Click here to switch to the map view.

The map label for this gene is murB

Identifier: 87199157

GI number: 87199157

Start: 1181540

End: 1182433

Strand: Direct

Name: murB

Synonym: Saro_1135

Alternate gene names: 87199157

Gene position: 1181540-1182433 (Clockwise)

Preceding gene: 87199156

Following gene: 87199158

Centisome position: 33.17

GC content: 65.66

Gene sequence:

>894_bases
GTGAGCAATTCGGTCCCTTCCAGCGTGAGGGGAAAACTGACCCCAGATGCCCCGCTCGCTCCGCTGGTCTGGTTCAAGTC
CGGTGGCACCGCCGATTGGCTGTTCGAACCACGGGACGTGGCCGACCTCCAGGATTTTCTCGCGGGCCTTGCCCCGGAAG
TGCCGGTCATGGCGCTGGGCCTCGGCTCCAATCTGATCGTGCGCGATGGTGGTGTGCCGGGCGTGGTGATCCGCCTCGGC
AAGGCCTTCGCCAAGGTCGCGAAGGTCGACGAGGTCACGCTCGATTGCGGCGGCGGCGCGAGCGGCATTCTCGTTTCCTC
GACCGCGCGCGACAACGGCATCGCCGGTCTCGAATTTCTCCGTTCGATTCCCGGCACGGTCGGCGGCTTCGTACGCATGA
ACGGCGGCGCCTATGGCCGCGAGGTCAAGGACGTGCTTGTCGATTGCGACGTCGTGATCCGCTCGGGCGAGATCGTCACC
CTGCCGCTGTCCGAACTCGGCTATACCTACCGTCATTCCAACCTGACCGACGGTTCGATCGTCGTCGCAGCCCGCTTTCG
CGGGCATCCCGGCAATCCGGAAGCGATCCAGGCCGAGATGGACCGCATCAGCGCCGCGCGCGAGGCTTCGCAGCCGCTGC
GTTCCAAGACCGGCGGCTCAACCTTCAAGAACCCCGATGGCGGCAAGGCCTGGGAACTGGTCGACAAGGCCGGCTGCCGC
GGCCTCCAGATCGGCGGCGCGCAGGTCAGCGAAAAGCACACCAATTTCCTCATCAACACCGGCACTGCCACCAGCGCCGA
GATCGAAGGCCTGGGCGAGGAAGTCCGCCGCCGCGTGAAGGCGAGTTCAGGCGTGGACCTCGAATGGGAAATCAAGAGGA
TAGGCCGGCCATGA

Upstream 100 bases:

>100_bases
CAGTGCAGGCGGGCGACATGGTCGTGTGCCTCGGCGCAGGTGACATCACCAAGTGGGCAGCAGGTCTTGCCGACGCGATC
GCGCGCGAAAGGGCTGGGGC

Downstream 100 bases:

>100_bases
CGGTGCCCGCCCATCGACTCGAGCCGAACGGAGAATGCTGAGAGTGTCCCTGCCCAAACTTCACGTTGCAGTCCTCATGG
GTGGCTGGTCCAGCGAACGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSNSVPSSVRGKLTPDAPLAPLVWFKSGGTADWLFEPRDVADLQDFLAGLAPEVPVMALGLGSNLIVRDGGVPGVVIRLG
KAFAKVAKVDEVTLDCGGGASGILVSSTARDNGIAGLEFLRSIPGTVGGFVRMNGGAYGREVKDVLVDCDVVIRSGEIVT
LPLSELGYTYRHSNLTDGSIVVAARFRGHPGNPEAIQAEMDRISAAREASQPLRSKTGGSTFKNPDGGKAWELVDKAGCR
GLQIGGAQVSEKHTNFLINTGTATSAEIEGLGEEVRRRVKASSGVDLEWEIKRIGRP

Sequences:

>Translated_297_residues
MSNSVPSSVRGKLTPDAPLAPLVWFKSGGTADWLFEPRDVADLQDFLAGLAPEVPVMALGLGSNLIVRDGGVPGVVIRLG
KAFAKVAKVDEVTLDCGGGASGILVSSTARDNGIAGLEFLRSIPGTVGGFVRMNGGAYGREVKDVLVDCDVVIRSGEIVT
LPLSELGYTYRHSNLTDGSIVVAARFRGHPGNPEAIQAEMDRISAAREASQPLRSKTGGSTFKNPDGGKAWELVDKAGCR
GLQIGGAQVSEKHTNFLINTGTATSAEIEGLGEEVRRRVKASSGVDLEWEIKRIGRP
>Mature_296_residues
SNSVPSSVRGKLTPDAPLAPLVWFKSGGTADWLFEPRDVADLQDFLAGLAPEVPVMALGLGSNLIVRDGGVPGVVIRLGK
AFAKVAKVDEVTLDCGGGASGILVSSTARDNGIAGLEFLRSIPGTVGGFVRMNGGAYGREVKDVLVDCDVVIRSGEIVTL
PLSELGYTYRHSNLTDGSIVVAARFRGHPGNPEAIQAEMDRISAAREASQPLRSKTGGSTFKNPDGGKAWELVDKAGCRG
LQIGGAQVSEKHTNFLINTGTATSAEIEGLGEEVRRRVKASSGVDLEWEIKRIGRP

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=290, Percent_Identity=27.9310344827586, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_NOVAD (Q2G993)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496414.1
- ProteinModelPortal:   Q2G993
- SMR:   Q2G993
- STRING:   Q2G993
- GeneID:   3916431
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1135
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- PhylomeDB:   Q2G993
- ProtClustDB:   PRK13905
- BioCyc:   NARO279238:SARO_1135-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 31221; Mature: 31090

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 171-171 ACT_SITE 220-220 ACT_SITE 290-290

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSVPSSVRGKLTPDAPLAPLVWFKSGGTADWLFEPRDVADLQDFLAGLAPEVPVMALG
CCCCCCCHHCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEE
LGSNLIVRDGGVPGVVIRLGKAFAKVAKVDEVTLDCGGGASGILVSSTARDNGIAGLEFL
CCCCEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEECCCCCCCCHHHHHH
RSIPGTVGGFVRMNGGAYGREVKDVLVDCDVVIRSGEIVTLPLSELGYTYRHSNLTDGSI
HHCCCCCCCEEEECCCCCCHHHHHHHHCCEEEEECCCEEEEEHHHCCCEEECCCCCCCCE
VVAARFRGHPGNPEAIQAEMDRISAAREASQPLRSKTGGSTFKNPDGGKAWELVDKAGCR
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCC
GLQIGGAQVSEKHTNFLINTGTATSAEIEGLGEEVRRRVKASSGVDLEWEIKRIGRP
EEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCC
>Mature Secondary Structure 
SNSVPSSVRGKLTPDAPLAPLVWFKSGGTADWLFEPRDVADLQDFLAGLAPEVPVMALG
CCCCCCHHCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEE
LGSNLIVRDGGVPGVVIRLGKAFAKVAKVDEVTLDCGGGASGILVSSTARDNGIAGLEFL
CCCCEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEECCCCCCCCHHHHHH
RSIPGTVGGFVRMNGGAYGREVKDVLVDCDVVIRSGEIVTLPLSELGYTYRHSNLTDGSI
HHCCCCCCCEEEECCCCCCHHHHHHHHCCEEEEECCCEEEEEHHHCCCEEECCCCCCCCE
VVAARFRGHPGNPEAIQAEMDRISAAREASQPLRSKTGGSTFKNPDGGKAWELVDKAGCR
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCC
GLQIGGAQVSEKHTNFLINTGTATSAEIEGLGEEVRRRVKASSGVDLEWEIKRIGRP
EEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA