Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 89053438

GI number: 89053438

Start: 905144

End: 905842

Strand: Direct

Name: hisG

Synonym: Jann_0947

Alternate gene names: 89053438

Gene position: 905144-905842 (Clockwise)

Preceding gene: 89053437

Following gene: 89053439

Centisome position: 20.96

GC content: 65.24

Gene sequence:

>699_bases
ATGATGACGCTCGGCGTGCCCTCCAAGGGGCGGTTGATGGAGAAGACATTCCAGTGGTTCGCCGCGCGCGGGATCGAGAT
GCGCCGCACCGGATCGGACCGCGATTATGGCGCGGAGGTAGCCGATATGCCGGTCGCCCTGCGTCTTCTGGCCGCCGGAG
AGATCCCGCGAGAATTGGCCGCTGGCCGCATCCATCTGGGTGTCACGGGCAGCGATCTGGTGCAGGAGCGTATCCCGGCC
TGGGACCAGGCTGTGGATATCGTGGCCGAGATGGGGTTCGGCCACGCCGATCTGATCATTGCCGTGCCCGCCTGGTGGGT
GGACGTCACCAGCCTTGATGATCTGGACGCCGTGGCCGCAGATTTCCGCGCCACACACGGCCACCGCTTGCGGATTGCCA
CGAAATACCATCGCCTCGTGCGTGATTTCCTGCGCGAGAAGGGCGTAGCCGATTATCAGCTGGTGGACAGCCAGGGCGCG
ACCGAGGGCACCGTCGCCCATGGCACGGCGGAGGCGATTGCTGATATCACCTCCACCGGAGAAACCTTGCGCGCCAACCA
CTTAGCTATTCTGGGCGACGGTTTGATCCATCGGTCGGAGGCGACGCTGTTCCGCTCGCGCACGGCTGTCTGGGGCGAGG
CCGAGCGTGCCGGACTTGACGCCATCACGTCACGTCTCGACCCACAGCAGACCGCGTAG

Upstream 100 bases:

>100_bases
ATGACGCGCTGACCCGGCAATTGGGCGGCGGGCGAGAGATCCCCGCCGTGGGGGGCGTGATCCGGCCTGAACTGGTCCTA
ACCGCGAAGGAGGCCGCCCG

Downstream 100 bases:

>100_bases
GCCAGTTCCCGCCAGTGTTGCCAGGCGGCACCAACGCGCAAAATACACCGAATATCACAGGTCAGGTTTCCCCGCGTTGA
AGGCCCGGTGTCCCAAGCGT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MMTLGVPSKGRLMEKTFQWFAARGIEMRRTGSDRDYGAEVADMPVALRLLAAGEIPRELAAGRIHLGVTGSDLVQERIPA
WDQAVDIVAEMGFGHADLIIAVPAWWVDVTSLDDLDAVAADFRATHGHRLRIATKYHRLVRDFLREKGVADYQLVDSQGA
TEGTVAHGTAEAIADITSTGETLRANHLAILGDGLIHRSEATLFRSRTAVWGEAERAGLDAITSRLDPQQTA

Sequences:

>Translated_232_residues
MMTLGVPSKGRLMEKTFQWFAARGIEMRRTGSDRDYGAEVADMPVALRLLAAGEIPRELAAGRIHLGVTGSDLVQERIPA
WDQAVDIVAEMGFGHADLIIAVPAWWVDVTSLDDLDAVAADFRATHGHRLRIATKYHRLVRDFLREKGVADYQLVDSQGA
TEGTVAHGTAEAIADITSTGETLRANHLAILGDGLIHRSEATLFRSRTAVWGEAERAGLDAITSRLDPQQTA
>Mature_232_residues
MMTLGVPSKGRLMEKTFQWFAARGIEMRRTGSDRDYGAEVADMPVALRLLAAGEIPRELAAGRIHLGVTGSDLVQERIPA
WDQAVDIVAEMGFGHADLIIAVPAWWVDVTSLDDLDAVAADFRATHGHRLRIATKYHRLVRDFLREKGVADYQLVDSQGA
TEGTVAHGTAEAIADITSTGETLRANHLAILGDGLIHRSEATLFRSRTAVWGEAERAGLDAITSRLDPQQTA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320896, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25251; Mature: 25251

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLGVPSKGRLMEKTFQWFAARGIEMRRTGSDRDYGAEVADMPVALRLLAAGEIPRELA
CCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
AGRIHLGVTGSDLVQERIPAWDQAVDIVAEMGFGHADLIIAVPAWWVDVTSLDDLDAVAA
CCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCHHEEEECCCCHHHHHHH
DFRATHGHRLRIATKYHRLVRDFLREKGVADYQLVDSQGATEGTVAHGTAEAIADITSTG
HHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCC
ETLRANHLAILGDGLIHRSEATLFRSRTAVWGEAERAGLDAITSRLDPQQTA
CHHHHCCEEEEECCHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMTLGVPSKGRLMEKTFQWFAARGIEMRRTGSDRDYGAEVADMPVALRLLAAGEIPRELA
CCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
AGRIHLGVTGSDLVQERIPAWDQAVDIVAEMGFGHADLIIAVPAWWVDVTSLDDLDAVAA
CCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCHHEEEECCCCHHHHHHH
DFRATHGHRLRIATKYHRLVRDFLREKGVADYQLVDSQGATEGTVAHGTAEAIADITSTG
HHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCC
ETLRANHLAILGDGLIHRSEATLFRSRTAVWGEAERAGLDAITSRLDPQQTA
CHHHHCCEEEEECCHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA