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The map label for this gene is tdcA [H]

Identifier: 87198565

GI number: 87198565

Start: 590232

End: 591146

Strand: Direct

Name: tdcA [H]

Synonym: Saro_0541

Alternate gene names: 87198565

Gene position: 590232-591146 (Clockwise)

Preceding gene: 87198564

Following gene: 87198566

Centisome position: 16.57

GC content: 66.12

Gene sequence:

>915_bases
ATGAGTGACGCCCCGCAGCACCGCCTGAAGATCGATCCGCGCGCCGTTTCCACGTTCTGGAAGGTGTGTGAAACCGGGTC
GATCAGCGGCGCGGCCCGCGCGCTCAATCTTTCCCAGCCGTCCGTCTCGAACACCATTGCGCTGCTTGAGCATCGCCTTG
GCGTTACCCTCTTCGCACGTTCACGCAGCGGCATCGTCCTGACGCCCGAAGGACTTGCCCTGCGCGACCGCGCCGAAGCA
ATGGTGCGGCTGCTTGAAACTGCGGTGGTCGAAGTCGATCACGCCGCCCGCAACATTGCCGGTCCATTGCGCATCGGCGG
CACGCCGGGCGCGCTGGTAAGCATCCTTCCCGAGGCGGTCGCCCGGATCGAGGCGCAGGTTGGCCCCTTTGCACTCAGCG
TGGTGGAAAGGCCCGATCCGCAGCTCGGCGACCTGTTGCGCAAGGGCACGATCGATCTTGCCTGCGTGACCACCGAGATC
GAGGAATGCCCGCCTGACCTTGCCGAAATCACCGTGTCCCGCGACCCCTTCGCGCTTGTCGTGGGACGCCGCCACGACGG
CCTTGGCGGCCGCGTCTCGCTGCGCGACGTGGCTGGCCTGCCCTGGGTCCTGCCTGAAGCGCAAGGCGCGTTTCGCCGGC
AGGTCGATGCGCTGTTCCTTGCTGCTGGCGTTCCGGTGCCGCGCAACGTCATCCGTTGCGACTCGCTTCTGACAACCAAG
GCCATCGTTCGCCATGGCGACCGGGTCACGATCCTTCCGCGTACGGTTGCCGCCGCCGAACTCACCATCGGCGTCCTGCG
CGCGATCGCCATCGAGGAGGCGACGTTCGAACGCAGCGTGGGTATTCGCTACCCCGTCGACAGAGGCTTGCCTCCGCTTG
GCCGTGCCTTCGTCGAAGCGCTTTCAAATCCATAG

Upstream 100 bases:

>100_bases
CCTGCCCGTTGCGGGCGGTGATCTCGGCTGAGCAGTCCAGAAGGCTATCGAGAAGGCATCTAACATAGACAGCCCTTATG
CCTGCGATTACGCTCGCGTG

Downstream 100 bases:

>100_bases
CTTGAGACAATGTTGCGCTCATAAGATGCTATTTTACCCGATGGACGGCCGGACATAAGTTCACCCGAAAGGCATTGGGA
GAAATCATGATCGATCGTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Tdc operon transcriptional activator [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSDAPQHRLKIDPRAVSTFWKVCETGSISGAARALNLSQPSVSNTIALLEHRLGVTLFARSRSGIVLTPEGLALRDRAEA
MVRLLETAVVEVDHAARNIAGPLRIGGTPGALVSILPEAVARIEAQVGPFALSVVERPDPQLGDLLRKGTIDLACVTTEI
EECPPDLAEITVSRDPFALVVGRRHDGLGGRVSLRDVAGLPWVLPEAQGAFRRQVDALFLAAGVPVPRNVIRCDSLLTTK
AIVRHGDRVTILPRTVAAAELTIGVLRAIAIEEATFERSVGIRYPVDRGLPPLGRAFVEALSNP

Sequences:

>Translated_304_residues
MSDAPQHRLKIDPRAVSTFWKVCETGSISGAARALNLSQPSVSNTIALLEHRLGVTLFARSRSGIVLTPEGLALRDRAEA
MVRLLETAVVEVDHAARNIAGPLRIGGTPGALVSILPEAVARIEAQVGPFALSVVERPDPQLGDLLRKGTIDLACVTTEI
EECPPDLAEITVSRDPFALVVGRRHDGLGGRVSLRDVAGLPWVLPEAQGAFRRQVDALFLAAGVPVPRNVIRCDSLLTTK
AIVRHGDRVTILPRTVAAAELTIGVLRAIAIEEATFERSVGIRYPVDRGLPPLGRAFVEALSNP
>Mature_303_residues
SDAPQHRLKIDPRAVSTFWKVCETGSISGAARALNLSQPSVSNTIALLEHRLGVTLFARSRSGIVLTPEGLALRDRAEAM
VRLLETAVVEVDHAARNIAGPLRIGGTPGALVSILPEAVARIEAQVGPFALSVVERPDPQLGDLLRKGTIDLACVTTEIE
ECPPDLAEITVSRDPFALVVGRRHDGLGGRVSLRDVAGLPWVLPEAQGAFRRQVDALFLAAGVPVPRNVIRCDSLLTTKA
IVRHGDRVTILPRTVAAAELTIGVLRAIAIEEATFERSVGIRYPVDRGLPPLGRAFVEALSNP

Specific function: Transcriptional activator for the tdcABCDE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789506, Length=247, Percent_Identity=27.5303643724696, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787601, Length=251, Percent_Identity=25.4980079681275, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI157672245, Length=267, Percent_Identity=29.2134831460674, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081904, Length=278, Percent_Identity=27.3381294964029, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788481, Length=268, Percent_Identity=31.3432835820896, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=27.1653543307087, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=24.5901639344262, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32496; Mature: 32365

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAPQHRLKIDPRAVSTFWKVCETGSISGAARALNLSQPSVSNTIALLEHRLGVTLFAR
CCCCCCCCEEECHHHHHHHHHHHCCCCCCCHHHEEECCCCCHHHHHHHHHHHCCEEEEEE
SRSGIVLTPEGLALRDRAEAMVRLLETAVVEVDHAARNIAGPLRIGGTPGALVSILPEAV
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHH
ARIEAQVGPFALSVVERPDPQLGDLLRKGTIDLACVTTEIEECPPDLAEITVSRDPFALV
HHHHHHCCCEEEEEECCCCCHHHHHHHCCCEEEEEEEECHHHCCCCHHHEEECCCCEEEE
VGRRHDGLGGRVSLRDVAGLPWVLPEAQGAFRRQVDALFLAAGVPVPRNVIRCDSLLTTK
EECCCCCCCCEEEHHHHCCCCEECCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHH
AIVRHGDRVTILPRTVAAAELTIGVLRAIAIEEATFERSVGIRYPVDRGLPPLGRAFVEA
HHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHH
LSNP
HCCC
>Mature Secondary Structure 
SDAPQHRLKIDPRAVSTFWKVCETGSISGAARALNLSQPSVSNTIALLEHRLGVTLFAR
CCCCCCCEEECHHHHHHHHHHHCCCCCCCHHHEEECCCCCHHHHHHHHHHHCCEEEEEE
SRSGIVLTPEGLALRDRAEAMVRLLETAVVEVDHAARNIAGPLRIGGTPGALVSILPEAV
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHH
ARIEAQVGPFALSVVERPDPQLGDLLRKGTIDLACVTTEIEECPPDLAEITVSRDPFALV
HHHHHHCCCEEEEEECCCCCHHHHHHHCCCEEEEEEEECHHHCCCCHHHEEECCCCEEEE
VGRRHDGLGGRVSLRDVAGLPWVLPEAQGAFRRQVDALFLAAGVPVPRNVIRCDSLLTTK
EECCCCCCCCEEEHHHHCCCCEECCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHH
AIVRHGDRVTILPRTVAAAELTIGVLRAIAIEEATFERSVGIRYPVDRGLPPLGRAFVEA
HHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHH
LSNP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]