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The map label for this gene is pdhB [H]

Identifier: 86750916

GI number: 86750916

Start: 4345173

End: 4346225

Strand: Reverse

Name: pdhB [H]

Synonym: RPB_3807

Alternate gene names: 86750916

Gene position: 4346225-4345173 (Counterclockwise)

Preceding gene: 86750917

Following gene: 86750915

Centisome position: 81.52

GC content: 68.0

Gene sequence:

>1053_bases
ATGAGCACGAGTTTCGCCGCCGCCATCCGTGATGGCCTCGCCACGGCGCTCGCCGCCGACGACAGCGTCATCTGCTTCGG
GCTCGGCACCGACGATCCCAAAGGCGTGTTCGGTACTACGCTCGATTTGCACAAGCAATTCGGCCCGGACCGGGTGTTCG
ACATGCCGACCTCGGAAGCGGCGATGACCGGGATCGCGATCGGCGCCGCGCTGAACGGGCTGCGCCCGGTGATGACGCAT
CAGCGGCTCGACTTCGCGCTGCTGTCGCTCGATCAATTGGTCAACAACGCCGCCAAATGGCGCTTCATGTTCGGCGGCGC
CCGCGGCGTGCCGATCACCATCCGGATGATCATCGGCCGCGGCTGGGGCCAGGGGCCGACGCATTCGCAGAGCCTGCAAT
CCTGGTTCGCGCATATTCCCGGGCTGAAAGTGGTGATGCCGACCACCGCCGAGGACGCCAAGGGCCTGCTGCTGGCCTCG
ATCTTCGACGACGATCCGGTGATCTTCCTCGAGCATCGCTGGCTGCACAATATGAATGGCGAGGTGCCCGCCGGCGACGT
CCGCGAACCGCTCGGCAAGGCGCGCGTGGTGCGTAGCGGTGACGCGGTGACGATCGTGGCGATGAGCTACATGACGGTGG
AGGCGCTGCACGCGGTCGATCACCTCGCCGCGCAGGGCATCAGTTGTGAGCTGATCGATCTGCGCACGATCCGCCCGCTG
GACTGGCCGGCGGTGATCGCCTCGGTGCACAAGACCGGCCGGCTGCTGGCGCTCGACCCCGGCCATCTCACCGGCGGCGT
CGCCGGCGAGATCGTGGCGCGGATCGCGACCGATCATTTCAGCAGCCTGACATGCGCGCCGCAGCGGCTCGCCGCGCCCG
ACGTGCCGGAAGCGACCAGCCCGGCGCTGACCAAGAATTATCACGTCCGCGCCGAGCACATCGCCGAGGCCGTCGGCCGG
ATGCTCGGCCGCGAGGTCGAGACCGCGTCGCTCGTTTCCAGACGCCAGTTCCCGCACGACGTGCCGGGCGACTGGTTCTC
CGGGCCGTTCTGA

Upstream 100 bases:

>100_bases
CCGAGATCGACGCCGAGATCGACGAGGCGTTCGCCTTCGCCGAGGCGTCGCCGTTTCCCGACGCGGGCGAGGCCTTCACC
GACGTCTATGCGAGGCCGGC

Downstream 100 bases:

>100_bases
GGGGGCGGTGATGGCACAGACATTCAACCTCATTGCGAGGAACGAAGCGACGAAGCAATCCAGGGGCGCCGACCGCGGCG
CTCTGGATTGCTTCGCTTCG

Product: acetoin dehydrogenase (TPP-dependent) beta chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSTSFAAAIRDGLATALAADDSVICFGLGTDDPKGVFGTTLDLHKQFGPDRVFDMPTSEAAMTGIAIGAALNGLRPVMTH
QRLDFALLSLDQLVNNAAKWRFMFGGARGVPITIRMIIGRGWGQGPTHSQSLQSWFAHIPGLKVVMPTTAEDAKGLLLAS
IFDDDPVIFLEHRWLHNMNGEVPAGDVREPLGKARVVRSGDAVTIVAMSYMTVEALHAVDHLAAQGISCELIDLRTIRPL
DWPAVIASVHKTGRLLALDPGHLTGGVAGEIVARIATDHFSSLTCAPQRLAAPDVPEATSPALTKNYHVRAEHIAEAVGR
MLGREVETASLVSRRQFPHDVPGDWFSGPF

Sequences:

>Translated_350_residues
MSTSFAAAIRDGLATALAADDSVICFGLGTDDPKGVFGTTLDLHKQFGPDRVFDMPTSEAAMTGIAIGAALNGLRPVMTH
QRLDFALLSLDQLVNNAAKWRFMFGGARGVPITIRMIIGRGWGQGPTHSQSLQSWFAHIPGLKVVMPTTAEDAKGLLLAS
IFDDDPVIFLEHRWLHNMNGEVPAGDVREPLGKARVVRSGDAVTIVAMSYMTVEALHAVDHLAAQGISCELIDLRTIRPL
DWPAVIASVHKTGRLLALDPGHLTGGVAGEIVARIATDHFSSLTCAPQRLAAPDVPEATSPALTKNYHVRAEHIAEAVGR
MLGREVETASLVSRRQFPHDVPGDWFSGPF
>Mature_349_residues
STSFAAAIRDGLATALAADDSVICFGLGTDDPKGVFGTTLDLHKQFGPDRVFDMPTSEAAMTGIAIGAALNGLRPVMTHQ
RLDFALLSLDQLVNNAAKWRFMFGGARGVPITIRMIIGRGWGQGPTHSQSLQSWFAHIPGLKVVMPTTAEDAKGLLLASI
FDDDPVIFLEHRWLHNMNGEVPAGDVREPLGKARVVRSGDAVTIVAMSYMTVEALHAVDHLAAQGISCELIDLRTIRPLD
WPAVIASVHKTGRLLALDPGHLTGGVAGEIVARIATDHFSSLTCAPQRLAAPDVPEATSPALTKNYHVRAEHIAEAVGRM
LGREVETASLVSRRQFPHDVPGDWFSGPF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=321, Percent_Identity=36.1370716510903, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI291084858, Length=321, Percent_Identity=34.2679127725857, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI4557353, Length=293, Percent_Identity=37.8839590443686, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI34101272, Length=293, Percent_Identity=37.8839590443686, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI133778974, Length=262, Percent_Identity=25.5725190839695, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=324, Percent_Identity=38.8888888888889, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17506935, Length=295, Percent_Identity=38.3050847457627, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17539652, Length=322, Percent_Identity=28.2608695652174, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=334, Percent_Identity=34.4311377245509, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21358145, Length=335, Percent_Identity=38.8059701492537, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24650940, Length=335, Percent_Identity=38.8059701492537, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI160714828, Length=293, Percent_Identity=35.8361774744027, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI160714832, Length=293, Percent_Identity=35.8361774744027, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37557; Mature: 37425

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSFAAAIRDGLATALAADDSVICFGLGTDDPKGVFGTTLDLHKQFGPDRVFDMPTSEA
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEECCCCCHH
AMTGIAIGAALNGLRPVMTHQRLDFALLSLDQLVNNAAKWRFMFGGARGVPITIRMIIGR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEEC
GWGQGPTHSQSLQSWFAHIPGLKVVMPTTAEDAKGLLLASIFDDDPVIFLEHRWLHNMNG
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEEHHHHCCCC
EVPAGDVREPLGKARVVRSGDAVTIVAMSYMTVEALHAVDHLAAQGISCELIDLRTIRPL
CCCCCHHHHHHHHHHEEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
DWPAVIASVHKTGRLLALDPGHLTGGVAGEIVARIATDHFSSLTCAPQRLAAPDVPEATS
CHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
PALTKNYHVRAEHIAEAVGRMLGREVETASLVSRRQFPHDVPGDWFSGPF
CCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STSFAAAIRDGLATALAADDSVICFGLGTDDPKGVFGTTLDLHKQFGPDRVFDMPTSEA
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEECCCCCHH
AMTGIAIGAALNGLRPVMTHQRLDFALLSLDQLVNNAAKWRFMFGGARGVPITIRMIIGR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEEC
GWGQGPTHSQSLQSWFAHIPGLKVVMPTTAEDAKGLLLASIFDDDPVIFLEHRWLHNMNG
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEEHHHHCCCC
EVPAGDVREPLGKARVVRSGDAVTIVAMSYMTVEALHAVDHLAAQGISCELIDLRTIRPL
CCCCCHHHHHHHHHHEEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
DWPAVIASVHKTGRLLALDPGHLTGGVAGEIVARIATDHFSSLTCAPQRLAAPDVPEATS
CHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCC
PALTKNYHVRAEHIAEAVGRMLGREVETASLVSRRQFPHDVPGDWFSGPF
CCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]