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The map label for this gene is yciC [H]

Identifier: 86747260

GI number: 86747260

Start: 144067

End: 145023

Strand: Reverse

Name: yciC [H]

Synonym: RPB_0133

Alternate gene names: 86747260

Gene position: 145023-144067 (Counterclockwise)

Preceding gene: 86747261

Following gene: 86747259

Centisome position: 2.72

GC content: 68.65

Gene sequence:

>957_bases
ATGACGGGATCGTCCGCGACCATTCCCGTCACGGTGATCGGCGGCTTTCTCGGCGCCGGCAAAACCACTTTCGTCAATCA
TCTGCTCGCCACCGGCAGCCCGCGCACCGCGGTGCTGGTCAATGATTTCGGCGAGATCAATGTCGATGCGACGCTGATCG
CCAGCCACGATGGCAGCACGATGACGCTGACCAACGGCTGCATCTGCTGCAGCATCGGCACCGGCTTCATCGACACGATG
TGCAAGGTGCTCGACGCCGAGGTGCCGTTCGAGCGCATCGTCATCGAAGCCTCGGGCGTCGGCGATCCGTGGAAGATCGC
CGAGATCGCGCTGATCGAGCCGAGCTTGCGGCTCGAGCGCGTCGTCGTCTTGGCCGATGCCAGCCGGATCGTACAACTGA
TCGACGACGCTCGCGTCGGCGACACCGTGTGCGGGCAGTTCGCGCAGTGCGACGTCGTACTGCTGAACAAGAGTGATCTG
GTCGATGTGGCCGGGCTCGCTGCCGCACGCGCCGCGTTGCTGGCGCTGCGCCCCGGTCTGCGTATCATCGAGACGTCGCG
AGCGGCGCTGCCGACATTGGCGTCGCTCGACGTGGGCGCTGCAATGTCGGCTTTTCGCGCCGACTCGCCCGACGCTGTGC
CGCGCGATCACGGCGCCGCGTTCCGGAGCTGGGCCTATCGCCGCGACGGCGCGTTCGATCGCGCCCGGATCGCCGGCGCA
TTGGCGGCGCTGCCGCCGGAGCTGCTGCGGCTGAAGGGGTCGTGCCGGCTCGCCGGCGAGGCCGGCGCCCACGTTTTCCA
GTTGGTCGACCGGGCATGGTCGCTGACGCCGCCGGCGCCTGATCAGCCTGTGTCCCCGGGCATCGTGCTGGTCGGCGTCG
GCACCTGCGATTTGCCGCCGCCGGCGGTGCTCGACGCGATCCTCGATCGCGCGCTGGCGGCCGGAGCCTCGTCATGA

Upstream 100 bases:

>100_bases
TGCTGGAGGATGATCCGCTCACGGTGGCGCCGGAGCGGCTGAAGGACATCGCGATCTGGGGCACCGTGGTCGGCGGCGTC
GTCCGGGAGGCGCCCCGGGC

Downstream 100 bases:

>100_bases
GCGCCGGTCTCGTCGTTTTGCCGATACGCACGCCGTGCGCATCGATCATCCTCGCCCTCGAACCTTCACAGCGGAGTTGA
ATCCATGAAGTTGACGAAGC

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTGSSATIPVTVIGGFLGAGKTTFVNHLLATGSPRTAVLVNDFGEINVDATLIASHDGSTMTLTNGCICCSIGTGFIDTM
CKVLDAEVPFERIVIEASGVGDPWKIAEIALIEPSLRLERVVVLADASRIVQLIDDARVGDTVCGQFAQCDVVLLNKSDL
VDVAGLAAARAALLALRPGLRIIETSRAALPTLASLDVGAAMSAFRADSPDAVPRDHGAAFRSWAYRRDGAFDRARIAGA
LAALPPELLRLKGSCRLAGEAGAHVFQLVDRAWSLTPPAPDQPVSPGIVLVGVGTCDLPPPAVLDAILDRALAAGASS

Sequences:

>Translated_318_residues
MTGSSATIPVTVIGGFLGAGKTTFVNHLLATGSPRTAVLVNDFGEINVDATLIASHDGSTMTLTNGCICCSIGTGFIDTM
CKVLDAEVPFERIVIEASGVGDPWKIAEIALIEPSLRLERVVVLADASRIVQLIDDARVGDTVCGQFAQCDVVLLNKSDL
VDVAGLAAARAALLALRPGLRIIETSRAALPTLASLDVGAAMSAFRADSPDAVPRDHGAAFRSWAYRRDGAFDRARIAGA
LAALPPELLRLKGSCRLAGEAGAHVFQLVDRAWSLTPPAPDQPVSPGIVLVGVGTCDLPPPAVLDAILDRALAAGASS
>Mature_317_residues
TGSSATIPVTVIGGFLGAGKTTFVNHLLATGSPRTAVLVNDFGEINVDATLIASHDGSTMTLTNGCICCSIGTGFIDTMC
KVLDAEVPFERIVIEASGVGDPWKIAEIALIEPSLRLERVVVLADASRIVQLIDDARVGDTVCGQFAQCDVVLLNKSDLV
DVAGLAAARAALLALRPGLRIIETSRAALPTLASLDVGAAMSAFRADSPDAVPRDHGAAFRSWAYRRDGAFDRARIAGAL
AALPPELLRLKGSCRLAGEAGAHVFQLVDRAWSLTPPAPDQPVSPGIVLVGVGTCDLPPPAVLDAILDRALAAGASS

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=212, Percent_Identity=29.7169811320755, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI223941779, Length=202, Percent_Identity=29.7029702970297, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI126722884, Length=212, Percent_Identity=29.2452830188679, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI146231952, Length=212, Percent_Identity=29.2452830188679, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI148727351, Length=212, Percent_Identity=28.7735849056604, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI223941776, Length=196, Percent_Identity=27.0408163265306, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI119120938, Length=108, Percent_Identity=37.037037037037, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87082430, Length=310, Percent_Identity=29.6774193548387, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788499, Length=155, Percent_Identity=32.9032258064516, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324356, Length=182, Percent_Identity=28.021978021978, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 32881; Mature: 32750

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSSATIPVTVIGGFLGAGKTTFVNHLLATGSPRTAVLVNDFGEINVDATLIASHDGST
CCCCCCEEEEEEECHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEECCCCE
MTLTNGCICCSIGTGFIDTMCKVLDAEVPFERIVIEASGVGDPWKIAEIALIEPSLRLER
EEEECCEEEEECCCHHHHHHHHHHCCCCCHHHEEEEECCCCCCCEEEEEEEECCCCCEEE
VVVLADASRIVQLIDDARVGDTVCGQFAQCDVVLLNKSDLVDVAGLAAARAALLALRPGL
EEEEECHHHHHHHHHCCCCCHHHHCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
RIIETSRAALPTLASLDVGAAMSAFRADSPDAVPRDHGAAFRSWAYRRDGAFDRARIAGA
EEEECCCHHCCHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
LAALPPELLRLKGSCRLAGEAGAHVFQLVDRAWSLTPPAPDQPVSPGIVLVGVGTCDLPP
HHHCCHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCC
PAVLDAILDRALAAGASS
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGSSATIPVTVIGGFLGAGKTTFVNHLLATGSPRTAVLVNDFGEINVDATLIASHDGST
CCCCCEEEEEEECHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEECCCCE
MTLTNGCICCSIGTGFIDTMCKVLDAEVPFERIVIEASGVGDPWKIAEIALIEPSLRLER
EEEECCEEEEECCCHHHHHHHHHHCCCCCHHHEEEEECCCCCCCEEEEEEEECCCCCEEE
VVVLADASRIVQLIDDARVGDTVCGQFAQCDVVLLNKSDLVDVAGLAAARAALLALRPGL
EEEEECHHHHHHHHHCCCCCHHHHCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
RIIETSRAALPTLASLDVGAAMSAFRADSPDAVPRDHGAAFRSWAYRRDGAFDRARIAGA
EEEECCCHHCCHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
LAALPPELLRLKGSCRLAGEAGAHVFQLVDRAWSLTPPAPDQPVSPGIVLVGVGTCDLPP
HHHCCHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCC
PAVLDAILDRALAAGASS
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]