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The map label for this gene is yngE [H]

Identifier: 87199660

GI number: 87199660

Start: 1718205

End: 1719818

Strand: Reverse

Name: yngE [H]

Synonym: Saro_1643

Alternate gene names: 87199660

Gene position: 1719818-1718205 (Counterclockwise)

Preceding gene: 87199661

Following gene: 87199659

Centisome position: 48.29

GC content: 65.37

Gene sequence:

>1614_bases
TTGAGCGCACCGGTCCTCTCGAGCAACGTCGACCTCAATTCCGAGCAGGCGCAGGCCCGCGCGGCGCATAACCGCGCGCT
GGCGGGGGAACTGCGCGAAAGAGTGGCGAAGGCTGCCCTCGGCGGCGACGAACGCAGCCGCGAACGGCACGTCTCGCGCG
GCAAACTCCTCCCCCGCGAGCGAGTGGAGCGACTGCTCGATCCCGGTGCGCCCTTTCTCGAGATCGGCCAACTCGCCGCG
AACGGCATGTACAACGACGAGGTGCCCGGTGCTGGGATCATTGCCGGGATAGGCCGGGTTTCGGGGCGCCAGTGCATGGT
CTTCGCCAACGACGCGACGGTGAAGGGCGGCACCTACTTCCCGATGACCGTGAAAAAGCACCTTCGCGCGCAGGAGATCG
CGGGCGAAAACCGCCTGCCCTGCATCTACCTGGTCGACAGCGGCGGTGCGAACCTGCCGAACCAGGCCGACGTCTTTCCC
GACCGCGACCACTTCGGCCGCTTCTTCTACAACCAGGCCAACATGAGCGCGCGCGGCATACCGCAGATCGCCAGCGTCAT
GGGATCGTGCACGGCGGGCGGCGCCTATGTGCCGGCGATGAGCGACGAGACCGTCATCGTGCGCGAACAGGGCACGATTT
TCCTCGCCGGACCGCCGCTGGTGAAGGCGGCGACGGGCGAAGAGATCACCGCCGAAGCACTTGGCGGTGGCGACCTTCAT
GCGCGCAAGTCTGGCGTGGTGGACCATCTGGCCGACAACGACGAGCATGCGTTGACCATCGTGCGGGACATCGTTTCGCA
TCTGGATGGGGTTGGACGTCTCGAGAACCCCGCCATGGCGGCGGTGCGGGAGGTGAAGGAGCCGATCTATCCGGCGGAGG
ATCTCTACTCGATCATCCCCGAGGACGTACGCGCCCCCTATGATGTGCACGAAGTGATCGCGCGGATCGTGGATGGCAGC
GAGTTCCACGAGTTCAAGGCACATTACGGCGCAACGCTGGTTTGCGGTTTTGCCCATATCCATGGACTTCCCGTCGCGAT
CCTTGCCAACAACGGCGTGCTCTTTTCCGAAAGCGCGCAGAAGGGCGCGCACTTCATCGAACTTGCCTGCCAGCGTCGCA
TTCCGTTGCTGTTCCTCCAGAACATCTCGGGCTTCATGGTAGGCGGAAAGTACGAGGCCGAAGGAATCGCCAAGCACGGT
GCAAAGCTGGTGACCGCCGTCGCCACTGCGCAGGTGCCCAAGATAACCGTGCTGATTGGCGGCAGCTTCGGCGCGGGCAA
CTATGGCATGTGCGGCAGGGCCTACCAGCCGCGCTTCCTGTTCACGTGGCCCAACGCCCGCATCTCGGTGATGGGCGGCG
AACAGGCCGCCTCGGTGCTCGCGACCGTCCACCGCGATGCGGACAAGTGGACGCCCGAGGAAGCCGAGGCCTTCAAGGCA
CCGATCCGCCAGAAGTACGAGGACGAAGGCAACCCTTACCACGCCACCGCAAGGCTGTGGGACGACGGCGTGATCGACCC
CGTCCAGACCCGCGACGTGCTGGGGCTCGCCCTCGAGGCCTGTCTCGAAGCGCCGATTGCGGAGGCGCCCCGGTTCGGGG
TGTTCAGGATGTGA

Upstream 100 bases:

>100_bases
ACTGGGAGATCTATGTGGGCGACCACGGCAACCGCGTGAAGGAGCGCTTTGTCACCAAAGTTCTTCCCTTCTTCACCCGT
CACCTGAAAGGCAGCACGCG

Downstream 100 bases:

>100_bases
TGGAGGCCAGACCGATGATCAAATCCCTCCTCGTCGCCAATCGCGGCGAAATTGCCTGTCGCGTGATCCGTACAGCGCGG
CGCATGGGCGTTCGCACAGT

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MSAPVLSSNVDLNSEQAQARAAHNRALAGELRERVAKAALGGDERSRERHVSRGKLLPRERVERLLDPGAPFLEIGQLAA
NGMYNDEVPGAGIIAGIGRVSGRQCMVFANDATVKGGTYFPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQADVFP
DRDHFGRFFYNQANMSARGIPQIASVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEEITAEALGGGDLH
ARKSGVVDHLADNDEHALTIVRDIVSHLDGVGRLENPAMAAVREVKEPIYPAEDLYSIIPEDVRAPYDVHEVIARIVDGS
EFHEFKAHYGATLVCGFAHIHGLPVAILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHG
AKLVTAVATAQVPKITVLIGGSFGAGNYGMCGRAYQPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTPEEAEAFKA
PIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLALEACLEAPIAEAPRFGVFRM

Sequences:

>Translated_537_residues
MSAPVLSSNVDLNSEQAQARAAHNRALAGELRERVAKAALGGDERSRERHVSRGKLLPRERVERLLDPGAPFLEIGQLAA
NGMYNDEVPGAGIIAGIGRVSGRQCMVFANDATVKGGTYFPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQADVFP
DRDHFGRFFYNQANMSARGIPQIASVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEEITAEALGGGDLH
ARKSGVVDHLADNDEHALTIVRDIVSHLDGVGRLENPAMAAVREVKEPIYPAEDLYSIIPEDVRAPYDVHEVIARIVDGS
EFHEFKAHYGATLVCGFAHIHGLPVAILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHG
AKLVTAVATAQVPKITVLIGGSFGAGNYGMCGRAYQPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTPEEAEAFKA
PIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLALEACLEAPIAEAPRFGVFRM
>Mature_536_residues
SAPVLSSNVDLNSEQAQARAAHNRALAGELRERVAKAALGGDERSRERHVSRGKLLPRERVERLLDPGAPFLEIGQLAAN
GMYNDEVPGAGIIAGIGRVSGRQCMVFANDATVKGGTYFPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQADVFPD
RDHFGRFFYNQANMSARGIPQIASVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEEITAEALGGGDLHA
RKSGVVDHLADNDEHALTIVRDIVSHLDGVGRLENPAMAAVREVKEPIYPAEDLYSIIPEDVRAPYDVHEVIARIVDGSE
FHEFKAHYGATLVCGFAHIHGLPVAILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHGA
KLVTAVATAQVPKITVLIGGSFGAGNYGMCGRAYQPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTPEEAEAFKAP
IRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLALEACLEAPIAEAPRFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=542, Percent_Identity=64.3911439114391, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=33.4637964774951, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=32.7683615819209, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI310133460, Length=147, Percent_Identity=59.1836734693878, Blast_Score=158, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=541, Percent_Identity=61.7375231053604, Blast_Score=683, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=520, Percent_Identity=34.0384615384615, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI25147362, Length=516, Percent_Identity=34.1085271317829, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24586065, Length=553, Percent_Identity=61.6636528028933, Blast_Score=687, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57789; Mature: 57658

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPVLSSNVDLNSEQAQARAAHNRALAGELRERVAKAALGGDERSRERHVSRGKLLPRE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
RVERLLDPGAPFLEIGQLAANGMYNDEVPGAGIIAGIGRVSGRQCMVFANDATVKGGTYF
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHEEHHHCCCCCEEEEEECCCEECCCEEC
PMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQADVFPDRDHFGRFFYNQANMSARGI
CHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCCCC
PQIASVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEEITAEALGGGDLH
HHHHHHHHCCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCCEEHHHCCCCCCH
ARKSGVVDHLADNDEHALTIVRDIVSHLDGVGRLENPAMAAVREVKEPIYPAEDLYSIIP
HHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCC
EDVRAPYDVHEVIARIVDGSEFHEFKAHYGATLVCGFAHIHGLPVAILANNGVLFSESAQ
HHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCEEEEHHHHHCCCCEEEEECCCEEEECCHH
KGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVTAVATAQVPKITVLIG
CCHHHHHHHHHCCCCEEEECCCCCEEECCEECCCHHHHHCHHHHHHHHHCCCCEEEEEEE
GSFGAGNYGMCGRAYQPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTPEEAEAFKA
CCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHH
PIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLALEACLEAPIAEAPRFGVFRM
HHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
>Mature Secondary Structure 
SAPVLSSNVDLNSEQAQARAAHNRALAGELRERVAKAALGGDERSRERHVSRGKLLPRE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
RVERLLDPGAPFLEIGQLAANGMYNDEVPGAGIIAGIGRVSGRQCMVFANDATVKGGTYF
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHEEHHHCCCCCEEEEEECCCEECCCEEC
PMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQADVFPDRDHFGRFFYNQANMSARGI
CHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCCCC
PQIASVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEEITAEALGGGDLH
HHHHHHHHCCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCCEEHHHCCCCCCH
ARKSGVVDHLADNDEHALTIVRDIVSHLDGVGRLENPAMAAVREVKEPIYPAEDLYSIIP
HHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCC
EDVRAPYDVHEVIARIVDGSEFHEFKAHYGATLVCGFAHIHGLPVAILANNGVLFSESAQ
HHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCEEEEHHHHHCCCCEEEEECCCEEEECCHH
KGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVTAVATAQVPKITVLIG
CCHHHHHHHHHCCCCEEEECCCCCEEECCEECCCHHHHHCHHHHHHHHHCCCCEEEEEEE
GSFGAGNYGMCGRAYQPRFLFTWPNARISVMGGEQAASVLATVHRDADKWTPEEAEAFKA
CCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHH
PIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLALEACLEAPIAEAPRFGVFRM
HHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]