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The map label for this gene is yxbG [H]

Identifier: 87199092

GI number: 87199092

Start: 1114693

End: 1115478

Strand: Direct

Name: yxbG [H]

Synonym: Saro_1070

Alternate gene names: 87199092

Gene position: 1114693-1115478 (Clockwise)

Preceding gene: 87199091

Following gene: 87199093

Centisome position: 31.3

GC content: 66.41

Gene sequence:

>786_bases
ATGAAGCTCGACAATACCGTTGCCGCCGTCGTCACCGGCGGCGCATCCGGCCTCGGCGCCGCGACCGCCCGCGCGCTTGC
CGCCAAGGGCGTGAAGGTCGCCATCTTCGACCTCCAGAAGGAAAAGGGCGAGGCCGTGGCTGCCGAAATCGGCGGCGTGT
TCTGCGAAGTGAACGTGACCAGCGACGAAAGCGTCGATGCCGGCTTCGCCAAGGCCCGCGCCGCGCACGGGCAGGAGCGC
ATCCTCGTCAACTGCGCGGGCACCGGCAATGCCATCAAGACCGCCAGCCGTTCCAAGGAAACCGGCGAGATCAAGCACTT
CCCGATGGATGCCTTCAACTGGATCATCCAGATCAACCTGGTCGGCACGTTCCGCTGCATCGCCAAGTCGGCGGCCGGCA
TGATGACGCTCGACCCCTGCGACGAGTTTGGCGAGCGTGGCGCGATCGTGAACACCGCTTCGGTTGCGGCGGAAGATGGC
CAGATGGGCCAGGCCGCCTACTCGGCGTCGAAGGGTGGCGTCGTTGGCATGACCCTGCCGATCGCGCGCGACCTGATGAG
CGAGGGCATCCGCGTCAACACCATCCTGCCCGGCATCTTCAACACCCCGCTGCTTCAGGGCGCGCCCGACAACGTCAAGG
CCGCGCTTGCCGCCTCGGTCCCGTTTCCCAAGCGCCTCGGCCAGCCGGAAGAGTATGCCAATCTCGCCTTGTGCATGATC
GAGACCGGCTATTTCAACGGCGAGGACGTCCGTCTCGACGGCGCCATCCGCATGGCGCCGCGCTGA

Upstream 100 bases:

>100_bases
GTACGGTTTGCAGACGATGTGCGAAGGCGGCGGCGTGGCCAACGTCACGATCATCGAGGCACTTTGAACATAACAAGCGT
TTGAGAGAGGATTACCCCAG

Downstream 100 bases:

>100_bases
TGTTTTGATGCGATGAGGGGCGGGGCAGTGCATCCCGCCCCCATCGAACGGGAGAGGTCATTTGGCCGAATACAAGCAGA
TCACGCTCGAAATTGCCGAC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKLDNTVAAVVTGGASGLGAATARALAAKGVKVAIFDLQKEKGEAVAAEIGGVFCEVNVTSDESVDAGFAKARAAHGQER
ILVNCAGTGNAIKTASRSKETGEIKHFPMDAFNWIIQINLVGTFRCIAKSAAGMMTLDPCDEFGERGAIVNTASVAAEDG
QMGQAAYSASKGGVVGMTLPIARDLMSEGIRVNTILPGIFNTPLLQGAPDNVKAALAASVPFPKRLGQPEEYANLALCMI
ETGYFNGEDVRLDGAIRMAPR

Sequences:

>Translated_261_residues
MKLDNTVAAVVTGGASGLGAATARALAAKGVKVAIFDLQKEKGEAVAAEIGGVFCEVNVTSDESVDAGFAKARAAHGQER
ILVNCAGTGNAIKTASRSKETGEIKHFPMDAFNWIIQINLVGTFRCIAKSAAGMMTLDPCDEFGERGAIVNTASVAAEDG
QMGQAAYSASKGGVVGMTLPIARDLMSEGIRVNTILPGIFNTPLLQGAPDNVKAALAASVPFPKRLGQPEEYANLALCMI
ETGYFNGEDVRLDGAIRMAPR
>Mature_261_residues
MKLDNTVAAVVTGGASGLGAATARALAAKGVKVAIFDLQKEKGEAVAAEIGGVFCEVNVTSDESVDAGFAKARAAHGQER
ILVNCAGTGNAIKTASRSKETGEIKHFPMDAFNWIIQINLVGTFRCIAKSAAGMMTLDPCDEFGERGAIVNTASVAAEDG
QMGQAAYSASKGGVVGMTLPIARDLMSEGIRVNTILPGIFNTPLLQGAPDNVKAALAASVPFPKRLGQPEEYANLALCMI
ETGYFNGEDVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=50, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=47.265625, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=30.9803921568627, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=28.4, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=31.0483870967742, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI59889578, Length=222, Percent_Identity=28.8288288288288, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=27.4131274131274, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=27.5193798449612, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=32.6771653543307, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789057, Length=267, Percent_Identity=29.9625468164794, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=261, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.1828793774319, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=28.8537549407115, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787905, Length=265, Percent_Identity=28.3018867924528, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=24.7104247104247, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=50.7936507936508, Blast_Score=243, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=31.1538461538462, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=30.2325581395349, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72000259, Length=272, Percent_Identity=26.8382352941176, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=25.7352941176471, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=25.8426966292135, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=239, Percent_Identity=27.1966527196653, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=51.5748031496063, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=33.7254901960784, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=28.968253968254, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21357041, Length=266, Percent_Identity=27.0676691729323, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571526, Length=266, Percent_Identity=27.0676691729323, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27091; Mature: 27091

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDNTVAAVVTGGASGLGAATARALAAKGVKVAIFDLQKEKGEAVAAEIGGVFCEVNVT
CCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEEEEEEC
SDESVDAGFAKARAAHGQERILVNCAGTGNAIKTASRSKETGEIKHFPMDAFNWIIQINL
CCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCCCCEEECCCCCEEEEEEEEE
VGTFRCIAKSAAGMMTLDPCDEFGERGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLP
EHHHHHHHHHCCCCEEECCHHHHCCCCCEEEEHHHCCCCCCCCHHHHCCCCCCEEEEEHH
IARDLMSEGIRVNTILPGIFNTPLLQGAPDNVKAALAASVPFPKRLGQPEEYANLALCMI
HHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHCCCCHHHHCEEEEEE
ETGYFNGEDVRLDGAIRMAPR
EECCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MKLDNTVAAVVTGGASGLGAATARALAAKGVKVAIFDLQKEKGEAVAAEIGGVFCEVNVT
CCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEEEEEEC
SDESVDAGFAKARAAHGQERILVNCAGTGNAIKTASRSKETGEIKHFPMDAFNWIIQINL
CCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCCCCEEECCCCCEEEEEEEEE
VGTFRCIAKSAAGMMTLDPCDEFGERGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLP
EHHHHHHHHHCCCCEEECCHHHHCCCCCEEEEHHHCCCCCCCCHHHHCCCCCCEEEEEHH
IARDLMSEGIRVNTILPGIFNTPLLQGAPDNVKAALAASVPFPKRLGQPEEYANLALCMI
HHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHCCCCHHHHCEEEEEE
ETGYFNGEDVRLDGAIRMAPR
EECCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]