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The map label for this gene is galK [H]

Identifier: 87198568

GI number: 87198568

Start: 593656

End: 594798

Strand: Direct

Name: galK [H]

Synonym: Saro_0544

Alternate gene names: 87198568

Gene position: 593656-594798 (Clockwise)

Preceding gene: 87198567

Following gene: 87198570

Centisome position: 16.67

GC content: 69.03

Gene sequence:

>1143_bases
GTGACCGCGCTGCATGACCGGCTCCTTGCCGGCTTTGCGCAAGCGTTCGGGGGAGAGCCGGAGCTTGTCGTGCGCGCGCC
CGGCCGGGTGAACCTGATCGGCGAACATACCGACTACAACGACGGCTTCGCCATGCCCGTGGCAATAGGCCAGGAAACGC
GCGTGGCCTTCCGCCCGGGCGGAACCGGGCTCAGGGTGGCCGCTCTGGACTTTGCCGAAGATGACGCGTTCGACAGCGCG
GCCCCGCAAAGGGCCGGCGGCGGTTGGCGCGATTATGTGCGCGGCGTGGTGGACGAACTCGTCCGCGCGGGGATTTCCGT
CCCTCCGGGCCAGCTTGCGATCGCAGGATCGATTGCCAAGGGGACCGGCCTGTCATCCTCGGCCTCGCTCGAGGTTGCCG
TCGCGCGTGTCCTGCTCGATGCAGCGGGTGAACGGATGGACCCCGTCAGCCTCGCGCTCCTTGCCCAGCGAGCGGAATGC
GATTTCGTCGGCGTTCGCTGCGGCAATCTCGATCAGATTGCCAGTGCTGCCACGACGCGCGGCCACGCGCTGCTGATCGA
TTGCCGCACCCTGGCGCTCAGGCAGATCGCCATGCCCGCCGACGTGGCGGTGATGATCGTGCAGTCAGGCGTGGTGCGCG
GATTGGTGGACGGCGAATACAACCAGCGCCGGCAGGAATGCGAACGCGCCGCCCGGACGCTCGGCGTGCCGGCGCTGCGC
GACGTCGACGAGGGGATGCTCGACGAGGCGTGCGGGCGGCTTGACGATCTTGCCTTCCTTCGCGCCCGCCATGTCTGCGG
CGACAATCGCCGGACGCGGGAGGCTGCCCGCGCGCTGGCCTCGGGCGATCTGGTCGCGATGGGGGCGCTCATGCGCGAAA
GCCATGTCTCGCAGGGTCGGGACTTCGGCATCACCGTGCCCCATACCGACGTGCTGGCAGCGCTGATGAACGAAGCGATC
GGCGAAGACGGCGGCGCTCGGCAGACGGGCGGCGGCTTTGGCGGCGCCGTCGTCGGCCTCATGCGACAGGACCGCGTCGC
GGCTGTGCGCGAAGCGGTCCTTGCCGTGTATCGGACGCCTGCCGGAGACGTGCCTGAAATCTGTATAGAGGTTCCTTCGG
ATGGGGCGGGACCGGTCGGCTGA

Upstream 100 bases:

>100_bases
TGCGCAAGTTCATGGTCGGCTTCGAGATGTTCGGCGAAAGCCAGCGCGACATCACCCCGGAGACCGCCGCCGCGCGTCTG
CGCGCGCTGGAGATCGACGC

Downstream 100 bases:

>100_bases
CCGCCCGCCCGTCCGATCAGAACGCGATGCTGAGCGAGCCGCGCACCGAATAGTCGACGCTGCCCTGGATCTGCTCGGCG
CCGCCGGCAAGTTGCCAGGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTALHDRLLAGFAQAFGGEPELVVRAPGRVNLIGEHTDYNDGFAMPVAIGQETRVAFRPGGTGLRVAALDFAEDDAFDSA
APQRAGGGWRDYVRGVVDELVRAGISVPPGQLAIAGSIAKGTGLSSSASLEVAVARVLLDAAGERMDPVSLALLAQRAEC
DFVGVRCGNLDQIASAATTRGHALLIDCRTLALRQIAMPADVAVMIVQSGVVRGLVDGEYNQRRQECERAARTLGVPALR
DVDEGMLDEACGRLDDLAFLRARHVCGDNRRTREAARALASGDLVAMGALMRESHVSQGRDFGITVPHTDVLAALMNEAI
GEDGGARQTGGGFGGAVVGLMRQDRVAAVREAVLAVYRTPAGDVPEICIEVPSDGAGPVG

Sequences:

>Translated_380_residues
MTALHDRLLAGFAQAFGGEPELVVRAPGRVNLIGEHTDYNDGFAMPVAIGQETRVAFRPGGTGLRVAALDFAEDDAFDSA
APQRAGGGWRDYVRGVVDELVRAGISVPPGQLAIAGSIAKGTGLSSSASLEVAVARVLLDAAGERMDPVSLALLAQRAEC
DFVGVRCGNLDQIASAATTRGHALLIDCRTLALRQIAMPADVAVMIVQSGVVRGLVDGEYNQRRQECERAARTLGVPALR
DVDEGMLDEACGRLDDLAFLRARHVCGDNRRTREAARALASGDLVAMGALMRESHVSQGRDFGITVPHTDVLAALMNEAI
GEDGGARQTGGGFGGAVVGLMRQDRVAAVREAVLAVYRTPAGDVPEICIEVPSDGAGPVG
>Mature_379_residues
TALHDRLLAGFAQAFGGEPELVVRAPGRVNLIGEHTDYNDGFAMPVAIGQETRVAFRPGGTGLRVAALDFAEDDAFDSAA
PQRAGGGWRDYVRGVVDELVRAGISVPPGQLAIAGSIAKGTGLSSSASLEVAVARVLLDAAGERMDPVSLALLAQRAECD
FVGVRCGNLDQIASAATTRGHALLIDCRTLALRQIAMPADVAVMIVQSGVVRGLVDGEYNQRRQECERAARTLGVPALRD
VDEGMLDEACGRLDDLAFLRARHVCGDNRRTREAARALASGDLVAMGALMRESHVSQGRDFGITVPHTDVLAALMNEAIG
EDGGARQTGGGFGGAVVGLMRQDRVAAVREAVLAVYRTPAGDVPEICIEVPSDGAGPVG

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=343, Percent_Identity=41.1078717201166, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI48527957, Length=424, Percent_Identity=27.3584905660377, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4503897, Length=422, Percent_Identity=27.2511848341232, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786972, Length=379, Percent_Identity=45.1187335092348, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71989053, Length=433, Percent_Identity=25.1732101616628, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24661292, Length=441, Percent_Identity=25.1700680272109, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355577, Length=441, Percent_Identity=25.1700680272109, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24661285, Length=441, Percent_Identity=25.1700680272109, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 39686; Mature: 39554

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00106 GALACTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALHDRLLAGFAQAFGGEPELVVRAPGRVNLIGEHTDYNDGFAMPVAIGQETRVAFRPG
CCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCCEEEEEEECCCCEEEECCC
GTGLRVAALDFAEDDAFDSAAPQRAGGGWRDYVRGVVDELVRAGISVPPGQLAIAGSIAK
CCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
GTGLSSSASLEVAVARVLLDAAGERMDPVSLALLAQRAECDFVGVRCGNLDQIASAATTR
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCC
GHALLIDCRTLALRQIAMPADVAVMIVQSGVVRGLVDGEYNQRRQECERAARTLGVPALR
CCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
DVDEGMLDEACGRLDDLAFLRARHVCGDNRRTREAARALASGDLVAMGALMRESHVSQGR
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
DFGITVPHTDVLAALMNEAIGEDGGARQTGGGFGGAVVGLMRQDRVAAVREAVLAVYRTP
CCCEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGDVPEICIEVPSDGAGPVG
CCCCCHHEEECCCCCCCCCC
>Mature Secondary Structure 
TALHDRLLAGFAQAFGGEPELVVRAPGRVNLIGEHTDYNDGFAMPVAIGQETRVAFRPG
CHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCCEEEEEEECCCCEEEECCC
GTGLRVAALDFAEDDAFDSAAPQRAGGGWRDYVRGVVDELVRAGISVPPGQLAIAGSIAK
CCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
GTGLSSSASLEVAVARVLLDAAGERMDPVSLALLAQRAECDFVGVRCGNLDQIASAATTR
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCC
GHALLIDCRTLALRQIAMPADVAVMIVQSGVVRGLVDGEYNQRRQECERAARTLGVPALR
CCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
DVDEGMLDEACGRLDDLAFLRARHVCGDNRRTREAARALASGDLVAMGALMRESHVSQGR
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
DFGITVPHTDVLAALMNEAIGEDGGARQTGGGFGGAVVGLMRQDRVAAVREAVLAVYRTP
CCCEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGDVPEICIEVPSDGAGPVG
CCCCCHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA