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The map label for this gene is acsA [H]

Identifier: 82702988

GI number: 82702988

Start: 2153459

End: 2154511

Strand: Direct

Name: acsA [H]

Synonym: Nmul_A1867

Alternate gene names: 82702988

Gene position: 2153459-2154511 (Clockwise)

Preceding gene: 82702982

Following gene: 82702989

Centisome position: 67.63

GC content: 55.56

Gene sequence:

>1053_bases
GTGGCGACGATTCAATCTATCCTCAATGAAACACGCACCTTTACACCCTCCGCTTCGTTCGTGGAACAAGCAAACGTATC
CGGAATGGAAGAATATGATGCCCTTTGCGCAGAGGCAGAAAAGGATGAGGCAGCATTCTGGTCCAGACTGGCGCGGGATC
ATATTTCCTGGCACAAACCATTTACCCGCGTACTGGATGAAACCAACCATCCGTTCTTTACCTGGTTCGATGACGGAGAA
CTGAATGTTTCATACAATTGTCTCGATCGGCACCAGGCCACCCAGTCGGACAAGGTTGCGCTTATTTTCGAGGCGGATGA
CGGCACCGTCACGCGCTGCACCTACCAGGATCTCTACCGCCGCGTATGCAGGTTTGCAAATGGTCTCAAGTCGCTGAATA
TCAGGAAAGGTGATCGCGTCGTTATCTACATGCCGATGAGTATCGAGGCGGTAGTGGCAATGCTGGCCTGCGCGCGCATC
GGTGCGACCCATTCAGTCGTGTTCGGTGGCTTTTCCGCCAAAAGCCTGCATGAGCGAATTATCGACGCAGGCGCGGTAGC
CGTGATTACCGCGGACGAGCAATGGCGCGGCGGCAAAATCAACTACCTGAAAGCCGTTGTCGAAGATGCGCTCGGTAGAG
GTGAAACGGACTCGGTGAAATCCGTGGTGGTCTACCAGCGAGGCAGCGGTGACCTGCAACTGGACGCCAATCGCGACATC
TGGTGGCATGATCTCATCCGGGATCAGAGCGAGACCTGTGAGCCCGAATGGGTGAACGCCGAGCATCCGCTATTTACGCT
CTACACCTCCGGTTCCACCGGCAAGCCAAAAGGCGTGCAACACTCTTCCGCGGGCTTTCTGCTGGGCGCCATCACGAGCA
TGCAATGGATTTTCGACTACAAGTCTTCCGATATCTTCTGGTGCACGGCCGACGTAGGCTGGGTCACGGGGCACACTTAT
GTGACTTATGGTCCGCTCGCCGTCGGGGCGACCCAGATCATATTCGAAGGCGCGTTCCTACTTATCCTGACGCGGGTCGC
TTCTGGAAAATGA

Upstream 100 bases:

>100_bases
CGGCATGCGTAAACGGCGGATCGGCATGAAAAAACTTATTACAAAAAGCGTCGAATGATACAATTTATCAGCCCAAACAA
AAATATTCAGGGAGGTAGCT

Downstream 100 bases:

>100_bases
TCCAGGATCATAAGGTGACCACGTTTTATACCGCCCCCACTGCCATCCGCTCGCTTATAAAACTCGGACCCGACCTGCCG
AAACAATATGACCTTTCCTC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MATIQSILNETRTFTPSASFVEQANVSGMEEYDALCAEAEKDEAAFWSRLARDHISWHKPFTRVLDETNHPFFTWFDDGE
LNVSYNCLDRHQATQSDKVALIFEADDGTVTRCTYQDLYRRVCRFANGLKSLNIRKGDRVVIYMPMSIEAVVAMLACARI
GATHSVVFGGFSAKSLHERIIDAGAVAVITADEQWRGGKINYLKAVVEDALGRGETDSVKSVVVYQRGSGDLQLDANRDI
WWHDLIRDQSETCEPEWVNAEHPLFTLYTSGSTGKPKGVQHSSAGFLLGAITSMQWIFDYKSSDIFWCTADVGWVTGHTY
VTYGPLAVGATQIIFEGAFLLILTRVASGK

Sequences:

>Translated_350_residues
MATIQSILNETRTFTPSASFVEQANVSGMEEYDALCAEAEKDEAAFWSRLARDHISWHKPFTRVLDETNHPFFTWFDDGE
LNVSYNCLDRHQATQSDKVALIFEADDGTVTRCTYQDLYRRVCRFANGLKSLNIRKGDRVVIYMPMSIEAVVAMLACARI
GATHSVVFGGFSAKSLHERIIDAGAVAVITADEQWRGGKINYLKAVVEDALGRGETDSVKSVVVYQRGSGDLQLDANRDI
WWHDLIRDQSETCEPEWVNAEHPLFTLYTSGSTGKPKGVQHSSAGFLLGAITSMQWIFDYKSSDIFWCTADVGWVTGHTY
VTYGPLAVGATQIIFEGAFLLILTRVASGK
>Mature_349_residues
ATIQSILNETRTFTPSASFVEQANVSGMEEYDALCAEAEKDEAAFWSRLARDHISWHKPFTRVLDETNHPFFTWFDDGEL
NVSYNCLDRHQATQSDKVALIFEADDGTVTRCTYQDLYRRVCRFANGLKSLNIRKGDRVVIYMPMSIEAVVAMLACARIG
ATHSVVFGGFSAKSLHERIIDAGAVAVITADEQWRGGKINYLKAVVEDALGRGETDSVKSVVVYQRGSGDLQLDANRDIW
WHDLIRDQSETCEPEWVNAEHPLFTLYTSGSTGKPKGVQHSSAGFLLGAITSMQWIFDYKSSDIFWCTADVGWVTGHTYV
TYGPLAVGATQIIFEGAFLLILTRVASGK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=359, Percent_Identity=43.1754874651811, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI253970489, Length=372, Percent_Identity=41.3978494623656, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI28416953, Length=307, Percent_Identity=46.9055374592834, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI13375727, Length=311, Percent_Identity=39.2282958199357, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI31982927, Length=331, Percent_Identity=28.0966767371601, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI38505220, Length=211, Percent_Identity=27.0142180094787, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI122937307, Length=279, Percent_Identity=25.089605734767, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790505, Length=312, Percent_Identity=49.0384615384615, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1786529, Length=294, Percent_Identity=40.4761904761905, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI71983001, Length=345, Percent_Identity=36.5217391304348, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71982997, Length=343, Percent_Identity=36.734693877551, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323182, Length=314, Percent_Identity=45.5414012738853, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6319264, Length=335, Percent_Identity=43.8805970149254, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24667955, Length=351, Percent_Identity=45.8689458689459, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI62472339, Length=237, Percent_Identity=56.1181434599156, Blast_Score=263, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24667959, Length=207, Percent_Identity=54.5893719806763, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI21355225, Length=338, Percent_Identity=36.9822485207101, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 38964; Mature: 38833

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIQSILNETRTFTPSASFVEQANVSGMEEYDALCAEAEKDEAAFWSRLARDHISWHKP
CCHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCH
FTRVLDETNHPFFTWFDDGELNVSYNCLDRHQATQSDKVALIFEADDGTVTRCTYQDLYR
HHHHHHCCCCCEEEEEECCEEEEEEEEHHHHCCCCCCCEEEEEECCCCCEEEEEHHHHHH
RVCRFANGLKSLNIRKGDRVVIYMPMSIEAVVAMLACARIGATHSVVFGGFSAKSLHERI
HHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
IDAGAVAVITADEQWRGGKINYLKAVVEDALGRGETDSVKSVVVYQRGSGDLQLDANRDI
HCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEECCCCCC
WWHDLIRDQSETCEPEWVNAEHPLFTLYTSGSTGKPKGVQHSSAGFLLGAITSMQWIFDY
HHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEEEEE
KSSDIFWCTADVGWVTGHTYVTYGPLAVGATQIIFEGAFLLILTRVASGK
CCCCEEEEECCCCEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATIQSILNETRTFTPSASFVEQANVSGMEEYDALCAEAEKDEAAFWSRLARDHISWHKP
CHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCH
FTRVLDETNHPFFTWFDDGELNVSYNCLDRHQATQSDKVALIFEADDGTVTRCTYQDLYR
HHHHHHCCCCCEEEEEECCEEEEEEEEHHHHCCCCCCCEEEEEECCCCCEEEEEHHHHHH
RVCRFANGLKSLNIRKGDRVVIYMPMSIEAVVAMLACARIGATHSVVFGGFSAKSLHERI
HHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
IDAGAVAVITADEQWRGGKINYLKAVVEDALGRGETDSVKSVVVYQRGSGDLQLDANRDI
HCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEECCCCCC
WWHDLIRDQSETCEPEWVNAEHPLFTLYTSGSTGKPKGVQHSSAGFLLGAITSMQWIFDY
HHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEEEEE
KSSDIFWCTADVGWVTGHTYVTYGPLAVGATQIIFEGAFLLILTRVASGK
CCCCEEEEECCCCEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA