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The map label for this gene is coaBC [H]

Identifier: 86747748

GI number: 86747748

Start: 701603

End: 703060

Strand: Direct

Name: coaBC [H]

Synonym: RPB_0622

Alternate gene names: 86747748

Gene position: 701603-703060 (Clockwise)

Preceding gene: 86747747

Following gene: 86747749

Centisome position: 13.16

GC content: 68.52

Gene sequence:

>1458_bases
ATGGCCAACCTGACGATCCGCAAACTCGACGACGCCCTCAAGGCCGAGCTGCGCCAGCGCGCGGCCGGCAACGGCCGCTC
GATGGAAGATGAGGTTCGCGTCATCCTGCGCGACGCGGTCCACCAGCGCCACGGGTTTGCCACCAGTTTGCCGCAAGCCG
GCGGCGCCGCCGCCGAGCCCGGTCCGGGTGACGTAAGTCCCGAAAATCAAACGGCTTTTGTCTCCGACCGCCCTTCGACC
GCCCGCATCACGCTGATCGTCGGCGGCGGCATCGCCGCCTACAAGGCGATGGATTTGATTCGTCGCCTGAAAGAGCGCGG
CGCCGAGGTTCGCGTCGTGCTCACCAAGGCCGCACAGCACTTCGTCACGCCGCTCACCGCGAGCGCGCTGTCGCATCAGC
GCTGCTACACCGATCTGTTCGACCCGCAGAGCGAGTTCGATGCCGGCCATATCAGGCTGGCGCGCGATTGCGATCTGATC
GTGGTTGCGCCCGCCACCGCGGACCTGATGGCCAAGATCGCGAATGGCCACGCAGACGATCTGGCCACCGCGATCCTGCT
GGCGACTAATCGCCAGGTCCTGCTCGCGCCTGCGATGAATCCGCTGATGTGGGCCAACGCCGCGACCCGCCGCAATGTCG
ATCAGTTGAAGCGCGACGGCATCGTCCTGGTCGGCCCCAATGCCGGCGAGATGGCCGAGCGCAATGAAGCCGGCACCGGC
CGGATGGCCGAGCCGGTTGAAATCGCTGCTGCCGCACAGGCACTTCTGGCGCCGCCGTCACCGCGTCCGCTGCTCGGCCG
GCGCGTGCTGATCACCGCGGGGCCGACCCACGAGCCGATCGATCCGGTGCGCTACATCGCCAACCGCTCCTCCGGCAAGC
AGGGCTACGCCATCGCCGCCGCGGCGGCCGCGGCCGGCGCCGAGGTGGTGCTGATCTCCGGCCCGGTCGATCTACGCGCC
CCCGACGGCGTGACGCTGACGCGTGTGGAGTCCGCGCGCGACATGCTGGATGCGGTGGAAGCCGCGCTGCCCGCCGACAT
CGCGATCTTCGCCGCCGCCGTCGCCGACTGGCGCGTCGCCAGCGAAGGCGGTCAGAAGATCAAGAAGGGCGAAGGCGGCC
CGCCGCCGCTGCAACTCACCGAGAACCCCGACATCCTGGCGACGGTCGCGAAGCTCGGCGACGACCGCCCGCCGCTGGTG
ATCGGCTTCGCCGCCGAGACCGAGAATCTGCTCGCCAATGCCAGGTCGAAACTCGCCCGCAAGGGCTGCGACTGGATCGT
CGCCAACGACGTCTCGGCCGCCGGCGGGGTCATGGGCGGCGACCGCAACACCGTGCATCTGCTGACGAAATCGGCCGACA
CCGTCGATGTGGAGTCGTGGCCTTTGATGACCAAGGACGACGTCGCAACCGCGCTGGTCGCGCGAATCGCGCGAGAACTG
GAAGTACACCAATCATGA

Upstream 100 bases:

>100_bases
GGCATTGCAGGCATTTGATGACTGCAGTGAATGCGCTCTGCGATGACCGCATCGCGGTCGTATATTGCTTGCGTTGCCTG
CATCCGCTAGTCTGCCGGCC

Downstream 100 bases:

>100_bases
GCCCCGCCATCGCCGTCGAGATCAAGCGCCTGCCCCACGCCGAAGGCCTGCCGCTGCCCGCGTATCAGTCCGCGCACGCC
GCCGGTCTCGATCTGTGCGC

Product: bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MANLTIRKLDDALKAELRQRAAGNGRSMEDEVRVILRDAVHQRHGFATSLPQAGGAAAEPGPGDVSPENQTAFVSDRPST
ARITLIVGGGIAAYKAMDLIRRLKERGAEVRVVLTKAAQHFVTPLTASALSHQRCYTDLFDPQSEFDAGHIRLARDCDLI
VVAPATADLMAKIANGHADDLATAILLATNRQVLLAPAMNPLMWANAATRRNVDQLKRDGIVLVGPNAGEMAERNEAGTG
RMAEPVEIAAAAQALLAPPSPRPLLGRRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAAAAGAEVVLISGPVDLRA
PDGVTLTRVESARDMLDAVEAALPADIAIFAAAVADWRVASEGGQKIKKGEGGPPPLQLTENPDILATVAKLGDDRPPLV
IGFAAETENLLANARSKLARKGCDWIVANDVSAAGGVMGGDRNTVHLLTKSADTVDVESWPLMTKDDVATALVARIAREL
EVHQS

Sequences:

>Translated_485_residues
MANLTIRKLDDALKAELRQRAAGNGRSMEDEVRVILRDAVHQRHGFATSLPQAGGAAAEPGPGDVSPENQTAFVSDRPST
ARITLIVGGGIAAYKAMDLIRRLKERGAEVRVVLTKAAQHFVTPLTASALSHQRCYTDLFDPQSEFDAGHIRLARDCDLI
VVAPATADLMAKIANGHADDLATAILLATNRQVLLAPAMNPLMWANAATRRNVDQLKRDGIVLVGPNAGEMAERNEAGTG
RMAEPVEIAAAAQALLAPPSPRPLLGRRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAAAAGAEVVLISGPVDLRA
PDGVTLTRVESARDMLDAVEAALPADIAIFAAAVADWRVASEGGQKIKKGEGGPPPLQLTENPDILATVAKLGDDRPPLV
IGFAAETENLLANARSKLARKGCDWIVANDVSAAGGVMGGDRNTVHLLTKSADTVDVESWPLMTKDDVATALVARIAREL
EVHQS
>Mature_484_residues
ANLTIRKLDDALKAELRQRAAGNGRSMEDEVRVILRDAVHQRHGFATSLPQAGGAAAEPGPGDVSPENQTAFVSDRPSTA
RITLIVGGGIAAYKAMDLIRRLKERGAEVRVVLTKAAQHFVTPLTASALSHQRCYTDLFDPQSEFDAGHIRLARDCDLIV
VAPATADLMAKIANGHADDLATAILLATNRQVLLAPAMNPLMWANAATRRNVDQLKRDGIVLVGPNAGEMAERNEAGTGR
MAEPVEIAAAAQALLAPPSPRPLLGRRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAAAAAAAGAEVVLISGPVDLRAP
DGVTLTRVESARDMLDAVEAALPADIAIFAAAVADWRVASEGGQKIKKGEGGPPPLQLTENPDILATVAKLGDDRPPLVI
GFAAETENLLANARSKLARKGCDWIVANDVSAAGGVMGGDRNTVHLLTKSADTVDVESWPLMTKDDVATALVARIARELE
VHQS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=169, Percent_Identity=35.5029585798817, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI87082301, Length=377, Percent_Identity=46.9496021220159, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17560194, Length=198, Percent_Identity=31.3131313131313, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 51077; Mature: 50946

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLTIRKLDDALKAELRQRAAGNGRSMEDEVRVILRDAVHQRHGFATSLPQAGGAAAEP
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GPGDVSPENQTAFVSDRPSTARITLIVGGGIAAYKAMDLIRRLKERGAEVRVVLTKAAQH
CCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHH
FVTPLTASALSHQRCYTDLFDPQSEFDAGHIRLARDCDLIVVAPATADLMAKIANGHADD
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHH
LATAILLATNRQVLLAPAMNPLMWANAATRRNVDQLKRDGIVLVGPNAGEMAERNEAGTG
HHHHHHEECCCCEEEECCCCCHHHCCCHHHCCHHHHHHCCEEEECCCCCCHHHCCCCCCC
RMAEPVEIAAAAQALLAPPSPRPLLGRRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAA
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCEEEEE
AAAAAGAEVVLISGPVDLRAPDGVTLTRVESARDMLDAVEAALPADIAIFAAAVADWRVA
HHHHCCCEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SEGGQKIKKGEGGPPPLQLTENPDILATVAKLGDDRPPLVIGFAAETENLLANARSKLAR
CCCCHHHHCCCCCCCCEEECCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
KGCDWIVANDVSAAGGVMGGDRNTVHLLTKSADTVDVESWPLMTKDDVATALVARIAREL
CCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
EVHQS
HHCCC
>Mature Secondary Structure 
ANLTIRKLDDALKAELRQRAAGNGRSMEDEVRVILRDAVHQRHGFATSLPQAGGAAAEP
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GPGDVSPENQTAFVSDRPSTARITLIVGGGIAAYKAMDLIRRLKERGAEVRVVLTKAAQH
CCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEHHHHH
FVTPLTASALSHQRCYTDLFDPQSEFDAGHIRLARDCDLIVVAPATADLMAKIANGHADD
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHH
LATAILLATNRQVLLAPAMNPLMWANAATRRNVDQLKRDGIVLVGPNAGEMAERNEAGTG
HHHHHHEECCCCEEEECCCCCHHHCCCHHHCCHHHHHHCCEEEECCCCCCHHHCCCCCCC
RMAEPVEIAAAAQALLAPPSPRPLLGRRVLITAGPTHEPIDPVRYIANRSSGKQGYAIAA
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCEEEEE
AAAAAGAEVVLISGPVDLRAPDGVTLTRVESARDMLDAVEAALPADIAIFAAAVADWRVA
HHHHCCCEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SEGGQKIKKGEGGPPPLQLTENPDILATVAKLGDDRPPLVIGFAAETENLLANARSKLAR
CCCCHHHHCCCCCCCCEEECCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
KGCDWIVANDVSAAGGVMGGDRNTVHLLTKSADTVDVESWPLMTKDDVATALVARIAREL
CCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
EVHQS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA