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The map label for this gene is acdA [H]

Identifier: 87199021

GI number: 87199021

Start: 1042925

End: 1044085

Strand: Direct

Name: acdA [H]

Synonym: Saro_0999

Alternate gene names: 87199021

Gene position: 1042925-1044085 (Clockwise)

Preceding gene: 87199013

Following gene: 87199022

Centisome position: 29.28

GC content: 64.6

Gene sequence:

>1161_bases
ATGTCTGACCTTGACGCCTTCCGCGCGGAAATCCGCGCCTGGCTCGAAGAGAACTGCCCCGCCGAAATGCGCGAACCCGT
CCGCGACGAGGGCGACGTCTGCTGGGGCGGCCGCAACTTCAAGTTCAAGAGCGAAGCGCAGAAGACCTGGATGGAACGCT
GCGCCGCCAAGGGCTACACGGTGCCCGACTGGCCCAAGCCTTATGGCGGTGCCGGCATGTCTCCGGCCGAGGCCAAGGTG
TGGCGCGAGGAGTGCGCCCGCATCGGCGCGCGTCCGCCGCTGTCCAGCTTCGGCATCTGGATGCTCGGCCCGGCGCTGCT
CAAGTTCGGCACCGAGGAACAGAAGGTCCACTATCTCAACCAGATCGCGCGCGGCGAGATCCGCTGGTGCCAGGGCTATT
CCGAACCCGGTTCCGGCTCGGACCTCGTCAGCCTGCAGACCTTCGGCGAGGACAAGGGCGATCACTGGGTCGTTAATGGC
CAGAAGATCTGGACATCCTATGCCGACAAGGCCGACTGGATCTTCTGTCTTGTCCGCACCGACAAGTCGAACAAGTACCA
GGGCATCAGCTTCCTCCTGTTCGACATGACGACGCCTGGCGTCACGACCAAGCCGATCAAGCTGATCAGCGGCAACTCGC
CGTTCTGCGAAACCTTCTTCGACAATGTCGTGGTGCCCAAGAGCCAGATCGTCGGCGAGTTGAACCGCGGCTGGGACGTT
GCCAAGTACCTGCTCGGCCACGAGCGCGAGATGATCTCGGGCGCAGGCGGCGGCGACCGTCTCAACGCGATCGGCGCGGT
CGTTGCGCGCAACGGTCTTGAAGACCCGATCCTGCGCGCGGAACTCGCGCAGTTCGACGTCGATGCGCTGGCCTATGCCT
GCATGGGCGAGAAGTTCCTCGACGAGGCCAAGGTCGGCCGCGCCCATCCTGCCCAGCCGAACATGATGAAGTATGCCGGC
ACCGAGCTGAACAAGCGGCGCCACGAACTGCTCATGGCGGCAGGCGGCGCCACGGCGCTTGAATGGGAAAGCGATCGCAC
CAGCGGCGGAACGCCCGCGCGCTCGTGGTTGCGCACCAAGGCGAACTCCATCGAGGGTGGGACCAGCGAGGTCATGCTCA
ACGTCATTTCCAAGCGCATTCTCGACCTGCCGGGAGCCTGA

Upstream 100 bases:

>100_bases
TGCAGGGATTGCCCGAAAGTCGGAGAATCCGGCCGCATTTCCGCCCTTGCCAGCAGCCTGCGACTCGCCTTAACCTCCCG
ATTAAGAGAGGAGCTTCACC

Downstream 100 bases:

>100_bases
TCGATGCCTCTTTACCACACCGAAGACCAGGCCATGCTGGCCGAAACCGTCACCGGCTTCATGGCCGATGAAGGTGCGAT
CAAGAAGCAGTTGCGGCACT

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSDLDAFRAEIRAWLEENCPAEMREPVRDEGDVCWGGRNFKFKSEAQKTWMERCAAKGYTVPDWPKPYGGAGMSPAEAKV
WREECARIGARPPLSSFGIWMLGPALLKFGTEEQKVHYLNQIARGEIRWCQGYSEPGSGSDLVSLQTFGEDKGDHWVVNG
QKIWTSYADKADWIFCLVRTDKSNKYQGISFLLFDMTTPGVTTKPIKLISGNSPFCETFFDNVVVPKSQIVGELNRGWDV
AKYLLGHEREMISGAGGGDRLNAIGAVVARNGLEDPILRAELAQFDVDALAYACMGEKFLDEAKVGRAHPAQPNMMKYAG
TELNKRRHELLMAAGGATALEWESDRTSGGTPARSWLRTKANSIEGGTSEVMLNVISKRILDLPGA

Sequences:

>Translated_386_residues
MSDLDAFRAEIRAWLEENCPAEMREPVRDEGDVCWGGRNFKFKSEAQKTWMERCAAKGYTVPDWPKPYGGAGMSPAEAKV
WREECARIGARPPLSSFGIWMLGPALLKFGTEEQKVHYLNQIARGEIRWCQGYSEPGSGSDLVSLQTFGEDKGDHWVVNG
QKIWTSYADKADWIFCLVRTDKSNKYQGISFLLFDMTTPGVTTKPIKLISGNSPFCETFFDNVVVPKSQIVGELNRGWDV
AKYLLGHEREMISGAGGGDRLNAIGAVVARNGLEDPILRAELAQFDVDALAYACMGEKFLDEAKVGRAHPAQPNMMKYAG
TELNKRRHELLMAAGGATALEWESDRTSGGTPARSWLRTKANSIEGGTSEVMLNVISKRILDLPGA
>Mature_385_residues
SDLDAFRAEIRAWLEENCPAEMREPVRDEGDVCWGGRNFKFKSEAQKTWMERCAAKGYTVPDWPKPYGGAGMSPAEAKVW
REECARIGARPPLSSFGIWMLGPALLKFGTEEQKVHYLNQIARGEIRWCQGYSEPGSGSDLVSLQTFGEDKGDHWVVNGQ
KIWTSYADKADWIFCLVRTDKSNKYQGISFLLFDMTTPGVTTKPIKLISGNSPFCETFFDNVVVPKSQIVGELNRGWDVA
KYLLGHEREMISGAGGGDRLNAIGAVVARNGLEDPILRAELAQFDVDALAYACMGEKFLDEAKVGRAHPAQPNMMKYAGT
ELNKRRHELLMAAGGATALEWESDRTSGGTPARSWLRTKANSIEGGTSEVMLNVISKRILDLPGA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=344, Percent_Identity=29.0697674418605, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4501859, Length=362, Percent_Identity=27.6243093922652, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226958412, Length=196, Percent_Identity=32.1428571428571, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226958414, Length=196, Percent_Identity=32.1428571428571, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501857, Length=400, Percent_Identity=24.25, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4557231, Length=201, Percent_Identity=27.363184079602, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI187960098, Length=201, Percent_Identity=27.363184079602, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4557235, Length=210, Percent_Identity=28.0952380952381, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI76496475, Length=210, Percent_Identity=28.0952380952381, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI7656849, Length=357, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21361497, Length=258, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508101, Length=247, Percent_Identity=30.3643724696356, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17538396, Length=194, Percent_Identity=34.5360824742268, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506239, Length=183, Percent_Identity=34.4262295081967, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32563615, Length=183, Percent_Identity=34.4262295081967, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=205, Percent_Identity=31.219512195122, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=352, Percent_Identity=25.2840909090909, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17534899, Length=225, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=213, Percent_Identity=29.1079812206573, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551932, Length=204, Percent_Identity=28.921568627451, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=191, Percent_Identity=30.8900523560209, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=27.7333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666513, Length=333, Percent_Identity=27.6276276276276, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355753, Length=192, Percent_Identity=33.8541666666667, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24646207, Length=176, Percent_Identity=30.1136363636364, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24660351, Length=143, Percent_Identity=31.4685314685315, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363737, Length=200, Percent_Identity=27, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42711; Mature: 42580

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLDAFRAEIRAWLEENCPAEMREPVRDEGDVCWGGRNFKFKSEAQKTWMERCAAKGYT
CCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCC
VPDWPKPYGGAGMSPAEAKVWREECARIGARPPLSSFGIWMLGPALLKFGTEEQKVHYLN
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCCHHHHHHHHH
QIARGEIRWCQGYSEPGSGSDLVSLQTFGEDKGDHWVVNGQKIWTSYADKADWIFCLVRT
HHHCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEECCHHHHHHHCCCCCEEEEEEEE
DKSNKYQGISFLLFDMTTPGVTTKPIKLISGNSPFCETFFDNVVVPKSQIVGELNRGWDV
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHCCCCCCHHHHHHHHCCCHHH
AKYLLGHEREMISGAGGGDRLNAIGAVVARNGLEDPILRAELAQFDVDALAYACMGEKFL
HHHHHCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DEAKVGRAHPAQPNMMKYAGTELNKRRHELLMAAGGATALEWESDRTSGGTPARSWLRTK
HHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHH
ANSIEGGTSEVMLNVISKRILDLPGA
HCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDLDAFRAEIRAWLEENCPAEMREPVRDEGDVCWGGRNFKFKSEAQKTWMERCAAKGYT
CHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCC
VPDWPKPYGGAGMSPAEAKVWREECARIGARPPLSSFGIWMLGPALLKFGTEEQKVHYLN
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCCHHHHHHHHH
QIARGEIRWCQGYSEPGSGSDLVSLQTFGEDKGDHWVVNGQKIWTSYADKADWIFCLVRT
HHHCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEECCHHHHHHHCCCCCEEEEEEEE
DKSNKYQGISFLLFDMTTPGVTTKPIKLISGNSPFCETFFDNVVVPKSQIVGELNRGWDV
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHCCCCCCHHHHHHHHCCCHHH
AKYLLGHEREMISGAGGGDRLNAIGAVVARNGLEDPILRAELAQFDVDALAYACMGEKFL
HHHHHCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DEAKVGRAHPAQPNMMKYAGTELNKRRHELLMAAGGATALEWESDRTSGGTPARSWLRTK
HHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHH
ANSIEGGTSEVMLNVISKRILDLPGA
HCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]