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The map label for this gene is phoR [H]

Identifier: 91786899

GI number: 91786899

Start: 1014571

End: 1016031

Strand: Direct

Name: phoR [H]

Synonym: Bpro_0999

Alternate gene names: 91786899

Gene position: 1014571-1016031 (Clockwise)

Preceding gene: 91786898

Following gene: 91786914

Centisome position: 19.51

GC content: 61.46

Gene sequence:

>1461_bases
ATGAGTCCCACCTCTGTGAACGACGCCGACGGGAGCGTTCAAACCAGGAGCGCTCCGGAGATCCCGCGCGAGGCTTGGGT
CGAAATGGAGTTGATCCATACGTTCATGCGGTATGCGCGGCCCTCACTGCATGCGGCATTGGCCCTGATTGTCGTTATCG
TGATGATCCTTTACGGGCATGTGGAGCCTGTCGGCCTCTGGCTATGGGCGGCGGCGGTCACGGCTGCGACCTTGGCGCGC
TTCTGGGTCATCGGCATCTACCACCGCACAATGCAGGGGGTCAGTGGTGCGCCGCTGCACGCTTTCATGGCGCGCTTCGC
CTGGATCTGGCCTTTAAGTGCCGTGATCTGGGGAAGTTCCATGTTTGTGTTCTTCCTGAAGGCGCCTATCTATGACCAGT
TCATCTGCATGACTGTTCTGGTTGGCATGGCCGGTTTTGCCGTCGGAACTTTCTCCTCCCACCTTCGCTGCTTTTCCGCT
TATGTCAATGGACTGGTGGCGTCGGTTCTGGCTGCACTGGTTTACCAGCTGGTGGTGGAGCGTGGCATCCCGTCCACGTT
CAATACCTACGGCATGGTGGCGCTGGTGCTGATTTACTGGGCCGTGATCCGCATTTCGGGCAAACGGTTTCATGAAGTGC
AGCGGGCCAATCTCGCATTGCAGTTTGACAATTCGAAATTGATCACTTCGCTGACAGAAAAGAGCCGGGCCGCACTGGAG
GCGGTAGAAATCAAGAACCGGTTTATCGCCAGCGCCGCCCATGATTTGCGGCAGCCGGTACACGCGCTGGGCCTGTATGC
GGACTGGCTGGCTGCTGAACCGCAATTCGTCTCGCAGATCGCGCCAAAAATCGTCCGCTCTACCCGGGCAGTCGAGGATT
TGTTCAACTCTCTTTTCGATCTTGCCGGACTGGATTCGGACCCCTCGAGGGTCAACCTGCAGGATGTTGATCTGGCGGGC
CTTCTCCAGGACCTGGAGGTGCAATACACCCCCCTGGCTGCGGAGCGTGGCCTGCGGCTGCGAACCCGGGTCGTGCCCGG
CCGCGTGAGGTCTGACCCGGTGCTGCTCAAGCGGCTGCTCGGCAACCTGCTGTCGAACGCCTTGCGAAACACGCACCAGG
GCGGCGTTCTGCTGGCAGTGCGGCGAAGACAGGGGGTGCGCTGCATCGAAATCTGGGACACCGGCGTGGGCATTGCCCAG
ACTCACCAGCAGGCGATCTTTCAGGAGTTTTACCGAATTCCCCAGCAGGGTACGGAAGAAGGCTTCGGCCTGGGGCTGGC
CATCGTCTCCCGCCTGAGCTACGTGCTCAACCACCCGGTGGGCATGTCATCCCGGGCGGGCCGGGGCAGTGTGTTCTGGG
TGGCGCTGACGAGTCCTGGCGATGACGCCGGAGGTGCGAGCCCGGCGGCTACAGCAGGCCCTGGGTCCGGGCGAGATGAC
TGGCCTGCGAGCGGCTCTTGA

Upstream 100 bases:

>100_bases
GGCAGCGCATTTGAACATTGTCAGCTGCGCGCAACGCTGTTTGTTGGCCACTGGAGCAGTAAAGGTCTGCCAATAGACAT
GCGACGGTAAACTGACAGCC

Downstream 100 bases:

>100_bases
CGTTCAGGCGCCGGAACAGGCGCCACAGATGCACCTTGACCGTGTGCTCGCTGATTTGAAGCTCTTCTGCGATGTCGCGG
TTACTCATGCCCTTGTCGAG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSPTSVNDADGSVQTRSAPEIPREAWVEMELIHTFMRYARPSLHAALALIVVIVMILYGHVEPVGLWLWAAAVTAATLAR
FWVIGIYHRTMQGVSGAPLHAFMARFAWIWPLSAVIWGSSMFVFFLKAPIYDQFICMTVLVGMAGFAVGTFSSHLRCFSA
YVNGLVASVLAALVYQLVVERGIPSTFNTYGMVALVLIYWAVIRISGKRFHEVQRANLALQFDNSKLITSLTEKSRAALE
AVEIKNRFIASAAHDLRQPVHALGLYADWLAAEPQFVSQIAPKIVRSTRAVEDLFNSLFDLAGLDSDPSRVNLQDVDLAG
LLQDLEVQYTPLAAERGLRLRTRVVPGRVRSDPVLLKRLLGNLLSNALRNTHQGGVLLAVRRRQGVRCIEIWDTGVGIAQ
THQQAIFQEFYRIPQQGTEEGFGLGLAIVSRLSYVLNHPVGMSSRAGRGSVFWVALTSPGDDAGGASPAATAGPGSGRDD
WPASGS

Sequences:

>Translated_486_residues
MSPTSVNDADGSVQTRSAPEIPREAWVEMELIHTFMRYARPSLHAALALIVVIVMILYGHVEPVGLWLWAAAVTAATLAR
FWVIGIYHRTMQGVSGAPLHAFMARFAWIWPLSAVIWGSSMFVFFLKAPIYDQFICMTVLVGMAGFAVGTFSSHLRCFSA
YVNGLVASVLAALVYQLVVERGIPSTFNTYGMVALVLIYWAVIRISGKRFHEVQRANLALQFDNSKLITSLTEKSRAALE
AVEIKNRFIASAAHDLRQPVHALGLYADWLAAEPQFVSQIAPKIVRSTRAVEDLFNSLFDLAGLDSDPSRVNLQDVDLAG
LLQDLEVQYTPLAAERGLRLRTRVVPGRVRSDPVLLKRLLGNLLSNALRNTHQGGVLLAVRRRQGVRCIEIWDTGVGIAQ
THQQAIFQEFYRIPQQGTEEGFGLGLAIVSRLSYVLNHPVGMSSRAGRGSVFWVALTSPGDDAGGASPAATAGPGSGRDD
WPASGS
>Mature_485_residues
SPTSVNDADGSVQTRSAPEIPREAWVEMELIHTFMRYARPSLHAALALIVVIVMILYGHVEPVGLWLWAAAVTAATLARF
WVIGIYHRTMQGVSGAPLHAFMARFAWIWPLSAVIWGSSMFVFFLKAPIYDQFICMTVLVGMAGFAVGTFSSHLRCFSAY
VNGLVASVLAALVYQLVVERGIPSTFNTYGMVALVLIYWAVIRISGKRFHEVQRANLALQFDNSKLITSLTEKSRAALEA
VEIKNRFIASAAHDLRQPVHALGLYADWLAAEPQFVSQIAPKIVRSTRAVEDLFNSLFDLAGLDSDPSRVNLQDVDLAGL
LQDLEVQYTPLAAERGLRLRTRVVPGRVRSDPVLLKRLLGNLLSNALRNTHQGGVLLAVRRRQGVRCIEIWDTGVGIAQT
HQQAIFQEFYRIPQQGTEEGFGLGLAIVSRLSYVLNHPVGMSSRAGRGSVFWVALTSPGDDAGGASPAATAGPGSGRDDW
PASGS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.7310924369748, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=269, Percent_Identity=30.1115241635688, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=25.6198347107438, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=28.3720930232558, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789149, Length=258, Percent_Identity=25.5813953488372, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=360, Percent_Identity=25, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787894, Length=217, Percent_Identity=28.110599078341, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=27.5720164609054, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=27.0742358078603, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53108; Mature: 52977

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTSVNDADGSVQTRSAPEIPREAWVEMELIHTFMRYARPSLHAALALIVVIVMILYGH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
VEPVGLWLWAAAVTAATLARFWVIGIYHRTMQGVSGAPLHAFMARFAWIWPLSAVIWGSS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCH
MFVFFLKAPIYDQFICMTVLVGMAGFAVGTFSSHLRCFSAYVNGLVASVLAALVYQLVVE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGIPSTFNTYGMVALVLIYWAVIRISGKRFHEVQRANLALQFDNSKLITSLTEKSRAALE
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHH
AVEIKNRFIASAAHDLRQPVHALGLYADWLAAEPQFVSQIAPKIVRSTRAVEDLFNSLFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGLDSDPSRVNLQDVDLAGLLQDLEVQYTPLAAERGLRLRTRVVPGRVRSDPVLLKRLL
HCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHH
GNLLSNALRNTHQGGVLLAVRRRQGVRCIEIWDTGVGIAQTHQQAIFQEFYRIPQQGTEE
HHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
GFGLGLAIVSRLSYVLNHPVGMSSRAGRGSVFWVALTSPGDDAGGASPAATAGPGSGRDD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
WPASGS
CCCCCC
>Mature Secondary Structure 
SPTSVNDADGSVQTRSAPEIPREAWVEMELIHTFMRYARPSLHAALALIVVIVMILYGH
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
VEPVGLWLWAAAVTAATLARFWVIGIYHRTMQGVSGAPLHAFMARFAWIWPLSAVIWGSS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCH
MFVFFLKAPIYDQFICMTVLVGMAGFAVGTFSSHLRCFSAYVNGLVASVLAALVYQLVVE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGIPSTFNTYGMVALVLIYWAVIRISGKRFHEVQRANLALQFDNSKLITSLTEKSRAALE
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHH
AVEIKNRFIASAAHDLRQPVHALGLYADWLAAEPQFVSQIAPKIVRSTRAVEDLFNSLFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGLDSDPSRVNLQDVDLAGLLQDLEVQYTPLAAERGLRLRTRVVPGRVRSDPVLLKRLL
HCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHH
GNLLSNALRNTHQGGVLLAVRRRQGVRCIEIWDTGVGIAQTHQQAIFQEFYRIPQQGTEE
HHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
GFGLGLAIVSRLSYVLNHPVGMSSRAGRGSVFWVALTSPGDDAGGASPAATAGPGSGRDD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCC
WPASGS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]