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The map label for this gene is glxR [H]

Identifier: 91788962

GI number: 91788962

Start: 3274587

End: 3275468

Strand: Reverse

Name: glxR [H]

Synonym: Bpro_3102

Alternate gene names: 91788962

Gene position: 3275468-3274587 (Counterclockwise)

Preceding gene: 91788963

Following gene: 91788961

Centisome position: 62.99

GC content: 61.56

Gene sequence:

>882_bases
ATGAGCAAGCTTGGTTTTATCGGCCTGGGCATCATGGGATCGCCGATGGCGTCCCACCTGATCACCGCAGGGCATGAGGT
TTTTCTGCACACGCGCAGCAAGGTACCTGCCGACCTGCTCACGGGCAAGGCGAAAGCCTGCAGTTCCATCCGCGAAGTGG
CCGAGCAGGCCGACATCATTTTTCTGATGCTGCCCGACACGCCCGATGTGGCCAAGGTGCTGTTCGGTGAAAACGGCGTG
GCCTCCGGTTTGACCAAAGGCAAGACGGTCGTCGACATGAGTTCCATCTCGCCGATGGAGACCAAGGAATTTGCCCAAAA
AATCAATGCACTGGATTGCGACTACCTCGATGCGCCGGTATCGGGCGGTGAAGTGGGCGCCAAAGCCGCCAGCCTCACCA
TCATGGTGGGTGGTCCCGACGCGGTATTTGAACGGGTCCGGCCGCTGTTTGAGCTGATGGGCAAGAACATCACGCTGGTG
GGTGGCAATGGCGACGGGCAAACCTGCAAGGTTGCCAACCAGATCATTGTGGCGCTGAACATCGCCGCTGTCGGTGAAGC
GCTGCTGTTCGCCAGCAAGGCGGGGGCTGACCCTGCCAAGGTGCGCCAGGCGCTGATGGGCGGTTTCGCCTCTTCCCGCA
TTCTTGAGGTGCACGGCGAACGCATGATCAAGCGGACTTTTGCACCGGGCTTCCGGATTGGCCTGCACCAGAAGGATTTG
AGCCTGGCCCTGGCCGGCGCGAGAACCCTGGGTGTGGCCCTGCCGCAAACCGCAGGGGCGGCGCAATTGATGCAGGCCTG
CAGCGCCAACGGCATGCAGGACCTCGATCACTCCGCGCTGGTGCGTGCGCTGGAGCTGATGGCCAACCATGAGATTGCCT
GA

Upstream 100 bases:

>100_bases
GGCAGCGACCTGGGCACCTTCCGCTCGGCCACGCAGGCCCTGCGCGACCGTTACCGCGCATGACGGATATTTCTTCAATA
ACTTGGACTGGAGTCACAAA

Downstream 100 bases:

>100_bases
AGGCCCCAGCCCCATCACCTGATTTCAGAGGTTCATGGCCGCAGGCTGCGGCTGGTTTTTTTCCAAACAGAGAAGGCAAG
ATCATGTCCATCAATCGAAG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSKLGFIGLGIMGSPMASHLITAGHEVFLHTRSKVPADLLTGKAKACSSIREVAEQADIIFLMLPDTPDVAKVLFGENGV
ASGLTKGKTVVDMSSISPMETKEFAQKINALDCDYLDAPVSGGEVGAKAASLTIMVGGPDAVFERVRPLFELMGKNITLV
GGNGDGQTCKVANQIIVALNIAAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMIKRTFAPGFRIGLHQKDL
SLALAGARTLGVALPQTAGAAQLMQACSANGMQDLDHSALVRALELMANHEIA

Sequences:

>Translated_293_residues
MSKLGFIGLGIMGSPMASHLITAGHEVFLHTRSKVPADLLTGKAKACSSIREVAEQADIIFLMLPDTPDVAKVLFGENGV
ASGLTKGKTVVDMSSISPMETKEFAQKINALDCDYLDAPVSGGEVGAKAASLTIMVGGPDAVFERVRPLFELMGKNITLV
GGNGDGQTCKVANQIIVALNIAAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMIKRTFAPGFRIGLHQKDL
SLALAGARTLGVALPQTAGAAQLMQACSANGMQDLDHSALVRALELMANHEIA
>Mature_292_residues
SKLGFIGLGIMGSPMASHLITAGHEVFLHTRSKVPADLLTGKAKACSSIREVAEQADIIFLMLPDTPDVAKVLFGENGVA
SGLTKGKTVVDMSSISPMETKEFAQKINALDCDYLDAPVSGGEVGAKAASLTIMVGGPDAVFERVRPLFELMGKNITLVG
GNGDGQTCKVANQIIVALNIAAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMIKRTFAPGFRIGLHQKDLS
LALAGARTLGVALPQTAGAAQLMQACSANGMQDLDHSALVRALELMANHEIA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=30.4794520547945, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=29.3286219081272, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=69.4158075601375, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=43.9862542955326, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1790315, Length=292, Percent_Identity=31.5068493150685, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=29.4520547945205, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=258, Percent_Identity=34.8837209302326, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24655230, Length=286, Percent_Identity=34.6153846153846, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19922568, Length=286, Percent_Identity=34.6153846153846, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=27.6595744680851, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30520; Mature: 30389

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLGFIGLGIMGSPMASHLITAGHEVFLHTRSKVPADLLTGKAKACSSIREVAEQADII
CCCCCEEECCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCEE
FLMLPDTPDVAKVLFGENGVASGLTKGKTVVDMSSISPMETKEFAQKINALDCDYLDAPV
EEECCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
SGGEVGAKAASLTIMVGGPDAVFERVRPLFELMGKNITLVGGNGDGQTCKVANQIIVALN
CCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEEHEEE
IAAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMIKRTFAPGFRIGLHQKDL
HHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHHHCCCCCEECCCCCCH
SLALAGARTLGVALPQTAGAAQLMQACSANGMQDLDHSALVRALELMANHEIA
HHHHHCHHHHHEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKLGFIGLGIMGSPMASHLITAGHEVFLHTRSKVPADLLTGKAKACSSIREVAEQADII
CCCCEEECCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCEE
FLMLPDTPDVAKVLFGENGVASGLTKGKTVVDMSSISPMETKEFAQKINALDCDYLDAPV
EEECCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
SGGEVGAKAASLTIMVGGPDAVFERVRPLFELMGKNITLVGGNGDGQTCKVANQIIVALN
CCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEEHEEE
IAAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMIKRTFAPGFRIGLHQKDL
HHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHHHCCCCCEECCCCCCH
SLALAGARTLGVALPQTAGAAQLMQACSANGMQDLDHSALVRALELMANHEIA
HHHHHCHHHHHEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]