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The map label for this gene is hisA [H]

Identifier: 91786710

GI number: 91786710

Start: 833944

End: 834684

Strand: Direct

Name: hisA [H]

Synonym: Bpro_0808

Alternate gene names: 91786710

Gene position: 833944-834684 (Clockwise)

Preceding gene: 91786709

Following gene: 91786711

Centisome position: 16.04

GC content: 60.05

Gene sequence:

>741_bases
ATGCTACTTATTCCCGCGATTGACCTGAAAGATGGTCACTGCGTTCGCCTCAAACAGGGCGACATGGATCAATCCACCAT
CTTCAGCGAAGACCCGGCGGCCATGGCGCGCAGCTGGGTCGACAAGGGCGCACGCCGCCTGCATCTGGTGGACCTGAACG
GCGCCTTTGCCGGCAAGCCGAAAAACGAGGCCGCCATCAAGAAAATCCTGGCCGAAGTCGGCAGCGAGATCGATGTGCAA
CTGGGCGGCGGTATTCGCGATCTCGACACCATAGAGCGTTATCTGGACGCCGGCCTGCGCTACGTGATCATCGGAACGGC
CGCGGTCAAGAACCCCGGCTTCCTGCAGGATGCCTGCACTGCCTTTGGCGGCCACATCATCGTCGGCCTGGATGCCAAGG
ATGGCAAGGTTGCTACCGATGGCTGGAGCAAGCTCACCGGCCACGAAGTGATCGACCTGGGCAAGAAATTCCAGGACTAC
GGCGTCGAGTCCATCATCTATACCGACATCGGCCGCGACGGCATGCTCAGCGGCATCAACATTGAAGCAACTGTCAGGCT
CGCGCAGGCGCTGACCATTCCGGTGATCGCCTCCGGCGGCCTGTCAAACATGGCCGACATTGAAGCGCTGTGCGACGTTG
AAGAAGAAGGCGTTGAAGGCGTGATCTGCGGCCGCTCCATTTACAGCGGCGATCTGGATTTTGCCGCAGCGCAGGCAAGA
GCTGATGAGCTGAACGGATGA

Upstream 100 bases:

>100_bases
TCCTGCACTGGAAGCCCTGAAGGCCGCCGGGCAGCAGGGCGACTCATCATAATTTCCAGCTCTTTGTTAACCCCGCCACC
TGTTTTCCTCTTACCGCAAC

Downstream 100 bases:

>100_bases
GCGCAGCTGCAACGAGTGGCAGGTTGTGCAGAGGGGCTGTAGTGGACGCGCATGACGGTTTAGTATTCCAGCCAGGGCCG
CGGAACCGGCTTCGCCGGGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLLIPAIDLKDGHCVRLKQGDMDQSTIFSEDPAAMARSWVDKGARRLHLVDLNGAFAGKPKNEAAIKKILAEVGSEIDVQ
LGGGIRDLDTIERYLDAGLRYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVIDLGKKFQDY
GVESIIYTDIGRDGMLSGINIEATVRLAQALTIPVIASGGLSNMADIEALCDVEEEGVEGVICGRSIYSGDLDFAAAQAR
ADELNG

Sequences:

>Translated_246_residues
MLLIPAIDLKDGHCVRLKQGDMDQSTIFSEDPAAMARSWVDKGARRLHLVDLNGAFAGKPKNEAAIKKILAEVGSEIDVQ
LGGGIRDLDTIERYLDAGLRYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVIDLGKKFQDY
GVESIIYTDIGRDGMLSGINIEATVRLAQALTIPVIASGGLSNMADIEALCDVEEEGVEGVICGRSIYSGDLDFAAAQAR
ADELNG
>Mature_246_residues
MLLIPAIDLKDGHCVRLKQGDMDQSTIFSEDPAAMARSWVDKGARRLHLVDLNGAFAGKPKNEAAIKKILAEVGSEIDVQ
LGGGIRDLDTIERYLDAGLRYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVIDLGKKFQDY
GVESIIYTDIGRDGMLSGINIEATVRLAQALTIPVIASGGLSNMADIEALCDVEEEGVEGVICGRSIYSGDLDFAAAQAR
ADELNG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=248, Percent_Identity=33.0645161290323, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788336, Length=227, Percent_Identity=25.1101321585903, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26089; Mature: 26089

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGHCVRLKQGDMDQSTIFSEDPAAMARSWVDKGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEEECCCCCCHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNEAAIKKILAEVGSEIDVQLGGGIRDLDTIERYLDAGLRYVIIGTAAVKNPGFLQDACT
CCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVIDLGKKFQDYGVESIIYTDIGRDGMLSGIN
HCCCEEEEEEECCCCEEECCCCHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
IEATVRLAQALTIPVIASGGLSNMADIEALCDVEEEGVEGVICGRSIYSGDLDFAAAQAR
HHHHHHHHHHHEEEEEECCCCCCHHHHHHHHCCHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNG
HHCCCC
>Mature Secondary Structure
MLLIPAIDLKDGHCVRLKQGDMDQSTIFSEDPAAMARSWVDKGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEEECCCCCCHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNEAAIKKILAEVGSEIDVQLGGGIRDLDTIERYLDAGLRYVIIGTAAVKNPGFLQDACT
CCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVIDLGKKFQDYGVESIIYTDIGRDGMLSGIN
HCCCEEEEEEECCCCEEECCCCHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
IEATVRLAQALTIPVIASGGLSNMADIEALCDVEEEGVEGVICGRSIYSGDLDFAAAQAR
HHHHHHHHHHHEEEEEECCCCCCHHHHHHHHCCHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA