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The map label for this gene is galE [H]

Identifier: 86750920

GI number: 86750920

Start: 4348909

End: 4349847

Strand: Reverse

Name: galE [H]

Synonym: RPB_3811

Alternate gene names: 86750920

Gene position: 4349847-4348909 (Counterclockwise)

Preceding gene: 86750921

Following gene: 86750919

Centisome position: 81.59

GC content: 64.11

Gene sequence:

>939_bases
ATGAAGATTCTGGTGACCGGCGCCTGCGGCTATGTCGGGACCACGCTGGTGCCGAAGCTGCTGGCGCGCGGCGACGAGGT
GGTGGCGTTCGACATCATGTGGTTCGGCAACGACCTCACCCCGCACCCGGCGCTGACGGTGGTGCGCGGCGACGTCCGCG
ACGCCGCGACGATTCCGCTCGACGGCATCGACGCCATCATCCATCTGGCGTCCGTCGCCAACGATCCGTGCGGCGATCTC
AATCCGAAACTGACCTGGGAGATCAGCGCGCTCGCCACCATGCAGCTCGCCGACCGCGCCGCGCGCGAAGGCATCAAGCG
CTTCATCTACGCGTCGTCCGGCAGCGTCTACGGCATCAAGGACGAAGAGCAGGTCACCGAGGATCTGACGCTGGAGCCGA
TCTCGGAATACAACAAGACCAAGATGGTGGCCGAGCGGGTGATGCTCAGCTACGCCGACGACATGGCGGTGCAGATCGTG
CGGCCGGCGACGGTGTGCGGGCCGTCGCCGCGGATGCGGCTCGACGTCTCGGTCAACATGCTGACCATGCAGGCGCTGAC
CAATGGCGAGATCACCGTGTTCGGCGGCAATCAGGTCCGCCCCAACATCCATATCGACGACATCACCGACCTCTATGTGA
TGCTGCTGGAGCGGCCCGAGCTGCGCGGCGTCTACAATGCCGGCTTCGAGAACATCTCGATCCTCGACATCGCCAGGATG
GTCGACGCCCAGGTGCCGACGAAGATCACCGTCACCGAATCCAACGACCCGCGCTCCTACCGGATCAATTCGGACAAACT
GCTGGCGACCGGCTTCAAGCCGAACAAGACGGTGAACGACGCGATCCGCGAGATCATCGTCAAGTTCCAGCGCGGCGAAT
TGAAGAACGAGGACCGGCACTACAATCTGCGCTGGATGCAGCGGGGCGTGCAGGCGTGA

Upstream 100 bases:

>100_bases
CTGACCGCGACGGCGGAGCCGATGGTTCCGGCGTGGCCCGCGACGCCCGACGTCTGCTTGTGCGAAATCTGCCCGTGAAC
CAACTCGATGGGATGACGCG

Downstream 100 bases:

>100_bases
CCCGACCGATCCCGGCATCCTCTCCCGACGCGAAGGCCGGCGCGGCGTTCGGCAAGGTGCTGGTGATCGGCAGCAATTCC
TTCACCGGCGCCGAGATGGT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKILVTGACGYVGTTLVPKLLARGDEVVAFDIMWFGNDLTPHPALTVVRGDVRDAATIPLDGIDAIIHLASVANDPCGDL
NPKLTWEISALATMQLADRAAREGIKRFIYASSGSVYGIKDEEQVTEDLTLEPISEYNKTKMVAERVMLSYADDMAVQIV
RPATVCGPSPRMRLDVSVNMLTMQALTNGEITVFGGNQVRPNIHIDDITDLYVMLLERPELRGVYNAGFENISILDIARM
VDAQVPTKITVTESNDPRSYRINSDKLLATGFKPNKTVNDAIREIIVKFQRGELKNEDRHYNLRWMQRGVQA

Sequences:

>Translated_312_residues
MKILVTGACGYVGTTLVPKLLARGDEVVAFDIMWFGNDLTPHPALTVVRGDVRDAATIPLDGIDAIIHLASVANDPCGDL
NPKLTWEISALATMQLADRAAREGIKRFIYASSGSVYGIKDEEQVTEDLTLEPISEYNKTKMVAERVMLSYADDMAVQIV
RPATVCGPSPRMRLDVSVNMLTMQALTNGEITVFGGNQVRPNIHIDDITDLYVMLLERPELRGVYNAGFENISILDIARM
VDAQVPTKITVTESNDPRSYRINSDKLLATGFKPNKTVNDAIREIIVKFQRGELKNEDRHYNLRWMQRGVQA
>Mature_312_residues
MKILVTGACGYVGTTLVPKLLARGDEVVAFDIMWFGNDLTPHPALTVVRGDVRDAATIPLDGIDAIIHLASVANDPCGDL
NPKLTWEISALATMQLADRAAREGIKRFIYASSGSVYGIKDEEQVTEDLTLEPISEYNKTKMVAERVMLSYADDMAVQIV
RPATVCGPSPRMRLDVSVNMLTMQALTNGEITVFGGNQVRPNIHIDDITDLYVMLLERPELRGVYNAGFENISILDIARM
VDAQVPTKITVTESNDPRSYRINSDKLLATGFKPNKTVNDAIREIIVKFQRGELKNEDRHYNLRWMQRGVQA

Specific function: Can have functions other than metabolism of galactose. It also could be involved in preparation of carbohydrate residues for incorporation into complex polymers, such as exopolysaccharides [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=308, Percent_Identity=26.2987012987013, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI193211614, Length=204, Percent_Identity=28.921568627451, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI8393516, Length=204, Percent_Identity=28.921568627451, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI310132178, Length=233, Percent_Identity=25.7510729613734, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI310113012, Length=233, Percent_Identity=25.7510729613734, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI239745448, Length=233, Percent_Identity=25.7510729613734, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786974, Length=276, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=228, Percent_Identity=30.7017543859649, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115532424, Length=322, Percent_Identity=23.2919254658385, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356223, Length=237, Percent_Identity=29.957805907173, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34638; Mature: 34638

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGACGYVGTTLVPKLLARGDEVVAFDIMWFGNDLTPHPALTVVRGDVRDAATIPL
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCC
DGIDAIIHLASVANDPCGDLNPKLTWEISALATMQLADRAAREGIKRFIYASSGSVYGIK
CHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHEEEECCCCEEECC
DEEQVTEDLTLEPISEYNKTKMVAERVMLSYADDMAVQIVRPATVCGPSPRMRLDVSVNM
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCCCCEEEEEEEEE
LTMQALTNGEITVFGGNQVRPNIHIDDITDLYVMLLERPELRGVYNAGFENISILDIARM
EEEEEECCCCEEEEECCEECCCEEECHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHH
VDAQVPTKITVTESNDPRSYRINSDKLLATGFKPNKTVNDAIREIIVKFQRGELKNEDRH
HCCCCCCEEEEECCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
YNLRWMQRGVQA
EEHHHHHCCCCC
>Mature Secondary Structure
MKILVTGACGYVGTTLVPKLLARGDEVVAFDIMWFGNDLTPHPALTVVRGDVRDAATIPL
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCC
DGIDAIIHLASVANDPCGDLNPKLTWEISALATMQLADRAAREGIKRFIYASSGSVYGIK
CHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHEEEECCCCEEECC
DEEQVTEDLTLEPISEYNKTKMVAERVMLSYADDMAVQIVRPATVCGPSPRMRLDVSVNM
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCCCCEEEEEEEEE
LTMQALTNGEITVFGGNQVRPNIHIDDITDLYVMLLERPELRGVYNAGFENISILDIARM
EEEEEECCCCEEEEECCEECCCEEECHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHH
VDAQVPTKITVTESNDPRSYRINSDKLLATGFKPNKTVNDAIREIIVKFQRGELKNEDRH
HCCCCCCEEEEECCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
YNLRWMQRGVQA
EEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788721 [H]