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The map label for this gene is hisC2

Identifier: 82703311

GI number: 82703311

Start: 2491657

End: 2492835

Strand: Direct

Name: hisC2

Synonym: Nmul_A2193

Alternate gene names: 82703311

Gene position: 2491657-2492835 (Clockwise)

Preceding gene: 82703310

Following gene: 82703312

Centisome position: 78.25

GC content: 56.32

Gene sequence:

>1179_bases
ATGAATATTTGCGATCTCGCTCCTGCATATATCCGTGCCATCAGTCCCTATCAGCCCGGCAAGCCTATTTCTGAACTGGC
CCGGGAGATGGGGATGGATGAACAGTCCATCATCAAGCTTGCGTCCAATGAAAACCCCCTGGGAACCAGTCCAATGGCCC
TGAACGCAATGAGCAAGGCGCTCGACGAGGTTTCGTTGTATCCGGACGGAAGCGGATTTGAGCTGAAAGCAGCGCTGTCC
GAGCGCTATGGCGTGACCAGCGATCAGATTGTGCTGGGCAACGGTTCCAATGACGTTCTGGAGTTGGCCGCGCGCGTATT
CCTGAAGCCGGGGGCCTCGACCGTTTACTCGCAGCATGCGTTTGCGGTTTATCCCCTGGTGACGAAAGCGGTGGGTGGAA
TCGGCATTTCCGTTCCCGCCCGGAACTATGGCCATGATCTTGACGCCATGCTGGATGCTGTCGCGCCTGAAACACGGGTT
GTATTTATTGCCAATCCCAACAATCCCACCGGCACCCTGCTGCCTGCCGACGATGTGCTGCGCTTTCTCGAGCGAGTGTC
CCCGGATGTGCTGGTCGTACTGGATGAAGCATACAACGAGTATCTGCCGCCCGCCCTCAAGGGAGATAGCATTGCCTGGC
TGAAGCAGTTTCCCAATCTCCTCATTACCCGCACTTTCTCCAAAGCTTACGGTATGGCAGGCGTGCGCGTCGGTTTCGGC
CTCGGGCATCCTGACGTCGCCGGTCTGATGAACCGCGTGCGCCAGCCATTCAACGTCAACAATATCGGTCTTGCCGGCGC
GGTGGCTGCGCTGCAGGATGAGGAGTTCGTAAAGCGTTCTTATGCGCTCAACCAGGCAGGCATGCTGCAGATTGTCACCG
GATTGCGGCAGATGGGAATCGAGTACATTCCGTCCTACGGGAATTTCCTGAGCTTTCGGGTGCCAGGCAATGTCAAGGCA
ATAAACGAGAGTCTGCTGAAGCAGGGTGTGATTGTCCGCCCCATCAGCATTTATGAAATGCCGGAACATCTCCGGGTAAC
TGTCGGGCTCGAATCTGAAAATGAGAAATTCCTGAAATCGCTGGCGATAGCCCTGGAGACGACGGAAGGGGCAGCAGCAG
ACACAATACCTGAGATGGCGGTAAGCTTTCCCAAAGTTGCATCGGGGGGAACAGCGTGA

Upstream 100 bases:

>100_bases
GCCGGGAAACGGGTTATTGCAAGCATGAATCCATGCTTTTTGTGCGATTGCCTGTCCTGTTGACGGTTATTATTTTCTGC
TTTTTCTTCCCTACCATCTT

Downstream 100 bases:

>100_bases
TCATAGTCATGAATAACGGCGCCACCGAAGAGCAGATCGAAACGGTGGTTGCAAAAATTCGAAGCTTCGACCTGGACGCG
AACGTTTCGCGTGGCACCGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNICDLAPAYIRAISPYQPGKPISELAREMGMDEQSIIKLASNENPLGTSPMALNAMSKALDEVSLYPDGSGFELKAALS
ERYGVTSDQIVLGNGSNDVLELAARVFLKPGASTVYSQHAFAVYPLVTKAVGGIGISVPARNYGHDLDAMLDAVAPETRV
VFIANPNNPTGTLLPADDVLRFLERVSPDVLVVLDEAYNEYLPPALKGDSIAWLKQFPNLLITRTFSKAYGMAGVRVGFG
LGHPDVAGLMNRVRQPFNVNNIGLAGAVAALQDEEFVKRSYALNQAGMLQIVTGLRQMGIEYIPSYGNFLSFRVPGNVKA
INESLLKQGVIVRPISIYEMPEHLRVTVGLESENEKFLKSLAIALETTEGAAADTIPEMAVSFPKVASGGTA

Sequences:

>Translated_392_residues
MNICDLAPAYIRAISPYQPGKPISELAREMGMDEQSIIKLASNENPLGTSPMALNAMSKALDEVSLYPDGSGFELKAALS
ERYGVTSDQIVLGNGSNDVLELAARVFLKPGASTVYSQHAFAVYPLVTKAVGGIGISVPARNYGHDLDAMLDAVAPETRV
VFIANPNNPTGTLLPADDVLRFLERVSPDVLVVLDEAYNEYLPPALKGDSIAWLKQFPNLLITRTFSKAYGMAGVRVGFG
LGHPDVAGLMNRVRQPFNVNNIGLAGAVAALQDEEFVKRSYALNQAGMLQIVTGLRQMGIEYIPSYGNFLSFRVPGNVKA
INESLLKQGVIVRPISIYEMPEHLRVTVGLESENEKFLKSLAIALETTEGAAADTIPEMAVSFPKVASGGTA
>Mature_392_residues
MNICDLAPAYIRAISPYQPGKPISELAREMGMDEQSIIKLASNENPLGTSPMALNAMSKALDEVSLYPDGSGFELKAALS
ERYGVTSDQIVLGNGSNDVLELAARVFLKPGASTVYSQHAFAVYPLVTKAVGGIGISVPARNYGHDLDAMLDAVAPETRV
VFIANPNNPTGTLLPADDVLRFLERVSPDVLVVLDEAYNEYLPPALKGDSIAWLKQFPNLLITRTFSKAYGMAGVRVGFG
LGHPDVAGLMNRVRQPFNVNNIGLAGAVAALQDEEFVKRSYALNQAGMLQIVTGLRQMGIEYIPSYGNFLSFRVPGNVKA
INESLLKQGVIVRPISIYEMPEHLRVTVGLESENEKFLKSLAIALETTEGAAADTIPEMAVSFPKVASGGTA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=369, Percent_Identity=28.1842818428184, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=25.9052924791086, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_NITMU (Q2Y6Y6)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412877.1
- ProteinModelPortal:   Q2Y6Y6
- SMR:   Q2Y6Y6
- STRING:   Q2Y6Y6
- GeneID:   3786218
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2193
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   VANEELI
- PhylomeDB:   Q2Y6Y6
- ProtClustDB:   PRK02731
- BioCyc:   NMUL323848:NMUL_A2193-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42072; Mature: 42072

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNICDLAPAYIRAISPYQPGKPISELAREMGMDEQSIIKLASNENPLGTSPMALNAMSKA
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
LDEVSLYPDGSGFELKAALSERYGVTSDQIVLGNGSNDVLELAARVFLKPGASTVYSQHA
HHHEECCCCCCCCEEHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCC
FAVYPLVTKAVGGIGISVPARNYGHDLDAMLDAVAPETRVVFIANPNNPTGTLLPADDVL
HHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCEECHHHHH
RFLERVSPDVLVVLDEAYNEYLPPALKGDSIAWLKQFPNLLITRTFSKAYGMAGVRVGFG
HHHHHCCCCEEEEEEHHHHHHCCCCCCCCCHHHHHHCCHHEEEHHHHHHHCCCCEEEECC
LGHPDVAGLMNRVRQPFNVNNIGLAGAVAALQDEEFVKRSYALNQAGMLQIVTGLRQMGI
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
EYIPSYGNFLSFRVPGNVKAINESLLKQGVIVRPISIYEMPEHLRVTVGLESENEKFLKS
HHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEHHEECCCEEEEEEECCCCHHHHHHH
LAIALETTEGAAADTIPEMAVSFPKVASGGTA
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNICDLAPAYIRAISPYQPGKPISELAREMGMDEQSIIKLASNENPLGTSPMALNAMSKA
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
LDEVSLYPDGSGFELKAALSERYGVTSDQIVLGNGSNDVLELAARVFLKPGASTVYSQHA
HHHEECCCCCCCCEEHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCC
FAVYPLVTKAVGGIGISVPARNYGHDLDAMLDAVAPETRVVFIANPNNPTGTLLPADDVL
HHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCEECHHHHH
RFLERVSPDVLVVLDEAYNEYLPPALKGDSIAWLKQFPNLLITRTFSKAYGMAGVRVGFG
HHHHHCCCCEEEEEEHHHHHHCCCCCCCCCHHHHHHCCHHEEEHHHHHHHCCCCEEEECC
LGHPDVAGLMNRVRQPFNVNNIGLAGAVAALQDEEFVKRSYALNQAGMLQIVTGLRQMGI
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCH
EYIPSYGNFLSFRVPGNVKAINESLLKQGVIVRPISIYEMPEHLRVTVGLESENEKFLKS
HHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEHHEECCCEEEEEEECCCCHHHHHHH
LAIALETTEGAAADTIPEMAVSFPKVASGGTA
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA