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The map label for this gene is pdhA [H]

Identifier: 86750917

GI number: 86750917

Start: 4346222

End: 4347193

Strand: Reverse

Name: pdhA [H]

Synonym: RPB_3808

Alternate gene names: 86750917

Gene position: 4347193-4346222 (Counterclockwise)

Preceding gene: 86750918

Following gene: 86750916

Centisome position: 81.54

GC content: 69.14

Gene sequence:

>972_bases
ATGAGCGAGCTGCCGCGCCGCCTGCTGTTTGACATGATGCGCATCCGCGCCGTCGAGGAGACGATCGCTAAGCGCTACGG
CGAGCAGAAGATGCGCTGCCCGACGCATCTGTCGGTCGGGCAGGAGGCGGTGGCGGCCGCGGCCGGCGCGGCACTGGAAC
CGGCCGATCTCGCCGTCAGCGGCCACCGCGCGCATGCGCATTATCTCGCCAAGGGCGGCTCGCTGAAGGCGATGATCGCC
GAGATCTACGGCCGTGTCACCGGCTGCTCGCGCGGCAAGGGCGGCTCGATGCATCTGATCGACGAGAGCGCCGGCTTCAT
GGGCTCGACCGCGATCGTCGGCGGCACCGTGCCGGTCGGCGTCGGGCTCGCTTATCCGATGAAGCTGAAGCGGACCGGGC
AGATTGCCTGCGTGTTCCTCGGCGACGCCGTGCCGGAGACCGGGGTGTTCTTCGAGGCGGTGAACTTCGCTGTGCTGAAG
AAACTCCCGGTGCTGTTCCTGTGTGAGAACAACGGCTATTCGGTGTATTCGCCGCTGTCGGTGCGCCAGCCGCCGGGGCG
CAGGCTGTACGAGATGGTCGCGGGCTTCGGCCTGCCCACGCATCACGGCGACGGCAACGACGCCCGCGCGGTGCACGCCG
CGCTGAGCGAGGGCGTCGCGGCGATCCGCGCCGGCGAGGGGCCGCGGTTCTACGAGTTCGAGACCTATCGCTGGCGCGAG
CATTGCGGCCCGAACTACGACAACGACATCGGCTATCGCAGCGCCGCCGAATACGAAGCGTGGAAGCTGCGCGATCCGGT
GCCGGCGCTGCAGCGCGCGCTGATCGGCGAGGGCGTAGTCAGCGAGTCCGGCATCGCCGCGATGCAGGCCGAGATCGACG
CCGAGATCGACGAGGCGTTCGCCTTCGCCGAGGCGTCGCCGTTTCCCGACGCGGGCGAGGCCTTCACCGACGTCTATGCG
AGGCCGGCATGA

Upstream 100 bases:

>100_bases
GCGCAGACCATCATGCATGTCGACGAATGGACCGCGTTCTTCGACGAGATCGGCTACACCGGCGACTACTACTGGTTCAT
CCCATGATCGGGTTGGTGCC

Downstream 100 bases:

>100_bases
GCACGAGTTTCGCCGCCGCCATCCGTGATGGCCTCGCCACGGCGCTCGCCGCCGACGACAGCGTCATCTGCTTCGGGCTC
GGCACCGACGATCCCAAAGG

Product: acetoin dehydrogenase (TPP-dependent) alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVSGHRAHAHYLAKGGSLKAMIA
EIYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVGVGLAYPMKLKRTGQIACVFLGDAVPETGVFFEAVNFAVLK
KLPVLFLCENNGYSVYSPLSVRQPPGRRLYEMVAGFGLPTHHGDGNDARAVHAALSEGVAAIRAGEGPRFYEFETYRWRE
HCGPNYDNDIGYRSAAEYEAWKLRDPVPALQRALIGEGVVSESGIAAMQAEIDAEIDEAFAFAEASPFPDAGEAFTDVYA
RPA

Sequences:

>Translated_323_residues
MSELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVSGHRAHAHYLAKGGSLKAMIA
EIYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVGVGLAYPMKLKRTGQIACVFLGDAVPETGVFFEAVNFAVLK
KLPVLFLCENNGYSVYSPLSVRQPPGRRLYEMVAGFGLPTHHGDGNDARAVHAALSEGVAAIRAGEGPRFYEFETYRWRE
HCGPNYDNDIGYRSAAEYEAWKLRDPVPALQRALIGEGVVSESGIAAMQAEIDAEIDEAFAFAEASPFPDAGEAFTDVYA
RPA
>Mature_322_residues
SELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVSGHRAHAHYLAKGGSLKAMIAE
IYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVGVGLAYPMKLKRTGQIACVFLGDAVPETGVFFEAVNFAVLKK
LPVLFLCENNGYSVYSPLSVRQPPGRRLYEMVAGFGLPTHHGDGNDARAVHAALSEGVAAIRAGEGPRFYEFETYRWREH
CGPNYDNDIGYRSAAEYEAWKLRDPVPALQRALIGEGVVSESGIAAMQAEIDAEIDEAFAFAEASPFPDAGEAFTDVYAR
PA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=310, Percent_Identity=32.5806451612903, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI291084742, Length=310, Percent_Identity=32.258064516129, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4505685, Length=310, Percent_Identity=32.258064516129, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI291084744, Length=317, Percent_Identity=31.5457413249211, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI11386135, Length=283, Percent_Identity=27.5618374558304, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI291084757, Length=310, Percent_Identity=30.3225806451613, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI258645172, Length=283, Percent_Identity=27.5618374558304, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17536047, Length=310, Percent_Identity=33.2258064516129, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32564172, Length=310, Percent_Identity=33.2258064516129, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI86563355, Length=284, Percent_Identity=29.5774647887324, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI86563357, Length=284, Percent_Identity=29.5774647887324, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=314, Percent_Identity=35.031847133758, Blast_Score=165, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24639740, Length=311, Percent_Identity=34.4051446945338, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24639744, Length=311, Percent_Identity=34.4051446945338, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI28571106, Length=311, Percent_Identity=34.4051446945338, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24639746, Length=311, Percent_Identity=34.4051446945338, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24639748, Length=312, Percent_Identity=32.6923076923077, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355903, Length=323, Percent_Identity=26.3157894736842, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34673; Mature: 34542

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVS
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHCCHHHHHHHHCCCCCCHHEEEC
GHRAHAHYLAKGGSLKAMIAEIYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVG
CCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCC
VGLAYPMKLKRTGQIACVFLGDAVPETGVFFEAVNFAVLKKLPVLFLCENNGYSVYSPLS
CCEECCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCEEECCCC
VRQPPGRRLYEMVAGFGLPTHHGDGNDARAVHAALSEGVAAIRAGEGPRFYEFETYRWRE
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHEEECCCCCCEEEEECHHHHH
HCGPNYDNDIGYRSAAEYEAWKLRDPVPALQRALIGEGVVSESGIAAMQAEIDAEIDEAF
HCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AFAEASPFPDAGEAFTDVYARPA
HHHCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVS
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHCCHHHHHHHHCCCCCCHHEEEC
GHRAHAHYLAKGGSLKAMIAEIYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVG
CCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCC
VGLAYPMKLKRTGQIACVFLGDAVPETGVFFEAVNFAVLKKLPVLFLCENNGYSVYSPLS
CCEECCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCEEECCCC
VRQPPGRRLYEMVAGFGLPTHHGDGNDARAVHAALSEGVAAIRAGEGPRFYEFETYRWRE
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHEEECCCCCCEEEEECHHHHH
HCGPNYDNDIGYRSAAEYEAWKLRDPVPALQRALIGEGVVSESGIAAMQAEIDAEIDEAF
HCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AFAEASPFPDAGEAFTDVYARPA
HHHCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA