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The map label for this gene is hisG

Identifier: 87200931

GI number: 87200931

Start: 3137282

End: 3137953

Strand: Direct

Name: hisG

Synonym: Saro_2919

Alternate gene names: 87200931

Gene position: 3137282-3137953 (Clockwise)

Preceding gene: 87200929

Following gene: 87200932

Centisome position: 88.09

GC content: 68.3

Gene sequence:

>672_bases
ATGTCCACCGCCGCACCGCTCGTTTTCGCCCTGCCGAAGGGCCGCATCCTCGACGAGGCCCTGCCTCTGCTCGAGAAGGC
CGGGATCGTGCCCGAGGCCGAGTTCTTCGACAAGTCCTCGCGCGCGCTGTCCTTTGCCACCAACCGGCCCGACGTGAAGA
TCATCCGCGTCCGCGCCTTCGACGTGGCGACCTTCGTGGCGCACGGCGCGGCCCATGCGGGCATCGTCGGCTCCGACGTG
ATCGACGAGTTCGATTACGCCGACCTCTACGCCCCCGTCGATCTCGACATCGGCCACTGCCGTCTCTCGGTGGCGGAACC
CGTCAGCATGGTCGAAAGCGGCGCCAATGCGCGCGAAAGCCACGCCCGCGTCGCCACCAAGTATCCCAACCTCACCCGCC
GCCACTTCGAAAAGCTGGGCGTGCAGGCAGAGGTGGTGAAGCTGAACGGCGCGATGGAGCTGGCTCCTTCGCTCGGCCTC
GCCAGCCGCATCGTCGATCTCGTCTCCACCGGCCGCACGCTCAAGGAGAACGGCCTTGTCGAGACGAGCCGCATCCTGCC
CGTCTCGGCGCGCCTGATCGTCAACCGCGCCGCCCTGAAGACCGACAGCGCCCGCCTCGGCGCGCTGGTCGATGCCTTCC
GCGCGATGGTCGCTGCAAAGGACGCCGCCTGA

Upstream 100 bases:

>100_bases
GGTCCGCCTGCCATTCGATCGCCTTTGCGACCTCTTCGATCTCCATGATCGGGTTCATTCGGTTGCCCTTTGCGCGTCGC
TGCCATAAGGGCGGCGGGTT

Downstream 100 bases:

>100_bases
TGCTGCGCCTCAGGTCCGGCGATCCCGATTTCGCCCGCGCCTTCGCACGCCTCGTCAAGGAGCGTCGTGAAAGCGATGAC
AACGTCGCGCGCGATGTCCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSTAAPLVFALPKGRILDEALPLLEKAGIVPEAEFFDKSSRALSFATNRPDVKIIRVRAFDVATFVAHGAAHAGIVGSDV
IDEFDYADLYAPVDLDIGHCRLSVAEPVSMVESGANARESHARVATKYPNLTRRHFEKLGVQAEVVKLNGAMELAPSLGL
ASRIVDLVSTGRTLKENGLVETSRILPVSARLIVNRAALKTDSARLGALVDAFRAMVAAKDAA

Sequences:

>Translated_223_residues
MSTAAPLVFALPKGRILDEALPLLEKAGIVPEAEFFDKSSRALSFATNRPDVKIIRVRAFDVATFVAHGAAHAGIVGSDV
IDEFDYADLYAPVDLDIGHCRLSVAEPVSMVESGANARESHARVATKYPNLTRRHFEKLGVQAEVVKLNGAMELAPSLGL
ASRIVDLVSTGRTLKENGLVETSRILPVSARLIVNRAALKTDSARLGALVDAFRAMVAAKDAA
>Mature_222_residues
STAAPLVFALPKGRILDEALPLLEKAGIVPEAEFFDKSSRALSFATNRPDVKIIRVRAFDVATFVAHGAAHAGIVGSDVI
DEFDYADLYAPVDLDIGHCRLSVAEPVSMVESGANARESHARVATKYPNLTRRHFEKLGVQAEVVKLNGAMELAPSLGLA
SRIVDLVSTGRTLKENGLVETSRILPVSARLIVNRAALKTDSARLGALVDAFRAMVAAKDAA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=232, Percent_Identity=32.3275862068966, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320896, Length=223, Percent_Identity=30.0448430493274, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_NOVAD (Q2G469)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_498188.1
- ProteinModelPortal:   Q2G469
- SMR:   Q2G469
- STRING:   Q2G469
- GeneID:   3917354
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2919
- NMPDR:   fig|48935.1.peg.3522
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   Q2G469
- ProtClustDB:   PRK01686
- BioCyc:   NARO279238:SARO_2919-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23801; Mature: 23669

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAAPLVFALPKGRILDEALPLLEKAGIVPEAEFFDKSSRALSFATNRPDVKIIRVRAF
CCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCCCCEEEEEEEHH
DVATFVAHGAAHAGIVGSDVIDEFDYADLYAPVDLDIGHCRLSVAEPVSMVESGANARES
HHHHHHHHCCHHCCCCCHHHHHHCCHHHEECCCCCCCCCEEEEHHHHHHHHHCCCCCHHH
HARVATKYPNLTRRHFEKLGVQAEVVKLNGAMELAPSLGLASRIVDLVSTGRTLKENGLV
HHHHHHCCCCHHHHHHHHHCCEEEEEEECCCHHHCCCCCHHHHHHHHHHCCCCHHHCCCE
ETSRILPVSARLIVNRAALKTDSARLGALVDAFRAMVAAKDAA
EHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STAAPLVFALPKGRILDEALPLLEKAGIVPEAEFFDKSSRALSFATNRPDVKIIRVRAF
CCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCCCCEEEEEEEHH
DVATFVAHGAAHAGIVGSDVIDEFDYADLYAPVDLDIGHCRLSVAEPVSMVESGANARES
HHHHHHHHCCHHCCCCCHHHHHHCCHHHEECCCCCCCCCEEEEHHHHHHHHHCCCCCHHH
HARVATKYPNLTRRHFEKLGVQAEVVKLNGAMELAPSLGLASRIVDLVSTGRTLKENGLV
HHHHHHCCCCHHHHHHHHHCCEEEEEEECCCHHHCCCCCHHHHHHHHHHCCCCHHHCCCE
ETSRILPVSARLIVNRAALKTDSARLGALVDAFRAMVAAKDAA
EHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA