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The map label for this gene is ffh [H]

Identifier: 88607548

GI number: 88607548

Start: 335584

End: 336933

Strand: Direct

Name: ffh [H]

Synonym: APH_0349

Alternate gene names: 88607548

Gene position: 335584-336933 (Clockwise)

Preceding gene: 88607670

Following gene: 88607820

Centisome position: 22.81

GC content: 43.19

Gene sequence:

>1350_bases
ATGTTTAACTCTTTAACCAAGGGGTTTTCTTCTGCGCTGCAAAGGTTAAGTGGAAAGCGGGAGATATCCAGCAAGGATTT
TGATCTTGTAATAGAAGATATAACTCAGGCATTGTTGGATGCGGATGTTAATCTTGGTGTTGTTGACGAATTTATAGAGA
ACGTAAAAAGCAAGATCGTAGGGGGCGATGTAGTTAAAGGGGTGCTCCCGGAGCAAATGGTCATAAAGCGTATAGAAGAG
TGTTTGATTGAAGTTTTAGGTAATGAGAAGAGCGCTCTTGATCTTAAGGGAAAGATTCCTGCAGTAATCATGATGGTTGG
GCTTCAAGGTGTTGGTAAGACTACTAACACAGTAAAAGTTGCACTGAGGTTAAAGAAGGATTCTAAAAACCCGTTGGTAG
CGTCTTTAGACGTATATCGTCCTGCAGCTCGAGAACAGCTGAAGGTTTTGGCTGATGGAGTTGGTATAGACAGTCTTCCC
ATCGTTGAGGAGCAAAAACCACTTGATATTGCGAAGCGTGCTATGAGGGAAGCGAGGCTCAAAGGGCACGATGTGGTGCT
TTTGGATACAGCGGGGCGCTTGCATATCAATCAGGACATGATAGATGAGCTGAAGTGTGTAAAGAAGGAGGTATCACCAG
CTGAAATTGTATTGGTTGTAGACTCCTTAATGGGGCAAGATGCCGTCACTATGGTGCGCAAGTTCAATGAGGAGTTAGGC
ATTACTGGGACGATCTTTACCAGGGCGGATGGTGATCCTAGGGGTGGTGCTATCTTGTCTATGAAGTTGGTTGCTGGATG
TCCTATAAAGTTCATGTCTACGGGAGAGAAGCCTGAAGATTTGGACGATTTCTATCCTGATAGAATAGCTCGTAGAATGT
TAAATATGGGAGATGTCGCATCTCTTGTAGAAAAGGCGGTAGAAGCGGTTGGCAAGGATACAATTAATGAGCTACAGGCG
AAGGCCAAGAAGGGTAAATTCGATTTGGATGATCTTGTTATTCAGCTGAAAGCTTTGAATAAAATGGGTGGTATTGCTAA
TATAATGAAGTTTATACCCGCTTTCGGTAACGATATAAAACGCAAAGTTGCGGGGATAGCTGATGACAGCAAAGTCGACA
TGTACATTGCGATTATTAACTCAATGACGAAGCAGGAGAGGGCGAATCCTGAGATACTGAATGGTGCGAGGAAGGCAAGG
ATAGCGAAGGGTGCGGGAGTTAAGGTTGATGCTGTAAATGCGTTGCTAAAGCAGTATAATCAGATGAATTCCATGATAAG
TAAGTTTAGTCAGATGAAGATGGATAAGATTGCAGATTCTGACATAATGAATCTTCTGAAGGGGAAGTAG

Upstream 100 bases:

>100_bases
GGTTCTACTGTATTATCAGCCAGGTCGCCATCTGGGGTTGTTAGCTCTACATTGCTTTTGGTTATGTTGAGTATTTGTAT
TATTGTTTTGGTATGGGCTT

Downstream 100 bases:

>100_bases
CCCGTTATTTTGGGATGTGACACGTGTGATATGCTTGCTACGTCATAGAGCGGGTGTATGGGAGTTTGCTTTTTGTGTTT
TCTAATTTTGGTGAGCGTGT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFNSLTKGFSSALQRLSGKREISSKDFDLVIEDITQALLDADVNLGVVDEFIENVKSKIVGGDVVKGVLPEQMVIKRIEE
CLIEVLGNEKSALDLKGKIPAVIMMVGLQGVGKTTNTVKVALRLKKDSKNPLVASLDVYRPAAREQLKVLADGVGIDSLP
IVEEQKPLDIAKRAMREARLKGHDVVLLDTAGRLHINQDMIDELKCVKKEVSPAEIVLVVDSLMGQDAVTMVRKFNEELG
ITGTIFTRADGDPRGGAILSMKLVAGCPIKFMSTGEKPEDLDDFYPDRIARRMLNMGDVASLVEKAVEAVGKDTINELQA
KAKKGKFDLDDLVIQLKALNKMGGIANIMKFIPAFGNDIKRKVAGIADDSKVDMYIAIINSMTKQERANPEILNGARKAR
IAKGAGVKVDAVNALLKQYNQMNSMISKFSQMKMDKIADSDIMNLLKGK

Sequences:

>Translated_449_residues
MFNSLTKGFSSALQRLSGKREISSKDFDLVIEDITQALLDADVNLGVVDEFIENVKSKIVGGDVVKGVLPEQMVIKRIEE
CLIEVLGNEKSALDLKGKIPAVIMMVGLQGVGKTTNTVKVALRLKKDSKNPLVASLDVYRPAAREQLKVLADGVGIDSLP
IVEEQKPLDIAKRAMREARLKGHDVVLLDTAGRLHINQDMIDELKCVKKEVSPAEIVLVVDSLMGQDAVTMVRKFNEELG
ITGTIFTRADGDPRGGAILSMKLVAGCPIKFMSTGEKPEDLDDFYPDRIARRMLNMGDVASLVEKAVEAVGKDTINELQA
KAKKGKFDLDDLVIQLKALNKMGGIANIMKFIPAFGNDIKRKVAGIADDSKVDMYIAIINSMTKQERANPEILNGARKAR
IAKGAGVKVDAVNALLKQYNQMNSMISKFSQMKMDKIADSDIMNLLKGK
>Mature_449_residues
MFNSLTKGFSSALQRLSGKREISSKDFDLVIEDITQALLDADVNLGVVDEFIENVKSKIVGGDVVKGVLPEQMVIKRIEE
CLIEVLGNEKSALDLKGKIPAVIMMVGLQGVGKTTNTVKVALRLKKDSKNPLVASLDVYRPAAREQLKVLADGVGIDSLP
IVEEQKPLDIAKRAMREARLKGHDVVLLDTAGRLHINQDMIDELKCVKKEVSPAEIVLVVDSLMGQDAVTMVRKFNEELG
ITGTIFTRADGDPRGGAILSMKLVAGCPIKFMSTGEKPEDLDDFYPDRIARRMLNMGDVASLVEKAVEAVGKDTINELQA
KAKKGKFDLDDLVIQLKALNKMGGIANIMKFIPAFGNDIKRKVAGIADDSKVDMYIAIINSMTKQERANPEILNGARKAR
IAKGAGVKVDAVNALLKQYNQMNSMISKFSQMKMDKIADSDIMNLLKGK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=438, Percent_Identity=29.9086757990868, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI226371618, Length=352, Percent_Identity=30.3977272727273, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI23308697, Length=305, Percent_Identity=27.2131147540984, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI295424842, Length=305, Percent_Identity=27.2131147540984, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=28.2758620689655, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=46.1176470588235, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1789874, Length=219, Percent_Identity=34.703196347032, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539958, Length=434, Percent_Identity=27.8801843317972, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193206261, Length=313, Percent_Identity=28.7539936102236, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=416, Percent_Identity=28.6057692307692, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6320498, Length=319, Percent_Identity=26.0188087774295, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17647949, Length=438, Percent_Identity=29.4520547945205, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49051; Mature: 49051

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNSLTKGFSSALQRLSGKREISSKDFDLVIEDITQALLDADVNLGVVDEFIENVKSKIV
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GGDVVKGVLPEQMVIKRIEECLIEVLGNEKSALDLKGKIPAVIMMVGLQGVGKTTNTVKV
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCCCCCEEEE
ALRLKKDSKNPLVASLDVYRPAAREQLKVLADGVGIDSLPIVEEQKPLDIAKRAMREARL
EEEEECCCCCCEEEEHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
KGHDVVLLDTAGRLHINQDMIDELKCVKKEVSPAEIVLVVDSLMGQDAVTMVRKFNEELG
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCHHEEEEHHHHHCCHHHHHHHHHHHHHC
ITGTIFTRADGDPRGGAILSMKLVAGCPIKFMSTGEKPEDLDDFYPDRIARRMLNMGDVA
CEEEEEEECCCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCHHH
SLVEKAVEAVGKDTINELQAKAKKGKFDLDDLVIQLKALNKMGGIANIMKFIPAFGNDIK
HHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHH
RKVAGIADDSKVDMYIAIINSMTKQERANPEILNGARKARIAKGAGVKVDAVNALLKQYN
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHH
QMNSMISKFSQMKMDKIADSDIMNLLKGK
HHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MFNSLTKGFSSALQRLSGKREISSKDFDLVIEDITQALLDADVNLGVVDEFIENVKSKIV
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GGDVVKGVLPEQMVIKRIEECLIEVLGNEKSALDLKGKIPAVIMMVGLQGVGKTTNTVKV
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCCCCCEEEE
ALRLKKDSKNPLVASLDVYRPAAREQLKVLADGVGIDSLPIVEEQKPLDIAKRAMREARL
EEEEECCCCCCEEEEHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
KGHDVVLLDTAGRLHINQDMIDELKCVKKEVSPAEIVLVVDSLMGQDAVTMVRKFNEELG
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCHHEEEEHHHHHCCHHHHHHHHHHHHHC
ITGTIFTRADGDPRGGAILSMKLVAGCPIKFMSTGEKPEDLDDFYPDRIARRMLNMGDVA
CEEEEEEECCCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCHHH
SLVEKAVEAVGKDTINELQAKAKKGKFDLDDLVIQLKALNKMGGIANIMKFIPAFGNDIK
HHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHH
RKVAGIADDSKVDMYIAIINSMTKQERANPEILNGARKARIAKGAGVKVDAVNALLKQYN
HHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHH
QMNSMISKFSQMKMDKIADSDIMNLLKGK
HHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]