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The map label for this gene is pgsA1 [H]

Identifier: 86749610

GI number: 86749610

Start: 2848317

End: 2848946

Strand: Direct

Name: pgsA1 [H]

Synonym: RPB_2490

Alternate gene names: 86749610

Gene position: 2848317-2848946 (Clockwise)

Preceding gene: 86749607

Following gene: 86749611

Centisome position: 53.42

GC content: 59.52

Gene sequence:

>630_bases
ATGTACTATGTAGACAACCAGCCCCTCCCGCCGTCGAAAGTCGAATGGTTTCGCCGGATCTGGGCTGGAAGCCGGGAACG
TCGCGTGAGCATTCCGAATATTATTACCCTGGGCCGGATTCTGCTGGTGCCGGTCATCGTCTGGGCCATTGCGTCGAATG
AAATGGCAGTCGCGTTCGCGGTCTTCGTGATCGCCGGCGTCAGCGACGCGATCGACGGCTTTCTCGCCAAGCGTTTCAAC
ATGAGCAGCGAGCTCGGTGCGTTGCTCGATCCGCTGGCCGACAAGGCGCTATTGGTGTCGATCTACGTGTCGCTCGGCAT
CTGGGGCGCGATCCCGCGCTGGCTGGTGATTCTGGTGGTGTCGCGCGACATCATGATCGTGGGAGCGGTGATCATTTCCT
GGCTGTTCGGCAAGCCGGTGCCGATGAAACCGTTGATGGTCTCGAAACTGAATACGGTGGCGCAGGTCGGATTTGCCGCA
TTGGTGCTCGGTGCGCTCGGCTTCGGGTTCGAGCCGGCGCCCTATGACCTAGTCTTGATGATTCTGGTGACGCTCTTGAC
GTTGCTTTCGGTCTCCTTCTATCTCGTGGAGTGGACGCGGCATATGAGCACGATCGAGCCTGGCCACTGA

Upstream 100 bases:

>100_bases
CGCGCTAGACCTAAGTCCCGCTTGTCCGCGTCCGACCAATGGTTTTGGGGTGGTTACGTCGGATTCCGCCGGCGTGCAAT
GGCTCGCAAGGGGACCCAGC

Downstream 100 bases:

>100_bases
AACGCGTCGGCCGGCCGCGCAGTGCGGGCCGGCATGGAGCGACCCCGTGGTAGTCCGCGTACAACCCCGTCAACTGGCCC
TGGACCTGCCGCACGCCGAA

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MYYVDNQPLPPSKVEWFRRIWAGSRERRVSIPNIITLGRILLVPVIVWAIASNEMAVAFAVFVIAGVSDAIDGFLAKRFN
MSSELGALLDPLADKALLVSIYVSLGIWGAIPRWLVILVVSRDIMIVGAVIISWLFGKPVPMKPLMVSKLNTVAQVGFAA
LVLGALGFGFEPAPYDLVLMILVTLLTLLSVSFYLVEWTRHMSTIEPGH

Sequences:

>Translated_209_residues
MYYVDNQPLPPSKVEWFRRIWAGSRERRVSIPNIITLGRILLVPVIVWAIASNEMAVAFAVFVIAGVSDAIDGFLAKRFN
MSSELGALLDPLADKALLVSIYVSLGIWGAIPRWLVILVVSRDIMIVGAVIISWLFGKPVPMKPLMVSKLNTVAQVGFAA
LVLGALGFGFEPAPYDLVLMILVTLLTLLSVSFYLVEWTRHMSTIEPGH
>Mature_209_residues
MYYVDNQPLPPSKVEWFRRIWAGSRERRVSIPNIITLGRILLVPVIVWAIASNEMAVAFAVFVIAGVSDAIDGFLAKRFN
MSSELGALLDPLADKALLVSIYVSLGIWGAIPRWLVILVVSRDIMIVGAVIISWLFGKPVPMKPLMVSKLNTVAQVGFAA
LVLGALGFGFEPAPYDLVLMILVTLLTLLSVSFYLVEWTRHMSTIEPGH

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=181, Percent_Identity=34.2541436464088, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI10092647, Length=181, Percent_Identity=34.2541436464088, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1788220, Length=180, Percent_Identity=31.6666666666667, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984838, Length=171, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71984834, Length=171, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320059, Length=114, Percent_Identity=29.8245614035088, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650130, Length=158, Percent_Identity=32.2784810126582, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650126, Length=158, Percent_Identity=32.2784810126582, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650128, Length=158, Percent_Identity=32.2784810126582, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 23021; Mature: 23021

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYVDNQPLPPSKVEWFRRIWAGSRERRVSIPNIITLGRILLVPVIVWAIASNEMAVAFA
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VFVIAGVSDAIDGFLAKRFNMSSELGALLDPLADKALLVSIYVSLGIWGAIPRWLVILVV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRDIMIVGAVIISWLFGKPVPMKPLMVSKLNTVAQVGFAALVLGALGFGFEPAPYDLVLM
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ILVTLLTLLSVSFYLVEWTRHMSTIEPGH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYYVDNQPLPPSKVEWFRRIWAGSRERRVSIPNIITLGRILLVPVIVWAIASNEMAVAFA
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VFVIAGVSDAIDGFLAKRFNMSSELGALLDPLADKALLVSIYVSLGIWGAIPRWLVILVV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRDIMIVGAVIISWLFGKPVPMKPLMVSKLNTVAQVGFAALVLGALGFGFEPAPYDLVLM
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ILVTLLTLLSVSFYLVEWTRHMSTIEPGH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]