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The map label for this gene is murC

Identifier: 87199156

GI number: 87199156

Start: 1180119

End: 1181543

Strand: Direct

Name: murC

Synonym: Saro_1134

Alternate gene names: 87199156

Gene position: 1180119-1181543 (Clockwise)

Preceding gene: 87199155

Following gene: 87199157

Centisome position: 33.13

GC content: 65.33

Gene sequence:

>1425_bases
ATGAAGGGCGTCGGCACCGAGATCGGCACGATCCATTTCGTCGGCATCGGCGGCATCGGCATGTCAGGCATTGCCGAGGT
CATGCACAACATGGGCTATTCGGTGCAGGGTTCGGACATGGCGGAAAGCTATGTCGTCGAAGGCCTGCGCTCGCGCGGGA
TCAAGGTGATGATCGGCCAGAAGGCCGAGAACGTCGCCGGCGTTGCCGTCGTCGTCACCTCGACCGCGGTCAAGCGCGAC
AATCCGGAAGTCGTCGCCGCGCTCGAGAACCGCATTCCCGTCGTCCGCCGCGCCGAAATGCTTGCCGAGCTAATGCGGCT
GAAAAGCACGGTCGCGGTTGCCGGTACCCACGGCAAGACCACCACGACTTCGATGGTCGCCTGTCTTCTTGACGCCGGGG
GGATCGATCCCACCGTCATCAATGGCGGCATCATCAATTCCTATGGCTCGAACGCGCGCCTGGGCGACAGCGACTGGATG
GTGGTGGAGGCCGACGAAAGCGACGGTTCCTTCCTGCGCCTCGACGGCACGCTTGCGGTCGTCACCAACATCGATCCCGA
GCATCTCGATCACTATGGCAGCTTCGAGCGAGTGAAGTCTGCCTTCGTCGAGTTCATCGAGAACGTGCCTTTCTATGGCG
CGGCGATGCTCTGCATCGACCATCCGGAAGTCCAGGCGATCATCCCCAAGGTGCGCGACCGCCGTGTCGTGACCTATGGC
TTCTCCGCCCAGGCCGACGTGCGCGGCGAGGGCGTGACCCCGATCCCGGGCGGCAACCGCTTCACCGCCGTGCTGCGCCA
GCGCGATGGCTCGTTCCGCCGCATCGAAGGCATCGAACTGCCGATGCCGGGCCGCCATAACGTTCAGAACGCGCTCGCCG
CTGTTGCCGTGGCGGTGGAAATGGGCGTCTCGGACGAACTCATTCGCGGCGGCTTTGCCAAGTTCGGCGGGGTCAAGCGC
CGCTTCACCAAGGTCGGTGAAGTCGACATTGGCTCTGGAGCAGTCACGATAATCGACGACTACGGCCACCATCCGGTCGA
AATCCGCGCCGTTCTGGCCGCCGCACGCGAGGGCGTGCAGGGCCGCGTCATCGCCGTTGTTCAGCCGCACCGCTTCACCC
GCCTGCGCGACCACATGGACGAGTTCCAGGGCGCCTTCAACGATGCTGACGTGGTCTATGCCGCGCCCGTCTATCCGGCC
GGCGAGCAGCCCATCGAAGGCGTGGACAGCGCGGCCATGGTCGAAGGCATCAAGGCGCGGGGCCACCGCAGCGCGCACCT
GACCACGGGTGCGGATGAGCTGGCGAAGGAGCTTGCCGCCACAGTGCAGGCGGGCGACATGGTCGTGTGCCTCGGCGCAG
GTGACATCACCAAGTGGGCAGCAGGTCTTGCCGACGCGATCGCGCGCGAAAGGGCTGGGGCGTGA

Upstream 100 bases:

>100_bases
ACCTCGCTGACCTCGTCGAAAGCTTCGGCGCCAGCCCGATCATGGACGTGATCCGCCTCGATTCCACCGTCTCGGCCGCA
TCCGGGCAGGAGCAACTGGC

Downstream 100 bases:

>100_bases
GCAATTCGGTCCCTTCCAGCGTGAGGGGAAAACTGACCCCAGATGCCCCGCTCGCTCCGCTGGTCTGGTTCAAGTCCGGT
GGCACCGCCGATTGGCTGTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKGVGTEIGTIHFVGIGGIGMSGIAEVMHNMGYSVQGSDMAESYVVEGLRSRGIKVMIGQKAENVAGVAVVVTSTAVKRD
NPEVVAALENRIPVVRRAEMLAELMRLKSTVAVAGTHGKTTTTSMVACLLDAGGIDPTVINGGIINSYGSNARLGDSDWM
VVEADESDGSFLRLDGTLAVVTNIDPEHLDHYGSFERVKSAFVEFIENVPFYGAAMLCIDHPEVQAIIPKVRDRRVVTYG
FSAQADVRGEGVTPIPGGNRFTAVLRQRDGSFRRIEGIELPMPGRHNVQNALAAVAVAVEMGVSDELIRGGFAKFGGVKR
RFTKVGEVDIGSGAVTIIDDYGHHPVEIRAVLAAAREGVQGRVIAVVQPHRFTRLRDHMDEFQGAFNDADVVYAAPVYPA
GEQPIEGVDSAAMVEGIKARGHRSAHLTTGADELAKELAATVQAGDMVVCLGAGDITKWAAGLADAIARERAGA

Sequences:

>Translated_474_residues
MKGVGTEIGTIHFVGIGGIGMSGIAEVMHNMGYSVQGSDMAESYVVEGLRSRGIKVMIGQKAENVAGVAVVVTSTAVKRD
NPEVVAALENRIPVVRRAEMLAELMRLKSTVAVAGTHGKTTTTSMVACLLDAGGIDPTVINGGIINSYGSNARLGDSDWM
VVEADESDGSFLRLDGTLAVVTNIDPEHLDHYGSFERVKSAFVEFIENVPFYGAAMLCIDHPEVQAIIPKVRDRRVVTYG
FSAQADVRGEGVTPIPGGNRFTAVLRQRDGSFRRIEGIELPMPGRHNVQNALAAVAVAVEMGVSDELIRGGFAKFGGVKR
RFTKVGEVDIGSGAVTIIDDYGHHPVEIRAVLAAAREGVQGRVIAVVQPHRFTRLRDHMDEFQGAFNDADVVYAAPVYPA
GEQPIEGVDSAAMVEGIKARGHRSAHLTTGADELAKELAATVQAGDMVVCLGAGDITKWAAGLADAIARERAGA
>Mature_474_residues
MKGVGTEIGTIHFVGIGGIGMSGIAEVMHNMGYSVQGSDMAESYVVEGLRSRGIKVMIGQKAENVAGVAVVVTSTAVKRD
NPEVVAALENRIPVVRRAEMLAELMRLKSTVAVAGTHGKTTTTSMVACLLDAGGIDPTVINGGIINSYGSNARLGDSDWM
VVEADESDGSFLRLDGTLAVVTNIDPEHLDHYGSFERVKSAFVEFIENVPFYGAAMLCIDHPEVQAIIPKVRDRRVVTYG
FSAQADVRGEGVTPIPGGNRFTAVLRQRDGSFRRIEGIELPMPGRHNVQNALAAVAVAVEMGVSDELIRGGFAKFGGVKR
RFTKVGEVDIGSGAVTIIDDYGHHPVEIRAVLAAAREGVQGRVIAVVQPHRFTRLRDHMDEFQGAFNDADVVYAAPVYPA
GEQPIEGVDSAAMVEGIKARGHRSAHLTTGADELAKELAATVQAGDMVVCLGAGDITKWAAGLADAIARERAGA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=462, Percent_Identity=46.3203463203463, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1790680, Length=483, Percent_Identity=27.7432712215321, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_NOVAD (Q2G994)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496413.1
- ProteinModelPortal:   Q2G994
- SMR:   Q2G994
- STRING:   Q2G994
- GeneID:   3916430
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1134
- NMPDR:   fig|48935.1.peg.666
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q2G994
- ProtClustDB:   PRK00421
- BioCyc:   NARO279238:SARO_1134-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50211; Mature: 50211

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVGTEIGTIHFVGIGGIGMSGIAEVMHNMGYSVQGSDMAESYVVEGLRSRGIKVMIGQ
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECC
KAENVAGVAVVVTSTAVKRDNPEVVAALENRIPVVRRAEMLAELMRLKSTVAVAGTHGKT
CCCCCCEEEEEEEEHHHCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCC
TTTSMVACLLDAGGIDPTVINGGIINSYGSNARLGDSDWMVVEADESDGSFLRLDGTLAV
HHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCCEEEEEECCCCCCEEEECCEEEE
VTNIDPEHLDHYGSFERVKSAFVEFIENVPFYGAAMLCIDHPEVQAIIPKVRDRRVVTYG
EECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEC
FSAQADVRGEGVTPIPGGNRFTAVLRQRDGSFRRIEGIELPMPGRHNVQNALAAVAVAVE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHH
MGVSDELIRGGFAKFGGVKRRFTKVGEVDIGSGAVTIIDDYGHHPVEIRAVLAAAREGVQ
CCCCHHHHHCCHHHHCCHHHHHHHCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCC
GRVIAVVQPHRFTRLRDHMDEFQGAFNDADVVYAAPVYPAGEQPIEGVDSAAMVEGIKAR
CEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
GHRSAHLTTGADELAKELAATVQAGDMVVCLGAGDITKWAAGLADAIARERAGA
CCCCEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGVGTEIGTIHFVGIGGIGMSGIAEVMHNMGYSVQGSDMAESYVVEGLRSRGIKVMIGQ
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEECC
KAENVAGVAVVVTSTAVKRDNPEVVAALENRIPVVRRAEMLAELMRLKSTVAVAGTHGKT
CCCCCCEEEEEEEEHHHCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCC
TTTSMVACLLDAGGIDPTVINGGIINSYGSNARLGDSDWMVVEADESDGSFLRLDGTLAV
HHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCCEEEEEECCCCCCEEEECCEEEE
VTNIDPEHLDHYGSFERVKSAFVEFIENVPFYGAAMLCIDHPEVQAIIPKVRDRRVVTYG
EECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEC
FSAQADVRGEGVTPIPGGNRFTAVLRQRDGSFRRIEGIELPMPGRHNVQNALAAVAVAVE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHH
MGVSDELIRGGFAKFGGVKRRFTKVGEVDIGSGAVTIIDDYGHHPVEIRAVLAAAREGVQ
CCCCHHHHHCCHHHHCCHHHHHHHCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCC
GRVIAVVQPHRFTRLRDHMDEFQGAFNDADVVYAAPVYPAGEQPIEGVDSAAMVEGIKAR
CEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
GHRSAHLTTGADELAKELAATVQAGDMVVCLGAGDITKWAAGLADAIARERAGA
CCCCEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA