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The map label for this gene is ndk [H]

Identifier: 86749605

GI number: 86749605

Start: 2844252

End: 2844674

Strand: Direct

Name: ndk [H]

Synonym: RPB_2485

Alternate gene names: 86749605

Gene position: 2844252-2844674 (Clockwise)

Preceding gene: 86749603

Following gene: 86749607

Centisome position: 53.35

GC content: 63.12

Gene sequence:

>423_bases
ATGGCTGTTCAACGAACTTTCTCGATCCTCAAGCCCGATGCGACCGAGCGCAACATCACCGGCGCGATCAATGCCCTGAT
CGAGAAGGCCGGCCTGCGCATCGTGGCGCAGAAGCGGATTCACATGACCCGCGGCCAGGCCGAGACCTTCTATGCGGTCC
ACAAGGAACGCCCGTTCTTCGGCGAACTGGTCGACTTCATGACCTCGGGCCCGGTCGTCGTGCAGGTGCTCGAAGGCGAG
GGGGCGATTGCGAAGTATCGCGACGTGATGGGCGCGACCGATCCGTCGAAGGCCGCGGACGGCACCATCCGCAAGCTGCA
TGCCAAATCGATCGGCGAAAACTCGGTGCACGGTTCGGATGCGCCGGAGACCGCTGCCATCGAGATCGCGCAGTTCTTCG
CCGGCAACGAAATCGTCGGCTGA

Upstream 100 bases:

>100_bases
GGGGAGGGCGGCGTTCGTCTGGTGGCGCGGCTTGCCGTGCCGCGGCGGCGCCGATATAAGCGCGCAACTCTCCCGCCCCA
AGCGTTTCAAGGACATTTCC

Downstream 100 bases:

>100_bases
GCCCCGCACCACACCACGTCCGCGGACCGCTGATCGGGCGGCCGCGGTCGTGGCAATCGGGTCGGCCTTGCTGAGCGGGG
GACCCGTCCTCGCTGTGCCG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAVQRTFSILKPDATERNITGAINALIEKAGLRIVAQKRIHMTRGQAETFYAVHKERPFFGELVDFMTSGPVVVQVLEGE
GAIAKYRDVMGATDPSKAADGTIRKLHAKSIGENSVHGSDAPETAAIEIAQFFAGNEIVG

Sequences:

>Translated_140_residues
MAVQRTFSILKPDATERNITGAINALIEKAGLRIVAQKRIHMTRGQAETFYAVHKERPFFGELVDFMTSGPVVVQVLEGE
GAIAKYRDVMGATDPSKAADGTIRKLHAKSIGENSVHGSDAPETAAIEIAQFFAGNEIVG
>Mature_139_residues
AVQRTFSILKPDATERNITGAINALIEKAGLRIVAQKRIHMTRGQAETFYAVHKERPFFGELVDFMTSGPVVVQVLEGEG
AIAKYRDVMGATDPSKAADGTIRKLHAKSIGENSVHGSDAPETAAIEIAQFFAGNEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=39.7058823529412, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=37.956204379562, Blast_Score=102, Evalue=9e-23,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=37.956204379562, Blast_Score=102, Evalue=9e-23,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=37.956204379562, Blast_Score=102, Evalue=9e-23,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=37.956204379562, Blast_Score=102, Evalue=9e-23,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=37.956204379562, Blast_Score=102, Evalue=9e-23,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=37.956204379562, Blast_Score=100, Evalue=3e-22,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=37.956204379562, Blast_Score=100, Evalue=3e-22,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=33.8235294117647, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=33.0827067669173, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=33.0827067669173, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=33.8235294117647, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=53.2374100719424, Blast_Score=154, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=40, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=38.2352941176471, Blast_Score=102, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=41.1764705882353, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=35.3383458646617, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15068; Mature: 14937

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQRTFSILKPDATERNITGAINALIEKAGLRIVAQKRIHMTRGQAETFYAVHKERPFF
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHCCCCCHHEEEHHCCCCHH
GELVDFMTSGPVVVQVLEGEGAIAKYRDVMGATDPSKAADGTIRKLHAKSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
APETAAIEIAQFFAGNEIVG
CCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVQRTFSILKPDATERNITGAINALIEKAGLRIVAQKRIHMTRGQAETFYAVHKERPFF
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHHCCCCCHHEEEHHCCCCHH
GELVDFMTSGPVVVQVLEGEGAIAKYRDVMGATDPSKAADGTIRKLHAKSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
APETAAIEIAQFFAGNEIVG
CCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA