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The map label for this gene is hisD

Identifier: 87200932

GI number: 87200932

Start: 3137953

End: 3139242

Strand: Direct

Name: hisD

Synonym: Saro_2920

Alternate gene names: 87200932

Gene position: 3137953-3139242 (Clockwise)

Preceding gene: 87200931

Following gene: 87200933

Centisome position: 88.11

GC content: 68.91

Gene sequence:

>1290_bases
ATGCTGCGCCTCAGGTCCGGCGATCCCGATTTCGCCCGCGCCTTCGCACGCCTCGTCAAGGAGCGTCGTGAAAGCGATGA
CAACGTCGCGCGCGATGTCCAGACCATCGTCGAGGACGTCCGCCTGCGCGGGGACGAGGCCCTTGCCGAATATACTGCAA
GGTTCGATGGCCACGCCCCCGCCGACGATGACTGGCGCATCTCGCCCGAGGCGTGCCGCGAAGCCTTCGACGCGCTCAAG
CCCGACCTTCGCGCCGCGCTCGAACTCGCGGCGGAACGCATCCGCGAATATCACAAGGCCCAGCTTCCCGGGGACCGCGA
CTACACCGACGCCACCGGCATGCGTCTCGGCGCGCGCTGGCGGCCCGTCGATGGCGCCGGTCTCTATGTGCCCGGAGGCC
GCGCCGCCTATCCCTCGTCGCTGCTGATGAACGCCATCCCCGCCAAGGTCGCGGGGGTCGAGCGTCTGGTCGTCGTCACC
CCCACGCCGAAGGGCGAGGCGAACCCCCTGGTCCTTGCCGCCGCGCACCTTGCCGGCGCGGACGAAGTCTGGCGCGTCGG
CGGGGCGCAGGCGGTTGCCGCGCTCGCCTATGGCACGAAGCGGATCAGGCCGGTCGACGTCATCACCGGTCCGGGCAACG
CCTGGGTGGCCGAGGCCAAGCGCCAGCTCTTCGGCGTCGTGGGCATCGACATGGTCGCCGGGCCTTCGGAAATCCTCGTC
ATCGCCGATGCGAAGAACGATCCGCAATGGATTGCCGCCGACCTCCTCAGCCAGGCCGAGCACGATCCCGTCGCGCAGTC
GATCCTCATCACGGACGACGCCGCATTCGCCGATCAGGTGGCCGACATGGTCGGAGTCGAGATCGCCATGCTGCCCACGG
CAAAGGTCGCCAAGGCAAGCTGGGACGCGCATGGCGTGATCATCGTGGTGGACTCGCTCGACGAAGCGCCCGCGCTCGCC
AATGCGCTCGCCGCCGAACACGTCGAGATCGCCACCGACGATCCCCAGGCCCTGTTCGACCGCATCCGCCACGCCGGATC
GGTCTTCCTCGGTCGCATGACCCCCGAAGCCGTTGGCGATTACGTTGCGGGACCGAACCACGTCCTGCCGACCGGTCGCC
GCGCGCGCTTTTCTTCGGGCCTCTCCGTTCTGGATTTCATGAAACGCACCAGCTTCATCGCGGCCACTGACGCCGCGCTC
GCCGCCGTCGGCCCCGCAGCCGTGGCCCTTGCCGAGGCAGAAGGCCTTGCCGCCCACGCCCGCTCCATCGAACTGAGGCT
CGGCATATGA

Upstream 100 bases:

>100_bases
GCCTGATCGTCAACCGCGCCGCCCTGAAGACCGACAGCGCCCGCCTCGGCGCGCTGGTCGATGCCTTCCGCGCGATGGTC
GCTGCAAAGGACGCCGCCTG

Downstream 100 bases:

>100_bases
CCCAGATTTCCGGAAAGGCCCGCGCCGCCGCGCGCCTCGCCGCCGTTCAGGCGCTCTACCAGGCCGACATGGAGCAGACC
CCGCTCCACCTCCTGCTCGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLRLRSGDPDFARAFARLVKERRESDDNVARDVQTIVEDVRLRGDEALAEYTARFDGHAPADDDWRISPEACREAFDALK
PDLRAALELAAERIREYHKAQLPGDRDYTDATGMRLGARWRPVDGAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLVVVT
PTPKGEANPLVLAAAHLAGADEVWRVGGAQAVAALAYGTKRIRPVDVITGPGNAWVAEAKRQLFGVVGIDMVAGPSEILV
IADAKNDPQWIAADLLSQAEHDPVAQSILITDDAAFADQVADMVGVEIAMLPTAKVAKASWDAHGVIIVVDSLDEAPALA
NALAAEHVEIATDDPQALFDRIRHAGSVFLGRMTPEAVGDYVAGPNHVLPTGRRARFSSGLSVLDFMKRTSFIAATDAAL
AAVGPAAVALAEAEGLAAHARSIELRLGI

Sequences:

>Translated_429_residues
MLRLRSGDPDFARAFARLVKERRESDDNVARDVQTIVEDVRLRGDEALAEYTARFDGHAPADDDWRISPEACREAFDALK
PDLRAALELAAERIREYHKAQLPGDRDYTDATGMRLGARWRPVDGAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLVVVT
PTPKGEANPLVLAAAHLAGADEVWRVGGAQAVAALAYGTKRIRPVDVITGPGNAWVAEAKRQLFGVVGIDMVAGPSEILV
IADAKNDPQWIAADLLSQAEHDPVAQSILITDDAAFADQVADMVGVEIAMLPTAKVAKASWDAHGVIIVVDSLDEAPALA
NALAAEHVEIATDDPQALFDRIRHAGSVFLGRMTPEAVGDYVAGPNHVLPTGRRARFSSGLSVLDFMKRTSFIAATDAAL
AAVGPAAVALAEAEGLAAHARSIELRLGI
>Mature_429_residues
MLRLRSGDPDFARAFARLVKERRESDDNVARDVQTIVEDVRLRGDEALAEYTARFDGHAPADDDWRISPEACREAFDALK
PDLRAALELAAERIREYHKAQLPGDRDYTDATGMRLGARWRPVDGAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLVVVT
PTPKGEANPLVLAAAHLAGADEVWRVGGAQAVAALAYGTKRIRPVDVITGPGNAWVAEAKRQLFGVVGIDMVAGPSEILV
IADAKNDPQWIAADLLSQAEHDPVAQSILITDDAAFADQVADMVGVEIAMLPTAKVAKASWDAHGVIIVVDSLDEAPALA
NALAAEHVEIATDDPQALFDRIRHAGSVFLGRMTPEAVGDYVAGPNHVLPTGRRARFSSGLSVLDFMKRTSFIAATDAAL
AAVGPAAVALAEAEGLAAHARSIELRLGI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=407, Percent_Identity=41.031941031941, Blast_Score=284, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=405, Percent_Identity=38.0246913580247, Blast_Score=255, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45566; Mature: 45566

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLRSGDPDFARAFARLVKERRESDDNVARDVQTIVEDVRLRGDEALAEYTARFDGHAP
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
ADDDWRISPEACREAFDALKPDLRAALELAAERIREYHKAQLPGDRDYTDATGMRLGARW
CCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEE
RPVDGAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLVVVTPTPKGEANPLVLAAAHLAGA
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEHHCCC
DEVWRVGGAQAVAALAYGTKRIRPVDVITGPGNAWVAEAKRQLFGVVGIDMVAGPSEILV
HHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEECCCCEEEE
IADAKNDPQWIAADLLSQAEHDPVAQSILITDDAAFADQVADMVGVEIAMLPTAKVAKAS
EEECCCCCHHHHHHHHHHCCCCCCHHEEEEECCHHHHHHHHHHHCCEEEECCCHHHHHCC
WDAHGVIIVVDSLDEAPALANALAAEHVEIATDDPQALFDRIRHAGSVFLGRMTPEAVGD
CCCCEEEEEEECCCCCHHHHHHHHHHCEEEECCCHHHHHHHHHHHCCEEEECCCHHHHHH
YVAGPNHVLPTGRRARFSSGLSVLDFMKRTSFIAATDAALAAVGPAAVALAEAEGLAAHA
HCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHEEHHHHHHHCCHHHHHHHHHCCHHHHH
RSIELRLGI
HEEEEEECC
>Mature Secondary Structure
MLRLRSGDPDFARAFARLVKERRESDDNVARDVQTIVEDVRLRGDEALAEYTARFDGHAP
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
ADDDWRISPEACREAFDALKPDLRAALELAAERIREYHKAQLPGDRDYTDATGMRLGARW
CCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEE
RPVDGAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLVVVTPTPKGEANPLVLAAAHLAGA
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEHHCCC
DEVWRVGGAQAVAALAYGTKRIRPVDVITGPGNAWVAEAKRQLFGVVGIDMVAGPSEILV
HHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEECCCCEEEE
IADAKNDPQWIAADLLSQAEHDPVAQSILITDDAAFADQVADMVGVEIAMLPTAKVAKAS
EEECCCCCHHHHHHHHHHCCCCCCHHEEEEECCHHHHHHHHHHHCCEEEECCCHHHHHCC
WDAHGVIIVVDSLDEAPALANALAAEHVEIATDDPQALFDRIRHAGSVFLGRMTPEAVGD
CCCCEEEEEEECCCCCHHHHHHHHHHCEEEECCCHHHHHHHHHHHCCEEEECCCHHHHHH
YVAGPNHVLPTGRRARFSSGLSVLDFMKRTSFIAATDAALAAVGPAAVALAEAEGLAAHA
HCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHEEHHHHHHHCCHHHHHHHHHCCHHHHH
RSIELRLGI
HEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA