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The map label for this gene is cysK [H]

Identifier: 89256496

GI number: 89256496

Start: 1125350

End: 1126273

Strand: Reverse

Name: cysK [H]

Synonym: FTL_1174

Alternate gene names: 89256496

Gene position: 1126273-1125350 (Counterclockwise)

Preceding gene: 89256498

Following gene: 89256495

Centisome position: 59.4

GC content: 31.06

Gene sequence:

>924_bases
ATGCTATCTTTAATAGGAAAGACTCCTATAATAAAACTTAAAAATACAATAAACAATCATAATCTTTATGCTAAGTGTGA
ATGGCTAAACCCAACTGGTAGTATCAAAGATCGTGTTGCGAAATATATCTTGGAAAACTTAATAAAAAACAAAAAAATAA
AACCTCAACAAGCAATTATCGAAGCAAGTTCAGGCAATATGGGAACATCTTTAGCTGCAATTGGTAAATTATACAAACAT
CCTGTGTACATTACATGTCCTGAGAAAACGGGACAAATAAAAAGAGAAATGATCAAAAGTTTTGGAGCAAACCTTACAAT
TTGTAAAAACACATCAGATCATACGGATCCAGATTTTTATGTAAATAAAGCTAAACAATTAACAGAAGATTTAGATGGAA
TATTAGTTAACCAATATGATAATTTATTAAATACAGAGTGTCATTACAAAACTACAGGTCAAGAAATAGTGGACTATTTT
TTAACACAAAATGTTGATATTGACTACTTTATAACGGTTGGGGGATCTGGCGGCACTATTACAGGATGTGCAAAGAAGAT
AAAAGAGTTTTTTCCAAAAACACAAGTTATTATGCCAGACCCTTATGGATCTGTTTATTATGATATTTTTTATCATGGAG
CACCTATTAAAGAAAACATACATAGCTATAAAGTAGAAGGTCCAGGTAACCCTGTCTTCTGTAAATCAATGGATCTTGCA
TATATTGACGAAATAATACAATTTAGTGATAATCAAGCAATACAAGCATGTCATGAGTTAGCTAGTGAACAAGGTATTTA
TGCTGGACATAGTAGCGGTGCTAACTATTTCATTGCTAAAAAACTACTCGAAAAATTACCACAACATCAGAGCTATAACA
TCCTTATAATGGTATTAGATAGCGGTATGAAATATGCTTTTTAA

Upstream 100 bases:

>100_bases
CCATTTACCATCCTATTAACAAATAAACTTGTTAAATAAGTTTCTTATAGCATACATTTTGTTAAAATATTCTAAGTCTT
AAAAAACATCGCCTAATCTA

Downstream 100 bases:

>100_bases
TAACGTAATTTAAAAATTCTCTATGCAACATTTTATATTTGCTGCTATTATTTAATTGTAATTGTTAAATATAGGAGTAG
ATAATATGCCAGGTATACTA

Product: cystathionine beta-synthase (cystein synthase)

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLSLIGKTPIIKLKNTINNHNLYAKCEWLNPTGSIKDRVAKYILENLIKNKKIKPQQAIIEASSGNMGTSLAAIGKLYKH
PVYITCPEKTGQIKREMIKSFGANLTICKNTSDHTDPDFYVNKAKQLTEDLDGILVNQYDNLLNTECHYKTTGQEIVDYF
LTQNVDIDYFITVGGSGGTITGCAKKIKEFFPKTQVIMPDPYGSVYYDIFYHGAPIKENIHSYKVEGPGNPVFCKSMDLA
YIDEIIQFSDNQAIQACHELASEQGIYAGHSSGANYFIAKKLLEKLPQHQSYNILIMVLDSGMKYAF

Sequences:

>Translated_307_residues
MLSLIGKTPIIKLKNTINNHNLYAKCEWLNPTGSIKDRVAKYILENLIKNKKIKPQQAIIEASSGNMGTSLAAIGKLYKH
PVYITCPEKTGQIKREMIKSFGANLTICKNTSDHTDPDFYVNKAKQLTEDLDGILVNQYDNLLNTECHYKTTGQEIVDYF
LTQNVDIDYFITVGGSGGTITGCAKKIKEFFPKTQVIMPDPYGSVYYDIFYHGAPIKENIHSYKVEGPGNPVFCKSMDLA
YIDEIIQFSDNQAIQACHELASEQGIYAGHSSGANYFIAKKLLEKLPQHQSYNILIMVLDSGMKYAF
>Mature_307_residues
MLSLIGKTPIIKLKNTINNHNLYAKCEWLNPTGSIKDRVAKYILENLIKNKKIKPQQAIIEASSGNMGTSLAAIGKLYKH
PVYITCPEKTGQIKREMIKSFGANLTICKNTSDHTDPDFYVNKAKQLTEDLDGILVNQYDNLLNTECHYKTTGQEIVDYF
LTQNVDIDYFITVGGSGGTITGCAKKIKEFFPKTQVIMPDPYGSVYYDIFYHGAPIKENIHSYKVEGPGNPVFCKSMDLA
YIDEIIQFSDNQAIQACHELASEQGIYAGHSSGANYFIAKKLLEKLPQHQSYNILIMVLDSGMKYAF

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=29.746835443038, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=29.746835443038, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=29.746835443038, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI11345492, Length=196, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=32.1311475409836, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=28.2894736842105, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=34.6153846153846, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=30.1003344481605, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=30.1003344481605, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=30.6709265175719, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17534315, Length=316, Percent_Identity=30.6962025316456, Blast_Score=123, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17561720, Length=285, Percent_Identity=29.1228070175439, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI115535073, Length=311, Percent_Identity=27.9742765273312, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=31.1111111111111, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=33.7423312883436, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643623, Length=270, Percent_Identity=31.8518518518519, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI20129101, Length=270, Percent_Identity=31.8518518518519, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34434; Mature: 34434

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLIGKTPIIKLKNTINNHNLYAKCEWLNPTGSIKDRVAKYILENLIKNKKIKPQQAII
CCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHEE
EASSGNMGTSLAAIGKLYKHPVYITCPEKTGQIKREMIKSFGANLTICKNTSDHTDPDFY
ECCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
VNKAKQLTEDLDGILVNQYDNLLNTECHYKTTGQEIVDYFLTQNVDIDYFITVGGSGGTI
HHHHHHHHHHHCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCH
TGCAKKIKEFFPKTQVIMPDPYGSVYYDIFYHGAPIKENIHSYKVEGPGNPVFCKSMDLA
HHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCHHCCCCEEEECCCCCEEEEECCCHH
YIDEIIQFSDNQAIQACHELASEQGIYAGHSSGANYFIAKKLLEKLPQHQSYNILIMVLD
HHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEE
SGMKYAF
CCCCCCC
>Mature Secondary Structure
MLSLIGKTPIIKLKNTINNHNLYAKCEWLNPTGSIKDRVAKYILENLIKNKKIKPQQAII
CCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHEE
EASSGNMGTSLAAIGKLYKHPVYITCPEKTGQIKREMIKSFGANLTICKNTSDHTDPDFY
ECCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
VNKAKQLTEDLDGILVNQYDNLLNTECHYKTTGQEIVDYFLTQNVDIDYFITVGGSGGTI
HHHHHHHHHHHCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCH
TGCAKKIKEFFPKTQVIMPDPYGSVYYDIFYHGAPIKENIHSYKVEGPGNPVFCKSMDLA
HHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCHHCCCCEEEECCCCCEEEEECCCHH
YIDEIIQFSDNQAIQACHELASEQGIYAGHSSGANYFIAKKLLEKLPQHQSYNILIMVLD
HHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEE
SGMKYAF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA