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The map label for this gene is acsA [H]

Identifier: 82702989

GI number: 82702989

Start: 2154508

End: 2155428

Strand: Direct

Name: acsA [H]

Synonym: Nmul_A1868

Alternate gene names: 82702989

Gene position: 2154508-2155428 (Clockwise)

Preceding gene: 82702988

Following gene: 82702990

Centisome position: 67.66

GC content: 56.13

Gene sequence:

>921_bases
ATGATCCAGGATCATAAGGTGACCACGTTTTATACCGCCCCCACTGCCATCCGCTCGCTTATAAAACTCGGACCCGACCT
GCCGAAACAATATGACCTTTCCTCATTGCGCCTGCTCGGTTCAGTGGGCGAACCGATCAACCCGGAAGCGTGGATGTGGT
ATTACACGACCGTTGGCCAATCCCGCTGTCCGTTGGTGGACACCTGGTGGCAAACCGAAACAGGCGCTCACATGATCGCC
CCCACGCCTGGAGCAGTAATGCTCAAGCCCGGTTCCTGCACTTTGCCGCTCCCCGGTATCAAAGCCGGTATCGTGGATGA
AGCCGGGCATGATGTGCCGGTAGGCAAAGGGGGGTTTCTCGTGATCAAGCGTCCGTTTCCTTCCCTGGCCCGCACCTTGT
GGGGAGATCCGGAACGCTTCAGAAATACCTATTTTCCCGAAGAGCTTGGCGGTAAATACTATCTCGCGGGAGATTCGGCT
CATCGCGATGCGGACGGCTATTTCTGGATCATGGGGCGCATCGACGATGTACTGACTGTTTCCGGCCACCGTTTAGGGAC
AATGGAAATCGAATCGGCGCTGGTAGCGAGCCCCTTGGTTGCTGAAGCCGCGGTGGTAGGCAAGCCGGATGAAATCAAAA
CCGAGGCCATCGTGGCTTTCGTGGTATTGAAAGGGGCTCGCCCGAAAGCAGAGGACGCTCATCGCATTGTGCAGGAATTG
CGCAATTGGGTATCGCAGGAGATCGGCCCCATCGCCCGGCCTGATGAAATCCGTTTTGGGGATAACCTGCCGAAAACCAG
GTCCGGCAAAATCATGCGCCGGTTGTTGCGCACGCTGGCAAGGGATGAAGAAATAACTCAGGATGTATCCACCCTGGAAA
ACCCGGCGATACTTGAACAATTGAAACAGGCGGTAGCGTAG

Upstream 100 bases:

>100_bases
GGCACACTTATGTGACTTATGGTCCGCTCGCCGTCGGGGCGACCCAGATCATATTCGAAGGCGCGTTCCTACTTATCCTG
ACGCGGGTCGCTTCTGGAAA

Downstream 100 bases:

>100_bases
TTGGGGAATCTGCGTCTCGGCCGGTTGCATGATGACGCGCGATCTTCATCGGACGTCGAGCCTGGAATGACCTCATCGCT
TTCTATTTTGCCTCCGCACA

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIQDHKVTTFYTAPTAIRSLIKLGPDLPKQYDLSSLRLLGSVGEPINPEAWMWYYTTVGQSRCPLVDTWWQTETGAHMIA
PTPGAVMLKPGSCTLPLPGIKAGIVDEAGHDVPVGKGGFLVIKRPFPSLARTLWGDPERFRNTYFPEELGGKYYLAGDSA
HRDADGYFWIMGRIDDVLTVSGHRLGTMEIESALVASPLVAEAAVVGKPDEIKTEAIVAFVVLKGARPKAEDAHRIVQEL
RNWVSQEIGPIARPDEIRFGDNLPKTRSGKIMRRLLRTLARDEEITQDVSTLENPAILEQLKQAVA

Sequences:

>Translated_306_residues
MIQDHKVTTFYTAPTAIRSLIKLGPDLPKQYDLSSLRLLGSVGEPINPEAWMWYYTTVGQSRCPLVDTWWQTETGAHMIA
PTPGAVMLKPGSCTLPLPGIKAGIVDEAGHDVPVGKGGFLVIKRPFPSLARTLWGDPERFRNTYFPEELGGKYYLAGDSA
HRDADGYFWIMGRIDDVLTVSGHRLGTMEIESALVASPLVAEAAVVGKPDEIKTEAIVAFVVLKGARPKAEDAHRIVQEL
RNWVSQEIGPIARPDEIRFGDNLPKTRSGKIMRRLLRTLARDEEITQDVSTLENPAILEQLKQAVA
>Mature_306_residues
MIQDHKVTTFYTAPTAIRSLIKLGPDLPKQYDLSSLRLLGSVGEPINPEAWMWYYTTVGQSRCPLVDTWWQTETGAHMIA
PTPGAVMLKPGSCTLPLPGIKAGIVDEAGHDVPVGKGGFLVIKRPFPSLARTLWGDPERFRNTYFPEELGGKYYLAGDSA
HRDADGYFWIMGRIDDVLTVSGHRLGTMEIESALVASPLVAEAAVVGKPDEIKTEAIVAFVVLKGARPKAEDAHRIVQEL
RNWVSQEIGPIARPDEIRFGDNLPKTRSGKIMRRLLRTLARDEEITQDVSTLENPAILEQLKQAVA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI253970489, Length=305, Percent_Identity=49.8360655737705, Blast_Score=301, Evalue=4e-82,
Organism=Homo sapiens, GI8923896, Length=305, Percent_Identity=49.8360655737705, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI28416953, Length=305, Percent_Identity=49.1803278688525, Blast_Score=267, Evalue=7e-72,
Organism=Homo sapiens, GI13375727, Length=314, Percent_Identity=35.3503184713376, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI122937307, Length=277, Percent_Identity=36.4620938628159, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI42544132, Length=280, Percent_Identity=34.6428571428571, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI38505220, Length=279, Percent_Identity=36.2007168458781, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI115511026, Length=217, Percent_Identity=35.9447004608295, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI58082049, Length=281, Percent_Identity=31.3167259786477, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI157311624, Length=281, Percent_Identity=30.2491103202847, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI157311622, Length=281, Percent_Identity=30.2491103202847, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI187761345, Length=233, Percent_Identity=30.4721030042918, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI187761343, Length=233, Percent_Identity=30.4721030042918, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI156151445, Length=278, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI195947378, Length=182, Percent_Identity=30.2197802197802, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1790505, Length=311, Percent_Identity=54.6623794212219, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1786529, Length=316, Percent_Identity=36.7088607594937, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1788107, Length=273, Percent_Identity=30.4029304029304, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI221142682, Length=283, Percent_Identity=24.3816254416961, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786810, Length=286, Percent_Identity=24.8251748251748, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI145693145, Length=293, Percent_Identity=24.9146757679181, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=298, Percent_Identity=45.6375838926174, Blast_Score=236, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71982997, Length=298, Percent_Identity=45.6375838926174, Blast_Score=236, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17569507, Length=281, Percent_Identity=24.5551601423488, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=136, Percent_Identity=33.0882352941176, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=270, Percent_Identity=24.0740740740741, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17557194, Length=129, Percent_Identity=32.5581395348837, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=321, Percent_Identity=47.3520249221184, Blast_Score=275, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6319264, Length=313, Percent_Identity=46.6453674121406, Blast_Score=275, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6319699, Length=273, Percent_Identity=25.2747252747253, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667955, Length=303, Percent_Identity=48.8448844884488, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI62472339, Length=303, Percent_Identity=48.8448844884488, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24667959, Length=303, Percent_Identity=48.8448844884488, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI21355225, Length=313, Percent_Identity=30.9904153354633, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI21355181, Length=286, Percent_Identity=25.8741258741259, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859661, Length=153, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=194, Percent_Identity=26.8041237113402, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922652, Length=289, Percent_Identity=24.2214532871972, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581924, Length=211, Percent_Identity=31.2796208530806, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 33779; Mature: 33779

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQDHKVTTFYTAPTAIRSLIKLGPDLPKQYDLSSLRLLGSVGEPINPEAWMWYYTTVGQ
CCCCCEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCC
SRCPLVDTWWQTETGAHMIAPTPGAVMLKPGSCTLPLPGIKAGIVDEAGHDVPVGKGGFL
CCCCEEECCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VIKRPFPSLARTLWGDPERFRNTYFPEELGGKYYLAGDSAHRDADGYFWIMGRIDDVLTV
EEECCCHHHHHHHCCCHHHHHCCCCHHHHCCEEEEECCCCCCCCCCEEEEEECCCCEEEE
SGHRLGTMEIESALVASPLVAEAAVVGKPDEIKTEAIVAFVVLKGARPKAEDAHRIVQEL
CCCEECHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHEEHHCCCCCCCHHHHHHHHHHH
RNWVSQEIGPIARPDEIRFGDNLPKTRSGKIMRRLLRTLARDEEITQDVSTLENPAILEQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
LKQAVA
HHHHCC
>Mature Secondary Structure
MIQDHKVTTFYTAPTAIRSLIKLGPDLPKQYDLSSLRLLGSVGEPINPEAWMWYYTTVGQ
CCCCCEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCC
SRCPLVDTWWQTETGAHMIAPTPGAVMLKPGSCTLPLPGIKAGIVDEAGHDVPVGKGGFL
CCCCEEECCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
VIKRPFPSLARTLWGDPERFRNTYFPEELGGKYYLAGDSAHRDADGYFWIMGRIDDVLTV
EEECCCHHHHHHHCCCHHHHHCCCCHHHHCCEEEEECCCCCCCCCCEEEEEECCCCEEEE
SGHRLGTMEIESALVASPLVAEAAVVGKPDEIKTEAIVAFVVLKGARPKAEDAHRIVQEL
CCCEECHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHEEHHCCCCCCCHHHHHHHHHHH
RNWVSQEIGPIARPDEIRFGDNLPKTRSGKIMRRLLRTLARDEEITQDVSTLENPAILEQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
LKQAVA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA