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The map label for this gene is hemA [H]

Identifier: 89054424

GI number: 89054424

Start: 1922201

End: 1923505

Strand: Direct

Name: hemA [H]

Synonym: Jann_1933

Alternate gene names: 89054424

Gene position: 1922201-1923505 (Clockwise)

Preceding gene: 89054423

Following gene: 89054425

Centisome position: 44.52

GC content: 64.75

Gene sequence:

>1305_bases
ATGTCTGGTCTGCGGCGGGAATCCCCTGCCCATAGCCATCGAACTGAGGGGGTCGAACAGCCCCCGACCGGGAGACCGCC
AGTGAACTACGATACCGCGCTCGACGCAGCCATCGGCAAGCTGCACGAGGAAGGCCGCTACCGCACATTCATTGATATCG
AACGGCGACGCGGCCAGTTTCCCCATGCGGTCTGGACACGGCCCGATGGGACCGAGCAGGACATCACGGTCTGGTGCGGC
AACGATTACCTCGGCATGGGGCAACATCCGGTTGTTCTGGACGCGATGAAAGAGGCGCTGGATGCCACGGGTGCGGGCTC
TGGCGGGACGCGGAATATCAGCGGCACGACGGTGTATCACAAGGCGCTTGAGGCGGAGTTGTGCGATCTGCACGGCAAAG
AGGGGGCGCTGCTGTTCACCTCGGCCTACATCGCCAATGACGCGACACTCTCGACGCTGCCCAAGCTGTTTCCGGGCCTG
ATCATCTATTCTGACGCGCTCAACCACGCCTCCATGATCGAAGGCGTGCGCCGCAATGGCGGGGCCAAGCGCATCTTCCG
CCACAACGATGTGGCCCACCTGCGGGAGCTGCTGCAGGCCGACGACCCTACCGCGCCGAAGCTGATCGCGTTCGAATCGA
TCTATTCGATGGACGGCGATTTCGGCCCGATTGAAGCGCTGTGCGATCTGGCGGACGAATTTGGCGCGCTGACCTATCTG
GATGAGGTCCACGCCGTCGGCATGTACGGGCCCCGGGGCGGCGGTGTGGCGGAACGCGACGGTCTGATGGACCGCGTCGA
CATCATCAACGGCACGCTGGGCAAGGCGTATGGCGTCCATGGCGGCTACATCGCGGCCTCGGCCCGGATGTGTGACGCGG
TGCGCAGCTATGCGCCCGGCTTCATCTTCACCACGTCCCTGCCGCCCGCCGTGGCGGCGGGGGCCGCGGCCTCCGTCCGG
CATCTGAAGACGGATCAGGCCCTGCGGGACCTGCACCAGGACCGCGCTGCCGTGCTGAAACTGCGCCTGAAGGGCATGGG
TCTGCCGATCATTGATCACGGCAGCCATATCGTGCCGGTGATGGTGGGCAACCCCGTCCACACCAAGGCGATTTCCGATG
CGCTTCTGGCGGATTTCGGCATCTACGTGCAGCCGATCAACTACCCCACCGTCCCTCGTGGCACGGAGCGGTTGCGGTTT
ACCCCGTCGCCGGTCCACGACACGGGCATGATCGACGGCTTGGTCCATGCCATGGACGGGTTGTGGTCCCATTGCGCGCT
GAACCGACAGGAATTGGCGGGCTGA

Upstream 100 bases:

>100_bases
CGCCATGGGGGGCCGTTTGCCGTAACGTCCGCGCCTTTGATCCAGATCAAAGCCCGCCTCGCGGCAAATTGTAGCTTGGC
GTTGGCGCGGCTTGCGCCAT

Downstream 100 bases:

>100_bases
CCGCGCCCGTTCCGATCTATCCACACGCTGCGCAGAATTTCAGCAAACAGCGTGTAGTCCCTTAAAAATTAACGAAAACG
ATGGGCGCAATCTTGCCGAA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSGLRRESPAHSHRTEGVEQPPTGRPPVNYDTALDAAIGKLHEEGRYRTFIDIERRRGQFPHAVWTRPDGTEQDITVWCG
NDYLGMGQHPVVLDAMKEALDATGAGSGGTRNISGTTVYHKALEAELCDLHGKEGALLFTSAYIANDATLSTLPKLFPGL
IIYSDALNHASMIEGVRRNGGAKRIFRHNDVAHLRELLQADDPTAPKLIAFESIYSMDGDFGPIEALCDLADEFGALTYL
DEVHAVGMYGPRGGGVAERDGLMDRVDIINGTLGKAYGVHGGYIAASARMCDAVRSYAPGFIFTTSLPPAVAAGAAASVR
HLKTDQALRDLHQDRAAVLKLRLKGMGLPIIDHGSHIVPVMVGNPVHTKAISDALLADFGIYVQPINYPTVPRGTERLRF
TPSPVHDTGMIDGLVHAMDGLWSHCALNRQELAG

Sequences:

>Translated_434_residues
MSGLRRESPAHSHRTEGVEQPPTGRPPVNYDTALDAAIGKLHEEGRYRTFIDIERRRGQFPHAVWTRPDGTEQDITVWCG
NDYLGMGQHPVVLDAMKEALDATGAGSGGTRNISGTTVYHKALEAELCDLHGKEGALLFTSAYIANDATLSTLPKLFPGL
IIYSDALNHASMIEGVRRNGGAKRIFRHNDVAHLRELLQADDPTAPKLIAFESIYSMDGDFGPIEALCDLADEFGALTYL
DEVHAVGMYGPRGGGVAERDGLMDRVDIINGTLGKAYGVHGGYIAASARMCDAVRSYAPGFIFTTSLPPAVAAGAAASVR
HLKTDQALRDLHQDRAAVLKLRLKGMGLPIIDHGSHIVPVMVGNPVHTKAISDALLADFGIYVQPINYPTVPRGTERLRF
TPSPVHDTGMIDGLVHAMDGLWSHCALNRQELAG
>Mature_433_residues
SGLRRESPAHSHRTEGVEQPPTGRPPVNYDTALDAAIGKLHEEGRYRTFIDIERRRGQFPHAVWTRPDGTEQDITVWCGN
DYLGMGQHPVVLDAMKEALDATGAGSGGTRNISGTTVYHKALEAELCDLHGKEGALLFTSAYIANDATLSTLPKLFPGLI
IYSDALNHASMIEGVRRNGGAKRIFRHNDVAHLRELLQADDPTAPKLIAFESIYSMDGDFGPIEALCDLADEFGALTYLD
EVHAVGMYGPRGGGVAERDGLMDRVDIINGTLGKAYGVHGGYIAASARMCDAVRSYAPGFIFTTSLPPAVAAGAAASVRH
LKTDQALRDLHQDRAAVLKLRLKGMGLPIIDHGSHIVPVMVGNPVHTKAISDALLADFGIYVQPINYPTVPRGTERLRFT
PSPVHDTGMIDGLVHAMDGLWSHCALNRQELAG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977440, Length=421, Percent_Identity=50.3562945368171, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI83977444, Length=421, Percent_Identity=50.3562945368171, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI83977442, Length=436, Percent_Identity=48.6238532110092, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI4502025, Length=409, Percent_Identity=50.6112469437653, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI40316939, Length=409, Percent_Identity=50.6112469437653, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=36.2694300518135, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=37.6811594202899, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI119220554, Length=367, Percent_Identity=29.4277929155313, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=29.8882681564246, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI5454084, Length=282, Percent_Identity=25.177304964539, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790046, Length=379, Percent_Identity=34.5646437994723, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=31.9767441860465, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=31.1224489795918, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32566772, Length=375, Percent_Identity=30.1333333333333, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17560912, Length=379, Percent_Identity=27.7044854881267, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=379, Percent_Identity=27.7044854881267, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=424, Percent_Identity=48.3490566037736, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320267, Length=353, Percent_Identity=30.8781869688385, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=290, Percent_Identity=24.1379310344828, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137420, Length=425, Percent_Identity=48.9411764705882, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24662918, Length=351, Percent_Identity=35.042735042735, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=27.7777777777778, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24653280, Length=293, Percent_Identity=24.9146757679181, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24653276, Length=293, Percent_Identity=24.9146757679181, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24653278, Length=293, Percent_Identity=24.9146757679181, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46838; Mature: 46706

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLRRESPAHSHRTEGVEQPPTGRPPVNYDTALDAAIGKLHEEGRYRTFIDIERRRGQF
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHHHCCCC
PHAVWTRPDGTEQDITVWCGNDYLGMGQHPVVLDAMKEALDATGAGSGGTRNISGTTVYH
CCEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
KALEAELCDLHGKEGALLFTSAYIANDATLSTLPKLFPGLIIYSDALNHASMIEGVRRNG
HHHHHHHHHCCCCCCEEEEEEEHHCCCCHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHCC
GAKRIFRHNDVAHLRELLQADDPTAPKLIAFESIYSMDGDFGPIEALCDLADEFGALTYL
CHHHHHHCCCHHHHHHHHHCCCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DEVHAVGMYGPRGGGVAERDGLMDRVDIINGTLGKAYGVHGGYIAASARMCDAVRSYAPG
HHHHHHCCCCCCCCCCCHHCCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC
FIFTTSLPPAVAAGAAASVRHLKTDQALRDLHQDRAAVLKLRLKGMGLPIIDHGSHIVPV
EEEECCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEE
MVGNPVHTKAISDALLADFGIYVQPINYPTVPRGTERLRFTPSPVHDTGMIDGLVHAMDG
EECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
LWSHCALNRQELAG
HHHHHCCCHHHHCC
>Mature Secondary Structure 
SGLRRESPAHSHRTEGVEQPPTGRPPVNYDTALDAAIGKLHEEGRYRTFIDIERRRGQF
CCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHHHCCCC
PHAVWTRPDGTEQDITVWCGNDYLGMGQHPVVLDAMKEALDATGAGSGGTRNISGTTVYH
CCEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
KALEAELCDLHGKEGALLFTSAYIANDATLSTLPKLFPGLIIYSDALNHASMIEGVRRNG
HHHHHHHHHCCCCCCEEEEEEEHHCCCCHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHCC
GAKRIFRHNDVAHLRELLQADDPTAPKLIAFESIYSMDGDFGPIEALCDLADEFGALTYL
CHHHHHHCCCHHHHHHHHHCCCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DEVHAVGMYGPRGGGVAERDGLMDRVDIINGTLGKAYGVHGGYIAASARMCDAVRSYAPG
HHHHHHCCCCCCCCCCCHHCCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC
FIFTTSLPPAVAAGAAASVRHLKTDQALRDLHQDRAAVLKLRLKGMGLPIIDHGSHIVPV
EEEECCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEE
MVGNPVHTKAISDALLADFGIYVQPINYPTVPRGTERLRFTPSPVHDTGMIDGLVHAMDG
EECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
LWSHCALNRQELAG
HHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928952 [H]