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The map label for this gene is pgl [H]

Identifier: 86749012

GI number: 86749012

Start: 2161756

End: 2162502

Strand: Reverse

Name: pgl [H]

Synonym: RPB_1889

Alternate gene names: 86749012

Gene position: 2162502-2161756 (Counterclockwise)

Preceding gene: 86749013

Following gene: 86749011

Centisome position: 40.56

GC content: 70.68

Gene sequence:

>747_bases
ATGAAGGTCGGCGATCATCGCCAGATCGTCACCGCTGCCGATGCCGAAGCGCTGGCGCGGGTCGCGGCGCAGCGGCTGAT
CGCCCGCATCGCGCTGCATCACGAGCGCCCGGCGATCTGCCTGACCGGCGGCTCCGGGCCGCAGCGGATGTTCGAACTGC
TCGCGGGCGAATTCGCCGATCGGATTCCATGGCCGCGCGTGCACTGGTTCATCAGCGACGAACGCTTCGTGCCGTTCGAT
AGCCCGCTAAGCAACATGGGCGCGATCAAGCGCGTGCTGCTCGACGGCCGCGCGCCGCCGCAGAACATCCACGCCATTCC
GGCGCACGACAGCGCCACCCCGGACGAGGCCGCGCAGCGCTACGCGCGCGACTTGCAGGCGTTCTACGGCGCGGCAACGC
TGGATCCCAAGCGGCCGCTGTTCGATCTGGTGCTCGGCGGCGTCGGCCCGGACGGCCACACCGCGTCGCTGTTTCCCGGC
TGGCCGCAGCTCGAGGTGACCGATCGCTGGGCCGCTGGGGTCGACACGGCGCATGTCGCGCCGTTCGTGCCGCGCGTCAC
CCTCACCTTTCCGGCGCTGGCGTCGTGTAGCGAGATGCTGTTCCTCGTCCACGGCGCGGCCAAGCGGGAGATCGTCGGCC
GCATCTTCGCGGGCGCCGATCTGCCGGCCAGCCGCGCCCGATCCAACGGCGAGACGGTGTGGCTGATCACCGAGGACGCG
CTGCCGGAGACCGTTCGTGAGCGCTGA

Upstream 100 bases:

>100_bases
GCGCCAACGGGCTTCAGACCTACGAAGCCGGCAGCGAAGGCCCGCAGGACGCCGAAACCCTGCTCGCCCGCGACGGCCGC
AACTGGCGCGGCTCGGCCAG

Downstream 100 bases:

>100_bases
CGATCCCCGAGCCCGCGTCCTGATCGTGATGGGCGTGTCCGGCTCCGGCAAGAGCACCATCGGCGAACGGCTCGCCGAGC
GGCTCGGCTGGGCCTATCAG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKVGDHRQIVTAADAEALARVAAQRLIARIALHHERPAICLTGGSGPQRMFELLAGEFADRIPWPRVHWFISDERFVPFD
SPLSNMGAIKRVLLDGRAPPQNIHAIPAHDSATPDEAAQRYARDLQAFYGAATLDPKRPLFDLVLGGVGPDGHTASLFPG
WPQLEVTDRWAAGVDTAHVAPFVPRVTLTFPALASCSEMLFLVHGAAKREIVGRIFAGADLPASRARSNGETVWLITEDA
LPETVRER

Sequences:

>Translated_248_residues
MKVGDHRQIVTAADAEALARVAAQRLIARIALHHERPAICLTGGSGPQRMFELLAGEFADRIPWPRVHWFISDERFVPFD
SPLSNMGAIKRVLLDGRAPPQNIHAIPAHDSATPDEAAQRYARDLQAFYGAATLDPKRPLFDLVLGGVGPDGHTASLFPG
WPQLEVTDRWAAGVDTAHVAPFVPRVTLTFPALASCSEMLFLVHGAAKREIVGRIFAGADLPASRARSNGETVWLITEDA
LPETVRER
>Mature_248_residues
MKVGDHRQIVTAADAEALARVAAQRLIARIALHHERPAICLTGGSGPQRMFELLAGEFADRIPWPRVHWFISDERFVPFD
SPLSNMGAIKRVLLDGRAPPQNIHAIPAHDSATPDEAAQRYARDLQAFYGAATLDPKRPLFDLVLGGVGPDGHTASLFPG
WPQLEVTDRWAAGVDTAHVAPFVPRVTLTFPALASCSEMLFLVHGAAKREIVGRIFAGADLPASRARSNGETVWLITEDA
LPETVRER

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=256, Percent_Identity=32.03125, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912586, Length=231, Percent_Identity=34.6320346320346, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI115533060, Length=208, Percent_Identity=32.2115384615385, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533058, Length=208, Percent_Identity=32.2115384615385, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324362, Length=215, Percent_Identity=33.0232558139535, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321957, Length=217, Percent_Identity=29.4930875576037, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319918, Length=245, Percent_Identity=30.6122448979592, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=226, Percent_Identity=30.0884955752212, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641119, Length=217, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 27044; Mature: 27044

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGDHRQIVTAADAEALARVAAQRLIARIALHHERPAICLTGGSGPQRMFELLAGEFAD
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
RIPWPRVHWFISDERFVPFDSPLSNMGAIKRVLLDGRAPPQNIHAIPAHDSATPDEAAQR
HCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHH
YARDLQAFYGAATLDPKRPLFDLVLGGVGPDGHTASLFPGWPQLEVTDRWAAGVDTAHVA
HHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCEEECCCHHCCCCCHHHC
PFVPRVTLTFPALASCSEMLFLVHGAAKREIVGRIFAGADLPASRARSNGETVWLITEDA
CCCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEECCC
LPETVRER
CCHHHHCC
>Mature Secondary Structure
MKVGDHRQIVTAADAEALARVAAQRLIARIALHHERPAICLTGGSGPQRMFELLAGEFAD
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
RIPWPRVHWFISDERFVPFDSPLSNMGAIKRVLLDGRAPPQNIHAIPAHDSATPDEAAQR
HCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHH
YARDLQAFYGAATLDPKRPLFDLVLGGVGPDGHTASLFPGWPQLEVTDRWAAGVDTAHVA
HHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCEEECCCHHCCCCCHHHC
PFVPRVTLTFPALASCSEMLFLVHGAAKREIVGRIFAGADLPASRARSNGETVWLITEDA
CCCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEECCC
LPETVRER
CCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]