Click here to switch to the map view.

The map label for this gene is hisZ

Identifier: 89053437

GI number: 89053437

Start: 904038

End: 905147

Strand: Direct

Name: hisZ

Synonym: Jann_0946

Alternate gene names: 89053437

Gene position: 904038-905147 (Clockwise)

Preceding gene: 89053436

Following gene: 89053438

Centisome position: 20.94

GC content: 67.12

Gene sequence:

>1110_bases
GTGACCCCCAAAGCTGCCATACGGGCCGAGGCGGAGGCGCTTCAGGCCACCTTCGCCGACGCCGTCCCCGTCGACGCCCC
CATGTTGGTCAGCGCGGAAACGCTGCTGGATCTCTACGGCGAAGACATCCGCGCGCGCGCCTTTACCACCCATGATCCGG
ACCGAGGCGAGCTGATGCTGCGTCCCGATTTCACCGTGCCCGTGGTCGAGATGCACATGATCGCCACAGAACAGGGGGGC
GCGGAACCTGCGCGCTATACCTATCTCGGCGAAGTGTTCCGCATGCAACACGCCGGAGCTGACCTGCCGTCGGAATACCT
GCAAGTGGGCTACGAGGTGTTCGACCGATCCGCGCCGTTGCAGGCGGACGCAGAGGTTTTTGCGCTGTTCTCTCAGGCAC
TGGCGGACGTTCCGACCCGCGCCGTCACAGGTGATATCGGCGTCCTTCTGGCGGCGATTGCGGCGCTTGAGACCACCGAC
GCGCGCAAGGCAGCGCTGCGGCGACACGTCTGGCGTCCGCGCCGCTTTCGCGCGTTGCTTGACCGGTTCACCGGGGCCGT
GCCCGCACCCCAAGGGCGTGACGCCTATCTTTCGGCGACCCGCGATCAGGGCCTCGCTGCGATGATCGCGCAGGCTGGCC
CGCCCATCGGCCTGCGTACCACCGATGAGATGACCGCACGCCTGCAACGGCTGGAAGATGACGCCGCCGCAGACCCCATA
GATCCCGCCCAGGCGGATGTGCTGAGCGATCTTCTGGCGCTGAAAGCACCGTTGGGGGAGGCTGTGGATATCCTTGCCAA
TTTCACCGTCGACCTGCCGGGGCTGGAGGGGGCCGTGGCCCGGGTTGCGGACCGGACGAAAGCGCTGGCCAATACGGGGA
TCGCCGTCGATGCCCTGCCGTTTGAGGTCTCTTACGGGCGCACGCAAATGGAATACTACGACGGCTTCGTCTTCGGCATC
CTGTCCGCCACGCCCGGCCATCCCCCGCTCGCAACCGGGGGGCGCTATGACGCGCTGACCCGGCAATTGGGCGGCGGGCG
AGAGATCCCCGCCGTGGGGGGCGTGATCCGGCCTGAACTGGTCCTAACCGCGAAGGAGGCCGCCCGATGA

Upstream 100 bases:

>100_bases
AGGATGCGACCTTGGAAGAGTGGAAATCCCAGCCCGCCCAGACAGAAGTCGCCGTCGCGGATCTGGTCGCTGAGGTCCAA
GCCATCATCGCACGTCACAA

Downstream 100 bases:

>100_bases
TGACGCTCGGCGTGCCCTCCAAGGGGCGGTTGATGGAGAAGACATTCCAGTGGTTCGCCGCGCGCGGGATCGAGATGCGC
CGCACCGGATCGGACCGCGA

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTPKAAIRAEAEALQATFADAVPVDAPMLVSAETLLDLYGEDIRARAFTTHDPDRGELMLRPDFTVPVVEMHMIATEQGG
AEPARYTYLGEVFRMQHAGADLPSEYLQVGYEVFDRSAPLQADAEVFALFSQALADVPTRAVTGDIGVLLAAIAALETTD
ARKAALRRHVWRPRRFRALLDRFTGAVPAPQGRDAYLSATRDQGLAAMIAQAGPPIGLRTTDEMTARLQRLEDDAAADPI
DPAQADVLSDLLALKAPLGEAVDILANFTVDLPGLEGAVARVADRTKALANTGIAVDALPFEVSYGRTQMEYYDGFVFGI
LSATPGHPPLATGGRYDALTRQLGGGREIPAVGGVIRPELVLTAKEAAR

Sequences:

>Translated_369_residues
MTPKAAIRAEAEALQATFADAVPVDAPMLVSAETLLDLYGEDIRARAFTTHDPDRGELMLRPDFTVPVVEMHMIATEQGG
AEPARYTYLGEVFRMQHAGADLPSEYLQVGYEVFDRSAPLQADAEVFALFSQALADVPTRAVTGDIGVLLAAIAALETTD
ARKAALRRHVWRPRRFRALLDRFTGAVPAPQGRDAYLSATRDQGLAAMIAQAGPPIGLRTTDEMTARLQRLEDDAAADPI
DPAQADVLSDLLALKAPLGEAVDILANFTVDLPGLEGAVARVADRTKALANTGIAVDALPFEVSYGRTQMEYYDGFVFGI
LSATPGHPPLATGGRYDALTRQLGGGREIPAVGGVIRPELVLTAKEAAR
>Mature_368_residues
TPKAAIRAEAEALQATFADAVPVDAPMLVSAETLLDLYGEDIRARAFTTHDPDRGELMLRPDFTVPVVEMHMIATEQGGA
EPARYTYLGEVFRMQHAGADLPSEYLQVGYEVFDRSAPLQADAEVFALFSQALADVPTRAVTGDIGVLLAAIAALETTDA
RKAALRRHVWRPRRFRALLDRFTGAVPAPQGRDAYLSATRDQGLAAMIAQAGPPIGLRTTDEMTARLQRLEDDAAADPID
PAQADVLSDLLALKAPLGEAVDILANFTVDLPGLEGAVARVADRTKALANTGIAVDALPFEVSYGRTQMEYYDGFVFGIL
SATPGHPPLATGGRYDALTRQLGGGREIPAVGGVIRPELVLTAKEAAR

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 39445; Mature: 39314

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKAAIRAEAEALQATFADAVPVDAPMLVSAETLLDLYGEDIRARAFTTHDPDRGELML
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEE
RPDFTVPVVEMHMIATEQGGAEPARYTYLGEVFRMQHAGADLPSEYLQVGYEVFDRSAPL
CCCCCCCHHHHEEEHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
QADAEVFALFSQALADVPTRAVTGDIGVLLAAIAALETTDARKAALRRHVWRPRRFRALL
CCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
DRFTGAVPAPQGRDAYLSATRDQGLAAMIAQAGPPIGLRTTDEMTARLQRLEDDAAADPI
HHHHCCCCCCCCCCHHEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
DPAQADVLSDLLALKAPLGEAVDILANFTVDLPGLEGAVARVADRTKALANTGIAVDALP
CHHHHHHHHHHHHHHCCCHHHHHHHHHCEEECCCCCHHHHHHHHHHHHHHHCCCEEECCC
FEVSYGRTQMEYYDGFVFGILSATPGHPPLATGGRYDALTRQLGGGREIPAVGGVIRPEL
EEECCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCE
VLTAKEAAR
EEECHHHCC
>Mature Secondary Structure 
TPKAAIRAEAEALQATFADAVPVDAPMLVSAETLLDLYGEDIRARAFTTHDPDRGELML
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEE
RPDFTVPVVEMHMIATEQGGAEPARYTYLGEVFRMQHAGADLPSEYLQVGYEVFDRSAPL
CCCCCCCHHHHEEEHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
QADAEVFALFSQALADVPTRAVTGDIGVLLAAIAALETTDARKAALRRHVWRPRRFRALL
CCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
DRFTGAVPAPQGRDAYLSATRDQGLAAMIAQAGPPIGLRTTDEMTARLQRLEDDAAADPI
HHHHCCCCCCCCCCHHEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
DPAQADVLSDLLALKAPLGEAVDILANFTVDLPGLEGAVARVADRTKALANTGIAVDALP
CHHHHHHHHHHHHHHCCCHHHHHHHHHCEEECCCCCHHHHHHHHHHHHHHHCCCEEECCC
FEVSYGRTQMEYYDGFVFGILSATPGHPPLATGGRYDALTRQLGGGREIPAVGGVIRPEL
EEECCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCE
VLTAKEAAR
EEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]