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The map label for this gene is proC [H]

Identifier: 83719785

GI number: 83719785

Start: 1438851

End: 1439663

Strand: Reverse

Name: proC [H]

Synonym: BTH_I1287

Alternate gene names: 83719785

Gene position: 1439663-1438851 (Counterclockwise)

Preceding gene: 83721068

Following gene: 83720404

Centisome position: 37.79

GC content: 71.83

Gene sequence:

>813_bases
ATGAAAATCGCATTCATCGGCGGCGGCAACATGGCGGCCGCGTTGATCGGCGGACTCGTCAGGCGCGGCGTCGCGGCGAG
CGAGCTGCTCGCCGTCGACATCAACGAAGATGCGCGTCAGCGCGCGCAAGCGCAATTCGGCGTGCGCACGGCGGCCGCCA
TCGACGCCACGCTCGCCGGCTACGACGCGATCGTGCTCGCCGTGAAGCCGCAGGTGCTCAAGGAGATCGCGACCGCGCTC
GCGCCGCATCTGTCGACACAGCTCGTCGTCAGCATCGCGGCCGGCATTCGCGGCGCGGACCTGTCGCGCTGGCTCGGCGA
TTACGCGCGCGTCGTGCGCACGATGCCGAACACGCCGGCGCTCGTCGGCCTCGGCGTGACCGGCCTGTCCGCACTGCCGG
GCGTCGACGCGGCGGGCCGCGATCTCGCATCGAAGGTGCTCGGCGCGGTCGGCGAGACGGTCTGGTTCGACGACGAATCG
CAGCTCGACGCCGTCACCGCGATCTCGGGCAGCGGCCCCGCGTACGTGTTCTATTTCATCGAGGCGCTGCAGGAAGCGGC
GCGCCAGCTCGGCATGAACGACGAGCAGGGCCGCGCGCTCGCGGTCGCGACGTTCGCGGGCGCCGCGCAGCTCGCGGTGC
AGTCGGGCGAGCCCGCGAGCGTGCTGCGCGAGCGCGTGACGTCGAAGGGCGGCACGACGGCGGCCGCGCTGGCGTCGTTC
GACGCGCAACACGTGAAGGACTCGATCGTGCGCGGCGTGCTCGCCGCACAGGCGCGCGCGAAGGAAATGGGCGACGAGCT
GGGCGCTGCGTAA

Upstream 100 bases:

>100_bases
GCCGAAGGCGCGACGATCGTGCGCATCGGCACCGCGATCTTCGGCGCGCGCGACTACGCCCACTGAACCCACCACCTTTC
CCTCAACGGTCTCATTCATC

Downstream 100 bases:

>100_bases
CCGGCGGCTCGCCGAATCCGGGCGCGGCTCGCCGAATCCGGGTTCGTTGTGCGCGCGCCGCGCTCGCGCCGTCCTTCTTC
TCTGCTCGGCGAGACTTGCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKIAFIGGGNMAAALIGGLVRRGVAASELLAVDINEDARQRAQAQFGVRTAAAIDATLAGYDAIVLAVKPQVLKEIATAL
APHLSTQLVVSIAAGIRGADLSRWLGDYARVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDES
QLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPASVLRERVTSKGGTTAAALASF
DAQHVKDSIVRGVLAAQARAKEMGDELGAA

Sequences:

>Translated_270_residues
MKIAFIGGGNMAAALIGGLVRRGVAASELLAVDINEDARQRAQAQFGVRTAAAIDATLAGYDAIVLAVKPQVLKEIATAL
APHLSTQLVVSIAAGIRGADLSRWLGDYARVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDES
QLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPASVLRERVTSKGGTTAAALASF
DAQHVKDSIVRGVLAAQARAKEMGDELGAA
>Mature_270_residues
MKIAFIGGGNMAAALIGGLVRRGVAASELLAVDINEDARQRAQAQFGVRTAAAIDATLAGYDAIVLAVKPQVLKEIATAL
APHLSTQLVVSIAAGIRGADLSRWLGDYARVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDES
QLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPASVLRERVTSKGGTTAAALASF
DAQHVKDSIVRGVLAAQARAKEMGDELGAA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=32.1969696969697, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=30.9963099630996, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=30.9963099630996, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=28.4132841328413, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=33.8289962825279, Blast_Score=127, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=33.0855018587361, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=27.1428571428571, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=28.0276816608997, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=36.3636363636364, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=32.2463768115942, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=39.0532544378698, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27566; Mature: 27566

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGLVRRGVAASELLAVDINEDARQRAQAQFGVRTAAAIDATLAG
CEEEEECCCHHHHHHHHHHHHCCCCHHHEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHC
YDAIVLAVKPQVLKEIATALAPHLSTQLVVSIAAGIRGADLSRWLGDYARVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
LVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDESQLDAVTAISGSGPAYVFYFI
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHEEECCCCCCHHHHHH
EALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPASVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHH
DAQHVKDSIVRGVLAAQARAKEMGDELGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGLVRRGVAASELLAVDINEDARQRAQAQFGVRTAAAIDATLAG
CEEEEECCCHHHHHHHHHHHHCCCCHHHEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHC
YDAIVLAVKPQVLKEIATALAPHLSTQLVVSIAAGIRGADLSRWLGDYARVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
LVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDESQLDAVTAISGSGPAYVFYFI
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHEEECCCCCCHHHHHH
EALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPASVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHH
DAQHVKDSIVRGVLAAQARAKEMGDELGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]