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The map label for this gene is yqeC [H]

Identifier: 86749014

GI number: 86749014

Start: 2164010

End: 2165047

Strand: Reverse

Name: yqeC [H]

Synonym: RPB_1891

Alternate gene names: 86749014

Gene position: 2165047-2164010 (Counterclockwise)

Preceding gene: 86749015

Following gene: 86749013

Centisome position: 40.61

GC content: 67.34

Gene sequence:

>1038_bases
ATGCAGCTCGGCATGGTCGGCCTCGGACGAATGGGCGGCAACATCGTTCGCCGCCTGATGAAAGATGGCCACCACGCCGT
GGTGTATGATCGGGACCCCCAAGCGGTCGACGCCCTGACGCGCGAAGGCGCGACGGGCGCCCAGGGCCTGGAAGATCTGG
TCCGCAAGCTCGACGCGCCGCGCGCGGTGTGGGTGATGCTGCCGGCCGGCCACATCACCGAGACCACCATCGAAGCGCTG
GGCAAGCTGCTGGCGCCGGGTGATGTGATCATCGATGGCGGCAACACCTTCTGGCAGGACGACATCCGCCGCGCCAAAAC
GCTCGAGGAAAACAGCATCAGCTACGTCGACGTCGGCACCTCCGGCGGCATCTGGGGCTATGAGCGCGGCTATTGCATGA
TGATCGGCGGCGACAAACCGGTCTTCGACCGGCTCGATCCGATCTTCGCCACGCTCGCCCCGGGGATCGGCGACATCCCG
CGCACGCCGGGCCGCGACGACCGCGACCCGCGCGTCGAGCAGGGCTACATCCATGCCGGCCCGGTCGGCGCCGGGCACTT
CGTCAAAATGGTGCACAACGGCATCGAATACGGCCTGATGCAGGCCTATGCCGAAGGCTTCGACATTCTCAAGAACGCCA
ATATCGACGCGCTGCCGAGCGAGCACCGGTTCGATCTCGACATCGCCGACATCGCCGAAGTGTGGCGGCGCGGCAGCGTG
ATCCCGTCCTGGCTGCTCGACCTCACCGCCTCCGCGCTCGCGCGCAACGGCGAGCTCGACACTTACTCCGGCTTCGTCGA
GGATTCCGGCGAGGGCCGCTGGACCATCAACGCGGCAATCGAGGAAGCCGTGCCCGCCGAAGTGCTGACCTCGGCGCTGT
ATGCGCGCTTCCGCTCGCGCAAGCAGCACACCTTCGCGGAGAAGATCCTGTCGGCGATGCGCGCGGGATTCGGCGGGCAC
AAGGAGCCGCAACAGCACCCGGACGCCGCGCATCAGGCCGCGCCGGAAATCCTCAAGCCGAAAGCGGAGCGCGCGTGA

Upstream 100 bases:

>100_bases
GTCGCTGGATAAGGCGATCCGCGACGCACTGAACTAACGACTGAACGACGACAACGAGGCTCCGCATTCAAGCGGAGCCC
GGACACATAGGAGATCCTTC

Downstream 100 bases:

>100_bases
CCACTCAGGCGAATCCACAGGTTCCGGACGGCTGCGCCTTCGTCATCTTCGGCGTCACCGGCGACCTCACTCACCGCCTG
GTGGTTCCGGCGTTGTACAA

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQLGMVGLGRMGGNIVRRLMKDGHHAVVYDRDPQAVDALTREGATGAQGLEDLVRKLDAPRAVWVMLPAGHITETTIEAL
GKLLAPGDVIIDGGNTFWQDDIRRAKTLEENSISYVDVGTSGGIWGYERGYCMMIGGDKPVFDRLDPIFATLAPGIGDIP
RTPGRDDRDPRVEQGYIHAGPVGAGHFVKMVHNGIEYGLMQAYAEGFDILKNANIDALPSEHRFDLDIADIAEVWRRGSV
IPSWLLDLTASALARNGELDTYSGFVEDSGEGRWTINAAIEEAVPAEVLTSALYARFRSRKQHTFAEKILSAMRAGFGGH
KEPQQHPDAAHQAAPEILKPKAERA

Sequences:

>Translated_345_residues
MQLGMVGLGRMGGNIVRRLMKDGHHAVVYDRDPQAVDALTREGATGAQGLEDLVRKLDAPRAVWVMLPAGHITETTIEAL
GKLLAPGDVIIDGGNTFWQDDIRRAKTLEENSISYVDVGTSGGIWGYERGYCMMIGGDKPVFDRLDPIFATLAPGIGDIP
RTPGRDDRDPRVEQGYIHAGPVGAGHFVKMVHNGIEYGLMQAYAEGFDILKNANIDALPSEHRFDLDIADIAEVWRRGSV
IPSWLLDLTASALARNGELDTYSGFVEDSGEGRWTINAAIEEAVPAEVLTSALYARFRSRKQHTFAEKILSAMRAGFGGH
KEPQQHPDAAHQAAPEILKPKAERA
>Mature_345_residues
MQLGMVGLGRMGGNIVRRLMKDGHHAVVYDRDPQAVDALTREGATGAQGLEDLVRKLDAPRAVWVMLPAGHITETTIEAL
GKLLAPGDVIIDGGNTFWQDDIRRAKTLEENSISYVDVGTSGGIWGYERGYCMMIGGDKPVFDRLDPIFATLAPGIGDIP
RTPGRDDRDPRVEQGYIHAGPVGAGHFVKMVHNGIEYGLMQAYAEGFDILKNANIDALPSEHRFDLDIADIAEVWRRGSV
IPSWLLDLTASALARNGELDTYSGFVEDSGEGRWTINAAIEEAVPAEVLTSALYARFRSRKQHTFAEKILSAMRAGFGGH
KEPQQHPDAAHQAAPEILKPKAERA

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=307, Percent_Identity=32.8990228013029, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1788341, Length=331, Percent_Identity=31.4199395770393, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI145693186, Length=220, Percent_Identity=25, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17542558, Length=342, Percent_Identity=30.9941520467836, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321695, Length=326, Percent_Identity=33.4355828220859, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321977, Length=347, Percent_Identity=31.4121037463977, Blast_Score=135, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24639279, Length=306, Percent_Identity=32.3529411764706, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 37631; Mature: 37631

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGMVGLGRMGGNIVRRLMKDGHHAVVYDRDPQAVDALTREGATGAQGLEDLVRKLDAP
CCCCCCCHHHCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
RAVWVMLPAGHITETTIEALGKLLAPGDVIIDGGNTFWQDDIRRAKTLEENSISYVDVGT
CEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEECC
SGGIWGYERGYCMMIGGDKPVFDRLDPIFATLAPGIGDIPRTPGRDDRDPRVEQGYIHAG
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECC
PVGAGHFVKMVHNGIEYGLMQAYAEGFDILKNANIDALPSEHRFDLDIADIAEVWRRGSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
IPSWLLDLTASALARNGELDTYSGFVEDSGEGRWTINAAIEEAVPAEVLTSALYARFRSR
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHCCHHHHHHHHHHHHHHH
KQHTFAEKILSAMRAGFGGHKEPQQHPDAAHQAAPEILKPKAERA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCHHHHCCCCCCC
>Mature Secondary Structure
MQLGMVGLGRMGGNIVRRLMKDGHHAVVYDRDPQAVDALTREGATGAQGLEDLVRKLDAP
CCCCCCCHHHCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
RAVWVMLPAGHITETTIEALGKLLAPGDVIIDGGNTFWQDDIRRAKTLEENSISYVDVGT
CEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEECC
SGGIWGYERGYCMMIGGDKPVFDRLDPIFATLAPGIGDIPRTPGRDDRDPRVEQGYIHAG
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECC
PVGAGHFVKMVHNGIEYGLMQAYAEGFDILKNANIDALPSEHRFDLDIADIAEVWRRGSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
IPSWLLDLTASALARNGELDTYSGFVEDSGEGRWTINAAIEEAVPAEVLTSALYARFRSR
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHCCHHHHHHHHHHHHHHH
KQHTFAEKILSAMRAGFGGHKEPQQHPDAAHQAAPEILKPKAERA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]