Click here to switch to the map view.

The map label for this gene is hmgA [H]

Identifier: 84625502

GI number: 84625502

Start: 4348489

End: 4349814

Strand: Reverse

Name: hmgA [H]

Synonym: XOO_3845

Alternate gene names: 84625502

Gene position: 4349814-4348489 (Counterclockwise)

Preceding gene: 84625503

Following gene: 84625494

Centisome position: 88.05

GC content: 64.78

Gene sequence:

>1326_bases
ATGCACAACCCGCAGCACTACATGACCGGCTTCGGCAATGAGTTTGCAACCGAGGCGGTGGCCGGCAGTCTACCGGTCGG
GCAGAACTCACCGCAGCGCGTGGCGCATGGCCTGTACGCCGAGCAGTTGTCCGGCACCGCCTTCACCGCGCCACGCGGCG
AGAACCGGCGCAGCTGGCTGTACCGCATTCGTCCGGCAGCGGTGCATGGCCGTTTCTCGCTGATCGAGCAGTCTCGGCTC
CACAACGACTTCGGCGGCGGCCCGGTACCGCCGGACCAGATGCGCTGGAGTCCACTGCCGTTGCCGGCCACGCCCACCGA
TTTCGTCGATGGCCTGTACACCATGGCCGGCAATGGCAGCCCGGAGGCGATGACCGGCGTGGCCGTGCATCTATATGCGG
CAAACGCGTCCATGCACGGGCGGTTCTTCTACAACGCCGACGGCGAGCTGCTGCTGGTGCCGCAGCTTGGCCGGTTGCGG
GTCTGCACCGAACTGGGCGTGCTCGAACTGGAGCCGCAACAGATCGGCGTGATACCGCGCGGTGTGCGTTTCCGGGTGGA
ACTGCTCGATAGTGCAGCGCGTGGCTATGTCTGCGAAAACTTCGGCGGCCTGCTGCGGCTGCCGGATCTGGGGCCGATTG
GTGCCAACGGCCTTGCCAATCCGCGCGATTTCGAGACCCCGCGTGCGGCGTTCGAGCAGCGCGACGGCGCATTCGAGCTG
GTCGCCAAGTTCCAGGGCCATCTGTGGCGGGCGGATATCGATCACTCGCCGCTGGATGTGGTCGCCTGGCACGGCAATTA
CGCGCCCTATCGTTACGACCTACGTCGCTTCAACACCATCGGCTCGATCAGCTTCGATCATCCCGATCCCAGCATCTTCA
CCGTGCTGACCTCGCCCAGCGACACGCACGGTACTGCGAACATGGATTTTGCGATCTTCCCGCCGCGTTGGCTGGTGGCG
CAGCACACCTTCCGCCCGCCGTGGTTCCATCGCAACGTCGCCAGCGAATTCATGGGGCTGGTACACGGCGTCTACGATGC
CAAGGCCGAAGGCTTCGCGCCCGGTGGGGCTTCGCTGCACAACTGCATGAGCGGGCACGGACCGGATGCGGCGACCTTCG
ACAAGGCCTCCCAGGCAGATCTCACGCGCCCGGACGTGATCGCTGAAACCATGGCTTTCATGTTCGAAACCCGCGCGGTG
TTGCGCCCCACGCAGCAGGCGTTGAGCGCGGCGCATCGGCAAGCCGATTACCAGCAGTGTTGGTCCGGATTGCGTGCCGC
ATTTCAGCATCCACCAGCGAAAAACACGACGTCGGTTTTACGGTAA

Upstream 100 bases:

>100_bases
ACGTGCTTAAAGCCCCTCCCTCGATGGGAGAGGGACCTGATCCACCCCAAGCCCAGCCTTCTGCGTTCGAGGAGGAGGGT
CGACATCCGGACGCGCCACC

Downstream 100 bases:

>100_bases
ACGGAGCGGGTCATACGTGTGCACTGTCTGCCCGCCAGCATTATTCGTTCTTTCAGTGGTCTGGACGCACGCACTTACCA
GCTCAAACGCGGCCCTACGA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MHNPQHYMTGFGNEFATEAVAGSLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWLYRIRPAAVHGRFSLIEQSRL
HNDFGGGPVPPDQMRWSPLPLPATPTDFVDGLYTMAGNGSPEAMTGVAVHLYAANASMHGRFFYNADGELLLVPQLGRLR
VCTELGVLELEPQQIGVIPRGVRFRVELLDSAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPRAAFEQRDGAFEL
VAKFQGHLWRADIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVA
QHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQADLTRPDVIAETMAFMFETRAV
LRPTQQALSAAHRQADYQQCWSGLRAAFQHPPAKNTTSVLR

Sequences:

>Translated_441_residues
MHNPQHYMTGFGNEFATEAVAGSLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWLYRIRPAAVHGRFSLIEQSRL
HNDFGGGPVPPDQMRWSPLPLPATPTDFVDGLYTMAGNGSPEAMTGVAVHLYAANASMHGRFFYNADGELLLVPQLGRLR
VCTELGVLELEPQQIGVIPRGVRFRVELLDSAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPRAAFEQRDGAFEL
VAKFQGHLWRADIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVA
QHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQADLTRPDVIAETMAFMFETRAV
LRPTQQALSAAHRQADYQQCWSGLRAAFQHPPAKNTTSVLR
>Mature_441_residues
MHNPQHYMTGFGNEFATEAVAGSLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWLYRIRPAAVHGRFSLIEQSRL
HNDFGGGPVPPDQMRWSPLPLPATPTDFVDGLYTMAGNGSPEAMTGVAVHLYAANASMHGRFFYNADGELLLVPQLGRLR
VCTELGVLELEPQQIGVIPRGVRFRVELLDSAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPRAAFEQRDGAFEL
VAKFQGHLWRADIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVA
QHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQADLTRPDVIAETMAFMFETRAV
LRPTQQALSAAHRQADYQQCWSGLRAAFQHPPAKNTTSVLR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=437, Percent_Identity=49.1990846681922, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17507969, Length=431, Percent_Identity=54.0603248259861, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583650, Length=431, Percent_Identity=51.508120649652, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 48542; Mature: 48542

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNPQHYMTGFGNEFATEAVAGSLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWL
CCCCCCHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCEE
YRIRPAAVHGRFSLIEQSRLHNDFGGGPVPPDQMRWSPLPLPATPTDFVDGLYTMAGNGS
EEECCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
PEAMTGVAVHLYAANASMHGRFFYNADGELLLVPQLGRLRVCTELGVLELEPQQIGVIPR
CCHHEEEEEEEEEECCCCCCEEEECCCCCEEEECCCCCEEEHHHCCCEEECHHHHCCCCC
GVRFRVELLDSAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPRAAFEQRDGAFEL
CCEEEHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHH
VAKFQGHLWRADIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSPS
HHHHHCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCEEEEEECCC
DTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLH
CCCCCCCCCEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
NCMSGHGPDAATFDKASQADLTRPDVIAETMAFMFETRAVLRPTQQALSAAHRQADYQQC
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
WSGLRAAFQHPPAKNTTSVLR
HHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure
MHNPQHYMTGFGNEFATEAVAGSLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWL
CCCCCCHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCEE
YRIRPAAVHGRFSLIEQSRLHNDFGGGPVPPDQMRWSPLPLPATPTDFVDGLYTMAGNGS
EEECCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
PEAMTGVAVHLYAANASMHGRFFYNADGELLLVPQLGRLRVCTELGVLELEPQQIGVIPR
CCHHEEEEEEEEEECCCCCCEEEECCCCCEEEECCCCCEEEHHHCCCEEECHHHHCCCCC
GVRFRVELLDSAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPRAAFEQRDGAFEL
CCEEEHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHH
VAKFQGHLWRADIDHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSPS
HHHHHCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCEEEEEECCC
DTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLH
CCCCCCCCCEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
NCMSGHGPDAATFDKASQADLTRPDVIAETMAFMFETRAVLRPTQQALSAAHRQADYQQC
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
WSGLRAAFQHPPAKNTTSVLR
HHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]