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The map label for this gene is cbs [H]

Identifier: 89054484

GI number: 89054484

Start: 1992420

End: 1993445

Strand: Direct

Name: cbs [H]

Synonym: Jann_1993

Alternate gene names: 89054484

Gene position: 1992420-1993445 (Clockwise)

Preceding gene: 89054483

Following gene: 89054485

Centisome position: 46.14

GC content: 63.65

Gene sequence:

>1026_bases
ATGACGATCCACTCCGACCTCGCCTCTGCCATCGGGAACACGCCCCTCATTCGCCTGCGTGCGGCGTCGGAGGCGACGGG
ATGCGAGATCCTGGGCAAGGCCGAATTCCTCAACCCCGGCCAATCGGTGAAGGACCGCGCCGCGCTCTTCATCATCCGTG
ATGCGGTCGCGCGCGGGGATCTGCGCCCCGGCGGCACCATCGTGGAGGGCACGGCGGGCAACACCGGTATCGGTCTTGCG
CTGGTGGGGGCCTCTCTGGGGTTCAAGACGGTGATCGTCATCCCCGACACGCAATCCCAGGAAAAGAAGGACATGATCCG
CATCGCGGGCGCGGAGTTGATCGAAGTGCCTGCGGTTCCCTATTCGAACCCCAACAACTACGTGAAATACTCTGGCCGCT
TGGCCGAACGTCTGGCGCAATCCGATCCCAACGGTGCGATCTGGGCCAACCAGTTCGACAATGTCGCCAACCGTCAGGCC
CATATCGACATGACGGGGCCCGAGATCTGGGAGCAGACGGAGGGCCGCGTGAACGGGTTCACCTGTGCCGTGGGCTCTGG
CGGAACGTTGGCGGGCGTCGGCATGGCCTTGCAGCCCAAGGGTGTAAAGGTGGCGCTGTCTGATCCCGAAGGGTCCGGCC
TCTACAAGTTATATACCGGGCAGGAGGCGGGCGGGAATTCCATCACTGAAGGGATAGGGCAGGGCCGCATCACCGCTAAT
CTTGAAGGGTTCACGCCCGATGCCTGCTATAAGATCCCCGACGCAGAGGCCCTGCCTATCGTCTACGATATCCTCGCCGA
CGAGGGGCTCTGTCTGGGGGGGTCCTCCGGGATCAACGTGGCGGGCGCGATCCGCATGGCGCGTGAGATGGGGCCGGGCC
ATACCATCGTGACGATCCTGTGTGACTACGGGACGCGGTATCAATCCAAGCTGTTTAACCCCGACTTCCTGCGCGAAAAG
GGCCTGCCCGTGCCGCAATGGATGGACGCAAAGGGGCGCGACGTCCCGCAGGTCTTCGCGGAATGA

Upstream 100 bases:

>100_bases
CGCTGCCGGGTTGGGTTGAGTTCACCCAAGGCGCGGCCTATCCATGCGGTGAGACCTGCGCCGGTTATCCACGCGAGACC
ATCCACGAAGGGCCAATGTC

Downstream 100 bases:

>100_bases
CGGCTATTGTCGGACGATTGCTGACAGCGCTATTTTTGGCGCTGATACCGGTTATGGCCGCTATGCCGGGTGCGGTTGTC
GCGCAGACGACGGCCCCCGA

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTIHSDLASAIGNTPLIRLRAASEATGCEILGKAEFLNPGQSVKDRAALFIIRDAVARGDLRPGGTIVEGTAGNTGIGLA
LVGASLGFKTVIVIPDTQSQEKKDMIRIAGAELIEVPAVPYSNPNNYVKYSGRLAERLAQSDPNGAIWANQFDNVANRQA
HIDMTGPEIWEQTEGRVNGFTCAVGSGGTLAGVGMALQPKGVKVALSDPEGSGLYKLYTGQEAGGNSITEGIGQGRITAN
LEGFTPDACYKIPDAEALPIVYDILADEGLCLGGSSGINVAGAIRMAREMGPGHTIVTILCDYGTRYQSKLFNPDFLREK
GLPVPQWMDAKGRDVPQVFAE

Sequences:

>Translated_341_residues
MTIHSDLASAIGNTPLIRLRAASEATGCEILGKAEFLNPGQSVKDRAALFIIRDAVARGDLRPGGTIVEGTAGNTGIGLA
LVGASLGFKTVIVIPDTQSQEKKDMIRIAGAELIEVPAVPYSNPNNYVKYSGRLAERLAQSDPNGAIWANQFDNVANRQA
HIDMTGPEIWEQTEGRVNGFTCAVGSGGTLAGVGMALQPKGVKVALSDPEGSGLYKLYTGQEAGGNSITEGIGQGRITAN
LEGFTPDACYKIPDAEALPIVYDILADEGLCLGGSSGINVAGAIRMAREMGPGHTIVTILCDYGTRYQSKLFNPDFLREK
GLPVPQWMDAKGRDVPQVFAE
>Mature_340_residues
TIHSDLASAIGNTPLIRLRAASEATGCEILGKAEFLNPGQSVKDRAALFIIRDAVARGDLRPGGTIVEGTAGNTGIGLAL
VGASLGFKTVIVIPDTQSQEKKDMIRIAGAELIEVPAVPYSNPNNYVKYSGRLAERLAQSDPNGAIWANQFDNVANRQAH
IDMTGPEIWEQTEGRVNGFTCAVGSGGTLAGVGMALQPKGVKVALSDPEGSGLYKLYTGQEAGGNSITEGIGQGRITANL
EGFTPDACYKIPDAEALPIVYDILADEGLCLGGSSGINVAGAIRMAREMGPGHTIVTILCDYGTRYQSKLFNPDFLREKG
LPVPQWMDAKGRDVPQVFAE

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=326, Percent_Identity=37.7300613496933, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI295821200, Length=326, Percent_Identity=37.7300613496933, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4557415, Length=326, Percent_Identity=37.7300613496933, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI2367138, Length=311, Percent_Identity=36.6559485530547, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788754, Length=327, Percent_Identity=36.3914373088685, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562970, Length=319, Percent_Identity=38.2445141065831, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=38.7622149837134, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=38.1578947368421, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI115535073, Length=325, Percent_Identity=35.0769230769231, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17561720, Length=330, Percent_Identity=34.8484848484849, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=326, Percent_Identity=32.5153374233129, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147552, Length=330, Percent_Identity=30.3030303030303, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32566672, Length=230, Percent_Identity=35.2173913043478, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=325, Percent_Identity=26.4615384615385, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=38.1538461538462, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321594, Length=337, Percent_Identity=32.3442136498516, Blast_Score=155, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24643623, Length=332, Percent_Identity=34.3373493975904, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI20129101, Length=332, Percent_Identity=34.3373493975904, Blast_Score=157, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 35947; Mature: 35816

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHSDLASAIGNTPLIRLRAASEATGCEILGKAEFLNPGQSVKDRAALFIIRDAVARGD
CCCHHHHHHHHCCCCEEEEEECCCCCCCEEEECHHHCCCCCCCHHHEEEEEEEHHHHCCC
LRPGGTIVEGTAGNTGIGLALVGASLGFKTVIVIPDTQSQEKKDMIRIAGAELIEVPAVP
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCC
YSNPNNYVKYSGRLAERLAQSDPNGAIWANQFDNVANRQAHIDMTGPEIWEQTEGRVNGF
CCCCCCEEEECCHHHHHHHHCCCCCCEECCHHHHHCCCEEEEECCCHHHHHHCCCCCCCE
TCAVGSGGTLAGVGMALQPKGVKVALSDPEGSGLYKLYTGQEAGGNSITEGIGQGRITAN
EEEECCCCCEEECCEEECCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHCCCCCEEEEE
LEGFTPDACYKIPDAEALPIVYDILADEGLCLGGSSGINVAGAIRMAREMGPGHTIVTIL
ECCCCCHHEEECCCCCCCHHHEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEE
CDYGTRYQSKLFNPDFLREKGLPVPQWMDAKGRDVPQVFAE
ECCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
TIHSDLASAIGNTPLIRLRAASEATGCEILGKAEFLNPGQSVKDRAALFIIRDAVARGD
CCHHHHHHHHCCCCEEEEEECCCCCCCEEEECHHHCCCCCCCHHHEEEEEEEHHHHCCC
LRPGGTIVEGTAGNTGIGLALVGASLGFKTVIVIPDTQSQEKKDMIRIAGAELIEVPAVP
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCC
YSNPNNYVKYSGRLAERLAQSDPNGAIWANQFDNVANRQAHIDMTGPEIWEQTEGRVNGF
CCCCCCEEEECCHHHHHHHHCCCCCCEECCHHHHHCCCEEEEECCCHHHHHHCCCCCCCE
TCAVGSGGTLAGVGMALQPKGVKVALSDPEGSGLYKLYTGQEAGGNSITEGIGQGRITAN
EEEECCCCCEEECCEEECCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHCCCCCEEEEE
LEGFTPDACYKIPDAEALPIVYDILADEGLCLGGSSGINVAGAIRMAREMGPGHTIVTIL
ECCCCCHHEEECCCCCCCHHHEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEE
CDYGTRYQSKLFNPDFLREKGLPVPQWMDAKGRDVPQVFAE
ECCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]