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The map label for this gene is mprA [H]

Identifier: 87199648

GI number: 87199648

Start: 1706922

End: 1707605

Strand: Reverse

Name: mprA [H]

Synonym: Saro_1631

Alternate gene names: 87199648

Gene position: 1707605-1706922 (Counterclockwise)

Preceding gene: 87199649

Following gene: 87199635

Centisome position: 47.95

GC content: 61.55

Gene sequence:

>684_bases
ATGAGAATACTCATCATCGAGGACGAGATCGAACTGGCGGGTGCCTTGCACCGTGGCCTTACCCAGGAAGGCTGCAAGGT
CACCCTCGCGACCGACGGCTCCACAGGGCTAGAGCTTGCAGCCTCCCTCGCATTCGACTTCATCCTGCTCGACGTGAACC
TGCCGGACATGGATGGTTTCGAAGTCTGCGCGCGCCTGCGCGAACAGGGTTCCACCATGCCGATCATCATGGTTACGGCG
CGTGACGAGATTGCAGATCGCATTCGCGGGCTCAAGGGTGGCGCGGATGATTACCTGACCAAGCCTTTCGCGTTCGAGGA
ACTGCTGGCGCGCATGGACGCGATCAAGCGTCGCATGGCACCCTCGCAAGGTGGCAAGGTACAGCCCGATGGACGGATCA
CCGTCGGCGACCTACACTTCGATCCGCGCACGATGACCCTGACGAGGGCAGGCACGCCGGTGCAGCTCACGGTCAAGGAA
ATGGGTGTACTGCGTCTCTTGATGGAATCGCCGGGCACGGTGATCTCGCGCACCGAAATCCTTCGCGCAGTCTGGGGAAT
GGAGGACGATCCCCTGACCAACATTGTCGAAGTCTACCTGAGCCGACTGCGCCGCAAGCTCCACGCCCTCGGCCCGCCAG
TGGTCGAAAACGTGCGTGGCTTCGGGTACCGCCTGATCGCTTAA

Upstream 100 bases:

>100_bases
TCGGTGGCACGATCAGCCTAGAGAGCCGGCTCCATGAAGGAACCCGGGTATCGATACGTCTCCCCCTCCCGCCAAGCGGG
ACGGCACATGGAATCATCGC

Downstream 100 bases:

>100_bases
AAAGGGGCGCCGGCAAGGCGCCCCTCTCGTTCAACTTACGAGGCCAGTCGCCCGGTTCCGCTATCCGGCGTGCGTTGCCG
CAGCCATTGCAGCGCCAGGA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRILIIEDEIELAGALHRGLTQEGCKVTLATDGSTGLELAASLAFDFILLDVNLPDMDGFEVCARLREQGSTMPIIMVTA
RDEIADRIRGLKGGADDYLTKPFAFEELLARMDAIKRRMAPSQGGKVQPDGRITVGDLHFDPRTMTLTRAGTPVQLTVKE
MGVLRLLMESPGTVISRTEILRAVWGMEDDPLTNIVEVYLSRLRRKLHALGPPVVENVRGFGYRLIA

Sequences:

>Translated_227_residues
MRILIIEDEIELAGALHRGLTQEGCKVTLATDGSTGLELAASLAFDFILLDVNLPDMDGFEVCARLREQGSTMPIIMVTA
RDEIADRIRGLKGGADDYLTKPFAFEELLARMDAIKRRMAPSQGGKVQPDGRITVGDLHFDPRTMTLTRAGTPVQLTVKE
MGVLRLLMESPGTVISRTEILRAVWGMEDDPLTNIVEVYLSRLRRKLHALGPPVVENVRGFGYRLIA
>Mature_227_residues
MRILIIEDEIELAGALHRGLTQEGCKVTLATDGSTGLELAASLAFDFILLDVNLPDMDGFEVCARLREQGSTMPIIMVTA
RDEIADRIRGLKGGADDYLTKPFAFEELLARMDAIKRRMAPSQGGKVQPDGRITVGDLHFDPRTMTLTRAGTPVQLTVKE
MGVLRLLMESPGTVISRTEILRAVWGMEDDPLTNIVEVYLSRLRRKLHALGPPVVENVRGFGYRLIA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=40.7079646017699, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=39.1111111111111, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=37.280701754386, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=36.4035087719298, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=35.2422907488987, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=34.6666666666667, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=35.2422907488987, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=34.5132743362832, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=35.8078602620087, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.8035714285714, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.2173913043478, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=34.6491228070175, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.6943231441048, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1790299, Length=133, Percent_Identity=29.3233082706767, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=32.4324324324324, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=123, Percent_Identity=34.9593495934959, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=31.6831683168317, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.9622641509434, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=129, Percent_Identity=31.0077519379845, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25060; Mature: 25060

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIIEDEIELAGALHRGLTQEGCKVTLATDGSTGLELAASLAFDFILLDVNLPDMDGF
CEEEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHEEEEEEEECCCCCCHH
EVCARLREQGSTMPIIMVTARDEIADRIRGLKGGADDYLTKPFAFEELLARMDAIKRRMA
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
PSQGGKVQPDGRITVGDLHFDPRTMTLTRAGTPVQLTVKEMGVLRLLMESPGTVISRTEI
CCCCCEECCCCCEEEEEEEECCCEEEEEECCCCEEEEHHHHHHHHHHHHCCCCHHHHHHH
LRAVWGMEDDPLTNIVEVYLSRLRRKLHALGPPVVENVRGFGYRLIA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECC
>Mature Secondary Structure
MRILIIEDEIELAGALHRGLTQEGCKVTLATDGSTGLELAASLAFDFILLDVNLPDMDGF
CEEEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHEEEEEEEECCCCCCHH
EVCARLREQGSTMPIIMVTARDEIADRIRGLKGGADDYLTKPFAFEELLARMDAIKRRMA
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
PSQGGKVQPDGRITVGDLHFDPRTMTLTRAGTPVQLTVKEMGVLRLLMESPGTVISRTEI
CCCCCEECCCCCEEEEEEEECCCEEEEEECCCCEEEEHHHHHHHHHHHHCCCCHHHHHHH
LRAVWGMEDDPLTNIVEVYLSRLRRKLHALGPPVVENVRGFGYRLIA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA