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The map label for this gene is kefC [H]

Identifier: 87198420

GI number: 87198420

Start: 431793

End: 433526

Strand: Direct

Name: kefC [H]

Synonym: Saro_0395

Alternate gene names: 87198420

Gene position: 431793-433526 (Clockwise)

Preceding gene: 87198419

Following gene: 87198421

Centisome position: 12.12

GC content: 63.55

Gene sequence:

>1734_bases
ATGGAGCCACATCCGGGAATCCCTTTTCTTCGAGAAGCGCTCGTTCTGCTTGCCGCTGCCGGGCTTGCGGTTCCGCTGCT
GAACCGGATCCGGGTAAATCCGATCCTTGGCTATCTGTTGATCGGCGGTGTGATCGGGCCATACGGGCTTGGGTTGCTTG
CGGCTGACTATCCGTTCCTTTCGCACGCGGTCATTTCCGATATCGCCGGTGTTCGCGGGCTGGCCGAGATCGGCGTGGTT
TTCCTGCTGTTCATGATCGGCCTGGAACTCTCGCTGGAACGGCTATGGTCGGGCCGCGCCCTCGTGTTTGGCATGGGATC
GCTCCAGATTCTGCTGACGGCCGGTCTGATCGCCTGGATCGCGACAGGTCTTGGTGTGGAGGAGCCCACCGCCCTGATCG
TCGGGGCAGCATTGTCCTTGTCGTCGACCGCGATCGTCATGCAGCTGCTCATTCACGGGCGCCGCCAATTTTCCGCGGTC
GGGAAGACCGGCTTTGCCATCCTGCTGATGCAGGACCTGGCGGTGGTGCCAATTCTCTTCATGGTCGGCGTGATTGCGAC
CCCGGGCAGCGGTGGTCTCGCTGCCGGCCTGGCGGGGGCGTTGGGGAAGGCGACACTGGCGATCGTTCTGATCTATCTGG
CCGGACGCCTATTGTTGAGGCCGGTACTGCGCCAGGTGGCGCAGACGCGTAGCCCGGAAATGTTCACCGCCGCGGTACTG
CTGACCGTCATCGGGGTCTCAGCGTTGACCGCCCGGTTCGGACTGTCCATGGCGCTGGGCGCCTTTCTCGCCGGGCTGCT
GTTGGCCGAGACCGAATACCGCCATCAGATCGAAGTCGACATCGAGCCTTTCAAAGGCCTCCTGCTGGGGCTTTTCTTCA
TGTCGGTCGGCATGGGCATCGACTGGCGTCAGGTTCTCGCCAGTCCGCTCGAGATTGCCGGGATGGTCACCGGGCTCTGG
CTGCTGAAGGCCGTGGTCATTACGGGATTGGCCATCGCCTTCGGCAGGCCGCGGCATGTCGCTGCGGAAGCCGGGATGTT
GCTGGGCCAGGGCGGCGAATTCGCCTTTGTCATCGTTGGGGTTGCAGCGGGCCTCGGTGTTGTTGGCGGCGTCCTTGAGC
AACAAATCCTGATTGTCACCGGCATCAGCATGCTGCTGACCCCGGTGGTCGCACATCTGGCTCGGCAGCTTTCTGCGGCA
ATGGAGCGCAAGCGTCTCGCAGCCGCGGCTGACACCGATGAGAGCTTCGCCGATTGCGAAGGTCATATCATCATCGCCGG
ATTTGGACGGGTCGGCCAGACTTTGGCCCGCGCGCTGGATGCGGAAAACGTGGCCTTTGTTGCGCTCGATGCCGATGCGG
CCATGACCGCAGGCCTGAAGGATCGGCACCTGCCGGTATTCTACGGCGATGCGTCGCGCAGCGAAATCCTGGCCAAGGCG
GGAATAGATCATGCCGCAGCCGTCGTCGTGACGATGAACGATCCGGAAGCTGCCAGCCGGATTGTTCACCAGATACACCA
GCGGTGGCCATCAATGCCGATCCACGCCCGGGCCAGGGATCCGGAGCACGCCCGCCGTCTCCTCGAACTGGGCGCCAGTT
TCTGCACCCCGGAGACGGTCGAGGCGAGTCTCCAGCTCGCCGCCAATGTCCTGGTGGGCGCCGGCGTGGACGCCGAAGTG
ACCCGGCGCAGGATCACCGAGCAGCGCGCCTATGAAACAGGTGACAGCCCTTGA

Upstream 100 bases:

>100_bases
TCGCGCTGGTCCATCTTGGCTGGCGCTTCTCATTGGCCCGGCAATGGCGTCGACGGATGCAGTCGGGCGCGGTGGACAGC
TACCAGGACGGGAAGGATTG

Downstream 100 bases:

>100_bases
AGGAGAGAGCAGATGACCACTCACGGCAAGCCGGTCCTTGTTGCGACCGATCTCAGTGCCAGAACTGACCGCGCGGTTGA
CCGGGCAACGCAACTTGCAG

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MEPHPGIPFLREALVLLAAAGLAVPLLNRIRVNPILGYLLIGGVIGPYGLGLLAADYPFLSHAVISDIAGVRGLAEIGVV
FLLFMIGLELSLERLWSGRALVFGMGSLQILLTAGLIAWIATGLGVEEPTALIVGAALSLSSTAIVMQLLIHGRRQFSAV
GKTGFAILLMQDLAVVPILFMVGVIATPGSGGLAAGLAGALGKATLAIVLIYLAGRLLLRPVLRQVAQTRSPEMFTAAVL
LTVIGVSALTARFGLSMALGAFLAGLLLAETEYRHQIEVDIEPFKGLLLGLFFMSVGMGIDWRQVLASPLEIAGMVTGLW
LLKAVVITGLAIAFGRPRHVAAEAGMLLGQGGEFAFVIVGVAAGLGVVGGVLEQQILIVTGISMLLTPVVAHLARQLSAA
MERKRLAAAADTDESFADCEGHIIIAGFGRVGQTLARALDAENVAFVALDADAAMTAGLKDRHLPVFYGDASRSEILAKA
GIDHAAAVVVTMNDPEAASRIVHQIHQRWPSMPIHARARDPEHARRLLELGASFCTPETVEASLQLAANVLVGAGVDAEV
TRRRITEQRAYETGDSP

Sequences:

>Translated_577_residues
MEPHPGIPFLREALVLLAAAGLAVPLLNRIRVNPILGYLLIGGVIGPYGLGLLAADYPFLSHAVISDIAGVRGLAEIGVV
FLLFMIGLELSLERLWSGRALVFGMGSLQILLTAGLIAWIATGLGVEEPTALIVGAALSLSSTAIVMQLLIHGRRQFSAV
GKTGFAILLMQDLAVVPILFMVGVIATPGSGGLAAGLAGALGKATLAIVLIYLAGRLLLRPVLRQVAQTRSPEMFTAAVL
LTVIGVSALTARFGLSMALGAFLAGLLLAETEYRHQIEVDIEPFKGLLLGLFFMSVGMGIDWRQVLASPLEIAGMVTGLW
LLKAVVITGLAIAFGRPRHVAAEAGMLLGQGGEFAFVIVGVAAGLGVVGGVLEQQILIVTGISMLLTPVVAHLARQLSAA
MERKRLAAAADTDESFADCEGHIIIAGFGRVGQTLARALDAENVAFVALDADAAMTAGLKDRHLPVFYGDASRSEILAKA
GIDHAAAVVVTMNDPEAASRIVHQIHQRWPSMPIHARARDPEHARRLLELGASFCTPETVEASLQLAANVLVGAGVDAEV
TRRRITEQRAYETGDSP
>Mature_577_residues
MEPHPGIPFLREALVLLAAAGLAVPLLNRIRVNPILGYLLIGGVIGPYGLGLLAADYPFLSHAVISDIAGVRGLAEIGVV
FLLFMIGLELSLERLWSGRALVFGMGSLQILLTAGLIAWIATGLGVEEPTALIVGAALSLSSTAIVMQLLIHGRRQFSAV
GKTGFAILLMQDLAVVPILFMVGVIATPGSGGLAAGLAGALGKATLAIVLIYLAGRLLLRPVLRQVAQTRSPEMFTAAVL
LTVIGVSALTARFGLSMALGAFLAGLLLAETEYRHQIEVDIEPFKGLLLGLFFMSVGMGIDWRQVLASPLEIAGMVTGLW
LLKAVVITGLAIAFGRPRHVAAEAGMLLGQGGEFAFVIVGVAAGLGVVGGVLEQQILIVTGISMLLTPVVAHLARQLSAA
MERKRLAAAADTDESFADCEGHIIIAGFGRVGQTLARALDAENVAFVALDADAAMTAGLKDRHLPVFYGDASRSEILAKA
GIDHAAAVVVTMNDPEAASRIVHQIHQRWPSMPIHARARDPEHARRLLELGASFCTPETVEASLQLAANVLVGAGVDAEV
TRRRITEQRAYETGDSP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=360, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786232, Length=572, Percent_Identity=37.2377622377622, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1789749, Length=563, Percent_Identity=36.7673179396092, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI1786685, Length=523, Percent_Identity=29.0630975143403, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 60493; Mature: 60493

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPHPGIPFLREALVLLAAAGLAVPLLNRIRVNPILGYLLIGGVIGPYGLGLLAADYPFL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
SHAVISDIAGVRGLAEIGVVFLLFMIGLELSLERLWSGRALVFGMGSLQILLTAGLIAWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
ATGLGVEEPTALIVGAALSLSSTAIVMQLLIHGRRQFSAVGKTGFAILLMQDLAVVPILF
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MVGVIATPGSGGLAAGLAGALGKATLAIVLIYLAGRLLLRPVLRQVAQTRSPEMFTAAVL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LTVIGVSALTARFGLSMALGAFLAGLLLAETEYRHQIEVDIEPFKGLLLGLFFMSVGMGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCCC
DWRQVLASPLEIAGMVTGLWLLKAVVITGLAIAFGRPRHVAAEAGMLLGQGGEFAFVIVG
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHEECCCCEEEHHHH
VAAGLGVVGGVLEQQILIVTGISMLLTPVVAHLARQLSAAMERKRLAAAADTDESFADCE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
GHIIIAGFGRVGQTLARALDAENVAFVALDADAAMTAGLKDRHLPVFYGDASRSEILAKA
CCEEEEECCHHHHHHHHHHCCCCEEEEEEECCHHHHCCCCCCCCCEEECCCCHHHHHHHC
GIDHAAAVVVTMNDPEAASRIVHQIHQRWPSMPIHARARDPEHARRLLELGASFCTPETV
CCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHCCCHHH
EASLQLAANVLVGAGVDAEVTRRRITEQRAYETGDSP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEPHPGIPFLREALVLLAAAGLAVPLLNRIRVNPILGYLLIGGVIGPYGLGLLAADYPFL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
SHAVISDIAGVRGLAEIGVVFLLFMIGLELSLERLWSGRALVFGMGSLQILLTAGLIAWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
ATGLGVEEPTALIVGAALSLSSTAIVMQLLIHGRRQFSAVGKTGFAILLMQDLAVVPILF
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MVGVIATPGSGGLAAGLAGALGKATLAIVLIYLAGRLLLRPVLRQVAQTRSPEMFTAAVL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LTVIGVSALTARFGLSMALGAFLAGLLLAETEYRHQIEVDIEPFKGLLLGLFFMSVGMGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCCC
DWRQVLASPLEIAGMVTGLWLLKAVVITGLAIAFGRPRHVAAEAGMLLGQGGEFAFVIVG
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHEECCCCEEEHHHH
VAAGLGVVGGVLEQQILIVTGISMLLTPVVAHLARQLSAAMERKRLAAAADTDESFADCE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
GHIIIAGFGRVGQTLARALDAENVAFVALDADAAMTAGLKDRHLPVFYGDASRSEILAKA
CCEEEEECCHHHHHHHHHHCCCCEEEEEEECCHHHHCCCCCCCCCEEECCCCHHHHHHHC
GIDHAAAVVVTMNDPEAASRIVHQIHQRWPSMPIHARARDPEHARRLLELGASFCTPETV
CCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHCCCHHH
EASLQLAANVLVGAGVDAEVTRRRITEQRAYETGDSP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA