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The map label for this gene is ubiB [H]

Identifier: 86747747

GI number: 86747747

Start: 699927

End: 701501

Strand: Direct

Name: ubiB [H]

Synonym: RPB_0621

Alternate gene names: 86747747

Gene position: 699927-701501 (Clockwise)

Preceding gene: 86747746

Following gene: 86747748

Centisome position: 13.13

GC content: 68.13

Gene sequence:

>1575_bases
GTGATCGCAGCACTCACTCATGTGGCGCGGCTCGCCCGCGCCGCCTTCGTGTTCGCGCGCGAGGGCGTGTTCGGCGTGGT
CGATCCGTCGCTGATTCCGCCGGCCGGCCAATTGCCGGTGCGCCTCGCGCGGCTGATCGAGCGGCCCGGCGCCAAATCCG
GCGCGCGGCTGTCGCGCGCGCTGACCCGGCTCGGCCCGGCCTATCTCAAGCTCGGCCAGTTCCTGGCGACGCGCCCCGAC
GTGGTCGGCGTGGCGATGGCGCGCGATCTCGAAGCGCTGCAGGACCGGCTGCCGCCGTTCGCGCAGGACGAGGCCGAGGC
GGTGATCGCGGCGTCGCTGGAGCGGCCGATCGCGCAGGCCTTCGTCAGCCTGTCGCCGCCGGTCGCCGCCGCCTCGATCG
CGCAGGTGCATCGCGGCGTCGTCGAGGTCGGCGGCGTGCACAAGCAGGTCGCGGTGAAGGTGCTGCGGCCCAACGTGTCG
GCGCGGTTCAGGCGCGACCTGTCGGATTTCTTCTTCGTCGCCGAGAAGGCCGAGATGTACTCGTCCGAGGCGCGGCGGCT
GCGACTGGTCGAAGTCATCAACACGATGTCGCGCTCGGTCGCGATGGAGATGGATCTGCGGCTGGAAGCCGCCGCCGCCT
CCGAGATGGCGGAGAACACCAAGGACGATCCGGACTTCCGCGTCCCCACCGTCGACTGGGACCGCACCACGCACAACGTG
CTGACGATGGAGTGGATCGACGGCATCCCGCTGAACGATCACAAGCGCCTCGCCGAAGCCAATGTCGACACCGTCGAGCT
CGGCCGCAAGGTGATCCAGAGCTTCCTGCGCCACGCGCTGCGCGACGGCTTCTTCCACGCCGACATGCATCCCGGCAATC
TGTTCCTCGACACCGAGGGGCGATTAGTTGCGGTCGATTTCGGCATCATGGGGCGGCTGCTGCCGAAGGAGCGGCGCTTC
CTCGCGGAGATTTTGCTCGGCTTCATCACCCGCAACTATCGCCGCGTCGCCGAAGTGCATTTCGAGGCCGGCTACGTGCC
GCCGCATCATTCGGTCGAGAATTTCGCGCAAGCCATCCGCGCCATCGGCGAGCCGATCCACAATCGCCTCGCCGAAGAAA
TCTCGATGGCGAAGCTCTTGACGCTGCTGCTCGAGGTCACCGGCCTGTTCGACATGCGGACCCGGCCGGAGTTGATACTT
CTGCAGAAGACCATGGTGGTGGTCGAAGGCGTCGCGCGCAGCTTCGATCCGAAGCTCGACATCTGGAAGGTCGCCGACCC
GGTGGTACGCGAATGGATTCAGCGCAACCTCGGCCCGATCGGCAAGGTCGAGGGCGTGCTCAGCGGCGCCGGCGAACTCG
GCCACACGCTGAGCGGACTGCCGACCATCGTGTCGCGCGCCGTCACCGTGCTGAACCAGCTCGAAGGCATGACCAAGGAC
GGCCTCGTCCTCGCGCCCGAGACCATCGCGGCGATCGGCCGCAACGAGCGGGGCCGCACCCGCGGGCGCACCATCGCGCT
GTGGGTGATCGCCGCGACCTTCATCGGGGTGCTGATCGCGCTGTCACGGTTCTGA

Upstream 100 bases:

>100_bases
CCGCCGATTTCGGCGAGATGATGCGCGAGGCCGGCTTCGCGCGCGTCAACTGGCAGGTGTTGTCCGGCGGCATCGTCGCG
CTGCATTCGGGCTGGCGTTT

Downstream 100 bases:

>100_bases
CGGCATTGCAGGCATTTGATGACTGCAGTGAATGCGCTCTGCGATGACCGCATCGCGGTCGTATATTGCTTGCGTTGCCT
GCATCCGCTAGTCTGCCGGC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MIAALTHVARLARAAFVFAREGVFGVVDPSLIPPAGQLPVRLARLIERPGAKSGARLSRALTRLGPAYLKLGQFLATRPD
VVGVAMARDLEALQDRLPPFAQDEAEAVIAASLERPIAQAFVSLSPPVAAASIAQVHRGVVEVGGVHKQVAVKVLRPNVS
ARFRRDLSDFFFVAEKAEMYSSEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTTHNV
LTMEWIDGIPLNDHKRLAEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDTEGRLVAVDFGIMGRLLPKERRF
LAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARSFDPKLDIWKVADPVVREWIQRNLGPIGKVEGVLSGAGELGHTLSGLPTIVSRAVTVLNQLEGMTKD
GLVLAPETIAAIGRNERGRTRGRTIALWVIAATFIGVLIALSRF

Sequences:

>Translated_524_residues
MIAALTHVARLARAAFVFAREGVFGVVDPSLIPPAGQLPVRLARLIERPGAKSGARLSRALTRLGPAYLKLGQFLATRPD
VVGVAMARDLEALQDRLPPFAQDEAEAVIAASLERPIAQAFVSLSPPVAAASIAQVHRGVVEVGGVHKQVAVKVLRPNVS
ARFRRDLSDFFFVAEKAEMYSSEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTTHNV
LTMEWIDGIPLNDHKRLAEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDTEGRLVAVDFGIMGRLLPKERRF
LAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARSFDPKLDIWKVADPVVREWIQRNLGPIGKVEGVLSGAGELGHTLSGLPTIVSRAVTVLNQLEGMTKD
GLVLAPETIAAIGRNERGRTRGRTIALWVIAATFIGVLIALSRF
>Mature_524_residues
MIAALTHVARLARAAFVFAREGVFGVVDPSLIPPAGQLPVRLARLIERPGAKSGARLSRALTRLGPAYLKLGQFLATRPD
VVGVAMARDLEALQDRLPPFAQDEAEAVIAASLERPIAQAFVSLSPPVAAASIAQVHRGVVEVGGVHKQVAVKVLRPNVS
ARFRRDLSDFFFVAEKAEMYSSEARRLRLVEVINTMSRSVAMEMDLRLEAAAASEMAENTKDDPDFRVPTVDWDRTTHNV
LTMEWIDGIPLNDHKRLAEANVDTVELGRKVIQSFLRHALRDGFFHADMHPGNLFLDTEGRLVAVDFGIMGRLLPKERRF
LAEILLGFITRNYRRVAEVHFEAGYVPPHHSVENFAQAIRAIGEPIHNRLAEEISMAKLLTLLLEVTGLFDMRTRPELIL
LQKTMVVVEGVARSFDPKLDIWKVADPVVREWIQRNLGPIGKVEGVLSGAGELGHTLSGLPTIVSRAVTVLNQLEGMTKD
GLVLAPETIAAIGRNERGRTRGRTIALWVIAATFIGVLIALSRF

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=300, Percent_Identity=26.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=27.7372262773723, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI217035081, Length=219, Percent_Identity=26.9406392694064, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI27363457, Length=183, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI217416386, Length=183, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI34147522, Length=271, Percent_Identity=27.3062730627306, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367309, Length=443, Percent_Identity=35.8916478555305, Blast_Score=269, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17559152, Length=304, Percent_Identity=25, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325148, Length=436, Percent_Identity=23.394495412844, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=323, Percent_Identity=23.8390092879257, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24662575, Length=331, Percent_Identity=29.3051359516616, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI22024280, Length=268, Percent_Identity=23.8805970149254, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859849, Length=294, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57741; Mature: 57741

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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CEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA