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The map label for this gene is rfbC [H]

Identifier: 84622379

GI number: 84622379

Start: 778033

End: 778590

Strand: Direct

Name: rfbC [H]

Synonym: XOO_0722

Alternate gene names: 84622379

Gene position: 778033-778590 (Clockwise)

Preceding gene: 84622378

Following gene: 84622380

Centisome position: 15.75

GC content: 59.68

Gene sequence:

>558_bases
GTGAAAATCGTCGAAACGCGTTTACCAGGTTGTGTCGTCATCGAGCCGGCAGTGTTCGGCGATGAGCGCGGATATTTCTT
CGAAACGTGGAATGCCGAGCGCTTCGGGCAACATGGTCTGCCGACGCAGTTCTTGCAGAGCAATGTCTCCACCTCGGCCA
AAGGCGTGTTGCGTGGTTTGCATTACCAGTGGCCGCGTCCTCAGGGCAAGCTGGTCAGCGTGCTGGAGGGTGAGGTCTAC
GATGTGGCGGTCGACGTGCGCCACGGCTCGCCCAACTTCGGGCAGTGGGCGGCAGTAGTGTTGAGCGCAGAAAACAAGAA
GCAGTTCTGGATACCGGAAGGGTTTGCGCACGGCTTTGCAGTGCTGTCGGAGCGAGCCGTGTTCAGTTACCTGTGCACCG
ACGTGTATGTGAAGGAGGCCGATGCCGGCGTGCGCTGGGATGATGCGGCGATCGGTATCGATTGGCCGATCAGCAATCCA
TTGCTCTCTGCAAAGGACGCCGCTGCGCCGTTTCTGGCCGATGTGCCCGCTGAGCGCTTGCCGGTGTATAAACCGTGA

Upstream 100 bases:

>100_bases
GCTGGATCGATGCGGAGCAATTGGAGCGTCTGGCCGCCCCGTTGCTGAAAAACGACTATGGCAAATATTTGCACGAATTG
GCTGTGCGAGGAGTAGTACC

Downstream 100 bases:

>100_bases
CCACGCTGGTTTTTGGCGCAAATGGGCAGGTGGGTACGGAATTGCTGCGTGCGCTGGCAGTCGATGGCGCCGTACAGGCC
ACCACGCGTAGTGGCCAGTT

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKIVETRLPGCVVIEPAVFGDERGYFFETWNAERFGQHGLPTQFLQSNVSTSAKGVLRGLHYQWPRPQGKLVSVLEGEVY
DVAVDVRHGSPNFGQWAAVVLSAENKKQFWIPEGFAHGFAVLSERAVFSYLCTDVYVKEADAGVRWDDAAIGIDWPISNP
LLSAKDAAAPFLADVPAERLPVYKP

Sequences:

>Translated_185_residues
MKIVETRLPGCVVIEPAVFGDERGYFFETWNAERFGQHGLPTQFLQSNVSTSAKGVLRGLHYQWPRPQGKLVSVLEGEVY
DVAVDVRHGSPNFGQWAAVVLSAENKKQFWIPEGFAHGFAVLSERAVFSYLCTDVYVKEADAGVRWDDAAIGIDWPISNP
LLSAKDAAAPFLADVPAERLPVYKP
>Mature_185_residues
MKIVETRLPGCVVIEPAVFGDERGYFFETWNAERFGQHGLPTQFLQSNVSTSAKGVLRGLHYQWPRPQGKLVSVLEGEVY
DVAVDVRHGSPNFGQWAAVVLSAENKKQFWIPEGFAHGFAVLSERAVFSYLCTDVYVKEADAGVRWDDAAIGIDWPISNP
LLSAKDAAAPFLADVPAERLPVYKP

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=170, Percent_Identity=50, Blast_Score=167, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17550412, Length=165, Percent_Identity=46.0606060606061, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 20479; Mature: 20479

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVETRLPGCVVIEPAVFGDERGYFFETWNAERFGQHGLPTQFLQSNVSTSAKGVLRGL
CCCCCCCCCCEEEECCCEECCCCCCEEEECCHHHCCCCCCCHHHHHHCCCCHHHHHHHHC
HYQWPRPQGKLVSVLEGEVYDVAVDVRHGSPNFGQWAAVVLSAENKKQFWIPEGFAHGFA
CCCCCCCCCCEEHEECCCEEEEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCHHHHHH
VLSERAVFSYLCTDVYVKEADAGVRWDDAAIGIDWPISNPLLSAKDAAAPFLADVPAERL
HHHHHHHHHHHHHHHEEECCCCCCEECCCEEEECCCCCCCCCCCCCCCCCHHHCCCHHHC
PVYKP
CCCCC
>Mature Secondary Structure
MKIVETRLPGCVVIEPAVFGDERGYFFETWNAERFGQHGLPTQFLQSNVSTSAKGVLRGL
CCCCCCCCCCEEEECCCEECCCCCCEEEECCHHHCCCCCCCHHHHHHCCCCHHHHHHHHC
HYQWPRPQGKLVSVLEGEVYDVAVDVRHGSPNFGQWAAVVLSAENKKQFWIPEGFAHGFA
CCCCCCCCCCEEHEECCCEEEEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCHHHHHH
VLSERAVFSYLCTDVYVKEADAGVRWDDAAIGIDWPISNPLLSAKDAAAPFLADVPAERL
HHHHHHHHHHHHHHHEEECCCCCCEECCCEEEECCCCCCCCCCCCCCCCCHHHCCCHHHC
PVYKP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]