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The map label for this gene is yngJ [H]

Identifier: 85373025

GI number: 85373025

Start: 233784

End: 234899

Strand: Direct

Name: yngJ [H]

Synonym: ELI_00990

Alternate gene names: 85373025

Gene position: 233784-234899 (Clockwise)

Preceding gene: 85373024

Following gene: 85373026

Centisome position: 7.66

GC content: 58.96

Gene sequence:

>1116_bases
ATGGCAGTCGAGAGCATTCGGCGCTTCCTCGACGAAAAGCTGGAGCCTGAAATTCGCGCTCACGGCGAATGCTTCATCGA
GCGGCCGTTGATGCAAAAATGGACCAGCGAACTTGCCGCCTTCGGTCATATCAGTGCCCCGCACCGCGAGGAATGGGGCG
GCCTCGATATGGGTTGGCTGACGCATCTCCTGATCTTCGAAGAGATCGCTTATTCGTCGCTTGATGTCGCTATTCCAGGT
TTCATCAACGCGGTCGGCGCCGAACTGATCCGGCGTAGCGCGTCACCTGAAATCCAGCAGCGTTACCTGCCCGGCTTGGT
CGCCGGCGAGCTCTTCGTCTCAATGGGCATTTCCGAGCCGGACGTAGGCTCAGATGTGGCGGCGGTAAGAACGCGAGCCA
TTCGCGACGGCGACTATTGGGTGATCAACGGCGAAAAAACGTGGATTACAAGTGGCGCATATTCGGACCTACTTATCTGC
ACCTGCCGGACCGGAGAGAAGGAGATCAGCCACATCCTGGTCGATCGCGCCGAAAGTCCCTATGAAGTGCGCGATATCGA
AAAGATGGCACTGAATGGTCAGTCGACCGCGCAGATTTTTCTTACCGATTGCCGCGTGCCTGCGTCCAACATGCTGGGCC
AGCCAGGCGATGGACTACGAAACACGTTGAAAGTCTTTGAGATCGCGCGCTGCCACATGGCAATGTGGAGCATCGGTATT
GCACGCCGCGCGCTGGACGAAGCGATCGCCTATTCGAAGGAGCGTTCCCAGCATGGCCGCAAGCTTGCGGGTCATCAACT
GATCGCCGACAAGCTTGCAACCATGGCAACACGGATCGACGCGGCGAGGCTACTGGCGCACCGGGCGATCTCGCTGGTCG
ACGCCGACGTGCGCGCTGAGGCTGAGTGCGCGATGGCCAAATGGTATGCTACGGAGATGGCGATTGGAGTGACGCGCGAT
GCACTTCAGATCCATGGTGGCAACGGCGTTACGCGTGAGTTCATCGTAGAACGGCTCGTGCGCGAAGCGATTATCTGCCC
GATCCCCGATGGCACGACGGAAATCCAGAAGCTCATCGTCTCGCGCGCGCTGACAGGCGTCGCCGCGTTTCGATAA

Upstream 100 bases:

>100_bases
CGGCGGGGTTCTGGGCGTGGAGGAAGCCGTCGTCGCAGTCACCATCCTTGGTCGTTAAGGAGCGGATAATATGGATTTTA
CACCCACTGACGAGCAGCGG

Downstream 100 bases:

>100_bases
CAGAAGGCGCCACCCGATGCACGAAGAACTAAGATACGACGACAAGGTGGTGATCGTAACCGGTGCGGGTGGAGGGCTCG
GCCGCGAGCATGCGCTAATG

Product: acyl-CoA dehydrogenase, short-chain specific

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MAVESIRRFLDEKLEPEIRAHGECFIERPLMQKWTSELAAFGHISAPHREEWGGLDMGWLTHLLIFEEIAYSSLDVAIPG
FINAVGAELIRRSASPEIQQRYLPGLVAGELFVSMGISEPDVGSDVAAVRTRAIRDGDYWVINGEKTWITSGAYSDLLIC
TCRTGEKEISHILVDRAESPYEVRDIEKMALNGQSTAQIFLTDCRVPASNMLGQPGDGLRNTLKVFEIARCHMAMWSIGI
ARRALDEAIAYSKERSQHGRKLAGHQLIADKLATMATRIDAARLLAHRAISLVDADVRAEAECAMAKWYATEMAIGVTRD
ALQIHGGNGVTREFIVERLVREAIICPIPDGTTEIQKLIVSRALTGVAAFR

Sequences:

>Translated_371_residues
MAVESIRRFLDEKLEPEIRAHGECFIERPLMQKWTSELAAFGHISAPHREEWGGLDMGWLTHLLIFEEIAYSSLDVAIPG
FINAVGAELIRRSASPEIQQRYLPGLVAGELFVSMGISEPDVGSDVAAVRTRAIRDGDYWVINGEKTWITSGAYSDLLIC
TCRTGEKEISHILVDRAESPYEVRDIEKMALNGQSTAQIFLTDCRVPASNMLGQPGDGLRNTLKVFEIARCHMAMWSIGI
ARRALDEAIAYSKERSQHGRKLAGHQLIADKLATMATRIDAARLLAHRAISLVDADVRAEAECAMAKWYATEMAIGVTRD
ALQIHGGNGVTREFIVERLVREAIICPIPDGTTEIQKLIVSRALTGVAAFR
>Mature_370_residues
AVESIRRFLDEKLEPEIRAHGECFIERPLMQKWTSELAAFGHISAPHREEWGGLDMGWLTHLLIFEEIAYSSLDVAIPGF
INAVGAELIRRSASPEIQQRYLPGLVAGELFVSMGISEPDVGSDVAAVRTRAIRDGDYWVINGEKTWITSGAYSDLLICT
CRTGEKEISHILVDRAESPYEVRDIEKMALNGQSTAQIFLTDCRVPASNMLGQPGDGLRNTLKVFEIARCHMAMWSIGIA
RRALDEAIAYSKERSQHGRKLAGHQLIADKLATMATRIDAARLLAHRAISLVDADVRAEAECAMAKWYATEMAIGVTRDA
LQIHGGNGVTREFIVERLVREAIICPIPDGTTEIQKLIVSRALTGVAAFR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=370, Percent_Identity=28.1081081081081, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=28.6549707602339, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4501859, Length=363, Percent_Identity=32.5068870523416, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI4557231, Length=323, Percent_Identity=34.3653250773994, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI187960098, Length=323, Percent_Identity=34.3653250773994, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4557233, Length=370, Percent_Identity=33.2432432432432, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI7656849, Length=317, Percent_Identity=31.8611987381703, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=29.144385026738, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=29.1777188328912, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=29.1777188328912, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=27.3936170212766, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503943, Length=281, Percent_Identity=32.0284697508897, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI7669494, Length=249, Percent_Identity=31.7269076305221, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI211971008, Length=384, Percent_Identity=24.4791666666667, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI48976061, Length=384, Percent_Identity=24.4791666666667, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1786223, Length=350, Percent_Identity=26.5714285714286, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081958, Length=323, Percent_Identity=28.4829721362229, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87082384, Length=298, Percent_Identity=29.5302013422819, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17569725, Length=326, Percent_Identity=32.8220858895706, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=371, Percent_Identity=30.188679245283, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534899, Length=324, Percent_Identity=33.0246913580247, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=371, Percent_Identity=29.6495956873315, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=359, Percent_Identity=29.2479108635098, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17533517, Length=319, Percent_Identity=30.7210031347962, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17508101, Length=362, Percent_Identity=29.2817679558011, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=27.5766016713092, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=26.790450928382, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=276, Percent_Identity=30.0724637681159, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71990804, Length=270, Percent_Identity=27.4074074074074, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71985192, Length=308, Percent_Identity=25.3246753246753, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=26.4150943396226, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=29.7777777777778, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=26.3940520446097, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=25.7510729613734, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562446, Length=267, Percent_Identity=29.9625468164794, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=275, Percent_Identity=26.9090909090909, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=275, Percent_Identity=26.9090909090909, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355753, Length=343, Percent_Identity=32.0699708454811, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24660351, Length=321, Percent_Identity=34.5794392523364, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=31.9783197831978, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21356377, Length=342, Percent_Identity=32.1637426900585, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24666513, Length=323, Percent_Identity=31.2693498452012, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281363737, Length=349, Percent_Identity=29.7994269340974, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI19920834, Length=282, Percent_Identity=32.2695035460993, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41040; Mature: 40908

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVESIRRFLDEKLEPEIRAHGECFIERPLMQKWTSELAAFGHISAPHREEWGGLDMGWL
CCHHHHHHHHHHHCCCHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHH
THLLIFEEIAYSSLDVAIPGFINAVGAELIRRSASPEIQQRYLPGLVAGELFVSMGISEP
HHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCCCCCC
DVGSDVAAVRTRAIRDGDYWVINGEKTWITSGAYSDLLICTCRTGEKEISHILVDRAESP
CCCCHHHHHHHHHEECCCEEEECCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCC
YEVRDIEKMALNGQSTAQIFLTDCRVPASNMLGQPGDGLRNTLKVFEIARCHMAMWSIGI
CHHHHHHHHHCCCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARRALDEAIAYSKERSQHGRKLAGHQLIADKLATMATRIDAARLLAHRAISLVDADVRAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AECAMAKWYATEMAIGVTRDALQIHGGNGVTREFIVERLVREAIICPIPDGTTEIQKLIV
HHHHHHHHHHHHHHHHEEHHHEEEECCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHH
SRALTGVAAFR
HHHHHHHHHCC
>Mature Secondary Structure 
AVESIRRFLDEKLEPEIRAHGECFIERPLMQKWTSELAAFGHISAPHREEWGGLDMGWL
CHHHHHHHHHHHCCCHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHH
THLLIFEEIAYSSLDVAIPGFINAVGAELIRRSASPEIQQRYLPGLVAGELFVSMGISEP
HHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHCCCCCC
DVGSDVAAVRTRAIRDGDYWVINGEKTWITSGAYSDLLICTCRTGEKEISHILVDRAESP
CCCCHHHHHHHHHEECCCEEEECCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCC
YEVRDIEKMALNGQSTAQIFLTDCRVPASNMLGQPGDGLRNTLKVFEIARCHMAMWSIGI
CHHHHHHHHHCCCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARRALDEAIAYSKERSQHGRKLAGHQLIADKLATMATRIDAARLLAHRAISLVDADVRAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AECAMAKWYATEMAIGVTRDALQIHGGNGVTREFIVERLVREAIICPIPDGTTEIQKLIV
HHHHHHHHHHHHHHHHEEHHHEEEECCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHH
SRALTGVAAFR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]