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The map label for this gene is panB [H]

Identifier: 86608186

GI number: 86608186

Start: 717483

End: 718268

Strand: Direct

Name: panB [H]

Synonym: CYB_0701

Alternate gene names: 86608186

Gene position: 717483-718268 (Clockwise)

Preceding gene: 86608184

Following gene: 86608188

Centisome position: 23.55

GC content: 60.69

Gene sequence:

>786_bases
ATGGCTGCTCTATCCATTCACCACTTTCGCCAGGCCAAACAGGCGGGTCAACCTTTGGTGGCCCTCACGGCTGCCGACTA
CGCCACCGCTCAGATTTTGGATCAGGCTGGGATCGACTTGATCCTGGTGGGCGACAGCTTGGCCATGACCCACTTGGGGT
ATACCAGCACCCTGCCCCTGACGCTGGAACAGATGCTCCATCACGCCCAGGCGGTGCGCCGCGGGGTAGAACGGGCCTTT
TTGGTGGCCGACTTGCCCTTCTTGACTTATCAAGTCCACAAAGAACAAGCTCTCCTCTCAGCAGGGCGGTTGATGAAGGA
GGCAGGAGTCAACGGGGTCAAGCTGGAGGGGGGCTACCCCGACATGGTGGAAACGGTGGCCTTTCTGGTGCAGCGGGGGA
TCCCGGTTTTGGGTCATATCGGCCTCACTCCGCAGGCCAAACATCAACTGGGAGGCTATCGCCAGCAGGGAAAAACCACT
CCGGAGGCGGAGCGTCTGCGACAAGAGGCCCTCAGCCTGGAACAAGCAGGGGCATTTGCCCTGGTTCTGGAGCACATGCC
GGCGGAATTGGCTGCCCAAATCTCGGCCCAAGTGGGGATCCCAACCCTGGGCATTGGAGCCGGGCCGGCCTGCGATGGGC
AGATTTTGGTCACCCACGACCTGCTGGGGCTGAGCGAGCGGCTCCCCCCTTTTGCCAAGGCCTATACCAATTTGAGACAG
GCGATCCGAGAAGCAGTGGAAGCTTTCGCCGACGATGTTCGCCAAAAAGTATTTCCCCCCCGCTGA

Upstream 100 bases:

>100_bases
TTCCCAGCCTCAAAGCCAAGCTTGCTTCCCCCACGGGGTGCGGTTGATGGGAAAGTGCTCCGCACCGCTGGCGGGAACGC
CCAGATGAGATCATAGGGAT

Downstream 100 bases:

>100_bases
AGGGATCCCTTACCCATTCAAAGCTTGGGCAGAGCATGACTCTAGTCAATAATAAGCTCAACTATACTGAAAATAATGTA
TAATATGTTCAGTACGGATT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAALSIHHFRQAKQAGQPLVALTAADYATAQILDQAGIDLILVGDSLAMTHLGYTSTLPLTLEQMLHHAQAVRRGVERAF
LVADLPFLTYQVHKEQALLSAGRLMKEAGVNGVKLEGGYPDMVETVAFLVQRGIPVLGHIGLTPQAKHQLGGYRQQGKTT
PEAERLRQEALSLEQAGAFALVLEHMPAELAAQISAQVGIPTLGIGAGPACDGQILVTHDLLGLSERLPPFAKAYTNLRQ
AIREAVEAFADDVRQKVFPPR

Sequences:

>Translated_261_residues
MAALSIHHFRQAKQAGQPLVALTAADYATAQILDQAGIDLILVGDSLAMTHLGYTSTLPLTLEQMLHHAQAVRRGVERAF
LVADLPFLTYQVHKEQALLSAGRLMKEAGVNGVKLEGGYPDMVETVAFLVQRGIPVLGHIGLTPQAKHQLGGYRQQGKTT
PEAERLRQEALSLEQAGAFALVLEHMPAELAAQISAQVGIPTLGIGAGPACDGQILVTHDLLGLSERLPPFAKAYTNLRQ
AIREAVEAFADDVRQKVFPPR
>Mature_260_residues
AALSIHHFRQAKQAGQPLVALTAADYATAQILDQAGIDLILVGDSLAMTHLGYTSTLPLTLEQMLHHAQAVRRGVERAFL
VADLPFLTYQVHKEQALLSAGRLMKEAGVNGVKLEGGYPDMVETVAFLVQRGIPVLGHIGLTPQAKHQLGGYRQQGKTTP
EAERLRQEALSLEQAGAFALVLEHMPAELAAQISAQVGIPTLGIGAGPACDGQILVTHDLLGLSERLPPFAKAYTNLRQA
IREAVEAFADDVRQKVFPPR

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=260, Percent_Identity=43.8461538461538, Blast_Score=203, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6319653, Length=264, Percent_Identity=37.8787878787879, Blast_Score=188, Evalue=8e-49,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28085; Mature: 27954

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALSIHHFRQAKQAGQPLVALTAADYATAQILDQAGIDLILVGDSLAMTHLGYTSTLPL
CCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCHH
TLEQMLHHAQAVRRGVERAFLVADLPFLTYQVHKEQALLSAGRLMKEAGVNGVKLEGGYP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCH
DMVETVAFLVQRGIPVLGHIGLTPQAKHQLGGYRQQGKTTPEAERLRQEALSLEQAGAFA
HHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCHHH
LVLEHMPAELAAQISAQVGIPTLGIGAGPACDGQILVTHDLLGLSERLPPFAKAYTNLRQ
HHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHH
AIREAVEAFADDVRQKVFPPR
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AALSIHHFRQAKQAGQPLVALTAADYATAQILDQAGIDLILVGDSLAMTHLGYTSTLPL
CCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCHH
TLEQMLHHAQAVRRGVERAFLVADLPFLTYQVHKEQALLSAGRLMKEAGVNGVKLEGGYP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCH
DMVETVAFLVQRGIPVLGHIGLTPQAKHQLGGYRQQGKTTPEAERLRQEALSLEQAGAFA
HHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCHHH
LVLEHMPAELAAQISAQVGIPTLGIGAGPACDGQILVTHDLLGLSERLPPFAKAYTNLRQ
HHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHH
AIREAVEAFADDVRQKVFPPR
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA