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The map label for this gene is yngE [H]

Identifier: 89053636

GI number: 89053636

Start: 1105992

End: 1107518

Strand: Direct

Name: yngE [H]

Synonym: Jann_1145

Alternate gene names: 89053636

Gene position: 1105992-1107518 (Clockwise)

Preceding gene: 89053634

Following gene: 89053637

Centisome position: 25.61

GC content: 65.23

Gene sequence:

>1527_bases
GTGGTCCGCGAGGCGGCGGATCTGGCGGCTGCGGGCGGGGGTGAGCGGTCGCGGGCGCGCCATGTCTCGCGGGGGAAAAT
GCTGCCGCGGGAGCGGGTGGCGAACCTGCTGGACCCGGGCTCTCCGTTTCTGGAGGTTGGCGCGGTTGCGGGGCACGGGC
TCTATGACGGGGCAGCCCCCTGTGGCGGCGTGATCGCGGGCGTGGGCCGTGTCCATGGGCGCGAGGTGATGGTGGTCTGC
AACGATGCCACCGTGAAGGGCGGCACGTATTATCCGATCACGGTCAAGAAGCACCTGCGCGCGCAAGAGATCGCCGAGGA
GTGTGGATTACCTTGTGTATATCTTGTGGATAGCGGCGGCGCGAACCTGCCCAATCAGGACGAGGTCTTCCCGGACCGCG
ACCATTTCGGGCGCATCTTTTACAATCAGGCGCGCATGTCCGCCAAGGGCATCGCGCAGATCGCGGTCGTGATGGGCTCG
TGTACGGCGGGCGGGGCCTATGTGCCTGCAATGGCGGATGTGTCCATCATCGTGAAGGAGCAGGGCACGATCTTTCTGGC
CGGCCCACCTTTGGTGAAGGCGGCGACCGGAGAGGTTGTTTCAGCGGAAGATCTGGGCGGCGGCGACGTGCATACGCGGC
TGTCGGGCGTGGCCGATTATCTGGCCGAAGACGACAATCATGCGCTGGCCTTGGCGCGGCGGGCCGTTGGGTCGCTGGAC
GGGTTCCGCGAAGACTACGGCGTCAGCTTGGGCGGGCGGCCCCCGGCCTATGACCCCGAAGACTTGCTTGGCGTCGTGCC
CGCATCCCTGACCACGCCCTACGACATCCGGGAGGTCATCGCGCGCGTCGTCGACGACAGCTATTTCGACGAGTTCAAGG
CGCGGTTCGGGGAGACAATTGTGTGTGGTTTCGCCGAGGTCATGGGTCTGCCCGTGGGCATCATCGCCAACAACGGCGTG
CTGTTTTCCGAGGCCGCCCAGAAGGCGGCGCATTTCGTGGAATTGTGCTCCAGCCGCAAGATCCCGTTGGTTTTCCTGCA
GAATATCACCGGCTTCATGGTGGGGCGCAAATACGAGAATGAAGGCATCGCGCGCCACGGGGCCAAGATGGTGACGGCTG
TGGCGACCACATCTGTGCCAAAGGTGACGATGCTGGTGGGCGGGTCGTTCGGGGCGGGAAACTACGGCATGGCGGGACGC
GCCTATTCGCCCCGGTTCCTGTGGTCGTGGCCCAATTCGCGGATTTCCGTGATGGGGGGCGCGCAGGCGGCGGGGGTTTT
GGCCACGGTCAAACGCGACGCGTTGGAGCGGGCGGGCGAGGACTGGTCGGCGGAGGCGGAGGCCGCCTTCAAGCAGCCCA
CGATTGATATGTTCGAGGAACAGTCGCATCCCTTGTATGCGTCCGCGCGGCTTTGGGATGACGGGGTCGTGGACCCTCGA
AAAACGCGCGAAGTCTTGGGGCTGTCGCTGGCGGCCGCGCTGAATGCCCCGATTGATGAGACGCGCTTTGGCGTCTTCCG
TATGTGA

Upstream 100 bases:

>100_bases
CTGTGGATTTGGAGTTGATCCGATGAGATTGAAATCATCCTTTGTTGCGGGATCAGATGACGCCCGAGCCAACCGTGCGG
CGCATCTGGAGGCGCTGGAC

Downstream 100 bases:

>100_bases
GCGTGGGGGAGGTTGGAATGAGTTCTATTGGCCAAGATGAAGGGGGGAGCGGTGTGACCCTGACGGAGTTGAGAGCCAAG
TATCCGGGCGCGGAAACCAG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MVREAADLAAAGGGERSRARHVSRGKMLPRERVANLLDPGSPFLEVGAVAGHGLYDGAAPCGGVIAGVGRVHGREVMVVC
NDATVKGGTYYPITVKKHLRAQEIAEECGLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQIAVVMGS
CTAGGAYVPAMADVSIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRLSGVADYLAEDDNHALALARRAVGSLD
GFREDYGVSLGGRPPAYDPEDLLGVVPASLTTPYDIREVIARVVDDSYFDEFKARFGETIVCGFAEVMGLPVGIIANNGV
LFSEAAQKAAHFVELCSSRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAVATTSVPKVTMLVGGSFGAGNYGMAGR
AYSPRFLWSWPNSRISVMGGAQAAGVLATVKRDALERAGEDWSAEAEAAFKQPTIDMFEEQSHPLYASARLWDDGVVDPR
KTREVLGLSLAAALNAPIDETRFGVFRM

Sequences:

>Translated_508_residues
MVREAADLAAAGGGERSRARHVSRGKMLPRERVANLLDPGSPFLEVGAVAGHGLYDGAAPCGGVIAGVGRVHGREVMVVC
NDATVKGGTYYPITVKKHLRAQEIAEECGLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQIAVVMGS
CTAGGAYVPAMADVSIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRLSGVADYLAEDDNHALALARRAVGSLD
GFREDYGVSLGGRPPAYDPEDLLGVVPASLTTPYDIREVIARVVDDSYFDEFKARFGETIVCGFAEVMGLPVGIIANNGV
LFSEAAQKAAHFVELCSSRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAVATTSVPKVTMLVGGSFGAGNYGMAGR
AYSPRFLWSWPNSRISVMGGAQAAGVLATVKRDALERAGEDWSAEAEAAFKQPTIDMFEEQSHPLYASARLWDDGVVDPR
KTREVLGLSLAAALNAPIDETRFGVFRM
>Mature_508_residues
MVREAADLAAAGGGERSRARHVSRGKMLPRERVANLLDPGSPFLEVGAVAGHGLYDGAAPCGGVIAGVGRVHGREVMVVC
NDATVKGGTYYPITVKKHLRAQEIAEECGLPCVYLVDSGGANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQIAVVMGS
CTAGGAYVPAMADVSIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRLSGVADYLAEDDNHALALARRAVGSLD
GFREDYGVSLGGRPPAYDPEDLLGVVPASLTTPYDIREVIARVVDDSYFDEFKARFGETIVCGFAEVMGLPVGIIANNGV
LFSEAAQKAAHFVELCSSRKIPLVFLQNITGFMVGRKYENEGIARHGAKMVTAVATTSVPKVTMLVGGSFGAGNYGMAGR
AYSPRFLWSWPNSRISVMGGAQAAGVLATVKRDALERAGEDWSAEAEAAFKQPTIDMFEEQSHPLYASARLWDDGVVDPR
KTREVLGLSLAAALNAPIDETRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=509, Percent_Identity=64.4400785854617, Blast_Score=665, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=497, Percent_Identity=32.1931589537223, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI295821216, Length=517, Percent_Identity=30.9477756286267, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI310133460, Length=118, Percent_Identity=60.1694915254237, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17552936, Length=497, Percent_Identity=61.569416498994, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=499, Percent_Identity=32.4649298597194, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI25147362, Length=499, Percent_Identity=32.4649298597194, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24586065, Length=524, Percent_Identity=63.3587786259542, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 53897; Mature: 53897

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREAADLAAAGGGERSRARHVSRGKMLPRERVANLLDPGSPFLEVGAVAGHGLYDGAAP
CCCCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
CGGVIAGVGRVHGREVMVVCNDATVKGGTYYPITVKKHLRAQEIAEECGLPCVYLVDSGG
CCHHHHHHHCCCCCEEEEEECCCEECCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCC
ANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQIAVVMGSCTAGGAYVPAMADVSIIVKE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEEC
QGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRLSGVADYLAEDDNHALALARRAVGSLD
CCEEEEECCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GFREDYGVSLGGRPPAYDPEDLLGVVPASLTTPYDIREVIARVVDDSYFDEFKARFGETI
CCHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCEE
VCGFAEVMGLPVGIIANNGVLFSEAAQKAAHFVELCSSRKIPLVFLQNITGFMVGRKYEN
EECHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCEECC
EGIARHGAKMVTAVATTSVPKVTMLVGGSFGAGNYGMAGRAYSPRFLWSWPNSRISVMGG
CCHHHHCHHHEEHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEEECC
AQAAGVLATVKRDALERAGEDWSAEAEAAFKQPTIDMFEEQSHPLYASARLWDDGVVDPR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCHH
KTREVLGLSLAAALNAPIDETRFGVFRM
HHHHHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure
MVREAADLAAAGGGERSRARHVSRGKMLPRERVANLLDPGSPFLEVGAVAGHGLYDGAAP
CCCCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
CGGVIAGVGRVHGREVMVVCNDATVKGGTYYPITVKKHLRAQEIAEECGLPCVYLVDSGG
CCHHHHHHHCCCCCEEEEEECCCEECCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCC
ANLPNQDEVFPDRDHFGRIFYNQARMSAKGIAQIAVVMGSCTAGGAYVPAMADVSIIVKE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEEC
QGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRLSGVADYLAEDDNHALALARRAVGSLD
CCEEEEECCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
GFREDYGVSLGGRPPAYDPEDLLGVVPASLTTPYDIREVIARVVDDSYFDEFKARFGETI
CCHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCEE
VCGFAEVMGLPVGIIANNGVLFSEAAQKAAHFVELCSSRKIPLVFLQNITGFMVGRKYEN
EECHHHHHCCCEEEEECCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCEECC
EGIARHGAKMVTAVATTSVPKVTMLVGGSFGAGNYGMAGRAYSPRFLWSWPNSRISVMGG
CCHHHHCHHHEEHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEEECC
AQAAGVLATVKRDALERAGEDWSAEAEAAFKQPTIDMFEEQSHPLYASARLWDDGVVDPR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCHH
KTREVLGLSLAAALNAPIDETRFGVFRM
HHHHHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]