGGGCGACCTGGGCGCCGAGGTCATCAAGGTGGAGCCGGTCG
AGGGCGACAGCACGCGCCGCCTGCTGGGCTCGGGCGCCGGATTTTTCCCGACCTTCAACCGCAACAAGAAAAGCATTGCG
CTCGACCTGAAGACGCCCGAAGGCGTGGAGGCCGCGCTGCGCCTGATTGCCACGGCAGACATCGTCAGCGAGAACTTCAA
ACCCGGCACCATGAAGAAGCTGGGTCTGGACTACGAGACGCTGAAGCAGCGCCACCCGCGCCTGATCTATGTCAGTCACA
AGGGTTTTTTGCCCGGGCCTTACGAGCATCGCACCGCCCTGGATGAAGTGGTGCAGATGATGGGCGGGCTGGCCTACATG
ACGGGCCGCAGCGGCGACCCCCTGCGCGCAGGCACCAGCGTCAACGACATCATGGGCGGCATGTTTGGCGCCATAGGGGC
GATGGCCGCCTTGCGCCAGCGCGAACGCACCGGGCTGGGCACGGAGGTGCAGTCGGCCTTGTTTGAAAACAATGTGTTCC
TGGTGGGCCAGCACATGATGCAGTTCGCCGCCACCGGCCATGCCGCCGCGCCCATGCCCAGCCGCATTTCGGCGTGGGCG
GTGTACGACGTGTTCACCGTGAAAGACGGCGAACAGATTTTTCTGGCGGCCGTCAGCGACAAGCAATGGGCGATTTTCTG
CAAGGCCTTTGGGCTGGACGAGCTGCTGGTCGACCCGCGCCTCAAAACCAACAACGACCGCGTGCGCGCCCGGGAGTGGA
TGATGCCCATCCTGCGCTCGCACCTGGCCGAGCGCAGCGCGGCTGAACTCCGCGCGGTGTTTGAAGCCAACGAATTGCCT
TTTGCACCCATCGTGCGGCCTGAAGAGCTTTTTGGGGATCCGCACCTGAACGCGACCGGTGGCCTGGCGCCCGTCCGGAT
GAACGACGGCAGCCAGTCCAAAGTGCCGCTGATGCCCTTCACGCTGGGCGGCAAACGGCCCGGTATCCGGCTGCAGCCGC
CGCTGCTGGGCGAGCACAGCCGCGAATTGCTGCTGGAGCTGGGCTATGGCGAAGACGCCATCCAGGCTTTCCAGAATTCC
GCCGAAAGCATCGCTCAAAGCAACCGTTAA

Upstream 100 bases:

>100_bases
GATCATGAAGCGGACCTTGCCGCTGGACGCTTGACAAGCGTCCGAGCTTCAGTGATTATTTCAACAGAAAGAACGACGTT
CTATCTTACAGAATTATTTA

Downstream 100 bases:

>100_bases
ACCCCAGACCCCCACCCCCAAGAAACCACACCCGGAGACACACCCTTGAACTTCAAACGACGCACCCTGATGACCACGAC
CCTGATGACGGCGGCACTGT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MNATMSNSHVLISEVGPRDGLQSVKATMPTADKLRWIDALYKAGVREIEVASFVPARLLPQMADAAEVVRHAITLPGLTV
MALVPNRRGAEAALAAGVHKLTMPVSASAAHSLANVRKTREEMVEEVRAISDLRRDLAPHVRLEAAISTAFGCTLQGEVP
EDDVIRLAAQCIAAGADESGLSDTVGYANPAQVRRLFRRLRAEIGRHAGAAHMHNTRGLGLANCLAAYDEGVRTFDASLG
GLGGCPYAPGASGNVVTEDLVFMFEAMGVPTGIDLEKLMAARAPLMAGLPGEPVYGMTPEAGLPRGFVQGARMTATATPI
PDESNNSSNSEISDTPLPYAGIRVVEFTHMVMGPTCGLLLGDLGAEVIKVEPVEGDSTRRLLGSGAGFFPTFNRNKKSIA
LDLKTPEGVEAALRLIATADIVSENFKPGTMKKLGLDYETLKQRHPRLIYVSHKGFLPGPYEHRTALDEVVQMMGGLAYM
TGRSGDPLRAGTSVNDIMGGMFGAIGAMAALRQRERTGLGTEVQSALFENNVFLVGQHMMQFAATGHAAAPMPSRISAWA
VYDVFTVKDGEQIFLAAVSDKQWAIFCKAFGLDELLVDPRLKTNNDRVRAREWMMPILRSHLAERSAAELRAVFEANELP
FAPIVRPEELFGDPHLNATGGLAPVRMNDGSQSKVPLMPFTLGGKRPGIRLQPPLLGEHSRELLLELGYGEDAIQAFQNS
AESIAQSNR

Sequences:

>Translated_729_residues
MNATMSNSHVLISEVGPRDGLQSVKATMPTADKLRWIDALYKAGVREIEVASFVPARLLPQMADAAEVVRHAITLPGLTV
MALVPNRRGAEAALAAGVHKLTMPVSASAAHSLANVRKTREEMVEEVRAISDLRRDLAPHVRLEAAISTAFGCTLQGEVP
EDDVIRLAAQCIAAGADESGLSDTVGYANPAQVRRLFRRLRAEIGRHAGAAHMHNTRGLGLANCLAAYDEGVRTFDASLG
GLGGCPYAPGASGNVVTEDLVFMFEAMGVPTGIDLEKLMAARAPLMAGLPGEPVYGMTPEAGLPRGFVQGARMTATATPI
PDESNNSSNSEISDTPLPYAGIRVVEFTHMVMGPTCGLLLGDLGAEVIKVEPVEGDSTRRLLGSGAGFFPTFNRNKKSIA
LDLKTPEGVEAALRLIATADIVSENFKPGTMKKLGLDYETLKQRHPRLIYVSHKGFLPGPYEHRTALDEVVQMMGGLAYM
TGRSGDPLRAGTSVNDIMGGMFGAIGAMAALRQRERTGLGTEVQSALFENNVFLVGQHMMQFAATGHAAAPMPSRISAWA
VYDVFTVKDGEQIFLAAVSDKQWAIFCKAFGLDELLVDPRLKTNNDRVRAREWMMPILRSHLAERSAAELRAVFEANELP
FAPIVRPEELFGDPHLNATGGLAPVRMNDGSQSKVPLMPFTLGGKRPGIRLQPPLLGEHSRELLLELGYGEDAIQAFQNS
AESIAQSNR
>Mature_729_residues
MNATMSNSHVLISEVGPRDGLQSVKATMPTADKLRWIDALYKAGVREIEVASFVPARLLPQMADAAEVVRHAITLPGLTV
MALVPNRRGAEAALAAGVHKLTMPVSASAAHSLANVRKTREEMVEEVRAISDLRRDLAPHVRLEAAISTAFGCTLQGEVP
EDDVIRLAAQCIAAGADESGLSDTVGYANPAQVRRLFRRLRAEIGRHAGAAHMHNTRGLGLANCLAAYDEGVRTFDASLG
GLGGCPYAPGASGNVVTEDLVFMFEAMGVPTGIDLEKLMAARAPLMAGLPGEPVYGMTPEAGLPRGFVQGARMTATATPI
PDESNNSSNSEISDTPLPYAGIRVVEFTHMVMGPTCGLLLGDLGAEVIKVEPVEGDSTRRLLGSGAGFFPTFNRNKKSIA
LDLKTPEGVEAALRLIATADIVSENFKPGTMKKLGLDYETLKQRHPRLIYVSHKGFLPGPYEHRTALDEVVQMMGGLAYM
TGRSGDPLRAGTSVNDIMGGMFGAIGAMAALRQRERTGLGTEVQSALFENNVFLVGQHMMQFAATGHAAAPMPSRISAWA
VYDVFTVKDGEQIFLAAVSDKQWAIFCKAFGLDELLVDPRLKTNNDRVRAREWMMPILRSHLAERSAAELRAVFEANELP
FAPIVRPEELFGDPHLNATGGLAPVRMNDGSQSKVPLMPFTLGGKRPGIRLQPPLLGEHSRELLLELGYGEDAIQAFQNS
AESIAQSNR

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG1804

COG function: function code C; Predicted acyl-CoA transferases/carnitine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI300863128, Length=399, Percent_Identity=32.5814536340852, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI62198232, Length=272, Percent_Identity=38.9705882352941, Blast_Score=195, Evalue=2e-49,
Organism=Homo sapiens, GI109150422, Length=272, Percent_Identity=38.2352941176471, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI109150427, Length=272, Percent_Identity=38.2352941176471, Blast_Score=193, Evalue=5e-49,
Organism=Homo sapiens, GI300863124, Length=421, Percent_Identity=32.3040380047506, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI300863126, Length=389, Percent_Identity=30.3341902313625, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI13376042, Length=421, Percent_Identity=29.4536817102138, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI266456254, Length=399, Percent_Identity=28.0701754385965, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI42794625, Length=399, Percent_Identity=28.0701754385965, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI260654708, Length=107, Percent_Identity=46.7289719626168, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI266458393, Length=277, Percent_Identity=29.6028880866426, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI266458397, Length=270, Percent_Identity=29.6296296296296, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI266458395, Length=117, Percent_Identity=38.4615384615385, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI42822893, Length=117, Percent_Identity=38.4615384615385, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI87082093, Length=327, Percent_Identity=34.2507645259939, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1788717, Length=413, Percent_Identity=31.7191283292978, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI1786222, Length=391, Percent_Identity=27.3657289002558, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786261, Length=283, Percent_Identity=24.3816254416961, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510563, Length=269, Percent_Identity=36.0594795539033, Blast_Score=180, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32564160, Length=318, Percent_Identity=23.8993710691824, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115535051, Length=318, Percent_Identity=21.6981132075472, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648431, Length=395, Percent_Identity=34.6835443037975, Blast_Score=218, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24582381, Length=276, Percent_Identity=39.1304347826087, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24585488, Length=323, Percent_Identity=26.625386996904, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 78252; Mature: 78252

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATMSNSHVLISEVGPRDGLQSVKATMPTADKLRWIDALYKAGVREIEVASFVPARLLP
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHCHHHHHH
QMADAAEVVRHAITLPGLTVMALVPNRRGAEAALAAGVHKLTMPVSASAAHSLANVRKTR
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCHHHEECCCCHHHHHHHHHHHHHH
EEMVEEVRAISDLRRDLAPHVRLEAAISTAFGCTLQGEVPEDDVIRLAAQCIAAGADESG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCC
LSDTVGYANPAQVRRLFRRLRAEIGRHAGAAHMHNTRGLGLANCLAAYDEGVRTFDASLG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
GLGGCPYAPGASGNVVTEDLVFMFEAMGVPTGIDLEKLMAARAPLMAGLPGEPVYGMTPE
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCC
AGLPRGFVQGARMTATATPIPDESNNSSNSEISDTPLPYAGIRVVEFTHMVMGPTCGLLL
CCCCHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCHHHHHH
GDLGAEVIKVEPVEGDSTRRLLGSGAGFFPTFNRNKKSIALDLKTPEGVEAALRLIATAD
HHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
IVSENFKPGTMKKLGLDYETLKQRHPRLIYVSHKGFLPGPYEHRTALDEVVQMMGGLAYM
HHHCCCCCCCHHHHCCCHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEE
TGRSGDPLRAGTSVNDIMGGMFGAIGAMAALRQRERTGLGTEVQSALFENNVFLVGQHMM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEHHHH
QFAATGHAAAPMPSRISAWAVYDVFTVKDGEQIFLAAVSDKQWAIFCKAFGLDELLVDPR
HHHHCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCHHHHCCCC
LKTNNDRVRAREWMMPILRSHLAERSAAELRAVFEANELPFAPIVRPEELFGDPHLNATG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCC
GLAPVRMNDGSQSKVPLMPFTLGGKRPGIRLQPPLLGEHSRELLLELGYGEDAIQAFQNS
CEEEEEECCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCHHHHEECCCCHHHHHHHHHH
AESIAQSNR
HHHHHHCCC
>Mature Secondary Structure
MNATMSNSHVLISEVGPRDGLQSVKATMPTADKLRWIDALYKAGVREIEVASFVPARLLP
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHCHHHHHH
QMADAAEVVRHAITLPGLTVMALVPNRRGAEAALAAGVHKLTMPVSASAAHSLANVRKTR
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCHHHEECCCCHHHHHHHHHHHHHH
EEMVEEVRAISDLRRDLAPHVRLEAAISTAFGCTLQGEVPEDDVIRLAAQCIAAGADESG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCC
LSDTVGYANPAQVRRLFRRLRAEIGRHAGAAHMHNTRGLGLANCLAAYDEGVRTFDASLG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
GLGGCPYAPGASGNVVTEDLVFMFEAMGVPTGIDLEKLMAARAPLMAGLPGEPVYGMTPE
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCC
AGLPRGFVQGARMTATATPIPDESNNSSNSEISDTPLPYAGIRVVEFTHMVMGPTCGLLL
CCCCHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCHHHHHH
GDLGAEVIKVEPVEGDSTRRLLGSGAGFFPTFNRNKKSIALDLKTPEGVEAALRLIATAD
HHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
IVSENFKPGTMKKLGLDYETLKQRHPRLIYVSHKGFLPGPYEHRTALDEVVQMMGGLAYM
HHHCCCCCCCHHHHCCCHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEE
TGRSGDPLRAGTSVNDIMGGMFGAIGAMAALRQRERTGLGTEVQSALFENNVFLVGQHMM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEHHHH
QFAATGHAAAPMPSRISAWAVYDVFTVKDGEQIFLAAVSDKQWAIFCKAFGLDELLVDPR
HHHHCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCHHHHCCCC
LKTNNDRVRAREWMMPILRSHLAERSAAELRAVFEANELPFAPIVRPEELFGDPHLNATG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCC
GLAPVRMNDGSQSKVPLMPFTLGGKRPGIRLQPPLLGEHSRELLLELGYGEDAIQAFQNS
CEEEEEECCCCCCCCCEEEEECCCCCCCCEECCCCCCCCCHHHHEECCCCHHHHHHHHHH
AESIAQSNR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]