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The map label for this gene is nrdZ [H]

Identifier: 89053442

GI number: 89053442

Start: 908458

End: 910731

Strand: Direct

Name: nrdZ [H]

Synonym: Jann_0951

Alternate gene names: 89053442

Gene position: 908458-910731 (Clockwise)

Preceding gene: 89053439

Following gene: 89053443

Centisome position: 21.04

GC content: 62.05

Gene sequence:

>2274_bases
GTGAGCCGATTTTCCGCCCCAATCGCCGAACAAATCTGGGACATGAAATACCGTTTGAAAGAGGCGGATGGCACCGCCAT
CGATGGCAGCGTTGAAGACACCTGGCGCCGCATCGCCAAGGCGCTGGCCGCGGTGGAAGACGACAGCGCCACGTGGGAAG
AGACGTTCTACACCGCGCTGGAAGACTTCAAGTACCTCCCCGCCGGGCGCATTGTGGCGGGCGCGGGCACCGGGCGCAGC
GTTACCTTGTTCAATTGTTTCGTCATGGGCACCGTGCCGGACAGCATGGGCGGTATCTTTGATATGCTGAAGGAAGCCGC
GCTGACGATGCAGCAGGGGGGTGGTATCGGTTACGATTTCTCCACCATCCGGCCCAAAGGCGCTGCGGTCAGCGGTGTCG
CGGCGGATGCCTCGGGGCCACTGTCGTTCATGGATGTCTGGGACGCCATGTGCCGCACAATCATGTCGGCGGGTTCGCGC
CGGGGCGCTATGATGGCCACGATGCGCTGCGACCACCCCGATATCGAAGATTTCATCGCCGCCAAACAGGACCCGGCCCG
CCTGCGCATGTTCAACATGTCCGTTCTGGCAACGGACCCCTTCATGGAAGCCGTGAAAGACGACGGCCCGTGGGATCTGG
TCTTTGGCGACAAGGTCTTCCGCACCGTTCAGGCGCGCGATCTGTGGAACCGCATCATGCGCGCAACCTATGATTATGCG
GAGCCCGGTGTGATCTTCATCGACCGCATCAATGCCGAGAACAACCTTAATTATGCCGAAACCATCTGCGCCACGAACCC
TTGCGGCGAGCAGCCCCTGCCGCCCTATGGCGCGTGCCTTTTGGGCTCCGTCAACCTGGCGCAGCTAGTCAGTGACCCGT
TCACGGACACCGCCGATCTGGACCCTATCAAGTTGGCGGATCTGACGGCCACCGCGATCCGGATGATGGACAATGTCGTC
GATACCTCTCGCTTCCCGCTGGATGCACAGGCGCAGGAGGCGCAGGCGAAGCGCCGCATTGGCCTTGGGGTCACCGGCCT
CGCCGACGCGCTGGCCATGTGTCGTCTGCGCTATGGGTCCGAGGAGGCGGCCGCCAAAACCGAAGACTGGATGGCGCGGA
TCGCCAACGCCTCCTACCGCGCCTCCGCCCTGCTGGCCGCCGAGAAGGGCGCGTTCCCCCTGTTTGACGCCGCTGAATAC
GCGAAAGCGCCAATGGTCCAGCGTCTGGATGCCGACGTCCAAGCGCTGATCGCCGAGCACGGGTTGCGAAACGCGCTCCT
GACCTCCATCGCGCCCACGGGCACGATTTCACTGTTCGCGGGCAATGTGTCGTCGGGGATCGAGCCGATTTTTGCGAATG
CCTACACCCGAAAAGTGCTGCAGGTGGACGGCACCCGGACGGAGGAGGAGGTCGTCGATTTCGCCGTCGCCAAATGGCGG
GACATGCACGGCGACACGCCGCTGCCCGACTATTTCGTCAACGCCCAGACCTTAGCGCCGCTGGACCATGTCCGTATGCA
GGCCGCCGCACAGCCCTGGATCGATTCAAGTATCTCCAAGACCATCAATGTGCCCGCCGACATCAGCTTTGAGGCGTTCA
AGGACGTCTACGCCGAAGCCTACGCGACCGGCTGTAAGGGCTGCACAACTTACCGCCCGAACGATGTGACCGGCTCTGTC
CTCAGCGTCAGTGAGGCGGACGACAAGCCACAGGCGATTGAGGCCATCGAGGCAGCATCCGGCGAAGTCGTCTACATGTC
CGAGCCGCTGCACCGCCCCAACGAGTTGGAAGGCAACACCTACAAGGTCAAATGGCCCGACAGCGAACATGCGCTTTATA
TCACCATCAACGACATTGTTCTGAACGGCCACCGCCGCCCGTTCGAGGTCTTCATCAATTCCAAGAACATGGAGCACTTC
GCCTGGACCGTGGCGCTGACTCGGATGATCTCCGCCGTGTTCCGGCGCGGGGGGGATGTGTCGTTTGTGGTGGAGGAACT
CAAAGCCGTCTTCGATCCCCGTGGCGGGGCCTGGATGCAGGGCAAATACGTCCCCTCGATCCTCGCGGCCATCGGCGGCG
TGATCGAAAAGCACATGATCGCCACGGGTTTTCTTGCGGGTGAAGGGATGGGTCTGAAGTCTGATCCTCAGGCCGCAGTC
GTCAATCTCGGCCAGAAACCCGGTCCCGCCTGCCCCTCCTGCGGGCAGTTCGATTTGCGGATGATGGAAGGCTGCCTGAC
TTGCGCTAATTGCGGATACTCCAAGTGCGGATAA

Upstream 100 bases:

>100_bases
AGAAGCACGATTCTGACGGCATGGCTGGTCTCAGGGCGACATTTGTGGCATACGGACTATCTCGTTGTTCCACCCCATCT
GTCATCAAGGACTGGTATCC

Downstream 100 bases:

>100_bases
GGCTCTGACATGCGGTTCCGGCGGGTGGAGGATCATTTGATCACGCTCCCCTCGGGCCGTCTTTTGTGGCGACGTGGCCA
TTGGGCGCGCATACCCGCAC

Product: ribonucleotide reductase large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MSRFSAPIAEQIWDMKYRLKEADGTAIDGSVEDTWRRIAKALAAVEDDSATWEETFYTALEDFKYLPAGRIVAGAGTGRS
VTLFNCFVMGTVPDSMGGIFDMLKEAALTMQQGGGIGYDFSTIRPKGAAVSGVAADASGPLSFMDVWDAMCRTIMSAGSR
RGAMMATMRCDHPDIEDFIAAKQDPARLRMFNMSVLATDPFMEAVKDDGPWDLVFGDKVFRTVQARDLWNRIMRATYDYA
EPGVIFIDRINAENNLNYAETICATNPCGEQPLPPYGACLLGSVNLAQLVSDPFTDTADLDPIKLADLTATAIRMMDNVV
DTSRFPLDAQAQEAQAKRRIGLGVTGLADALAMCRLRYGSEEAAAKTEDWMARIANASYRASALLAAEKGAFPLFDAAEY
AKAPMVQRLDADVQALIAEHGLRNALLTSIAPTGTISLFAGNVSSGIEPIFANAYTRKVLQVDGTRTEEEVVDFAVAKWR
DMHGDTPLPDYFVNAQTLAPLDHVRMQAAAQPWIDSSISKTINVPADISFEAFKDVYAEAYATGCKGCTTYRPNDVTGSV
LSVSEADDKPQAIEAIEAASGEVVYMSEPLHRPNELEGNTYKVKWPDSEHALYITINDIVLNGHRRPFEVFINSKNMEHF
AWTVALTRMISAVFRRGGDVSFVVEELKAVFDPRGGAWMQGKYVPSILAAIGGVIEKHMIATGFLAGEGMGLKSDPQAAV
VNLGQKPGPACPSCGQFDLRMMEGCLTCANCGYSKCG

Sequences:

>Translated_757_residues
MSRFSAPIAEQIWDMKYRLKEADGTAIDGSVEDTWRRIAKALAAVEDDSATWEETFYTALEDFKYLPAGRIVAGAGTGRS
VTLFNCFVMGTVPDSMGGIFDMLKEAALTMQQGGGIGYDFSTIRPKGAAVSGVAADASGPLSFMDVWDAMCRTIMSAGSR
RGAMMATMRCDHPDIEDFIAAKQDPARLRMFNMSVLATDPFMEAVKDDGPWDLVFGDKVFRTVQARDLWNRIMRATYDYA
EPGVIFIDRINAENNLNYAETICATNPCGEQPLPPYGACLLGSVNLAQLVSDPFTDTADLDPIKLADLTATAIRMMDNVV
DTSRFPLDAQAQEAQAKRRIGLGVTGLADALAMCRLRYGSEEAAAKTEDWMARIANASYRASALLAAEKGAFPLFDAAEY
AKAPMVQRLDADVQALIAEHGLRNALLTSIAPTGTISLFAGNVSSGIEPIFANAYTRKVLQVDGTRTEEEVVDFAVAKWR
DMHGDTPLPDYFVNAQTLAPLDHVRMQAAAQPWIDSSISKTINVPADISFEAFKDVYAEAYATGCKGCTTYRPNDVTGSV
LSVSEADDKPQAIEAIEAASGEVVYMSEPLHRPNELEGNTYKVKWPDSEHALYITINDIVLNGHRRPFEVFINSKNMEHF
AWTVALTRMISAVFRRGGDVSFVVEELKAVFDPRGGAWMQGKYVPSILAAIGGVIEKHMIATGFLAGEGMGLKSDPQAAV
VNLGQKPGPACPSCGQFDLRMMEGCLTCANCGYSKCG
>Mature_756_residues
SRFSAPIAEQIWDMKYRLKEADGTAIDGSVEDTWRRIAKALAAVEDDSATWEETFYTALEDFKYLPAGRIVAGAGTGRSV
TLFNCFVMGTVPDSMGGIFDMLKEAALTMQQGGGIGYDFSTIRPKGAAVSGVAADASGPLSFMDVWDAMCRTIMSAGSRR
GAMMATMRCDHPDIEDFIAAKQDPARLRMFNMSVLATDPFMEAVKDDGPWDLVFGDKVFRTVQARDLWNRIMRATYDYAE
PGVIFIDRINAENNLNYAETICATNPCGEQPLPPYGACLLGSVNLAQLVSDPFTDTADLDPIKLADLTATAIRMMDNVVD
TSRFPLDAQAQEAQAKRRIGLGVTGLADALAMCRLRYGSEEAAAKTEDWMARIANASYRASALLAAEKGAFPLFDAAEYA
KAPMVQRLDADVQALIAEHGLRNALLTSIAPTGTISLFAGNVSSGIEPIFANAYTRKVLQVDGTRTEEEVVDFAVAKWRD
MHGDTPLPDYFVNAQTLAPLDHVRMQAAAQPWIDSSISKTINVPADISFEAFKDVYAEAYATGCKGCTTYRPNDVTGSVL
SVSEADDKPQAIEAIEAASGEVVYMSEPLHRPNELEGNTYKVKWPDSEHALYITINDIVLNGHRRPFEVFINSKNMEHFA
WTVALTRMISAVFRRGGDVSFVVEELKAVFDPRGGAWMQGKYVPSILAAIGGVIEKHMIATGFLAGEGMGLKSDPQAAVV
NLGQKPGPACPSCGQFDLRMMEGCLTCANCGYSKCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=447, Percent_Identity=27.7404921700224, Blast_Score=162, Evalue=1e-39,
Organism=Escherichia coli, GI1789030, Length=533, Percent_Identity=23.4521575984991, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI2367133, Length=462, Percent_Identity=24.4588744588745, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17555242, Length=442, Percent_Identity=28.5067873303167, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322123, Length=466, Percent_Identity=27.6824034334764, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320914, Length=461, Percent_Identity=27.765726681128, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17352481, Length=471, Percent_Identity=28.0254777070064, Blast_Score=161, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 82217; Mature: 82086

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFSAPIAEQIWDMKYRLKEADGTAIDGSVEDTWRRIAKALAAVEDDSATWEETFYTAL
CCCCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFKYLPAGRIVAGAGTGRSVTLFNCFVMGTVPDSMGGIFDMLKEAALTMQQGGGIGYDF
HHHHCCCCCCEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
STIRPKGAAVSGVAADASGPLSFMDVWDAMCRTIMSAGSRRGAMMATMRCDHPDIEDFIA
CCCCCCCCEEECEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
AKQDPARLRMFNMSVLATDPFMEAVKDDGPWDLVFGDKVFRTVQARDLWNRIMRATYDYA
CCCCCCCEEEEEEEEEECCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCC
EPGVIFIDRINAENNLNYAETICATNPCGEQPLPPYGACLLGSVNLAQLVSDPFTDTADL
CCCEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHCCCCCCCCCC
DPIKLADLTATAIRMMDNVVDTSRFPLDAQAQEAQAKRRIGLGVTGLADALAMCRLRYGS
CCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
EEAAAKTEDWMARIANASYRASALLAAEKGAFPLFDAAEYAKAPMVQRLDADVQALIAEH
HHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHH
GLRNALLTSIAPTGTISLFAGNVSSGIEPIFANAYTRKVLQVDGTRTEEEVVDFAVAKWR
HHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
DMHGDTPLPDYFVNAQTLAPLDHVRMQAAAQPWIDSSISKTINVPADISFEAFKDVYAEA
HCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHH
YATGCKGCTTYRPNDVTGSVLSVSEADDKPQAIEAIEAASGEVVYMSEPLHRPNELEGNT
HHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCE
YKVKWPDSEHALYITINDIVLNGHRRPFEVFINSKNMEHFAWTVALTRMISAVFRRGGDV
EEEECCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCH
SFVVEELKAVFDPRGGAWMQGKYVPSILAAIGGVIEKHMIATGFLAGEGMGLKSDPQAAV
HHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHH
VNLGQKPGPACPSCGQFDLRMMEGCLTCANCGYSKCG
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRFSAPIAEQIWDMKYRLKEADGTAIDGSVEDTWRRIAKALAAVEDDSATWEETFYTAL
CCCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFKYLPAGRIVAGAGTGRSVTLFNCFVMGTVPDSMGGIFDMLKEAALTMQQGGGIGYDF
HHHHCCCCCCEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
STIRPKGAAVSGVAADASGPLSFMDVWDAMCRTIMSAGSRRGAMMATMRCDHPDIEDFIA
CCCCCCCCEEECEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
AKQDPARLRMFNMSVLATDPFMEAVKDDGPWDLVFGDKVFRTVQARDLWNRIMRATYDYA
CCCCCCCEEEEEEEEEECCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCC
EPGVIFIDRINAENNLNYAETICATNPCGEQPLPPYGACLLGSVNLAQLVSDPFTDTADL
CCCEEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHCCCCCCCCCC
DPIKLADLTATAIRMMDNVVDTSRFPLDAQAQEAQAKRRIGLGVTGLADALAMCRLRYGS
CCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
EEAAAKTEDWMARIANASYRASALLAAEKGAFPLFDAAEYAKAPMVQRLDADVQALIAEH
HHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHH
GLRNALLTSIAPTGTISLFAGNVSSGIEPIFANAYTRKVLQVDGTRTEEEVVDFAVAKWR
HHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
DMHGDTPLPDYFVNAQTLAPLDHVRMQAAAQPWIDSSISKTINVPADISFEAFKDVYAEA
HCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHH
YATGCKGCTTYRPNDVTGSVLSVSEADDKPQAIEAIEAASGEVVYMSEPLHRPNELEGNT
HHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCE
YKVKWPDSEHALYITINDIVLNGHRRPFEVFINSKNMEHFAWTVALTRMISAVFRRGGDV
EEEECCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCH
SFVVEELKAVFDPRGGAWMQGKYVPSILAAIGGVIEKHMIATGFLAGEGMGLKSDPQAAV
HHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHH
VNLGQKPGPACPSCGQFDLRMMEGCLTCANCGYSKCG
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]