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The map label for this gene is fadA [H]

Identifier: 87199091

GI number: 87199091

Start: 1113487

End: 1114659

Strand: Direct

Name: fadA [H]

Synonym: Saro_1069

Alternate gene names: 87199091

Gene position: 1113487-1114659 (Clockwise)

Preceding gene: 87199085

Following gene: 87199092

Centisome position: 31.26

GC content: 64.96

Gene sequence:

>1173_bases
ATGGCTACAGCCTATATCGTCGATGCGGTTCGCACGGCAGGCGGTCGGCGCGGGGGCAGGCTTGCGGGCGTCCATCCGGT
GGACCTCGCCGCTCGCAGCCTCGATGCGATCGTCGCGCGCACCGGCATCGACCCGACCGCGGTCGACGACGTCATCATGG
GCTGCGTCACCCAGGCCGGTCAGCAGGCAATGCAGGTGGGCCGCAACGCGGTGCTCGCCTCGAAGCTGCTGCCGCAGTCG
ACGCCGGCCGTCACCATCGACCGCCAGTGCGGTTCTTCGCAGCAGGCGATCCAGTTCGCGGCGCAGGCTGTCATGTCTGG
CGTGCAGGATATGGTCATCGCGGCGGGCGTCGAGAGCATGAGCCGCGTGCCGATGGGCTCCAACGCCACGTTCCACATGA
AGGAGGGGCTCGGTCACTACAAGTCGCCGGGGCTGGAAGAAAAGTATCCCGGGGTCATGTTCTCCCAGTTCATGGGCGCG
GAAATGATCGTGAAGAAGCATGGCTTCACCAAGGACGATCTCGACCGCTTCTCGCTGGACAGCCATCGCAAGGCGATTGC
GGCAACCAATGCCCAGGCCTTCGCGAACGAAATCGTGCCGGTAGAGATCGAGACGCCCGAAGGCCCCGCAATGCACACCG
TGGACGAAGGTATCCGCTTCGACGCTACGCTCGAGGGCATCGCCGGCGTCAAGCTGCTCAGCCCCGAAGGCTCGCTCACC
GCTGCCAGCTCCAGCCAGATCTGCGATGGTTCGAGTGCCGTGCTGGTCGTGTCGGAAGCTGCGCTCAAGGCGCATGGACT
TACCCCGCTGGCGCGCATCCACAATCTGACAGTGACCGCGGGCGATCCGGTGATCATGCTCGAAGAGCCGCTCTTCGCCA
CCGATCGTGCATTGCAGCGCGCGGGCATGAAGATTTCCGACATCGACCTATACGAAGTGAACGAGGCGTTCGCCTCCGTT
CCGATGGCTTGGCTGAAGCACACCGGCGCCGATCCGGAAAAGCTCAACGTCAACGGCGGCGCGATCGCGCTTGGCCATCC
GCTGGGCGCTTCGGGCAGCAAGCTCATGGCGACGCTCGTCCACGCCCTGCGCGCGCGGGGCGGAAAGTACGGTTTGCAGA
CGATGTGCGAAGGCGGCGGCGTGGCCAACGTCACGATCATCGAGGCACTTTGA

Upstream 100 bases:

>100_bases
CTATGGGGTGGAGCGGCTGTCTCCACAAGCCTGCTTGACCAGCGGCCTTGCGGTCCTTAATCGTTCGATTAAAGAGTATT
CGAGAGGAGTCGGAGAAGAA

Downstream 100 bases:

>100_bases
ACATAACAAGCGTTTGAGAGAGGATTACCCCAGATGAAGCTCGACAATACCGTTGCCGCCGTCGTCACCGGCGGCGCATC
CGGCCTCGGCGCCGCGACCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MATAYIVDAVRTAGGRRGGRLAGVHPVDLAARSLDAIVARTGIDPTAVDDVIMGCVTQAGQQAMQVGRNAVLASKLLPQS
TPAVTIDRQCGSSQQAIQFAAQAVMSGVQDMVIAAGVESMSRVPMGSNATFHMKEGLGHYKSPGLEEKYPGVMFSQFMGA
EMIVKKHGFTKDDLDRFSLDSHRKAIAATNAQAFANEIVPVEIETPEGPAMHTVDEGIRFDATLEGIAGVKLLSPEGSLT
AASSSQICDGSSAVLVVSEAALKAHGLTPLARIHNLTVTAGDPVIMLEEPLFATDRALQRAGMKISDIDLYEVNEAFASV
PMAWLKHTGADPEKLNVNGGAIALGHPLGASGSKLMATLVHALRARGGKYGLQTMCEGGGVANVTIIEAL

Sequences:

>Translated_390_residues
MATAYIVDAVRTAGGRRGGRLAGVHPVDLAARSLDAIVARTGIDPTAVDDVIMGCVTQAGQQAMQVGRNAVLASKLLPQS
TPAVTIDRQCGSSQQAIQFAAQAVMSGVQDMVIAAGVESMSRVPMGSNATFHMKEGLGHYKSPGLEEKYPGVMFSQFMGA
EMIVKKHGFTKDDLDRFSLDSHRKAIAATNAQAFANEIVPVEIETPEGPAMHTVDEGIRFDATLEGIAGVKLLSPEGSLT
AASSSQICDGSSAVLVVSEAALKAHGLTPLARIHNLTVTAGDPVIMLEEPLFATDRALQRAGMKISDIDLYEVNEAFASV
PMAWLKHTGADPEKLNVNGGAIALGHPLGASGSKLMATLVHALRARGGKYGLQTMCEGGGVANVTIIEAL
>Mature_389_residues
ATAYIVDAVRTAGGRRGGRLAGVHPVDLAARSLDAIVARTGIDPTAVDDVIMGCVTQAGQQAMQVGRNAVLASKLLPQST
PAVTIDRQCGSSQQAIQFAAQAVMSGVQDMVIAAGVESMSRVPMGSNATFHMKEGLGHYKSPGLEEKYPGVMFSQFMGAE
MIVKKHGFTKDDLDRFSLDSHRKAIAATNAQAFANEIVPVEIETPEGPAMHTVDEGIRFDATLEGIAGVKLLSPEGSLTA
ASSSQICDGSSAVLVVSEAALKAHGLTPLARIHNLTVTAGDPVIMLEEPLFATDRALQRAGMKISDIDLYEVNEAFASVP
MAWLKHTGADPEKLNVNGGAIALGHPLGASGSKLMATLVHALRARGGKYGLQTMCEGGGVANVTIIEAL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=38.618925831202, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=34.5177664974619, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI148539872, Length=384, Percent_Identity=35.15625, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=33.7531486146096, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=31.6784869976359, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=25.9640102827763, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=38.6363636363636, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=39.4014962593516, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788554, Length=395, Percent_Identity=39.746835443038, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=37.75, Blast_Score=227, Evalue=8e-61,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=28.9411764705882, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=383, Percent_Identity=36.8146214099217, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=33.2506203473945, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=32.3232323232323, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=28.4382284382284, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=29.8469387755102, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=34.25, Blast_Score=185, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6322031, Length=348, Percent_Identity=31.6091954022989, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=34.75, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=36.3867684478371, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=34.0852130325814, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=27.9620853080569, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24585051, Length=385, Percent_Identity=24.6753246753247, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921506, Length=400, Percent_Identity=23.5, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40695; Mature: 40564

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAYIVDAVRTAGGRRGGRLAGVHPVDLAARSLDAIVARTGIDPTAVDDVIMGCVTQAG
CCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QQAMQVGRNAVLASKLLPQSTPAVTIDRQCGSSQQAIQFAAQAVMSGVQDMVIAAGVESM
HHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRVPMGSNATFHMKEGLGHYKSPGLEEKYPGVMFSQFMGAEMIVKKHGFTKDDLDRFSLD
HCCCCCCCCEEEEHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHCCH
SHRKAIAATNAQAFANEIVPVEIETPEGPAMHTVDEGIRFDATLEGIAGVKLLSPEGSLT
HHHHHHHHCCHHHHHHCEEEEEEECCCCCCCHHHHCCCEECEECCCCCCEEEECCCCCEE
AASSSQICDGSSAVLVVSEAALKAHGLTPLARIHNLTVTAGDPVIMLEEPLFATDRALQR
ECCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHEEEEEECCCCEEEECCCCHHHHHHHHH
AGMKISDIDLYEVNEAFASVPMAWLKHTGADPEKLNVNGGAIALGHPLGASGSKLMATLV
CCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HALRARGGKYGLQTMCEGGGVANVTIIEAL
HHHHHCCCCCCHHHHHCCCCEEEEEEEEEC
>Mature Secondary Structure 
ATAYIVDAVRTAGGRRGGRLAGVHPVDLAARSLDAIVARTGIDPTAVDDVIMGCVTQAG
CHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QQAMQVGRNAVLASKLLPQSTPAVTIDRQCGSSQQAIQFAAQAVMSGVQDMVIAAGVESM
HHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRVPMGSNATFHMKEGLGHYKSPGLEEKYPGVMFSQFMGAEMIVKKHGFTKDDLDRFSLD
HCCCCCCCCEEEEHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHCCH
SHRKAIAATNAQAFANEIVPVEIETPEGPAMHTVDEGIRFDATLEGIAGVKLLSPEGSLT
HHHHHHHHCCHHHHHHCEEEEEEECCCCCCCHHHHCCCEECEECCCCCCEEEECCCCCEE
AASSSQICDGSSAVLVVSEAALKAHGLTPLARIHNLTVTAGDPVIMLEEPLFATDRALQR
ECCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHEEEEEECCCCEEEECCCCHHHHHHHHH
AGMKISDIDLYEVNEAFASVPMAWLKHTGADPEKLNVNGGAIALGHPLGASGSKLMATLV
CCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HALRARGGKYGLQTMCEGGGVANVTIIEAL
HHHHHCCCCCCHHHHHCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA