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The map label for this gene is fadE12 [H]

Identifier: 87199022

GI number: 87199022

Start: 1044089

End: 1045228

Strand: Direct

Name: fadE12 [H]

Synonym: Saro_1000

Alternate gene names: 87199022

Gene position: 1044089-1045228 (Clockwise)

Preceding gene: 87199021

Following gene: 87199023

Centisome position: 29.32

GC content: 65.0

Gene sequence:

>1140_bases
ATGCCTCTTTACCACACCGAAGACCAGGCCATGCTGGCCGAAACCGTCACCGGCTTCATGGCCGATGAAGGTGCGATCAA
GAAGCAGTTGCGGCACTATCGCGACATGAATTGCCAGGACGGCTTCGGCCATGCCCTGTGGAAGCAGTTTGCCGAAATGG
GCCTGACCGGGATGCTGGCGTCCGAGGCCGACGGCGGGCTGGCCATGGGCCATGTCGAGGCGGGTATCGTTCTGCGCGAG
ATTGGCCGCAACCTCACGCCTTCGCCCTTCCTGACCACTTCGGTCATGGGCGTCACGGCCCTCTCGGGCGGGTCGGACGA
GCTGCGCGGGCGCTGGCTTCCCGGCGTGATCGCCGGCGACAGCGTGCTTGCCGTCGCCATCGACGAAAGCCCCAAGCACC
GACCCGAACGCATCGCCTGCCGCGCCGAGAAGGCGGGCAACGGCTTCCGCCTCCAGGGCCGCAAGGCCTTCGTGGTCCAC
GGCGCATCTGCGGACGCGATCATCGTTGCTGCGCGCACCTCGGGCAGCGACACCGATGTTGACGGCATCACGCTGTTCGC
CGTTCCGAAGGATGCGGCCGGCATTGCCCACGAGAACCTCCGTCTCGTCGACAGTACGATGGCCAGCAACGTGACCTTCG
ACAATGTCGAGCTGGACGGCGACTGCGTGATCGGCGAGGTCGATGGCGGGCGCGAACTGCTGAACAGGGTGCTCAACGTC
GGTCGCATCGGCTCAGCCGCTGAAATGACCGGGGTCGGGCAGGGCGCGTTCGACATCACCACCGCCTATCTCAAGACGCG
CAAGCAGTTCGGCAAGCTGATCGGGGAATTCCAGGCGCTCCAGCACCGGGCCGCGCACCTCTACTCCGAGCTGGAGATTG
CCGAGGCCGCCGTCATCAAGGCGCAGCAGCTTCTCGACGGCAATTCCGAAAAGGCGGACCTGATGATCTCGGTCGCCAAG
GCCAAGGCTGGCAAGGCTTGCAACCTGGCAGTGCGCGAGGGTGTGCAGATGCACGGCGGCGTGGGCATGACCGACGAATT
CGACATCGGTCTCTACATGAAGCGCGACCGCTCGCTGTCCGAGTTCATGGGGGACCAGTACTACCACGCCGAACGGGTCG
CGCAGCTCAGCGGATATTGA

Upstream 100 bases:

>100_bases
GTGGTTGCGCACCAAGGCGAACTCCATCGAGGGTGGGACCAGCGAGGTCATGCTCAACGTCATTTCCAAGCGCATTCTCG
ACCTGCCGGGAGCCTGATCG

Downstream 100 bases:

>100_bases
CGCTTCGACAGGTCGGGATGTGTCGGCGGCGGGACAGTACCGCTGTCCGTCCCGAACCTGTCGAAGGACCAGGGTACAAC
GGCCGCAAAGCAGGTCGGAA

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPLYHTEDQAMLAETVTGFMADEGAIKKQLRHYRDMNCQDGFGHALWKQFAEMGLTGMLASEADGGLAMGHVEAGIVLRE
IGRNLTPSPFLTTSVMGVTALSGGSDELRGRWLPGVIAGDSVLAVAIDESPKHRPERIACRAEKAGNGFRLQGRKAFVVH
GASADAIIVAARTSGSDTDVDGITLFAVPKDAAGIAHENLRLVDSTMASNVTFDNVELDGDCVIGEVDGGRELLNRVLNV
GRIGSAAEMTGVGQGAFDITTAYLKTRKQFGKLIGEFQALQHRAAHLYSELEIAEAAVIKAQQLLDGNSEKADLMISVAK
AKAGKACNLAVREGVQMHGGVGMTDEFDIGLYMKRDRSLSEFMGDQYYHAERVAQLSGY

Sequences:

>Translated_379_residues
MPLYHTEDQAMLAETVTGFMADEGAIKKQLRHYRDMNCQDGFGHALWKQFAEMGLTGMLASEADGGLAMGHVEAGIVLRE
IGRNLTPSPFLTTSVMGVTALSGGSDELRGRWLPGVIAGDSVLAVAIDESPKHRPERIACRAEKAGNGFRLQGRKAFVVH
GASADAIIVAARTSGSDTDVDGITLFAVPKDAAGIAHENLRLVDSTMASNVTFDNVELDGDCVIGEVDGGRELLNRVLNV
GRIGSAAEMTGVGQGAFDITTAYLKTRKQFGKLIGEFQALQHRAAHLYSELEIAEAAVIKAQQLLDGNSEKADLMISVAK
AKAGKACNLAVREGVQMHGGVGMTDEFDIGLYMKRDRSLSEFMGDQYYHAERVAQLSGY
>Mature_378_residues
PLYHTEDQAMLAETVTGFMADEGAIKKQLRHYRDMNCQDGFGHALWKQFAEMGLTGMLASEADGGLAMGHVEAGIVLREI
GRNLTPSPFLTTSVMGVTALSGGSDELRGRWLPGVIAGDSVLAVAIDESPKHRPERIACRAEKAGNGFRLQGRKAFVVHG
ASADAIIVAARTSGSDTDVDGITLFAVPKDAAGIAHENLRLVDSTMASNVTFDNVELDGDCVIGEVDGGRELLNRVLNVG
RIGSAAEMTGVGQGAFDITTAYLKTRKQFGKLIGEFQALQHRAAHLYSELEIAEAAVIKAQQLLDGNSEKADLMISVAKA
KAGKACNLAVREGVQMHGGVGMTDEFDIGLYMKRDRSLSEFMGDQYYHAERVAQLSGY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=27.1739130434783, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501859, Length=310, Percent_Identity=27.0967741935484, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI226958414, Length=326, Percent_Identity=27.9141104294479, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4557233, Length=313, Percent_Identity=25.8785942492013, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4501857, Length=315, Percent_Identity=26.984126984127, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI21361497, Length=337, Percent_Identity=23.4421364985163, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI76496475, Length=334, Percent_Identity=23.0538922155689, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557235, Length=334, Percent_Identity=23.0538922155689, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7656849, Length=316, Percent_Identity=24.0506329113924, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187960098, Length=315, Percent_Identity=25.3968253968254, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4557231, Length=315, Percent_Identity=25.3968253968254, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081958, Length=365, Percent_Identity=24.3835616438356, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786223, Length=313, Percent_Identity=27.1565495207668, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=350, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=25.78125, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71990804, Length=260, Percent_Identity=28.8461538461538, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71985184, Length=362, Percent_Identity=25.414364640884, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17533517, Length=313, Percent_Identity=23.961661341853, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=28.448275862069, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=328, Percent_Identity=24.6951219512195, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=332, Percent_Identity=21.6867469879518, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=287, Percent_Identity=27.1777003484321, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=336, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=322, Percent_Identity=22.0496894409938, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=406, Percent_Identity=23.3990147783251, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17505929, Length=321, Percent_Identity=27.1028037383178, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17551932, Length=267, Percent_Identity=27.7153558052434, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=368, Percent_Identity=27.445652173913, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24666513, Length=364, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21356377, Length=307, Percent_Identity=26.7100977198697, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646207, Length=327, Percent_Identity=24.7706422018349, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363737, Length=327, Percent_Identity=24.1590214067278, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920834, Length=390, Percent_Identity=22.8205128205128, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 40592; Mature: 40460

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLYHTEDQAMLAETVTGFMADEGAIKKQLRHYRDMNCQDGFGHALWKQFAEMGLTGMLA
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
SEADGGLAMGHVEAGIVLREIGRNLTPSPFLTTSVMGVTALSGGSDELRGRWLPGVIAGD
CCCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEECCCCHHHCCCCCCCEEECC
SVLAVAIDESPKHRPERIACRAEKAGNGFRLQGRKAFVVHGASADAIIVAARTSGSDTDV
CEEEEEECCCCCCCCHHHEEEHHCCCCCEEEECCEEEEEECCCCCEEEEEEECCCCCCCC
DGITLFAVPKDAAGIAHENLRLVDSTMASNVTFDNVELDGDCVIGEVDGGRELLNRVLNV
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCEECCEEECCCEEEEECCCHHHHHHHHHCC
GRIGSAAEMTGVGQGAFDITTAYLKTRKQFGKLIGEFQALQHRAAHLYSELEIAEAAVIK
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQQLLDGNSEKADLMISVAKAKAGKACNLAVREGVQMHGGVGMTDEFDIGLYMKRDRSLS
HHHHHCCCCCCCEEEEEEECCCCCCCEEHHHHCCCHHCCCCCCCCCCCCEEEEECCCCHH
EFMGDQYYHAERVAQLSGY
HHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLYHTEDQAMLAETVTGFMADEGAIKKQLRHYRDMNCQDGFGHALWKQFAEMGLTGMLA
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
SEADGGLAMGHVEAGIVLREIGRNLTPSPFLTTSVMGVTALSGGSDELRGRWLPGVIAGD
CCCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEECCCCHHHCCCCCCCEEECC
SVLAVAIDESPKHRPERIACRAEKAGNGFRLQGRKAFVVHGASADAIIVAARTSGSDTDV
CEEEEEECCCCCCCCHHHEEEHHCCCCCEEEECCEEEEEECCCCCEEEEEEECCCCCCCC
DGITLFAVPKDAAGIAHENLRLVDSTMASNVTFDNVELDGDCVIGEVDGGRELLNRVLNV
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCEECCEEECCCEEEEECCCHHHHHHHHHCC
GRIGSAAEMTGVGQGAFDITTAYLKTRKQFGKLIGEFQALQHRAAHLYSELEIAEAAVIK
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQQLLDGNSEKADLMISVAKAKAGKACNLAVREGVQMHGGVGMTDEFDIGLYMKRDRSLS
HHHHHCCCCCCCEEEEEEECCCCCCCEEHHHHCCCHHCCCCCCCCCCCCEEEEECCCCHH
EFMGDQYYHAERVAQLSGY
HHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]