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The map label for this gene is zwf [H]

Identifier: 86749013

GI number: 86749013

Start: 2162499

End: 2164013

Strand: Reverse

Name: zwf [H]

Synonym: RPB_1890

Alternate gene names: 86749013

Gene position: 2164013-2162499 (Counterclockwise)

Preceding gene: 86749014

Following gene: 86749012

Centisome position: 40.59

GC content: 63.89

Gene sequence:

>1515_bases
GTGACCACTCAGGCGAATCCACAGGTTCCGGACGGCTGCGCCTTCGTCATCTTCGGCGTCACCGGCGACCTCACTCACCG
CCTGGTGGTTCCGGCGTTGTACAATCTCGCCGAAGCCGATCTGCTGCCGGAGAAATTCTGCGTGGTCGGCATCACTCGCT
CGGAGATGTCGAGCGAGGACCTGCGCGCCAGCCTGATGCACGGCCTGCGTAAATTCGCGACGCGGCCGGTGAACGAGGAT
GTCGCCGACAAGCTGCTGTACTGCGTGACGGCGGTCAGCGCCGATCCGTCCGACCCGCCCTCGTTCGACCGGCTGCGCGA
GCGGCTGGAAAAGCTCGAGGCCAATCGCAACACCGGCGGCAACCGGCTGTTCTATCTGGCGACACCGCCCGATGCCTTCG
CGCCGATCGCGACCGAACTCGGTCGTGCCGGCCTGCTGCAGGGCAATGATCAGGCGTGGCGCCGGTTGATCGTCGAGAAG
CCGTTCGGCACCGACCTCGCCTCCGCCAAAGCGCTGAACGACCATCTGCTCGGCATCGTCGCCGAACACGATCTGTACCG
GATCGATCATTATCTCGGCAAAGAGACGGTGCAGAACATCCTGGTGCTACGTTTTTCCAACGGCATGTTCGAGCCGATCT
GGAACAGGGATCATATCGACCACATCCAGATCACCGTCGACGAAAAGCTTGGCGTCGGCCATCGCGGCAGCTTCTACGAC
AAGACCGGCGCGCTACGCGACATGGTGCCGAACCATCTGTTCCAGTTGCTGTCGCTGGTGGCGATGGAGCCGCCGGCGCA
TTTCAACGCGCATTCGGTGCGCTCGGCCAAGGCCGAAGTGCTCACCGCGATTCAGGTGCAGAACGAAGAGGAAGCGCTGC
GCAATTCGGTCCGCGCACAATACATCGCCGGCAAGGTCGGCGACACCGAGATCCCTGATTATCGCAGCGTCAAGGATGTC
GCGCCAGGCAGCACCACCGAAACCTATGCGGCGCTGAAGCTGACGATCGACAACTGGCGCTGGGCCGGCGTGCCGTTCTA
TCTGCGCACCGGCAAGGCGCTCGGCGCCAAGCGTACCGAGGTCGCGATCAAGTTCAAGCAGGCGCCGTTCGCGATGTTCC
GCTGCACGCCGGTGGAGCAATTGTCGCAGAACTATCTGGTGATCGGGATCGAGCCGGTCGAAGGCATTTCACTGCAGTTC
AACACCAAGATTCCCGGCCCGACGATCGCGATCGACGGCGTCGAGATGAGCTTCCGCTACAAGGATTACTTCAAGGTCGC
GCCGAGCAACGGCTACGAGACGCTGCTGCACGACTGCATGATCGGCGACAACATCCTGTTCCAGCGCGCCGACGGCGTCG
AGGCCGGCTGGCGCGCGGTGCAGCCGTTCCTCGATGCCTGGGAGAGGGCGGGCGCCAACGGGCTTCAGACCTACGAAGCC
GGCAGCGAAGGCCCGCAGGACGCCGAAACCCTGCTCGCCCGCGACGGCCGCAACTGGCGCGGCTCGGCCAGATGA

Upstream 100 bases:

>100_bases
CGATGCGCGCGGGATTCGGCGGGCACAAGGAGCCGCAACAGCACCCGGACGCCGCGCATCAGGCCGCGCCGGAAATCCTC
AAGCCGAAAGCGGAGCGCGC

Downstream 100 bases:

>100_bases
AGGTCGGCGATCATCGCCAGATCGTCACCGCTGCCGATGCCGAAGCGCTGGCGCGGGTCGCGGCGCAGCGGCTGATCGCC
CGCATCGCGCTGCATCACGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTTQANPQVPDGCAFVIFGVTGDLTHRLVVPALYNLAEADLLPEKFCVVGITRSEMSSEDLRASLMHGLRKFATRPVNED
VADKLLYCVTAVSADPSDPPSFDRLRERLEKLEANRNTGGNRLFYLATPPDAFAPIATELGRAGLLQGNDQAWRRLIVEK
PFGTDLASAKALNDHLLGIVAEHDLYRIDHYLGKETVQNILVLRFSNGMFEPIWNRDHIDHIQITVDEKLGVGHRGSFYD
KTGALRDMVPNHLFQLLSLVAMEPPAHFNAHSVRSAKAEVLTAIQVQNEEEALRNSVRAQYIAGKVGDTEIPDYRSVKDV
APGSTTETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTEVAIKFKQAPFAMFRCTPVEQLSQNYLVIGIEPVEGISLQF
NTKIPGPTIAIDGVEMSFRYKDYFKVAPSNGYETLLHDCMIGDNILFQRADGVEAGWRAVQPFLDAWERAGANGLQTYEA
GSEGPQDAETLLARDGRNWRGSAR

Sequences:

>Translated_504_residues
MTTQANPQVPDGCAFVIFGVTGDLTHRLVVPALYNLAEADLLPEKFCVVGITRSEMSSEDLRASLMHGLRKFATRPVNED
VADKLLYCVTAVSADPSDPPSFDRLRERLEKLEANRNTGGNRLFYLATPPDAFAPIATELGRAGLLQGNDQAWRRLIVEK
PFGTDLASAKALNDHLLGIVAEHDLYRIDHYLGKETVQNILVLRFSNGMFEPIWNRDHIDHIQITVDEKLGVGHRGSFYD
KTGALRDMVPNHLFQLLSLVAMEPPAHFNAHSVRSAKAEVLTAIQVQNEEEALRNSVRAQYIAGKVGDTEIPDYRSVKDV
APGSTTETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTEVAIKFKQAPFAMFRCTPVEQLSQNYLVIGIEPVEGISLQF
NTKIPGPTIAIDGVEMSFRYKDYFKVAPSNGYETLLHDCMIGDNILFQRADGVEAGWRAVQPFLDAWERAGANGLQTYEA
GSEGPQDAETLLARDGRNWRGSAR
>Mature_503_residues
TTQANPQVPDGCAFVIFGVTGDLTHRLVVPALYNLAEADLLPEKFCVVGITRSEMSSEDLRASLMHGLRKFATRPVNEDV
ADKLLYCVTAVSADPSDPPSFDRLRERLEKLEANRNTGGNRLFYLATPPDAFAPIATELGRAGLLQGNDQAWRRLIVEKP
FGTDLASAKALNDHLLGIVAEHDLYRIDHYLGKETVQNILVLRFSNGMFEPIWNRDHIDHIQITVDEKLGVGHRGSFYDK
TGALRDMVPNHLFQLLSLVAMEPPAHFNAHSVRSAKAEVLTAIQVQNEEEALRNSVRAQYIAGKVGDTEIPDYRSVKDVA
PGSTTETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTEVAIKFKQAPFAMFRCTPVEQLSQNYLVIGIEPVEGISLQFN
TKIPGPTIAIDGVEMSFRYKDYFKVAPSNGYETLLHDCMIGDNILFQRADGVEAGWRAVQPFLDAWERAGANGLQTYEAG
SEGPQDAETLLARDGRNWRGSAR

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=496, Percent_Identity=35.8870967741936, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI109389365, Length=496, Percent_Identity=35.8870967741936, Blast_Score=299, Evalue=5e-81,
Organism=Homo sapiens, GI52145310, Length=249, Percent_Identity=37.7510040160643, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1788158, Length=499, Percent_Identity=36.2725450901804, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17538218, Length=497, Percent_Identity=36.6197183098592, Blast_Score=324, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=34.7107438016529, Blast_Score=286, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24643350, Length=496, Percent_Identity=35.6854838709677, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24643352, Length=496, Percent_Identity=35.6854838709677, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI221513548, Length=486, Percent_Identity=29.0123456790123, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55931; Mature: 55800

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQANPQVPDGCAFVIFGVTGDLTHRLVVPALYNLAEADLLPEKFCVVGITRSEMSSED
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCHHH
LRASLMHGLRKFATRPVNEDVADKLLYCVTAVSADPSDPPSFDRLRERLEKLEANRNTGG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
NRLFYLATPPDAFAPIATELGRAGLLQGNDQAWRRLIVEKPFGTDLASAKALNDHLLGIV
CEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEE
AEHDLYRIDHYLGKETVQNILVLRFSNGMFEPIWNRDHIDHIQITVDEKLGVGHRGSFYD
ECCHHHHHHHHHCHHHHHHEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
KTGALRDMVPNHLFQLLSLVAMEPPAHFNAHSVRSAKAEVLTAIQVQNEEEALRNSVRAQ
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEECCHHHHHHHHHHHH
YIAGKVGDTEIPDYRSVKDVAPGSTTETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTE
HHCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCCCCCEE
VAIKFKQAPFAMFRCTPVEQLSQNYLVIGIEPVEGISLQFNTKIPGPTIAIDGVEMSFRY
EEEEEECCCEEEEECCCHHHHCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCEEEEEE
KDYFKVAPSNGYETLLHDCMIGDNILFQRADGVEAGWRAVQPFLDAWERAGANGLQTYEA
CEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECCC
GSEGPQDAETLLARDGRNWRGSAR
CCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTQANPQVPDGCAFVIFGVTGDLTHRLVVPALYNLAEADLLPEKFCVVGITRSEMSSED
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHCCHHH
LRASLMHGLRKFATRPVNEDVADKLLYCVTAVSADPSDPPSFDRLRERLEKLEANRNTGG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
NRLFYLATPPDAFAPIATELGRAGLLQGNDQAWRRLIVEKPFGTDLASAKALNDHLLGIV
CEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEE
AEHDLYRIDHYLGKETVQNILVLRFSNGMFEPIWNRDHIDHIQITVDEKLGVGHRGSFYD
ECCHHHHHHHHHCHHHHHHEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
KTGALRDMVPNHLFQLLSLVAMEPPAHFNAHSVRSAKAEVLTAIQVQNEEEALRNSVRAQ
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEECCHHHHHHHHHHHH
YIAGKVGDTEIPDYRSVKDVAPGSTTETYAALKLTIDNWRWAGVPFYLRTGKALGAKRTE
HHCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCCCCCEE
VAIKFKQAPFAMFRCTPVEQLSQNYLVIGIEPVEGISLQFNTKIPGPTIAIDGVEMSFRY
EEEEEECCCEEEEECCCHHHHCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCEEEEEE
KDYFKVAPSNGYETLLHDCMIGDNILFQRADGVEAGWRAVQPFLDAWERAGANGLQTYEA
CEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECCC
GSEGPQDAETLLARDGRNWRGSAR
CCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]