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The map label for this gene is dxr

Identifier: 88607594

GI number: 88607594

Start: 457401

End: 458558

Strand: Direct

Name: dxr

Synonym: APH_0440

Alternate gene names: 88607594

Gene position: 457401-458558 (Clockwise)

Preceding gene: 88606884

Following gene: 88607378

Centisome position: 31.09

GC content: 40.33

Gene sequence:

>1158_bases
GTGAAAAAGGTATCAGTTTTCGGTTCTACAGGATTTATAGGTAAAACTACTGTAGGTATTTTATCGGGTAATACAGAAGA
TTTTAAGGTTATTGCGCTTGTAGCTGGTAGTAACGTGAGCTTGTTGGCGCAGCAGGCTAAGTTATTAAATGCTGAAATGG
CGGTTATTGCTGATGATGCTCAATATGAGGAGCTTAAAAGGTCTTTACATGGTTCAGGTATAAGGGTTGCTGCTGGTAAG
GAGGCTGTGCTTGAAGCGGCTGCCCTTAGTGTAGATACCGCTGTAATGGCTATCACTGGTATTGTGGCTTTAAGTGCGGT
GATGCGGCTGATAGAAAGTGGTGTAGGTACTATTGCTTTAGCCAGCAAGGAGAGTGTAGTTTGTGGGGGAGTTCTTCTAA
GGGATGCTGCTTGTAAAAGTGGAACTAGGATTGTTCCGGTGGATTCAGAGCATAATGCGGTTTTTCGTCTATTATCTCAG
GGGGATAATCCCTATAAGATTACAATTACGGCTTCAGGAGGGCCTTTTCTGCATTGGTCTCATGATCAATTAAAAAGTGT
TACAATAGAAGATGCGCTAGTTCATCCAGTTTGGAAAATGGGTAAGAAAATCTCTGTGGATAGTGCAACGATGATGAATA
AAGCTTTGGAAGTATTAGAAGCTAGTTACCTTTTTGAGCTCGGATATAGGAAAATAGATGTTGTGATTCATCCGGAATCA
ATAGTTCATGCTTTGGCGTTTTATCAGGATGGAACTTCTACTGCGTTAATGTCGTTGCCGGATATGAGTATCCCAATACT
TCATGCGTTATATTGGCCTCATAGGAAGGAGGTGTCTGTAAGGGAGGTGGATTTAATTGCGTATGGCAAATTGACCTTTA
TTAGGCCTGATTTTGAGAGATTTCCGGCACTGAAGGCTGCATTTGATATTTTACAGTCTTCTGAGAGGGATGTTGCAAGT
ATAGTATTTAATGCTGCAAATGAAGTTGCGGTGGAGTCATTTTTAAATTCCGAGATTACTTTTTTAGAGATAGTTAATAT
TGTTTTGCATGTGATGAACAAGGTTCCTTATGGAAAAGTCTCTTCTCTAGCAGACATAATGGAATATGATTTATTAGGCA
GGTGTATAGCTAGAGAGGTTATTAGCGATGCGTCTTAA

Upstream 100 bases:

>100_bases
ATAGCTACTCTGAGCTAATCTCTGCATAAGCAAGTAAGCAGTAGGAAGATCATGTGTTGTAAGAGTTACTAGTGGAGTTT
TTTGTATACGGTAGAGGTGT

Downstream 100 bases:

>100_bases
TTAAGCTTTTTCGATATGAGGAAACAGTTTAGCATTTTTGGTGATACTTTAAATGCGATAAATGTTGTATTGGATTGCTT
AATGGTGTTATTTATTCTAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKKVSVFGSTGFIGKTTVGILSGNTEDFKVIALVAGSNVSLLAQQAKLLNAEMAVIADDAQYEELKRSLHGSGIRVAAGK
EAVLEAAALSVDTAVMAITGIVALSAVMRLIESGVGTIALASKESVVCGGVLLRDAACKSGTRIVPVDSEHNAVFRLLSQ
GDNPYKITITASGGPFLHWSHDQLKSVTIEDALVHPVWKMGKKISVDSATMMNKALEVLEASYLFELGYRKIDVVIHPES
IVHALAFYQDGTSTALMSLPDMSIPILHALYWPHRKEVSVREVDLIAYGKLTFIRPDFERFPALKAAFDILQSSERDVAS
IVFNAANEVAVESFLNSEITFLEIVNIVLHVMNKVPYGKVSSLADIMEYDLLGRCIAREVISDAS

Sequences:

>Translated_385_residues
MKKVSVFGSTGFIGKTTVGILSGNTEDFKVIALVAGSNVSLLAQQAKLLNAEMAVIADDAQYEELKRSLHGSGIRVAAGK
EAVLEAAALSVDTAVMAITGIVALSAVMRLIESGVGTIALASKESVVCGGVLLRDAACKSGTRIVPVDSEHNAVFRLLSQ
GDNPYKITITASGGPFLHWSHDQLKSVTIEDALVHPVWKMGKKISVDSATMMNKALEVLEASYLFELGYRKIDVVIHPES
IVHALAFYQDGTSTALMSLPDMSIPILHALYWPHRKEVSVREVDLIAYGKLTFIRPDFERFPALKAAFDILQSSERDVAS
IVFNAANEVAVESFLNSEITFLEIVNIVLHVMNKVPYGKVSSLADIMEYDLLGRCIAREVISDAS
>Mature_385_residues
MKKVSVFGSTGFIGKTTVGILSGNTEDFKVIALVAGSNVSLLAQQAKLLNAEMAVIADDAQYEELKRSLHGSGIRVAAGK
EAVLEAAALSVDTAVMAITGIVALSAVMRLIESGVGTIALASKESVVCGGVLLRDAACKSGTRIVPVDSEHNAVFRLLSQ
GDNPYKITITASGGPFLHWSHDQLKSVTIEDALVHPVWKMGKKISVDSATMMNKALEVLEASYLFELGYRKIDVVIHPES
IVHALAFYQDGTSTALMSLPDMSIPILHALYWPHRKEVSVREVDLIAYGKLTFIRPDFERFPALKAAFDILQSSERDVAS
IVFNAANEVAVESFLNSEITFLEIVNIVLHVMNKVPYGKVSSLADIMEYDLLGRCIAREVISDAS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=401, Percent_Identity=39.1521197007481, Blast_Score=265, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_ANAPZ (Q2GKQ8)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505043.1
- ProteinModelPortal:   Q2GKQ8
- SMR:   Q2GKQ8
- STRING:   Q2GKQ8
- GeneID:   3930540
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0440
- NMPDR:   fig|212042.5.peg.429
- TIGR:   APH_0440
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q2GKQ8
- ProtClustDB:   PRK05447
- BioCyc:   APHA212042:APH_0440-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41580; Mature: 41580

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 172-172 BINDING 195-195 BINDING 217-217

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVSVFGSTGFIGKTTVGILSGNTEDFKVIALVAGSNVSLLAQQAKLLNAEMAVIADDA
CCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEECCH
QYEELKRSLHGSGIRVAAGKEAVLEAAALSVDTAVMAITGIVALSAVMRLIESGVGTIAL
HHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ASKESVVCGGVLLRDAACKSGTRIVPVDSEHNAVFRLLSQGDNPYKITITASGGPFLHWS
ECCCCEEECHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEC
HDQLKSVTIEDALVHPVWKMGKKISVDSATMMNKALEVLEASYLFELGYRKIDVVIHPES
HHHHHEEEHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
IVHALAFYQDGTSTALMSLPDMSIPILHALYWPHRKEVSVREVDLIAYGKLTFIRPDFER
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEEECEEEEECCCHHH
FPALKAAFDILQSSERDVASIVFNAANEVAVESFLNSEITFLEIVNIVLHVMNKVPYGKV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
SSLADIMEYDLLGRCIAREVISDAS
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKVSVFGSTGFIGKTTVGILSGNTEDFKVIALVAGSNVSLLAQQAKLLNAEMAVIADDA
CCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEECCH
QYEELKRSLHGSGIRVAAGKEAVLEAAALSVDTAVMAITGIVALSAVMRLIESGVGTIAL
HHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ASKESVVCGGVLLRDAACKSGTRIVPVDSEHNAVFRLLSQGDNPYKITITASGGPFLHWS
ECCCCEEECHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEC
HDQLKSVTIEDALVHPVWKMGKKISVDSATMMNKALEVLEASYLFELGYRKIDVVIHPES
HHHHHEEEHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
IVHALAFYQDGTSTALMSLPDMSIPILHALYWPHRKEVSVREVDLIAYGKLTFIRPDFER
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEEECEEEEECCCHHH
FPALKAAFDILQSSERDVASIVFNAANEVAVESFLNSEITFLEIVNIVLHVMNKVPYGKV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
SSLADIMEYDLLGRCIAREVISDAS
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA