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The map label for this gene is fabG [C]

Identifier: 85373026

GI number: 85373026

Start: 234916

End: 235830

Strand: Direct

Name: fabG [C]

Synonym: ELI_00995

Alternate gene names: 85373026

Gene position: 234916-235830 (Clockwise)

Preceding gene: 85373025

Following gene: 85373027

Centisome position: 7.7

GC content: 57.81

Gene sequence:

>915_bases
ATGCACGAAGAACTAAGATACGACGACAAGGTGGTGATCGTAACCGGTGCGGGTGGAGGGCTCGGCCGCGAGCATGCGCT
AATGTTCGGCAAACGCGGTGCAAGGCTGGTTGTCAACGACCTCGGAGGGGATCGAATGGGGGATGGACGATCTTCCAGCG
CAGCGGATCGGGTCGTCGAAGAGATACGATCTGCCGGCGGCGAAGCGGTTGCCAATTATGATTCGGTCGAGGATGGCGCT
CGAATCGTCGAAACTGCGCTCGATGCGTTCGGCACGATCGATGTCGTGATAAACAACGCCGGCATCCTGCGCGACGTCAG
CTTCCACAAGATGACAGACCAGGACTGGACGTTGATCCAGAACATCCACCTCAACGGCAGCCGGGCCGTCACTCAAGCGG
CATGGCCGACGCTGCGCAACAAGGCCTACGGCCGTGTCATCATGACCAGTTCGGCGGCGGGCATCTACGGCAATTTTGGC
CAGGCGAATTATGCAGCTGCCAAATTGGGTATCCTAGGTCTCGCCAATGCACTGGCCGAGGAAGGGCGTTCGCGGAACAT
CAACGTCAATACGATCGCTCCAATCGCGGCTTCGAGGATGACTGAAACGGTCTTTCCCAAGGCGTTGCTCGACAGGTTGC
GGCCTGAGGCGGTCAGTGCGTTGGTTGGCTGGCTCGCGCACGAAAGCTGTTACGAGACCAAAGGGTTGTTCGAAATCGGT
GCCGGTTATGTCGCGAAACTTCGTTGGGAACGGACGTGCGGTTATCACTTGGGCAGGAACGGCATTTTCGCGCCCGAAGA
AATTGCCCAGCATTGGAACAGTATCGTCGATTTCACAGACGCTGAGCATCCAACTGTCATGAACGACAGCCTCGATGCAG
TACAGCGGATCATGGCGGACGATCGCCGGGATTAA

Upstream 100 bases:

>100_bases
ATCTGCCCGATCCCCGATGGCACGACGGAAATCCAGAAGCTCATCGTCTCGCGCGCGCTGACAGGCGTCGCCGCGTTTCG
ATAACAGAAGGCGCCACCCG

Downstream 100 bases:

>100_bases
TCCAAACGTATTGGTTGGCTGGCCCGAGGACTATGCTCAACACCTCTGGCATTGACATGAGCAAAAGGAATACATCGGCC
GCATATTGAATTTGACGATT

Product: short-chain dehydrogenase

Products: estrone; NADH; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHEELRYDDKVVIVTGAGGGLGREHALMFGKRGARLVVNDLGGDRMGDGRSSSAADRVVEEIRSAGGEAVANYDSVEDGA
RIVETALDAFGTIDVVINNAGILRDVSFHKMTDQDWTLIQNIHLNGSRAVTQAAWPTLRNKAYGRVIMTSSAAGIYGNFG
QANYAAAKLGILGLANALAEEGRSRNINVNTIAPIAASRMTETVFPKALLDRLRPEAVSALVGWLAHESCYETKGLFEIG
AGYVAKLRWERTCGYHLGRNGIFAPEEIAQHWNSIVDFTDAEHPTVMNDSLDAVQRIMADDRRD

Sequences:

>Translated_304_residues
MHEELRYDDKVVIVTGAGGGLGREHALMFGKRGARLVVNDLGGDRMGDGRSSSAADRVVEEIRSAGGEAVANYDSVEDGA
RIVETALDAFGTIDVVINNAGILRDVSFHKMTDQDWTLIQNIHLNGSRAVTQAAWPTLRNKAYGRVIMTSSAAGIYGNFG
QANYAAAKLGILGLANALAEEGRSRNINVNTIAPIAASRMTETVFPKALLDRLRPEAVSALVGWLAHESCYETKGLFEIG
AGYVAKLRWERTCGYHLGRNGIFAPEEIAQHWNSIVDFTDAEHPTVMNDSLDAVQRIMADDRRD
>Mature_304_residues
MHEELRYDDKVVIVTGAGGGLGREHALMFGKRGARLVVNDLGGDRMGDGRSSSAADRVVEEIRSAGGEAVANYDSVEDGA
RIVETALDAFGTIDVVINNAGILRDVSFHKMTDQDWTLIQNIHLNGSRAVTQAAWPTLRNKAYGRVIMTSSAAGIYGNFG
QANYAAAKLGILGLANALAEEGRSRNINVNTIAPIAASRMTETVFPKALLDRLRPEAVSALVGWLAHESCYETKGLFEIG
AGYVAKLRWERTCGYHLGRNGIFAPEEIAQHWNSIVDFTDAEHPTVMNDSLDAVQRIMADDRRD

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=300, Percent_Identity=59, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=31.2977099236641, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=27.734375, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI157739938, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4503817, Length=187, Percent_Identity=26.7379679144385, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40807363, Length=233, Percent_Identity=27.8969957081545, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40254992, Length=198, Percent_Identity=29.7979797979798, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI20149619, Length=196, Percent_Identity=28.0612244897959, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI126723191, Length=188, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=210, Percent_Identity=32.8571428571429, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082100, Length=189, Percent_Identity=31.7460317460317, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787526, Length=248, Percent_Identity=26.2096774193548, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790717, Length=197, Percent_Identity=29.9492385786802, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787905, Length=217, Percent_Identity=29.4930875576037, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789208, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082160, Length=187, Percent_Identity=26.7379679144385, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=27.9166666666667, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=279, Percent_Identity=55.1971326164875, Blast_Score=323, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI17555706, Length=205, Percent_Identity=32.6829268292683, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=29.5546558704453, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI193203117, Length=231, Percent_Identity=27.7056277056277, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=236, Percent_Identity=28.3898305084746, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=220, Percent_Identity=27.7272727272727, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=27.6041666666667, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=27.1698113207547, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=199, Percent_Identity=27.6381909547739, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=201, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=244, Percent_Identity=27.0491803278689, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=247, Percent_Identity=25.9109311740891, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=195, Percent_Identity=30.2564102564103, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=175, Percent_Identity=26.8571428571429, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=208, Percent_Identity=25.9615384615385, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=244, Percent_Identity=25.8196721311475, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=199, Percent_Identity=26.6331658291457, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=303, Percent_Identity=50.1650165016502, Blast_Score=314, Evalue=9e-87,
Organism=Drosophila melanogaster, GI18859837, Length=283, Percent_Identity=52.2968197879859, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=30.2788844621514, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24640492, Length=192, Percent_Identity=29.6875, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI23397609, Length=190, Percent_Identity=30, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357041, Length=192, Percent_Identity=28.6458333333333, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281364892, Length=198, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357673, Length=195, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21358495, Length=188, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571526, Length=192, Percent_Identity=28.6458333333333, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356301, Length=191, Percent_Identity=26.1780104712042, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355631, Length=174, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.62

Molecular weight: Translated: 33003; Mature: 33003

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEELRYDDKVVIVTGAGGGLGREHALMFGKRGARLVVNDLGGDRMGDGRSSSAADRVVE
CCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
EIRSAGGEAVANYDSVEDGARIVETALDAFGTIDVVINNAGILRDVSFHKMTDQDWTLIQ
HHHHCCCCEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCEEECHHHHCCCCCCEEEE
NIHLNGSRAVTQAAWPTLRNKAYGRVIMTSSAAGIYGNFGQANYAAAKLGILGLANALAE
EEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EGRSRNINVNTIAPIAASRMTETVFPKALLDRLRPEAVSALVGWLAHESCYETKGLFEIG
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHC
AGYVAKLRWERTCGYHLGRNGIFAPEEIAQHWNSIVDFTDAEHPTVMNDSLDAVQRIMAD
CCHHEEEEHHHHCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHC
DRRD
CCCC
>Mature Secondary Structure
MHEELRYDDKVVIVTGAGGGLGREHALMFGKRGARLVVNDLGGDRMGDGRSSSAADRVVE
CCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
EIRSAGGEAVANYDSVEDGARIVETALDAFGTIDVVINNAGILRDVSFHKMTDQDWTLIQ
HHHHCCCCEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCCEEECHHHHCCCCCCEEEE
NIHLNGSRAVTQAAWPTLRNKAYGRVIMTSSAAGIYGNFGQANYAAAKLGILGLANALAE
EEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EGRSRNINVNTIAPIAASRMTETVFPKALLDRLRPEAVSALVGWLAHESCYETKGLFEIG
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHC
AGYVAKLRWERTCGYHLGRNGIFAPEEIAQHWNSIVDFTDAEHPTVMNDSLDAVQRIMAD
CCHHEEEEHHHHCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHC
DRRD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: estradiol-17beta; NAD+; NADP+

Specific reaction: estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]