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The map label for this gene is gacA [H]

Identifier: 91786783

GI number: 91786783

Start: 901723

End: 902355

Strand: Direct

Name: gacA [H]

Synonym: Bpro_0881

Alternate gene names: 91786783

Gene position: 901723-902355 (Clockwise)

Preceding gene: 91786776

Following gene: 91786785

Centisome position: 17.34

GC content: 56.56

Gene sequence:

>633_bases
ATGATAAAAATTGGAATTGTTGATGACCATGCCATCGTGCGTTCGGGACTCAAACAGTTTTTCTCGGACCAGGTGGATCT
GCGTGTCGTCGGTGAGGCCGCCAGCGGCCGCGAGGCGATTGACCTGGTTCGAAATGTCGAGCTGGACATTCTGGTCATGG
ACCTGTCCATGCCCGGCCAGAGCGGCATCGATGCACTGGCCATGATCCGCGCCAAAGCCCCCGACGTCGGCATTCTTATC
CTGAGCGGCTACCCCGAGGAACACTATGCGGTCAACCTGATTCGCCAAGGGGCCAGTGGCTACCTCAACAAGGAGTGCGA
TCCGTCTGAAATTGTCGATGCCATCCGTGTCATCTCGCTTGGCAAGCGCTACATCACGCCGGCGGTGGCAGAACTGCTGG
CGCAACAACTGAACCGGCCCCACGACGTCGCCTCCCACGAGCAATTGTCGGAACGGGAGTTTCAGGTGTTCCTGAAGCTG
GCCAAAGGGGAAACGGCCGGTGATATTGCAAAAGCGCTTTCGCTGAGCGTGAAAACCGTCAGTACCTACAGAACCCGCGT
GATGGAAAAAATGAGTCTGGCGTCGAACAGCGATCTGACCTACTACGCGCTCAAGAACAAGTTGATTGACTGA

Upstream 100 bases:

>100_bases
TAATGGGCACTAAAGCCAATGCGGATGTCCGGTCCGGCCATCCTTTTCATTGCGTTGATTGCGTTGCCTGCTCGTGCGGG
CTTTATGGAAAGACAGCGAC

Downstream 100 bases:

>100_bases
CTTCAAGCAGTACTGCCGCTCTGCTGGATGCCGCTCTGCTGGATGCAATAGTCCACCAGCGCGTCAATTTCGTTGGACTT
GTCAAACACCGCATCGACGC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Global activator [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIKIGIVDDHAIVRSGLKQFFSDQVDLRVVGEAASGREAIDLVRNVELDILVMDLSMPGQSGIDALAMIRAKAPDVGILI
LSGYPEEHYAVNLIRQGASGYLNKECDPSEIVDAIRVISLGKRYITPAVAELLAQQLNRPHDVASHEQLSEREFQVFLKL
AKGETAGDIAKALSLSVKTVSTYRTRVMEKMSLASNSDLTYYALKNKLID

Sequences:

>Translated_210_residues
MIKIGIVDDHAIVRSGLKQFFSDQVDLRVVGEAASGREAIDLVRNVELDILVMDLSMPGQSGIDALAMIRAKAPDVGILI
LSGYPEEHYAVNLIRQGASGYLNKECDPSEIVDAIRVISLGKRYITPAVAELLAQQLNRPHDVASHEQLSEREFQVFLKL
AKGETAGDIAKALSLSVKTVSTYRTRVMEKMSLASNSDLTYYALKNKLID
>Mature_210_residues
MIKIGIVDDHAIVRSGLKQFFSDQVDLRVVGEAASGREAIDLVRNVELDILVMDLSMPGQSGIDALAMIRAKAPDVGILI
LSGYPEEHYAVNLIRQGASGYLNKECDPSEIVDAIRVISLGKRYITPAVAELLAQQLNRPHDVASHEQLSEREFQVFLKL
AKGETAGDIAKALSLSVKTVSTYRTRVMEKMSLASNSDLTYYALKNKLID

Specific function: Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=36.4928909952607, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=34.6733668341709, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=31.0679611650485, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=28.0788177339901, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=31.8681318681319, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786747, Length=204, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788546, Length=200, Percent_Identity=26, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082052, Length=111, Percent_Identity=32.4324324324324, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23043; Mature: 23043

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIGIVDDHAIVRSGLKQFFSDQVDLRVVGEAASGREAIDLVRNVELDILVMDLSMPGQ
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCC
SGIDALAMIRAKAPDVGILILSGYPEEHYAVNLIRQGASGYLNKECDPSEIVDAIRVISL
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GKRYITPAVAELLAQQLNRPHDVASHEQLSEREFQVFLKLAKGETAGDIAKALSLSVKTV
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRTRVMEKMSLASNSDLTYYALKNKLID
HHHHHHHHHHHHHCCCCCEEEEEEHHHCCC
>Mature Secondary Structure
MIKIGIVDDHAIVRSGLKQFFSDQVDLRVVGEAASGREAIDLVRNVELDILVMDLSMPGQ
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCC
SGIDALAMIRAKAPDVGILILSGYPEEHYAVNLIRQGASGYLNKECDPSEIVDAIRVISL
CCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GKRYITPAVAELLAQQLNRPHDVASHEQLSEREFQVFLKLAKGETAGDIAKALSLSVKTV
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRTRVMEKMSLASNSDLTYYALKNKLID
HHHHHHHHHHHHHCCCCCEEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9159518; 10984043 [H]